Ona Wu

Summary

Affiliation: Aarhus University Hospital
Country: Denmark

Publications

  1. ncbi request reprint Characterizing physiological heterogeneity of infarction risk in acute human ischaemic stroke using MRI
    Ona Wu
    Center for Functionally Integrative Neuroscience, Department of Neuroradiology, Arhus University Hospital, Arhus C, Denmark
    Brain 129:2384-93. 2006
  2. doi request reprint Comparison of 10 perfusion MRI parameters in 97 sub-6-hour stroke patients using voxel-based receiver operating characteristics analysis
    Søren Christensen
    Center of Functionally Integrative Neuroscience, Department of Neuroradiology, Aarhus University Hospital, Building 30, Nørrebrogade 44, 8000 Aarhus C, Denmark
    Stroke 40:2055-61. 2009
  3. doi request reprint Inferring origin of vascular supply from tracer arrival timing patterns using bolus tracking MRI
    Søren Christensen
    Center for Functionally Integrative Neuroscience, Arhus University Hospital, Arhus, Denmark
    J Magn Reson Imaging 27:1371-81. 2008
  4. ncbi request reprint Ischemic injury detected by diffusion imaging 11 minutes after stroke
    Niels Hjort
    Department of Neuroradiology, Center for Functionally Integrative Neuroscience, Arhus University Hospital, Arhus, Denmark
    Ann Neurol 58:462-5. 2005
  5. ncbi request reprint Applying instance-based techniques to prediction of final outcome in acute stroke
    Christian Gottrup
    DIMAC A S, Højbjerg, Denmark
    Artif Intell Med 33:223-36. 2005
  6. doi request reprint Acute stroke imaging research roadmap
    Max Wintermark
    University of California, San Francisco, Department of Radiology, Neuroradiology Section, 505 Parnassus Avenue, Box 0628, San Francisco, CA 94143 0628, USA
    Stroke 39:1621-8. 2008
  7. doi request reprint Severity of leukoaraiosis and susceptibility to infarct growth in acute stroke
    Hakan Ay
    A A Martinos Center for Biomedical Imaging and Stroke Service, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 2301, Charlestown, MA 02129, USA
    Stroke 39:1409-13. 2008
  8. doi request reprint Interexaminer difference in infarct volume measurements on MRI: a source of variance in stroke research
    Hakan Ay
    Stroke Service, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 2301, Charlestown MA 02129, USA
    Stroke 39:1171-6. 2008
  9. ncbi request reprint Infarct prediction and treatment assessment with MRI-based algorithms in experimental stroke models
    Ona Wu
    Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
    J Cereb Blood Flow Metab 27:196-204. 2007
  10. ncbi request reprint Magnetic resonance perfusion-weighted imaging of acute cerebral infarction: effect of the calculation methods and underlying vasculopathy
    Kei Yamada
    Massachusetts General Hospital NMR Center, Harvard Medical School, Boston, USA
    Stroke 33:87-94. 2002

