Mikael R Andersen

Summary

Country: Denmark

Publications

  1. pmc Accurate prediction of secondary metabolite gene clusters in filamentous fungi
    Mikael R Andersen
    Center for Microbial Biotechnology, Department of Systems Biology, Technical University of Denmark, DK 2800 Kongens Lyngby, Denmark
    Proc Natl Acad Sci U S A 110:E99-107. 2013
  2. pmc Systemic analysis of the response of Aspergillus niger to ambient pH
    Mikael R Andersen
    Department of Systems Biology, Center for Microbial Biotechnology, Technical University of Denmark, DK 2800 Kgs Lyngby, Denmark
    Genome Biol 10:R47. 2009
  3. pmc Studies of the production of fungal polyketides in Aspergillus nidulans by using systems biology tools
    Gianni Panagiotou
    Center for Microbial Biotechnology, Department of Systems Biology, Building 223, Technical University of Denmark, DK 2800 Kongens Lyngby, Denmark
    Appl Environ Microbiol 75:2212-20. 2009
  4. pmc Mapping the polysaccharide degradation potential of Aspergillus niger
    Mikael R Andersen
    Department of Systems Biology, Technical University of Denmark, Kgs Lyngby, Denmark
    BMC Genomics 13:313. 2012
  5. pmc Comparative genomics of citric-acid-producing Aspergillus niger ATCC 1015 versus enzyme-producing CBS 513.88
    Mikael R Andersen
    Center for Microbial Biotechnology, Department of Systems Biology, Technical University of Denmark, DK 2800 Kongens Lyngby, Denmark
    Genome Res 21:885-97. 2011
  6. pmc Systems analysis unfolds the relationship between the phosphoketolase pathway and growth in Aspergillus nidulans
    Gianni Panagiotou
    Center for Microbial Biotechnology, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark
    PLoS ONE 3:e3847. 2008
  7. doi request reprint Combining Stable Isotope Labeling and Molecular Networking for Biosynthetic Pathway Characterization
    Andreas Klitgaard
    Department of Systems Biology, Technical University of Denmark, DK 2800 Kongens Lyngby, Denmark
    Anal Chem 87:6520-6. 2015
  8. pmc A trispecies Aspergillus microarray: comparative transcriptomics of three Aspergillus species
    Mikael R Andersen
    Center for Microbial Biotechnology, BioCentrum DTU, Technical University of Denmark, DK 2800 Kgs Lyngby, Denmark
    Proc Natl Acad Sci U S A 105:4387-92. 2008
  9. doi request reprint Supercluster takes a walk on the wild side
    Jakob B Nielsen
    Department of Systems Biology, Technical University of Denmark, DK 2800, Kgs Lyngby, Denmark
    Trends Microbiol 21:617-8. 2013
  10. pmc Aggressive dereplication using UHPLC-DAD-QTOF: screening extracts for up to 3000 fungal secondary metabolites
    Andreas Klitgaard
    Department of Systems Biology, Søltofts Plads, Technical University of Denmark, 2800 Kgs, Lyngby, Denmark
    Anal Bioanal Chem 406:1933-43. 2014

