C Gluud

Summary

Affiliation: Copenhagen Trial Unit
Country: Denmark

Publications

  1. ncbi [Evidence-based clinical practice]
    Christian Gluud
    Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, H S Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 24:541-7. 2002
  2. ncbi The culture of designing hepato-biliary randomised trials
    Christian Gluud
    The Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Department 7102, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, DK 2100 Copenhagen, Denmark
    J Hepatol 44:607-15. 2006
  3. pmc Clarithromycin for 2 weeks for stable coronary heart disease: 6-year follow-up of the CLARICOR randomized trial and updated meta-analysis of antibiotics for coronary heart disease
    Christian Gluud
    The Copenhagen Trial Unit, Center for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Cardiology 111:280-7. 2008
  4. ncbi Ursodeoxycholic acid for primary biliary cirrhosis
    C Gluud
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital, H S Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark, DK 2100
    Cochrane Database Syst Rev . 2002
  5. pmc Constraint-induced movement therapy: trial sequential analysis applied to Cochrane collaboration systematic review results
    Greta Castellini
    Health Professional Science of Rehabilitation, University of Milan, Via Festa del Perdono, 7, 20122 Milan, Italy
    Trials 15:512. 2014
  6. pmc The DiaS trial: dialectical behavior therapy versus collaborative assessment and management of suicidality on self-harm in patients with a recent suicide attempt and borderline personality disorder traits - study protocol for a randomized controlled trial
    Kate Andreasson
    Mental Health Centre Copenhagen, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark
    Trials 15:194. 2014
  7. pmc Likely country of origin in publications on randomised controlled trials and controlled clinical trials during the last 60 years
    Christian Gluud
    The Cochrane Hepato Biliary Group, The Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark
    Trials 8:7. 2007
  8. pmc A phase II randomized clinical trial on cerebral near-infrared spectroscopy plus a treatment guideline versus treatment as usual for extremely preterm infants during the first three days of life (SafeBoosC): study protocol for a randomized controlled tria
    Simon Hyttel-Sorensen
    Department of Neonatology, Rigshospitalet, Blegdamsvej 9, Copenhagen DK 2100, Denmark
    Trials 14:120. 2013
  9. pmc The Nordic aortic valve intervention (NOTION) trial comparing transcatheter versus surgical valve implantation: study protocol for a randomised controlled trial
    Hans Gustav Thyregod
    Department of Cardiothoracic Surgery, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Denmark
    Trials 14:11. 2013
  10. pmc 'Third wave' cognitive therapy versus mentalization-based therapy for major depressive disorder. A protocol for a randomised clinical trial
    Janus Christian Jakobsen
    Psychiatric Research Unit, Copenhagen University Hospital and Region Zealand, Roskilde, Denmark
    BMC Psychiatry 12:232. 2012

Detail Information

Publications128 found, 100 shown here

  1. ncbi [Evidence-based clinical practice]
    Christian Gluud
    Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, H S Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 24:541-7. 2002
    ..By investments in education, applied research, and The Cochrane Collaboration, evidence-based medicine may form a stronger basis for clinical practice...
  2. ncbi The culture of designing hepato-biliary randomised trials
    Christian Gluud
    The Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Department 7102, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, DK 2100 Copenhagen, Denmark
    J Hepatol 44:607-15. 2006
  3. pmc Clarithromycin for 2 weeks for stable coronary heart disease: 6-year follow-up of the CLARICOR randomized trial and updated meta-analysis of antibiotics for coronary heart disease
    Christian Gluud
    The Copenhagen Trial Unit, Center for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Cardiology 111:280-7. 2008
    ..Here we report the 6-year mortality of clarithromycin- versus placebo-exposed patients and updated meta-analyses...
  4. ncbi Ursodeoxycholic acid for primary biliary cirrhosis
    C Gluud
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital, H S Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark, DK 2100
    Cochrane Database Syst Rev . 2002
    ..Primary biliary cirrhosis is a rare autoimmune liver disease and an effective treatment has been difficult to establish. Some randomised clinical trials have found an effect of ursodeoxycholic acid for primary biliary cirrhosis...
  5. pmc Constraint-induced movement therapy: trial sequential analysis applied to Cochrane collaboration systematic review results
    Greta Castellini
    Health Professional Science of Rehabilitation, University of Milan, Via Festa del Perdono, 7, 20122 Milan, Italy
    Trials 15:512. 2014
    ..Our aim was to demonstrate TSA results on randomized controlled trials (RCTs) included in a Cochrane systematic review on the effectiveness of constraint-induced movement therapy (CIMT) for stroke patients...
  6. pmc The DiaS trial: dialectical behavior therapy versus collaborative assessment and management of suicidality on self-harm in patients with a recent suicide attempt and borderline personality disorder traits - study protocol for a randomized controlled trial
    Kate Andreasson
    Mental Health Centre Copenhagen, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark
    Trials 15:194. 2014
    ..Both treatments have previously shown effects in this group of patients on suicide ideation and self-harm compared with treatment as usual...
  7. pmc Likely country of origin in publications on randomised controlled trials and controlled clinical trials during the last 60 years
    Christian Gluud
    The Cochrane Hepato Biliary Group, The Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark
    Trials 8:7. 2007
    ..The number of publications on clinical trials is unknown as well as the countries publishing most trial reports. To try to examine these questions we performed an ecological study...