Detail Information

Publications25

  1. ncbi request reprint Characterizing physiological heterogeneity of infarction risk in acute human ischaemic stroke using MRI
    Ona Wu
    Center for Functionally Integrative Neuroscience, Department of Neuroradiology, Arhus University Hospital, Arhus C, Denmark
    Brain 129:2384-93. 2006
    ..MRI-based algorithms may therefore provide a more sensitive means for monitoring therapeutic effects on a voxel-wise basis...
  2. doi request reprint Comparison of 10 perfusion MRI parameters in 97 sub-6-hour stroke patients using voxel-based receiver operating characteristics analysis
    Søren Christensen
    Center of Functionally Integrative Neuroscience, Department of Neuroradiology, Aarhus University Hospital, Building 30, Nørrebrogade 44, 8000 Aarhus C, Denmark
    Stroke 40:2055-61. 2009
    ..We sought to compare 10 different perfusion parameters by their ability to predict tissue infarction in acute ischemic stroke...
  3. doi request reprint Inferring origin of vascular supply from tracer arrival timing patterns using bolus tracking MRI
    Søren Christensen
    Center for Functionally Integrative Neuroscience, Arhus University Hospital, Arhus, Denmark
    J Magn Reson Imaging 27:1371-81. 2008
    ..Collateral blood supply is believed to be of paramount importance in acute stroke, yet clinical evaluation is challenging as the gold standard digital subtraction angiography is often not feasible in the acute scenario...
  4. ncbi request reprint Ischemic injury detected by diffusion imaging 11 minutes after stroke
    Niels Hjort
    Department of Neuroradiology, Center for Functionally Integrative Neuroscience, Arhus University Hospital, Arhus, Denmark
    Ann Neurol 58:462-5. 2005
    ..The data show early, abrupt diffusion changes in hypoperfused tissue, adding to our understanding of the progression of microstructural abnormalities in the hyperacute phase of stroke...
  5. ncbi request reprint Applying instance-based techniques to prediction of final outcome in acute stroke
    Christian Gottrup
    DIMAC A S, Højbjerg, Denmark
    Artif Intell Med 33:223-36. 2005
    ..This requires an accurate prediction of the extent of infarction if untreated. In this study, we investigate the applicability of highly flexible instance-based (IB) methods for such predictions...
  6. doi request reprint Acute stroke imaging research roadmap
    Max Wintermark
    University of California, San Francisco, Department of Radiology, Neuroradiology Section, 505 Parnassus Avenue, Box 0628, San Francisco, CA 94143 0628, USA
    Stroke 39:1621-8. 2008
    ..The present article summarizes these recommendations and examines practical steps to achieve them...
  7. doi request reprint Severity of leukoaraiosis and susceptibility to infarct growth in acute stroke
    Hakan Ay
    A A Martinos Center for Biomedical Imaging and Stroke Service, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 2301, Charlestown, MA 02129, USA
    Stroke 39:1409-13. 2008
    ..We hypothesized that the volume of LA correlated with the proportion of initially ischemic but eventually infarcted tissue in acute human stroke...
  8. doi request reprint Interexaminer difference in infarct volume measurements on MRI: a source of variance in stroke research
    Hakan Ay
    Stroke Service, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 2301, Charlestown MA 02129, USA
    Stroke 39:1171-6. 2008
    ..We sought to quantify the variance imposed by measurement error in DWI and PWI lesion volume measurements in ischemic stroke...
  9. ncbi request reprint Infarct prediction and treatment assessment with MRI-based algorithms in experimental stroke models
    Ona Wu
    Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
    J Cereb Blood Flow Metab 27:196-204. 2007
    ..Our study shows that predictive algorithms are promising metrics for diagnosis, prognosis and therapeutic evaluation after acute stroke that can translate readily from preclinical to clinical settings...
  10. ncbi request reprint Magnetic resonance perfusion-weighted imaging of acute cerebral infarction: effect of the calculation methods and underlying vasculopathy
    Kei Yamada
    Massachusetts General Hospital NMR Center, Harvard Medical School, Boston, USA
    Stroke 33:87-94. 2002
    ..Steno-occlusive disease in the parent vessels is another factor that may affect the results of the PWI. The purpose of this study was to elucidate the effect of the calculation methods and underlying vasculopathy on PWI...
  11. ncbi request reprint Evolution of water diffusion and anisotropy in hyperacute stroke: significant correlation between fractional anisotropy and T2
    Yelda Ozsunar
    Department of Radiology, School of Medicine, Adnan Menderes University, Aydin, Turkey
    AJNR Am J Neuroradiol 25:699-705. 2004
    ..Our purpose was to correlate fractional anisotropy (FA) measurements with the clinical time of stroke onset, apparent diffusion coefficients (ADC), and T2 signal intensity...
  12. ncbi request reprint Tracer arrival timing-insensitive technique for estimating flow in MR perfusion-weighted imaging using singular value decomposition with a block-circulant deconvolution matrix
    Ona Wu
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Massachusetts Institute of Technology Harvard Medical School, Boston, Massachusetts 02129, USA
