Ulla Knorr

Summary

Affiliation: Copenhagen University Hospital
Country: Denmark

Publications

  1. pmc Rationale and design of the participant, investigator, observer, and data-analyst-blinded randomized AGENDA trial on associations between gene-polymorphisms, endophenotypes for depression and antidepressive intervention: the effect of escitalopram versus
    Ulla Knorr
    Department of Psychiatry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Trials 10:66. 2009
  2. doi The effect of selective serotonin reuptake inhibitors in healthy subjects. A systematic review
    Ulla Knorr
    Department of Psychiatry, University Hospital of Copenhagen, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
    Nord J Psychiatry 64:153-63. 2010
  3. doi Salivary cortisol in depressed patients versus control persons: a systematic review and meta-analysis
    Ulla Knorr
    Department of Psychiatry, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark
    Psychoneuroendocrinology 35:1275-86. 2010
  4. doi The effect of escitalopram versus placebo on perceived stress and salivary cortisol in healthy first-degree relatives of patients with depression-A randomised trial
    Ulla Knorr
    Psychiatric Centre Copenhagen, Rigshospitalet, Copenhagen University Hospital, Denmark
    Psychiatry Res 200:354-60. 2012
  5. pmc Effect of chronic escitalopram versus placebo on personality traits in healthy first-degree relatives of patients with depression: a randomized trial
    Ulla Knorr
    Psychiatric Centre Copenhagen, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark
    PLoS ONE 7:e31980. 2012
  6. doi Effect of escitalopram versus placebo on GRα messenger RNA expression in peripheral blood cells of healthy individuals with a family history of depression - a secondary outcome analysis from the randomized AGENDA trial
    Ulla Knorr
    a Psychiatric Centre Copenhagen, Rigshospitalet, Copenhagen University Hospital, Denmark
    Nord J Psychiatry 70:297-302. 2016
  7. pmc Escitalopram and neuroendocrine response in healthy first-degree relatives to depressed patients--a randomized placebo-controlled trial
    Ulla Knorr
    Department of Psychiatry Copenhagen, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    PLoS ONE 6:e21224. 2011
  8. doi No effect of escitalopram versus placebo on brain-derived neurotrophic factor in healthy individuals: a randomised trial
    Ulla Knorr
    1Psychiatric Centre Copenhagen, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Acta Neuropsychiatr 28:101-9. 2016
  9. doi Cognitive deficits in the remitted state of unipolar depressive disorder
    Bo Jacob Hasselbalch
    Psychiatric Centre Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark
    Neuropsychology 26:642-51. 2012
  10. doi No evidence for an anti-inflammatory effect of escitalopram intervention in healthy individuals with a family history of depression
    Eva Haastrup
    Department of Clinical Immunology, Blood Bank, National University Hospital, Copenhagen, Denmark
    J Neuroimmunol 243:69-72. 2012