  8. pmc A phase II randomized clinical trial on cerebral near-infrared spectroscopy plus a treatment guideline versus treatment as usual for extremely preterm infants during the first three days of life (SafeBoosC): study protocol for a randomized controlled tria
    Simon Hyttel-Sorensen
    Department of Neonatology, Rigshospitalet, Blegdamsvej 9, Copenhagen DK 2100, Denmark
    Trials 14:120. 2013
    ....
  9. pmc The Nordic aortic valve intervention (NOTION) trial comparing transcatheter versus surgical valve implantation: study protocol for a randomised controlled trial
    Hans Gustav Thyregod
    Department of Cardiothoracic Surgery, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Denmark
    Trials 14:11. 2013
    ..Whether transcatheter aortic valve implantation (TAVI) can be offered with improved safety and similar effectiveness in a population including low-risk patients has yet to be examined in a randomised setting...
  10. pmc 'Third wave' cognitive therapy versus mentalization-based therapy for major depressive disorder. A protocol for a randomised clinical trial
    Janus Christian Jakobsen
    Psychiatric Research Unit, Copenhagen University Hospital and Region Zealand, Roskilde, Denmark
    BMC Psychiatry 12:232. 2012
    ..No randomised trial has compared the effects of these two interventions for patients with major depression...
  11. pmc Instructor feedback versus no instructor feedback on performance in a laparoscopic virtual reality simulator: a randomized educational trial
    Jeanett Oestergaard
    Department of Obstetrics and Gynecology, Juliane Marie Centre, Centre for Women, Children and Reproduction, Rigshospitalet, University Hospital of Copenhagen, Blegdamsvej 9, Copenhagen 2100, Denmark
    BMC Med Educ 12:7. 2012
    ..The purpose of this trial is to investigate the impact of instructor feedback regarding time, repetitions and self-perception when training complex operational tasks on a virtual reality simulator...
  12. pmc Typical investigational medicinal products follow relatively uniform regulations in 10 European Clinical Research Infrastructures Network (ECRIN) countries
    Christian Gluud
    Copenhagen Trial Unit CTU, Centre for Clinical Intervention Research, and the Danish Clinical Research Infrastructures Network DCRIN, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Trials 13:27. 2012
    ..In order to facilitate multinational clinical research, regulatory requirements need to become international and harmonised. The EU introduced the Directive 2001/20/EC in 2004, regulating investigational medicinal products in Europe...
  13. pmc The effect of five years versus two years of specialised assertive intervention for first episode psychosis - OPUS II: study protocol for a randomized controlled trial
    Marianne Melau
    Psychiatric Centre Copenhagen, Copenhagen University, Faculty of Health Sciences, Copenhagen, Denmark
    Trials 12:72. 2011
    ..The major objective of the OPUS II trial is to evaluate the effects of five years of OPUS treatment versus two years of OPUS treatment...
  14. pmc Cognitive training plus a comprehensive psychosocial programme (OPUS) versus the comprehensive psychosocial programme alone for patients with first-episode schizophrenia (the NEUROCOM trial): a study protocol for a centrally randomised, observer-blinded m
    Lone Vesterager
    Psychiatric Centre Copenhagen, Copenhagen University Hospital, DK 2400, Copenhagen, Denmark
    Trials 12:35. 2011
    ..It is hypothesized that addition of cognitive training to a comprehensive psychosocial programme (OPUS) enhances both cognitive and everyday functional capacity of patients more than the comprehensive psychosocial programme alone...
  15. pmc Randomised social-skills training and parental training plus standard treatment versus standard treatment of children with attention deficit hyperactivity disorder - the SOSTRA trial protocol
    Ole Jakob Storebø
    Child Psychiatric Daytime Clinic, Child and Adolescent Psychiatric Centre, Region Zealand, Holbaek, Denmark
    Trials 12:18. 2011
    ..Social-skills training may benefit ADHD children in their social interactions. We want to examine the effects of social-skills training on difficulties related to the children's ADHD symptoms and social interactions...
  16. pmc The effects of centralised and specialised combined pharmacological and psychological intervention compared with decentralised and non-specialised treatment in the early course of severe unipolar and bipolar affective disorders--design of two randomised c
    Lars Vedel Kessing
    Mood Disorder Clinic, Psychiatric Centre Copenhagen, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Trials 12:32. 2011
    ..It is not known whether centralised and specialised secondary care intervention initiated early after the onset of the diseases can prevent the progression and thereby improve the prognosis...
  17. pmc Common definition for categories of clinical research: a prerequisite for a survey on regulatory requirements by the European Clinical Research Infrastructures Network (ECRIN)
    Christine Kubiak
    Institut Thématique Santé Publique, Institut National de la Sante et de la Recherche Medicale INSERM, Paris, France
    Trials 10:95. 2009
    ..Thorough knowledge of the regulatory requirements is a challenging prerequisite for conducting multinational clinical studies in Europe given their complexity and heterogeneity in regulation and perception across the EU member states...
  18. pmc Rationale and design of the participant, investigator, observer, and data-analyst-blinded randomized AGENDA trial on associations between gene-polymorphisms, endophenotypes for depression and antidepressive intervention: the effect of escitalopram versus
    Ulla Knorr
    Department of Psychiatry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Trials 10:66. 2009
    ..The primary outcome measure is the change in plasma cortisol in the dexamethasone-corticotrophin releasing hormone test from baseline to the end of intervention...
  19. pmc Compassionate use of interventions: results of a European Clinical Research Infrastructures Network (ECRIN) survey of ten European countries
    Kate Whitfield
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital DCRIN, Copenhagen, DK 2100, Denmark
    Trials 11:104. 2010
    ..We sought to understand how such programmes are regulated in ten European Union countries...