Collaborators

Detail Information

Publications13

  1. pmc Accurate prediction of secondary metabolite gene clusters in filamentous fungi
    Mikael R Andersen
    Center for Microbial Biotechnology, Department of Systems Biology, Technical University of Denmark, DK 2800 Kongens Lyngby, Denmark
    Proc Natl Acad Sci U S A 110:E99-107. 2013
    ....
  2. pmc Systemic analysis of the response of Aspergillus niger to ambient pH
    Mikael R Andersen
    Department of Systems Biology, Center for Microbial Biotechnology, Technical University of Denmark, DK 2800 Kgs Lyngby, Denmark
    Genome Biol 10:R47. 2009
    ..While it is known that the mechanisms regulating this production are tied to the levels of ambient pH, the reasons and mechanisms for this are poorly understood...
  3. pmc Studies of the production of fungal polyketides in Aspergillus nidulans by using systems biology tools
    Gianni Panagiotou
    Center for Microbial Biotechnology, Department of Systems Biology, Building 223, Technical University of Denmark, DK 2800 Kongens Lyngby, Denmark
    Appl Environ Microbiol 75:2212-20. 2009
    ....
  4. pmc Mapping the polysaccharide degradation potential of Aspergillus niger
    Mikael R Andersen
    Department of Systems Biology, Technical University of Denmark, Kgs Lyngby, Denmark
    BMC Genomics 13:313. 2012
    ..In plant-biomass degrading fungi, these enzymes are regulated and released by complex regulatory structures. In this study, we present a methodology for evaluating the potential of a given fungus for polysaccharide degradation...
  5. pmc Comparative genomics of citric-acid-producing Aspergillus niger ATCC 1015 versus enzyme-producing CBS 513.88
    Mikael R Andersen
    Center for Microbial Biotechnology, Department of Systems Biology, Technical University of Denmark, DK 2800 Kongens Lyngby, Denmark
    Genome Res 21:885-97. 2011
    ..88 strain. Our results and data sets from this integrative systems biology analysis resulted in a snapshot of fungal evolution and will support further optimization of cell factories based on filamentous fungi...
  6. pmc Systems analysis unfolds the relationship between the phosphoketolase pathway and growth in Aspergillus nidulans
    Gianni Panagiotou
    Center for Microbial Biotechnology, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark
    PLoS ONE 3:e3847. 2008
    ..niger and A. oryzae. Here we identified the gene coding for a novel metabolic pathway in A. nidulans, namely the phosphoketolase pathway, and investigated the role of an increased phosphoketolase activity...
  7. doi request reprint Combining Stable Isotope Labeling and Molecular Networking for Biosynthetic Pathway Characterization
    Andreas Klitgaard
    Department of Systems Biology, Technical University of Denmark, DK 2800 Kongens Lyngby, Denmark
    Anal Chem 87:6520-6. 2015
    ....
  8. pmc A trispecies Aspergillus microarray: comparative transcriptomics of three Aspergillus species
    Mikael R Andersen
    Center for Microbial Biotechnology, BioCentrum DTU, Technical University of Denmark, DK 2800 Kgs Lyngby, Denmark
    Proc Natl Acad Sci U S A 105:4387-92. 2008
    ..With this case example, we present a validated tool for transcriptome analysis of three Aspergillus species and a methodology for conducting cross-species evolutionary studies within a genus using comparative transcriptomics...
  9. doi request reprint Supercluster takes a walk on the wild side
    Jakob B Nielsen
    Department of Systems Biology, Technical University of Denmark, DK 2800, Kgs Lyngby, Denmark
    Trends Microbiol 21:617-8. 2013
    ..The analysis demonstrates that gene regulation takes place at different layers and that genes belonging to specific clusters are intertwined. ..
  10. pmc Aggressive dereplication using UHPLC-DAD-QTOF: screening extracts for up to 3000 fungal secondary metabolites
    Andreas Klitgaard
    Department of Systems Biology, Søltofts Plads, Technical University of Denmark, 2800 Kgs, Lyngby, Denmark
    Anal Bioanal Chem 406:1933-43. 2014
    ....
  11. pmc Proteome analysis of Aspergillus niger: lactate added in starch-containing medium can increase production of the mycotoxin fumonisin B2 by modifying acetyl-CoA metabolism
    Louise M Sørensen
    Department of Systems Biology, Søltofts Plads, Technical University of Denmark, DK 2800 Kgs Lyngby, Denmark
    BMC Microbiol 9:255. 2009
    ..niger and hence very little is known about production and regulation of this metabolite. Proteome analysis was used with the purpose to reveal how fumonisin B2 production by A. niger is influenced by starch and lactate in the medium...
  12. pmc An Integrated Metabolomic and Genomic Mining Workflow To Uncover the Biosynthetic Potential of Bacteria
    Maria Maansson
    Department of Systems Biology, Technical University of Denmark, Kgs Lyngby, Denmark
    mSystems 1:. 2016
    ..Combining chemical analysis and genetics is an efficient "mining" workflow for identifying diverse pharmaceutical candidates in a broad range of microorganisms and therefore of great use in bioprospecting...
  13. pmc Hydrophobins from Aspergillus species cannot be clearly divided into two classes
    Britt G Jensen
    Center for Microbial Biotechnology, Department of Systems Biology, Technical University of Denmark, Søltofts Plads, Building 221 223, DK 2800 Kgs, Lyngby, Denmark
    BMC Res Notes 3:344. 2010
    ....