Collaborators

Detail Information

Publications18

  1. pmc Rationale and design of the participant, investigator, observer, and data-analyst-blinded randomized AGENDA trial on associations between gene-polymorphisms, endophenotypes for depression and antidepressive intervention: the effect of escitalopram versus
    Ulla Knorr
    Department of Psychiatry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Trials 10:66. 2009
    ..The primary outcome measure is the change in plasma cortisol in the dexamethasone-corticotrophin releasing hormone test from baseline to the end of intervention...
  2. doi The effect of selective serotonin reuptake inhibitors in healthy subjects. A systematic review
    Ulla Knorr
    Department of Psychiatry, University Hospital of Copenhagen, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
    Nord J Psychiatry 64:153-63. 2010
    ....
  3. doi Salivary cortisol in depressed patients versus control persons: a systematic review and meta-analysis
    Ulla Knorr
    Department of Psychiatry, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark
    Psychoneuroendocrinology 35:1275-86. 2010
    ..Based on the available studies there is not firm evidence for a difference of salivary cortisol in depressed patients and control persons and salivary cortisol is unable to discriminate between persons with and without depression...
  4. doi The effect of escitalopram versus placebo on perceived stress and salivary cortisol in healthy first-degree relatives of patients with depression-A randomised trial
    Ulla Knorr
    Psychiatric Centre Copenhagen, Rigshospitalet, Copenhagen University Hospital, Denmark
    Psychiatry Res 200:354-60. 2012
    ..However, change in salivary cortisol was one out of multiple outcome measures. The results of the present trial do not refute salivary cortisol as a potential endophenotype for depression...
  5. pmc Effect of chronic escitalopram versus placebo on personality traits in healthy first-degree relatives of patients with depression: a randomized trial
    Ulla Knorr
    Psychiatric Centre Copenhagen, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark
    PLoS ONE 7:e31980. 2012
    ..The present trial is the first to test the hypothesis that escitalopram may reduce neuroticism in healthy first-degree relatives of patients with major depressive disorder (MD)...
  6. doi Effect of escitalopram versus placebo on GRα messenger RNA expression in peripheral blood cells of healthy individuals with a family history of depression - a secondary outcome analysis from the randomized AGENDA trial
    Ulla Knorr
    a Psychiatric Centre Copenhagen, Rigshospitalet, Copenhagen University Hospital, Denmark
    Nord J Psychiatry 70:297-302. 2016
    ..The decrease in GRα mRNA expression levels may reflect a decrease in the HPA axis activity...
  7. pmc Escitalopram and neuroendocrine response in healthy first-degree relatives to depressed patients--a randomized placebo-controlled trial
    Ulla Knorr
    Department of Psychiatry Copenhagen, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    PLoS ONE 6:e21224. 2011
    ....
  8. doi No effect of escitalopram versus placebo on brain-derived neurotrophic factor in healthy individuals: a randomised trial
    Ulla Knorr
    1Psychiatric Centre Copenhagen, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Acta Neuropsychiatr 28:101-9. 2016
    ..We aimed to study the effect of an antidepressant intervention on peripheral BDNF in healthy individuals with a family history of depression...
  9. doi Cognitive deficits in the remitted state of unipolar depressive disorder
    Bo Jacob Hasselbalch
    Psychiatric Centre Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark
    Neuropsychology 26:642-51. 2012
    ..Patients with unipolar depressive disorder may present with cognitive deficits in the remitted state, and the aim of the present study was to investigate whether cognitive deficits within specific cognitive domains are present...
  10. doi No evidence for an anti-inflammatory effect of escitalopram intervention in healthy individuals with a family history of depression
    Eva Haastrup
    Department of Clinical Immunology, Blood Bank, National University Hospital, Copenhagen, Denmark
    J Neuroimmunol 243:69-72. 2012
    ..Our data does thus not support the hypothesis of a global anti-inflammatory effect of escitalopram on cytokines in healthy subjects...
  11. doi Discrete neurocognitive subgroups in fully or partially remitted bipolar disorder: Associations with functional abilities
    Johan Høy Jensen
    Psychiatric Centre Copenhagen, Copenhagen University Hospital, Rigshospitalet Department 6233, Blegdamsvej 9, DK 2100 Copenhagen, Denmark Electronic address
    J Affect Disord 205:378-386. 2016
    ..Neurocognitive impairment in remitted patients with bipolar disorder contributes to functional disabilities. However, the pattern and impact of these deficits are unclear...
  12. doi Differences in psychomotor activity in patients suffering from unipolar and bipolar affective disorder in the remitted or mild/moderate depressive state
    Maria Faurholt-Jepsen
    The Copenhagen Affective Disorder Clinic, Psychiatric Centre Copenhagen, Rigshospitalet, Denmark
    J Affect Disord 141:457-63. 2012
    ..Studies measuring differences in psychomotor activity between unipolar and bipolar disorder show divergent results and none have used a combined heart rate and movement monitor for measuring activity during free-living conditions...
  13. doi Impaired down-regulation of negative emotion in self-referent social situations in bipolar disorder: A pilot study of a novel experimental paradigm
    Hanne L Kjærstad
    Psychiatric Centre Copenhagen, Copenhagen University Hospital, Rigshospitalet, Dep 6233, Blegdamsvej 9, DK 2100 Rigshospitalet, Copenhagen, Denmark
    Psychiatry Res 238:318-25. 2016
    ..Findings highlight the novel social scenario paradigm as a sensitive test for detection of ER difficulties in BD...
  14. doi Cognitive impairment in the remitted state of unipolar depressive disorder: a systematic review
    Bo Jacob Hasselbalch
    Department of Psychiatry, University Hospital of Copenhagen, Rigshospitalet, Denmark
    J Affect Disord 134:20-31. 2011
    ..It is unclear whether cognitive impairment is prevalent in the remitted state of unipolar disorder...
  15. doi The BDNF Val66Met polymorphism: relation to familiar risk of affective disorder, BDNF levels and salivary cortisol
    Maj Vinberg
    Department of Psychiatry, Rigshospitalet, University Hospital of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Psychoneuroendocrinology 34:1380-9. 2009
    ..The aim of the present study was to investigate whether the BDNF Val66Met polymorphism is associated with a familiar risk of affective disorder and whether these genotypes affect whole blood BDNF level and salivary cortisol...
  16. doi Optimising screening for cognitive dysfunction in bipolar disorder: Validation and evaluation of objective and subjective tools
    Johan Høy Jensen
    Psychiatric Centre Copenhagen, Copenhagen University Hospital, Rigshospitalet Dep 6233, Blegdamsvej 9, DK 2100, Copenhagen, Denmark
    J Affect Disord 187:10-9. 2015
    ..The objective was to validate and evaluate instruments to screen for and monitor cognitive impairments, and improve the understanding of the association between cognitive measures and socio-occupational capacity...
  17. doi Volume of the adrenal and pituitary glands in depression
    Lars Vedel Kessing
    Department of Psychiatry, University of Copenhagen, Rigshospitalet, Denmark
    Psychoneuroendocrinology 36:19-27. 2011
    ....
  18. pmc Familial risk for major depression is associated with lower striatal 5-HT₄ receptor binding
    Karine Madsen
    Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark Drs Madsen, Torstensen, Holst, Haahr, Frokjaer, Fisher, and Knudsen Center for Integrated Molecular Brain Imaging, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark Drs Madsen, Holst, Haahr, Frokjaer, Iversen, Fisher, and Knudsen Department of Biostatistics, University of Copenhagen, Denmark Dr Holst Psychiatric Centre Copenhagen, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark Dr Knorr PET and Cyclotron Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark Dr Brandt Larsen Center for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark Dr Iversen
    Int J Neuropsychopharmacol 18:. 2014
    ..The aim of this study was to determine whether familial risk for MDD is associated with cerebral 5-HT4 receptor binding as measured with [(11)C]SB207145 brain PET imaging. Familial risk is the most potent risk factor of MDD...