  20. pmc Prolonged-release melatonin versus placebo for benzodiazepine discontinuation in patients with schizophrenia: a randomized clinical trial - the SMART trial protocol
    Lone Baandrup
    Center for Neuropsychiatric Schizophrenia Research CNSR and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research CINS, University of Copenhagen, Mental Health Centre Glostrup, Mental Health Services Capital Region of Denmark, Glostrup, Denmark
    BMC Psychiatry 11:160. 2011
    ..Furthermore, we aim to investigate the association of benzodiazepine dose reduction with the following clinically important variables: sleep, psychophysiology, cognition, social function, and quality of life...
  21. pmc Estimating required information size by quantifying diversity in random-effects model meta-analyses
    Jørn Wetterslev
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 3344, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    BMC Med Res Methodol 9:86. 2009
    ..The required information size in a meta-analysis may be calculated from an anticipated a priori intervention effect or from an intervention effect suggested by trials with low-risk of bias...
  22. pmc Evidence at a glance: error matrix approach for overviewing available evidence
    Frederik Keus
    The Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    BMC Med Res Methodol 10:90. 2010
    ..We aimed at conceptualizing a visual assessment tool, i.e., a matrix for overviewing studies and their data in order to assess the clinical evidence at a glance...
  23. pmc The Hand Eczema Trial (HET): Design of a randomised clinical trial of the effect of classification and individual counselling versus no intervention among health-care workers with hand eczema
    Kristina Sophie Ibler
    Department of Dermatology, Roskilde Hospital, Roskilde, Denmark
    BMC Dermatol 10:8. 2010
    ..32 per 1000 person-years. Consequences of hand eczema include chronic severe eczema, prolonged sick leave, unemployment, and impaired quality of life. New preventive strategies are needed to reduce occupational hand eczema...
  24. ncbi Hepatology may have problems with putative surrogate outcome measures
    Christian Gluud
    The Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, DK 2100 Copenhagen, Denmark
    J Hepatol 46:734-42. 2007
    ..The challenge is to develop reliable surrogates, both to facilitate the development of new interventions and to ensure our patients and us that these interventions are effective clinically...
  25. ncbi [The GCP directive--consequences for clinical drug research]
    Christian N Gluud
    Copenhagen Trial Unit, Center for Klinisk Interventionsforskning, Afsnit 7102, H S Rigshospitalet, Blegdamsvej 9, DK 2100 København Ø
    Ugeskr Laeger 165:1662-4. 2003
    ..Patients will be assured the same quality in trials irrespective of the industry or investigator being the sponsor and may look forward to quality improvement of drug trials...
  26. pmc Evidence based diagnostics
    Christian Gluud
    Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, H S Rigshospitalet, Copenhagen University Hospital, DK 2100 Copenhagen, Denmark
    BMJ 330:724-6. 2005
  27. pmc Mortality from cirrhosis: lack of progress over the last 35 years
    C Gluud
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 7102, Rigshospitalet, Copenhagen University Hospital, DK 2100 Copenhagen, Denmark
    Gut 54:1523-6. 2005
  28. doi Meta-analysis: antioxidant supplements for liver diseases - the Cochrane Hepato-Biliary Group
    G Bjelakovic
    Centre for Clinical Intervention Research, Copenhagen University Hospital, Rigshospitalet, Denmark
    Aliment Pharmacol Ther 32:356-67. 2010
    ..Several liver diseases have been associated with oxidative stress. Accordingly, antioxidants have been suggested as potential therapeutics for various liver diseases. The evidence supporting these suggestions is equivocal...
  29. ncbi Funding, disease area, and internal validity of hepatobiliary randomized clinical trials
    Lise Lotte Kjaergard
    The Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital, Rigshospitalet, Denmark
    Am J Gastroenterol 97:2708-13. 2002
    ..The aim of this study was to assess whether funding and the disease area are related to the internal validity of hepatobiliary randomized clinical trials...
  30. ncbi Colchicine for alcoholic and non-alcoholic liver fibrosis or cirrhosis
    A Rambaldi
    The Cochrane Hepato-Biliary Group, The Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital, H:S Kommunehospitalet, Copenhagen, Denmark
    Liver 21:129-36. 2001
    ..41; CI 2.24, 8.70; p< 0.001). CONCLUSIONS: Colchicine should not be used for liver fibrosis or liver cirrhosis irrespective of etiology. Future trials on colchicine for liver diseases ought to be large...
  31. ncbi The journal impact factor as a predictor of trial quality and outcomes: cohort study of hepatobiliary randomized clinical trials
    Lise L Gluud
    The Cochrane Hepato Biliary Group, The Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen, Denmark
    Am J Gastroenterol 100:2431-5. 2005
    ..To examine the association between the impact factor and characteristics of hepatobiliary randomized clinical trials...
  32. ncbi Cochrane systematic review: pegylated interferon plus ribavirin vs. interferon plus ribavirin for chronic hepatitis C
    M Simin
    The Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Aliment Pharmacol Ther 25:1153-62. 2007
    ..About 170 million patients worldwide have chronic hepatitis C. Pegylated interferon plus ribavirin is currently the recommended therapy...
  33. ncbi Meta-analysis: ribavirin plus interferon vs. interferon monotherapy for chronic hepatitic C - an updated Cochrane review
    J Brok
    Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Denmark
    Aliment Pharmacol Ther 32:840-50. 2010
    ..Multiple randomized trials have been published on antiviral treatment for chronic hepatitis C...
