J Brok

Summary

Affiliation: Copenhagen Trial Unit
Country: Denmark

Publications

  1. ncbi Ribavirin plus interferon versus interferon for chronic hepatitis C
    J Brok
    Centre for Clinical Intervention Research, Copenhagen University Hospital, Copenhagen Trial Unit, Department 7102, H S Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark, 2100 Ø
    Cochrane Database Syst Rev . 2005
  2. ncbi Ribavirin monotherapy for chronic hepatitis C
    J Brok
    Centre for Clinical Intervention Research, Copenhagen University Hospital, Copenhagen Trial Unit, Department 7102, H S Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark 2100 Ø
    Cochrane Database Syst Rev . 2005
  3. ncbi Interventions for paracetamol (acetaminophen) overdose
    J Brok
    Copenhagen University Hospital, Copenhagen Trial Unit, Dept 7102, H S Rigshospitalet, Blegdamsvej 9, Copenhagen Ø, Denmark, 2100 Kbh Ø
    Cochrane Database Syst Rev . 2006
  4. doi Apparently conclusive meta-analyses may be inconclusive--Trial sequential analysis adjustment of random error risk due to repetitive testing of accumulating data in apparently conclusive neonatal meta-analyses
    Jesper Brok
    The Copenhagen Trial Unit, Center for Clinical Intervention Research, Department 3344, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Int J Epidemiol 38:287-98. 2009
  5. doi Trial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analyses
    Jesper Brok
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Cochrane Hepato Biliary Group, Dept 3344, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Epidemiol 61:763-9. 2008
  6. ncbi Agreement between Cochrane Neonatal reviews and clinical practice guidelines for newborns in Denmark: a cross-sectional study
    J Brok
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 3344, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Arch Dis Child Fetal Neonatal Ed 93:F225-9. 2008
  7. ncbi Agreement between Cochrane Neonatal Group reviews and clinical guidelines for newborns at a Copenhagen University Hospital - a cross-sectional study
    Jesper Brok
    The Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital, H S Rigshospitalet, Denmark
    Acta Paediatr 96:39-43. 2007
  8. ncbi Effects of adding ribavirin to interferon to treat chronic hepatitis C infection: a systematic review and meta-analysis of randomized trials
    Jesper Brok
    The Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Center for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Arch Intern Med 165:2206-12. 2005
  9. ncbi Cochrane systematic review: pegylated interferon plus ribavirin vs. interferon plus ribavirin for chronic hepatitis C
    M Simin
    The Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Aliment Pharmacol Ther 25:1153-62. 2007
  10. ncbi Meta-analysis: ribavirin plus interferon vs. interferon monotherapy for chronic hepatitic C - an updated Cochrane review
    J Brok
    Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Denmark
    Aliment Pharmacol Ther 32:840-50. 2010