    Magn Reson Med 50:164-74. 2003
    ..Shift maps can continue to provide a sensitive reflection of disturbed hemodynamics...
  13. ncbi request reprint Transient ischemic attack with infarction: a unique syndrome?
    Hakan Ay
    Department of A A Martinos Center for Biomedical Imaging and Stroke Service, Department of Radiology, Boston, MA 02129, USA
    Ann Neurol 57:679-86. 2005
    ..3% in those with ischemic stroke. TIA with infarction appears to have unique features separate from TIA without infarction and ischemic stroke. We propose identifying TSI as a separate clinical syndrome with distinct prognostic features...
  14. ncbi request reprint Rapid breakdown of microvascular barriers and subsequent hemorrhagic transformation after delayed recombinant tissue plasminogen activator treatment in a rat embolic stroke model
    Rick M Dijkhuizen
    Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Mass, USA
    Stroke 33:2100-4. 2002
    ..Our aim was to characterize acute effects of rtPA administration on the integrity of microvascular barriers...
  15. pmc Acute stroke imaging research roadmap
    Max Wintermark
    Department of Radiology, University of California, San Francisco, CA 94143 0628, USA
    AJNR Am J Neuroradiol 29:e23-30. 2008
    ..The present article summarizes these recommendations and examines practical steps to achieve them...
  16. ncbi request reprint Diffusion magnetic resonance imaging of acute ischemic stroke
    Pamela W Schaefer
    Neuroradiology Division, Stroke Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Semin Roentgenol 37:219-29. 2002
  17. ncbi request reprint Correlation between brain reorganization, ischemic damage, and neurologic status after transient focal cerebral ischemia in rats: a functional magnetic resonance imaging study
    Rick M Dijkhuizen
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 23:510-7. 2003
    ....
  18. doi request reprint MRI detection of early blood-brain barrier disruption: parenchymal enhancement predicts focal hemorrhagic transformation after thrombolysis
    Niels Hjort
    Stroke 39:1025-8. 2008
    ..Blood-brain barrier disruption may be a predictor of hemorrhagic transformation (HT) in ischemic stroke. We hypothesize that parenchymal enhancement (PE) on postcontrast T1-weighted MRI predicts and localizes subsequent HT...
  19. ncbi request reprint Manganese-enhanced MRI of brain plasticity in relation to functional recovery after experimental stroke
    Jet P van der Zijden
    Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
    J Cereb Blood Flow Metab 28:832-40. 2008
    ..Our data suggest that the plateau stage of functional recovery is associated with restoration of ipsilateral sensorimotor pathways and enhanced interhemispheric connectivity...
  20. ncbi request reprint Changes in neuronal connectivity after stroke in rats as studied by serial manganese-enhanced MRI
    Jet P van der Zijden
    Image Sciences Institute, University Medical Center Utrecht, Bolognalaan 50, 3584 CJ, Utrecht, The Netherlands
    Neuroimage 34:1650-7. 2007
    ..This study demonstrates that MEMRI enables in vivo assessment of spatiotemporal alterations in neuronal connectivity after stroke, which may lead to improved insights in mechanisms underlying functional loss and recovery after stroke...
  21. ncbi request reprint Frontal connections and cognitive changes in normal aging rhesus monkeys: a DTI study
    Nikos Makris
    Harvard Medical School Department of Neurology, Center for Morphometric Analysis, Massachusetts General Hospital, Boston, MA 02129, United States
    Neurobiol Aging 28:1556-67. 2007
    ..To our knowledge this is the first investigation reporting such alterations in the aging monkey...
  22. ncbi request reprint Effects of tracer arrival time on flow estimates in MR perfusion-weighted imaging
    Ona Wu
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology Harvard Medical School, Boston, 02129, USA
    Magn Reson Med 50:856-64. 2003
    ..These conditions may occur in practice due to the application of a user-selected AIF that is not the "true AIF" and therefore caution must be taken in interpreting CBF and MTT estimates...
  23. ncbi request reprint Diffusion tensor imaging as potential biomarker of white matter injury in diffuse axonal injury
    Thierry A G M Huisman
    MGH NMR Center, Division of Neuroradiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    AJNR Am J Neuroradiol 25:370-6. 2004
    ..Our objective was to determine if changes in anisotropic diffusion in TBI correlate with acute Glasgow coma scale (GCS) and/or Rankin scores at discharge...
  24. ncbi request reprint In vivo 1H magnetic resonance spectroscopy, T2-weighted and diffusion-weighted MRI during lithium-pilocarpine-induced status epilepticus in the rat
    Pieter van Eijsden
    Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Brain Res 1030:11-8. 2004
    ..These pathological phenomena are the first to contribute to the pathophysiology of spontaneous recurrent seizures in a later stage in this animal model...
  25. ncbi request reprint Technical aspects of perfusion-weighted imaging
    Ona Wu
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    Neuroimaging Clin N Am 15:623-37, xi. 2005
    ..Understanding the technical aspects of PWI may improve comprehension of the capabilities and limitations of this technique...