  34. pmc Interferon alfa with or without ribavirin for chronic hepatitis C: systematic review of randomised trials
    L L Kjaergard
    Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Center for Clinical Research, Rigshospitalet, DK 2100, Copenhagen, Denmark
    BMJ 323:1151-5. 2001
    ..To assess the efficacy and safety of interferon alfa with or without ribavirin for treatment of chronic hepatitis C...
  35. ncbi The Best Bypass Surgery Trial: rationale and design of a randomized clinical trial with blinded outcome assessment of conventional versus off-pump coronary artery bypass grafting
    Christian H Møller
    Department of Cardiothoracic Surgery, The Heart Center, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Contemp Clin Trials 28:540-7. 2007
    ..Patients with a moderate- to high-risk of complications after CCAB may have additional benefit from OPCAB...
  36. doi Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases
    G Bjelakovic
    Copenhagen University Hospital, Rigshospitalet, Department 3344, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Blegdamsvej 9, Copenhagen, Denmark, DK 2100
    Cochrane Database Syst Rev . 2008
    ..Animal and physiological research as well as observational studies suggest that antioxidant supplements may improve survival...
  37. doi Compliance with and short-term adverse events from clarithromycin versus placebo in patients with stable coronary heart disease: the CLARICOR trial
    C M Jespersen
    The Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Antimicrob Chemother 64:411-5. 2009
    ....
  38. pmc ExStroke Pilot Trial of the effect of repeated instructions to improve physical activity after ischaemic stroke: a multinational randomised controlled clinical trial
    Gudrun Boysen
    Department of Neurology, Bispebjerg Hospital, Copenhagen University Hospital, Bispebjerg Bakke 23, DK 2400 Copenhagen NV, Denmark
    BMJ 339:b2810. 2009
    ..To investigate if repeated verbal instructions about physical activity to patients with ischaemic stroke could increase long term physical activity...
  39. ncbi Reported methodologic quality and discrepancies between large and small randomized trials in meta-analyses
    L L Kjaergard
    Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Center for Clinical Intervention Research, Copenhagen University Hospital, H S Rigshospitalet, DK 2100 Copenhagen, Denmark
    Ann Intern Med 135:982-9. 2001
    ..To explore whether reported methodologic quality affects estimated intervention effects in randomized trials and contributes to discrepancies between the results of large randomized trials and small randomized trials in meta-analyses...
  40. ncbi Quality assessment of reports on clinical trials in the Journal of Hepatology
    C Gluud
    The Copenhagen Trial Unit, Institute of Preventive Medicine, Copenhagen University Hospital, Denmark
    J Hepatol 29:321-7. 1998
    ..The aims were to identify all fully reported randomised clinical trials in the Journal of Hepatology and to make a qualitative assessment of the reporting...
  41. ncbi Misuse of randomization: a review of Chinese randomized trials of herbal medicines for chronic hepatitis B
    Jianping Liu
    The Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital, H S Rigshospitalet, Denmark
    Am J Chin Med 30:173-6. 2002
    ..05 level of probability for the two treatments and 13.3% (20/150) imbalanced at the 0.01 level in the randomization. It is suggested that there may exist misunderstanding of the concept and the misuse of randomization based on the review...
  42. doi Interleukin-2 receptor antagonists as induction therapy after heart transplantation: systematic review with meta-analysis of randomized trials
    Christian H Møller
    Copenhagen Trial Unit, Center for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    J Heart Lung Transplant 27:835-42. 2008
    ..Interleukin-2 receptor antagonists (IL-2Ras) are used increasingly for induction therapy. We conducted a systematic review of randomized trials assessing IL-2Ras...
  43. ncbi Citation bias of hepato-biliary randomized clinical trials
    Lise L Kjaergard
    The Cochrane Hepato Biliary Group, The Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital, Copenhagen, Denmark
    J Clin Epidemiol 55:407-10. 2002
    ..We concluded that positive trials are cited significantly more often than negative trials. The association was not explained by disease area or methodological quality...
  44. pmc Effect of perioperative beta blockade in patients with diabetes undergoing major non-cardiac surgery: randomised placebo controlled, blinded multicentre trial
    Anne Benedicte Juul
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, H S Rigshospitalet, Copenhagen University Hospital, Denmark
    BMJ 332:1482. 2006
    ..To evaluate the long term effects of perioperative beta blockade on mortality and cardiac morbidity in patients with diabetes undergoing major non-cardiac surgery...
  45. ncbi Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis
    Jørn Wetterslev
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, Copenhagen, Denmark
    J Clin Epidemiol 61:64-75. 2008
    ..Trial sequential analysis (TSA) corresponds to group sequential analysis of a single trial and may be applied to meta-analysis to evaluate the evidence...
  46. doi Clinical outcomes in randomized trials of off- vs. on-pump coronary artery bypass surgery: systematic review with meta-analyses and trial sequential analyses
    Christian H Møller
    Department of Cardio Thoracic Surgery, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Eur Heart J 29:2601-16. 2008
    ..To assess the clinical outcomes of off- vs. on-pump coronary artery bypass surgery in randomized trials...
  47. ncbi Agreement between Cochrane Neonatal Group reviews and clinical guidelines for newborns at a Copenhagen University Hospital - a cross-sectional study
    Jesper Brok
    The Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital, H S Rigshospitalet, Denmark
    Acta Paediatr 96:39-43. 2007
    ....
  48. pmc Non-absorbable disaccharides for hepatic encephalopathy: systematic review of randomised trials
    Bodil Als-Nielsen
    Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital, Department 7102, H S Rigshospitalet, DK 2100 Copenhagen, Denmark
    BMJ 328:1046. 2004
    ..To assess the effects of non-absorbable disaccharides (lactulose and lactitol) in patients with hepatic encephalopathy...