Detail Information

Publications18

  1. ncbi Ribavirin plus interferon versus interferon for chronic hepatitis C
    J Brok
    Centre for Clinical Intervention Research, Copenhagen University Hospital, Copenhagen Trial Unit, Department 7102, H S Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark, 2100 Ø
    Cochrane Database Syst Rev . 2005
    ..The disease progresses without symptoms for several decades and most patients are diagnosed based on the presence of hepatitis C virus ribonucleic acid and elevated transaminases...
  2. ncbi Ribavirin monotherapy for chronic hepatitis C
    J Brok
    Centre for Clinical Intervention Research, Copenhagen University Hospital, Copenhagen Trial Unit, Department 7102, H S Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark 2100 Ø
    Cochrane Database Syst Rev . 2005
    ..Hepatitis C is a major cause of liver-related morbidity and mortality. The disease progresses without symptoms for several decades. Ribavirin monotherapy may represent a treatment for some patients...
  3. ncbi Interventions for paracetamol (acetaminophen) overdose
    J Brok
    Copenhagen University Hospital, Copenhagen Trial Unit, Dept 7102, H S Rigshospitalet, Blegdamsvej 9, Copenhagen Ø, Denmark, 2100 Kbh Ø
    Cochrane Database Syst Rev . 2006
    ..Inhibition of absorption, removal from the vascular system, antidotes, and liver transplantation are interventions for paracetamol poisoning...
  4. doi Apparently conclusive meta-analyses may be inconclusive--Trial sequential analysis adjustment of random error risk due to repetitive testing of accumulating data in apparently conclusive neonatal meta-analyses
    Jesper Brok
    The Copenhagen Trial Unit, Center for Clinical Intervention Research, Department 3344, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Int J Epidemiol 38:287-98. 2009
    ..This is analogous to sequential monitoring boundaries in a single trial...
  5. doi Trial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analyses
    Jesper Brok
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Cochrane Hepato Biliary Group, Dept 3344, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Epidemiol 61:763-9. 2008
    ..Meta-analyses not reaching information size are analyzed with trial sequential monitoring boundaries analogous to interim monitoring boundaries in a single trial...
  6. ncbi Agreement between Cochrane Neonatal reviews and clinical practice guidelines for newborns in Denmark: a cross-sectional study
    J Brok
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 3344, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Arch Dis Child Fetal Neonatal Ed 93:F225-9. 2008
    ..To assess agreement between Cochrane Neonatal Group reviews and clinical practice guidelines in Denmark...
  7. ncbi Agreement between Cochrane Neonatal Group reviews and clinical guidelines for newborns at a Copenhagen University Hospital - a cross-sectional study
    Jesper Brok
    The Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital, H S Rigshospitalet, Denmark
    Acta Paediatr 96:39-43. 2007
    ....
  8. ncbi Effects of adding ribavirin to interferon to treat chronic hepatitis C infection: a systematic review and meta-analysis of randomized trials
    Jesper Brok
    The Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Center for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Arch Intern Med 165:2206-12. 2005
    ..However, combination therapy is associated with increased risk for adverse events...
  9. ncbi Cochrane systematic review: pegylated interferon plus ribavirin vs. interferon plus ribavirin for chronic hepatitis C
    M Simin
    The Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Aliment Pharmacol Ther 25:1153-62. 2007
    ..About 170 million patients worldwide have chronic hepatitis C. Pegylated interferon plus ribavirin is currently the recommended therapy...
  10. ncbi Meta-analysis: ribavirin plus interferon vs. interferon monotherapy for chronic hepatitic C - an updated Cochrane review
    J Brok
    Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Denmark
    Aliment Pharmacol Ther 32:840-50. 2010
    ..Multiple randomized trials have been published on antiviral treatment for chronic hepatitis C...
  11. ncbi Hepatology may have problems with putative surrogate outcome measures
    Christian Gluud
    The Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, DK 2100 Copenhagen, Denmark
    J Hepatol 46:734-42. 2007
    ..The challenge is to develop reliable surrogates, both to facilitate the development of new interventions and to ensure our patients and us that these interventions are effective clinically...
  12. pmc Estimating required information size by quantifying diversity in random-effects model meta-analyses
    Jørn Wetterslev
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 3344, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    BMC Med Res Methodol 9:86. 2009
    ..The required information size in a meta-analysis may be calculated from an anticipated a priori intervention effect or from an intervention effect suggested by trials with low-risk of bias...
  13. ncbi Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis
    Jørn Wetterslev
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, Copenhagen, Denmark
    J Clin Epidemiol 61:64-75. 2008
    ..Trial sequential analysis (TSA) corresponds to group sequential analysis of a single trial and may be applied to meta-analysis to evaluate the evidence...
  14. ncbi Ribavirin monotherapy for chronic hepatitis C infection: a Cochrane Hepato-Biliary Group systematic review and meta-analysis of randomized trials
    Jesper Brok
    The Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Center for Clinical Intervention Research, Copenhagen University Hospital, Denmark
    Am J Gastroenterol 101:842-7. 2006
    ..We conducted a systematic review to assess the benefits and harms of ribavirin monotherapy for patients with chronic hepatitis C...
  15. ncbi Interventions for paracetamol (acetaminophen) overdoses
    J Brok
    Centre for Clinical Intervention Research, Copenhagen University Hospital, Department 71 02, H S Rigshospitalet, Copenhagen Ø, Denmark, DK 2100
    Cochrane Database Syst Rev . 2002
    ..Interventions for paracetamol poisoning encompass inhibition of absorption, removal from the vascular system, antidotes, and liver transplantation...
  16. pmc Inconsistent reporting of surrogate outcomes in randomised clinical trials: cohort study
    Jeppe Lerche la Cour
    Copenhagen Trial Unit, Rigshospitalet, Copenhagen University Hospital, DK 2100 Copenhagen, Denmark
    BMJ 341:c3653. 2010
    ..To assess if authors of randomised clinical trials convey the fact that they have used surrogate outcomes and discussed their validity...
  17. pmc Effect of hepatitis B immunisation in newborn infants of mothers positive for hepatitis B surface antigen: systematic review and meta-analysis
    Chuanfang Lee
    Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Copenhagen University Hospital, Denmark
    BMJ 332:328-36. 2006
    ..To evaluate the effects of hepatitis B vaccine and immunoglobulin in newborn infants of mothers positive for hepatitis B surface antigen...