  49. ncbi Effects of adding ribavirin to interferon to treat chronic hepatitis C infection: a systematic review and meta-analysis of randomized trials
    Jesper Brok
    The Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Center for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Arch Intern Med 165:2206-12. 2005
    ..However, combination therapy is associated with increased risk for adverse events...
  50. doi Trial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analyses
    Jesper Brok
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Cochrane Hepato Biliary Group, Dept 3344, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Epidemiol 61:763-9. 2008
    ..Meta-analyses not reaching information size are analyzed with trial sequential monitoring boundaries analogous to interim monitoring boundaries in a single trial...
  51. ncbi The Diabetic Postoperative Mortality and Morbidity (DIPOM) trial: rationale and design of a multicenter, randomized, placebo-controlled, clinical trial of metoprolol for patients with diabetes mellitus who are undergoing major noncardiac surgery
    Anne Benedicte Juul
    Copenhagen Trial Unit, Center for Clinical Intervention Research, H S Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Am Heart J 147:677-83. 2004
    ..Patients with diabetes mellitus are at a high-risk for postoperative cardiac morbidity and mortality. They may, therefore, benefit from perioperative beta-blockade...
  52. ncbi [Reporting adverse reactions and events in randomised clinical trials]
    Bianca Hemmingsen
    Copenhagen Trial Unit, Center for Klinisk Interventionsforskning, Rigshospitalet, 2100 København Ø, Denmark
    Ugeskr Laeger 172:2381-4. 2010
    ....
  53. ncbi Association of funding and conclusions in randomized drug trials: a reflection of treatment effect or adverse events?
    Bodil Als-Nielsen
    The Copenhagen Trial Unit, Center for Clinical Intervention Research, Copenhagen University Hospital, Copenhagen, Denmark
    JAMA 290:921-8. 2003
    ..Previous studies indicate that industry-sponsored trials tend to draw proindustry conclusions...
  54. ncbi Artificial and bioartificial support systems for acute and acute-on-chronic liver failure: a systematic review
    Lise L Kjaergard
    The Cochrane Hepato Biliary Group, The Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital, H S Rigshospitalet, Blegdamsvej 9, DK 2100, Copenhagen, Denmark
    JAMA 289:217-22. 2003
    ..Artificial and bioartificial support systems may provide a "bridge" for patients with severe liver disease to recovery or transplantation...
  55. doi Graft patency after off-pump versus on-pump coronary artery surgery in high-risk patients
    Christian H Møller
    Department of Cardio Thoracic Surgery, Rigshospitalet, Copenhagen University Hospital, Denmark
    Scand Cardiovasc J 44:161-7. 2010
    ..To compare angiographic graft patency in high-risk patients randomly allocated to off-pump vs. on-pump coronary artery bypass grafting (CABG)...
  56. doi Peginterferon alpha-2a is associated with higher sustained virological response than peginterferon alfa-2b in chronic hepatitis C: systematic review of randomized trials
    Tahany Awad
    Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Center for Clinical Intervention Research, Department 3344, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Hepatology 51:1176-84. 2010
    ..The meta-analysis of adverse events leading to treatment discontinuation included 11 trials and revealed no significant differences between the two peginterferons...
  57. doi No major differences in 30-day outcomes in high-risk patients randomized to off-pump versus on-pump coronary bypass surgery: the best bypass surgery trial
    Christian H Møller
    Cardiothoracic Surgery, Department 2152, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Circulation 121:498-504. 2010
    ..Our objective was to compare 30-day outcomes in high-risk patients randomized to coronary artery bypass grafting without or with cardiopulmonary bypass...
  58. doi Tacrolimus versus cyclosporine as primary immunosuppression after heart transplantation: systematic review with meta-analyses and trial sequential analyses of randomised trials
    Luit Penninga
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, Cochrane Hepato Biliary Group, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Eur J Clin Pharmacol 66:1177-87. 2010
    ..We conducted a systematic review of randomized trials to compare the benefits and harms of tacrolimus versus cyclosporine as primary immunosuppression after heart transplantation...
  59. ncbi Artificial and bioartificial support systems for liver failure: a Cochrane Hepato-Biliary Group Protocol
    Jianping Liu
    The Cochrane Hepato Biliary Group, The Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital, H S Rigshospitalet, Blegdamsvej 9, DK 2100, Copenhagen, Denmark
    Liver 22:433-8. 2002
    ..This review is to evaluate the beneficial and harmful effects of artificial and bioartificial support systems for acute and acute-on-chronic liver failure...
  60. doi Hepato-biliary clinical trials and their inclusion in the Cochrane Hepato-Biliary Group register and reviews
    Sarah Louise Klingenberg
    The Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 3344, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    J Gastroenterol Hepatol 26:649-56. 2011
    ..In this overview, we present the growth of The CHBG Controlled Trials Register, as well as the systematic reviews that have been produced since March 1996...
  61. doi Apparently conclusive meta-analyses may be inconclusive--Trial sequential analysis adjustment of random error risk due to repetitive testing of accumulating data in apparently conclusive neonatal meta-analyses
    Jesper Brok
    The Copenhagen Trial Unit, Center for Clinical Intervention Research, Department 3344, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Int J Epidemiol 38:287-98. 2009
    ..This is analogous to sequential monitoring boundaries in a single trial...
  62. ncbi Antioxidant supplements for preventing gastrointestinal cancers
    G Bjelakovic
    Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Dept 7102, H S Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Cochrane Database Syst Rev . 2004
    ..Oxidative stress may cause gastrointestinal cancers. The evidence on whether antioxidant supplements are effective in preventing gastrointestinal cancers is contradictory...
  63. ncbi Ribavirin monotherapy for chronic hepatitis C infection: a Cochrane Hepato-Biliary Group systematic review and meta-analysis of randomized trials
    Jesper Brok
    The Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Center for Clinical Intervention Research, Copenhagen University Hospital, Denmark
    Am J Gastroenterol 101:842-7. 2006
    ..We conducted a systematic review to assess the benefits and harms of ribavirin monotherapy for patients with chronic hepatitis C...
  64. doi High serum YKL-40 concentration is associated with cardiovascular and all-cause mortality in patients with stable coronary artery disease
    Jens Kastrup
    Department of Medicine B, Cardiac Catheterization Laboratory 2014, The Heart Centre, Rigshospitalet, Copenhagen University Hospital and Faculty of Health Sciences, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Eur Heart J 30:1066-72. 2009
    ..Macrophages in atherosclerotic plaques secrete YKL-40. We tested the hypothesis if high serum YKL-40 concentration predicts coronary events and death of patients with stable coronary artery disease (CAD)...
  65. ncbi WITHDRAWN: Ribavirin with or without alpha interferon for chronic hepatitis C
    L L Gluud
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Rigshospitalet, Dept 3344, Blegdamsvej 9, Copenhagen, Denmark, DK 2100
    Cochrane Database Syst Rev . 2007
    ....
  66. doi Intra-articular sodium hyaluronate 2 mL versus physiological saline 20 mL versus physiological saline 2 mL for painful knee osteoarthritis: a randomized clinical trial
    C Lundsgaard
    Department of Geriatrics and Rheumatology, Glostrup Hospital the county of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark
    Scand J Rheumatol 37:142-50. 2008
    ..We conducted a randomized, patient- and observer-blind trial to evaluate these interventions in patients with painful knee osteoarthritis...
  67. ncbi Cyclosporin A for primary biliary cirrhosis
    Y Gong
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, Cochrane Hepato Biliary Group, Rigshospitalet, Dept 3344, Blegdamsvej 9, Copenhagen, Denmark, DK 2100
    Cochrane Database Syst Rev . 2007
    ..Cyclosporin A has been used for patients with primary biliary cirrhosis, but the therapeutic responses in randomised clinical trials have been heterogeneous...
  68. ncbi Azathioprine for primary biliary cirrhosis
    Y Gong
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, Cochrane Hepato Biliary Group, Rigshospitalet, Dept 3344, Blegdamsvej 9, Copenhagen, Denmark, DK 2100
    Cochrane Database Syst Rev . 2007
    ..Azathioprine is used for patients with primary biliary cirrhosis, but the therapeutic responses in randomised clinical trials have been conflicting...
  69. ncbi Ribavirin with or without alpha interferon for chronic hepatitis C
    L L Kjaergard
    The Copenhagen Trial Unit, Centre for Clinical Intervention Research, H S Rigshospitalet, Blegdamsvej 9, Dept 7102, Copenhagen, Denmark, DK 2100
    Cochrane Database Syst Rev . 2002
    ....
  70. ncbi Benzodiazepine receptor antagonists for acute and chronic hepatic encephalopathy
    B Als-Nielsen
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital, H S Rigshospitalet, Dep 7701, Blegdamsvej 9, Copenhagen, Denmark, DK 2100
    Cochrane Database Syst Rev . 2001
    ..Several trials have assessed benzodiazepine receptor antagonists for hepatic encephalopathy, but the results are conflicting...
  71. ncbi Ribavirin with or without alpha interferon versus no intervention, placebo or alpha interferon for chronic hepatitis C
    L L Kjaergard
    The Copenhagen Trial Unit, Centre for Clinical Intervention Research, H S Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark, DK 2100
    Cochrane Database Syst Rev . 2002
    ....
  72. ncbi Anabolic-androgenic steroids for alcoholic liver disease
    A Rambaldi
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital, H S Rigshopitalet, Blegdamsvej 9, Department 7201, Copenhagen, Denmark, DK 2100
    Cochrane Database Syst Rev . 2003
    ..Alcohol is one of the most common causes of liver disease in the Western World today. Randomised clinical trials have examined the effects of anabolic-androgenic steroids for alcoholic liver disease...
  73. ncbi Meta-analysis of propylthiouracil for alcoholic liver disease--a Cochrane Hepato-Biliary Group Review
    A Rambaldi
    Cochrane Hepato-Biliary Group, The Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital, H:S Rigshopitalet, Copenhagen, Denmark
    Liver 21:398-404. 2001
    ....
  74. ncbi Ribavirin plus interferon versus interferon for chronic hepatitis C
    J Brok
    Centre for Clinical Intervention Research, Copenhagen University Hospital, Copenhagen Trial Unit, Department 7102, H S Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark, 2100 Ø
    Cochrane Database Syst Rev . 2005
    ..The disease progresses without symptoms for several decades and most patients are diagnosed based on the presence of hepatitis C virus ribonucleic acid and elevated transaminases...
  75. ncbi Interventions for paracetamol (acetaminophen) overdoses
    J Brok
    Centre for Clinical Intervention Research, Copenhagen University Hospital, Department 71 02, H S Rigshospitalet, Copenhagen Ø, Denmark, DK 2100
    Cochrane Database Syst Rev . 2002
    ..Interventions for paracetamol poisoning encompass inhibition of absorption, removal from the vascular system, antidotes, and liver transplantation...
  76. ncbi Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases
    A Rambaldi
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 7102, H S Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, Copenhagen, Denmark, DK 2100
    Cochrane Database Syst Rev . 2005
    ..Randomised clinical trials have assessed whether extracts of milk thistle, Silybum marianum (L) Gaertneri, have any effect in patients with alcoholic and/or hepatitis B or C virus liver diseases...
  77. ncbi Branched-chain amino acids for hepatic encephalopathy
    B Als-Nielsen
    Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital, H S Rigshospitalet, Dep 7102, Blegdamsvej 9, Copenhagen, Denmark
    Cochrane Database Syst Rev . 2003
    ..Hepatic encephalopathy may be caused by a decreased plasma ratio of branched-chain amino acids (BCAA) to aromatic amino acids. Treatment with BCAA may therefore have a beneficial effect on patients with hepatic encephalopathy...
  78. ncbi Ribavirin monotherapy for chronic hepatitis C
    J Brok
    Centre for Clinical Intervention Research, Copenhagen University Hospital, Copenhagen Trial Unit, Department 7102, H S Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark 2100 Ø
    Cochrane Database Syst Rev . 2005
    ..Hepatitis C is a major cause of liver-related morbidity and mortality. The disease progresses without symptoms for several decades. Ribavirin monotherapy may represent a treatment for some patients...
  79. ncbi Agreement between Cochrane Neonatal reviews and clinical practice guidelines for newborns in Denmark: a cross-sectional study
    J Brok
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 3344, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Arch Dis Child Fetal Neonatal Ed 93:F225-9. 2008
    ..To assess agreement between Cochrane Neonatal Group reviews and clinical practice guidelines in Denmark...
  80. doi Exercise program for prevention of groin pain in football players: a cluster-randomized trial
    P Holmich
    Department of Orthopaedic Surgery, Orthopaedic Research Centre, Amager Hospital, Copenhagen University Hospital, Copenhagen, Denmark
    Scand J Med Sci Sports 20:814-21. 2010
    ..A univariate analysis showed that having had a previous groin injury almost doubles the risk of developing a new groin injury and playing at a higher level almost triples the risk of developing a groin injury...
  81. ncbi Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic cochrane hepato-biliary group review with meta-analyses of randomized clinical trials
    Andrea Rambaldi
    Copenhagen Trial Unit, Center for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Denmark
    Am J Gastroenterol 100:2583-91. 2005
    ..Our objectives were to assess the beneficial and harmful effects of milk thistle (MT) or MT constituents versus placebo or no intervention in patients with alcoholic liver disease and/or hepatitis B and/or C liver diseases...
  82. doi Can trial sequential monitoring boundaries reduce spurious inferences from meta-analyses?
    Kristian Thorlund
    Copenhagen Trial Unit, Center for Clinical Intervention Research, Copenhagen University Hospital, Department 3344, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Int J Epidemiol 38:276-86. 2009
    ..e. applying trial sequential monitoring boundaries)...
  83. ncbi The effects of a randomised multi-centre trial and international accreditation on availability and quality of clinical guidelines
    Anne Benedicte Juul
    The Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Int J Health Care Qual Assur Inc Leadersh Health Serv 18:321-8. 2005
    ..To examine the availability and quality of clinical guidelines on perioperative diabetes care in hospital units before and after a randomised clinical trial (RCT) and international accreditation...
  84. doi Trial sequential analyses of meta-analyses of complications in laparoscopic vs. small-incision cholecystectomy: more randomized patients are needed
    Frederik Keus
    The Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Center for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    J Clin Epidemiol 63:246-56. 2010
    ..Trial sequential analysis (TSA) evaluates random errors in meta-analysis. We analyzed meta-analyses on laparoscopic vs. small-incision cholecystectomy regarding different outcome measures for the occurrence of type I errors...
  85. pmc Randomised placebo controlled multicentre trial to assess short term clarithromycin for patients with stable coronary heart disease: CLARICOR trial
    Christian M Jespersen
    Bispebjerg Hospital, Copenhagen University Hospital, Department of Cardiology Y, Bispebjerg Bakke 23, DK 2400 Copenhagen, Denmark
    BMJ 332:22-7. 2006
    ..To determine if the macrolide clarithromycin affects mortality and cardiovascular morbidity in patients with stable coronary heart disease...
  86. doi Chlamydia pneumoniae IgG and IgA antibody titers and prognosis in patients with coronary heart disease: results from the CLARICOR trial
    Jørgen Hilden
    The Copenhagen Trial Unit, Center for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, DK 2100 Copenhagen, Denmark
    Diagn Microbiol Infect Dis 66:385-92. 2010
    ..Smoking-related lung disease probably underlies the link between heart disease and increased IgG titers...
  87. ncbi Ursodeoxycholic acid for patients with primary biliary cirrhosis: an updated systematic review and meta-analysis of randomized clinical trials using Bayesian approach as sensitivity analyses
    Yan Gong
    The Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Center for Clinical Intervention Research, Department 7102, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Am J Gastroenterol 102:1799-807. 2007
    ..Ursodeoxycholic acid (UDCA) is used for primary biliary cirrhosis (PBC), but the beneficial effects remain controversial...
  88. ncbi D-penicillamine for primary biliary cirrhosis
    Y Gong
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital, Dept 7102, Blegdamsvej 9, H S Rigshospitalet, Copenhagen, DK 2100, Denmark
    Cochrane Database Syst Rev . 2004
    ..D-penicillamine is used for patients with primary biliary cirrhosis due to its hepatic copper decreasing and immunomodulatory potentials. The results from randomised clinical trials have been inconsistent...
  89. ncbi Colchicine for alcoholic and non-alcoholic liver fibrosis and cirrhosis
    A Rambaldi
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 7102, H S Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, Copenhagen, Denmark, DK 2100
    Cochrane Database Syst Rev . 2005
    ..Colchicine is an anti-inflammatory and anti-fibrotic medication. Several randomised clinical trials have addressed the question whether colchicine has any efficacy in patients with alcoholic or non-alcoholic fibrosis and cirrhosis...
  90. ncbi Anabolic-androgenic steroids for alcoholic liver disease
    A Rambaldi
    Centre for Clinical Intervention Research, Copenhagen Trial Unit, Department 7102, H S Rigshospitalet, Blegdamsvej 9, Copenhagen University Hospital, Copenhagen, Denmark
    Cochrane Database Syst Rev . 2006
    ..Alcohol is one of the most common causes of liver disease in the Western World. Randomised clinical trials have examined the effects of anabolic-androgenic steroids for alcoholic liver disease...
  91. ncbi Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases
    A Rambaldi
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, Cochrane Hepato Biliary Group, Rigshospitalet, Dept 3344, Blegdamsvej 9, Copenhagen, Denmark, DK 2100
    Cochrane Database Syst Rev . 2007
    ..Randomised clinical trials have assessed whether extracts of milk thistle, Silybum marianum (L) Gaertneri, have any effect in patients with alcoholic and/or hepatitis B or C virus liver diseases...
  92. ncbi Methotrexate for primary biliary cirrhosis
    Y Gong
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital, Dept 7102, Blegdamsvej 9, H S Rigshospitalet, Copenhagen, Denmark, DK 2100
    Cochrane Database Syst Rev . 2005
    ..Methotrexate, a folic acid antagonist with immunosuppressive properties, has been used to treat patients with primary biliary cirrhosis. The therapeutic responses to methotrexate in randomised clinical trials have been heterogeneous...
  93. ncbi Dopaminergic agonists for hepatic encephalopathy
    B Als-Nielsen
    Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital, Department 7102, H S Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Cochrane Database Syst Rev . 2004
    ..Hepatic encephalopathy may be associated with an impairment of the dopaminergic neurotransmission. Dopaminergic agonists may therefore have a beneficial effect on patients with hepatic encephalopathy...
  94. ncbi Propylthiouracil for alcoholic liver disease
    A Rambaldi
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital, H S Rigshopitalet, Blegdamsvej 9, Copenhagen, Denmark, DK 2100
    Cochrane Database Syst Rev . 2002
    ..Alcohol is the most common cause of liver disease in the Western world today. Randomised clinical trials have addressed the question whether propylthiouracil has any efficacy in patients with alcoholic liver disease...
  95. ncbi Colchicine for alcoholic and non-alcoholic liver fibrosis and cirrhosis
    A Rambaldi
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital, H S Rigshopitalet, Blegdamsvej 9, Dep 77 01, Copenhagen, Denmark, DK 2100
    Cochrane Database Syst Rev . 2001
    ..Several randomised clinical trials have addressed the question whether colchicine has any efficacy in patients with alcoholic as well as non-alcoholic fibrosis and cirrhosis...
  96. doi Robustness assessments are needed to reduce bias in meta-analyses that include zero-event randomized trials
    F Keus
    Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Denmark
    Am J Gastroenterol 104:546-51. 2009
    ..Zero-event trials may create analytic problems. We explored how different methods may impact inferences from meta-analyses containing zero-event trials...
  97. ncbi S-adenosyl-L-methionine for alcoholic liver diseases
    A Rambaldi
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital, H S Rigshopitalet, Blegdamsvej 9, Copenhagen, Denmark, DK 2100
    Cochrane Database Syst Rev . 2001
    ..Randomised clinical trials have addressed the question whether SAMe has any efficacy in patients with alcoholic liver diseases...
  98. doi Systematic review: glucocorticosteroids for alcoholic hepatitis--a Cochrane Hepato-Biliary Group systematic review with meta-analyses and trial sequential analyses of randomized clinical trials
    A Rambaldi
    The Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 3344, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Aliment Pharmacol Ther 27:1167-78. 2008
    ..Glucocorticosteroids versus placebo or no intervention for patients with alcoholic hepatitis have been evaluated for more than 35 years. However, the results of randomized trials and meta-analyses differ substantially...
  99. ncbi Interventions for paracetamol (acetaminophen) overdose
    J Brok
    Copenhagen University Hospital, Copenhagen Trial Unit, Dept 7102, H S Rigshospitalet, Blegdamsvej 9, Copenhagen Ø, Denmark, 2100 Kbh Ø
    Cochrane Database Syst Rev . 2006
    ..Inhibition of absorption, removal from the vascular system, antidotes, and liver transplantation are interventions for paracetamol poisoning...
  100. ncbi Sequential combination of glucocorticosteroids and alfa interferon versus alfa interferon alone for HBeAg-positive chronic hepatitis B
    M T Mellerup
    The Copenhagen Trial Unit, Copenhagen University Hospital, H S Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark, DK 2100
    Cochrane Database Syst Rev . 2002
    ..Alfa interferon has been shown to increase the rates of HBeAg-clearance as well as seroconversion to anti-HBe, but response rates are unsatisfactory. Glucocorticosteroid pretreatment may increase the response to alfa interferon...