Kasper Thorsen

Summary

Affiliation: Aarhus University Hospital
Country: Denmark

Publications

  1. pmc Tumor-specific usage of alternative transcription start sites in colorectal cancer identified by genome-wide exon array analysis
    Kasper Thorsen
    Department of Molecular Medicine, Aarhus University Hospital, Skejby, 8200 Aarhus N, Denmark
    BMC Genomics 12:505. 2011
  2. pmc Keratin23 (KRT23) knockdown decreases proliferation and affects the DNA damage response of colon cancer cells
    Karin Birkenkamp-Demtroder
    Department of Molecular Medicine MOMA, Aarhus University Hospital, Skejby, Aarhus N, Denmark
    PLoS ONE 8:e73593. 2013
  3. pmc Alternative splicing of SLC39A14 in colorectal cancer is regulated by the Wnt pathway
    Kasper Thorsen
    Department of Molecular Medicine, Aarhus University Hospital, Skejby, DK 8200 Aarhus N, Denmark
    Mol Cell Proteomics 10:M110.002998. 2011
  4. ncbi request reprint Frequent genomic loss at chr16p13.2 is associated with poor prognosis in colorectal cancer
    Claus Lindbjerg Andersen
    Department of Molecular Medicine MOMA, Aarhus University Hospital, Skejby, Aarhus N, Denmark
    Int J Cancer 129:1848-58. 2011
  5. doi request reprint MiRNA-362-3p induces cell cycle arrest through targeting of E2F1, USF2 and PTPN1 and is associated with recurrence of colorectal cancer
    Lise Lotte Christensen
    Department of Molecular Medicine, Aarhus University Hospital, Denmark
    Int J Cancer 133:67-78. 2013
  6. pmc Functional screening identifies miRNAs influencing apoptosis and proliferation in colorectal cancer
    Lise Lotte Christensen
    Colorectal Cancer Research Group, Department of Molecular Medicine MOMA, Aarhus University Hospital, University of Aarhus, Aarhus, Denmark
    PLoS ONE 9:e96767. 2014
  7. doi request reprint Identification and validation of highly frequent CpG island hypermethylation in colorectal adenomas and carcinomas
    Bodil Oster
    Department of Molecular Medicine, Aarhus University Hospital, Skejby, Denmark
    Int J Cancer 129:2855-66. 2011
  8. ncbi request reprint Mutational context and diverse clonal development in early and late bladder cancer
    Iver Nordentoft
    Department of Molecular Medicine, Aarhus University Hospital, Brendstrupgaardsvej 100, 8200 Aarhus, Denmark
    Cell Rep 7:1649-63. 2014
  9. doi request reprint Non-CpG island promoter hypomethylation and miR-149 regulate the expression of SRPX2 in colorectal cancer
    Bodil Øster
    Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark
    Int J Cancer 132:2303-15. 2013
  10. doi request reprint Alternative splicing in colon, bladder, and prostate cancer identified by exon array analysis
    Kasper Thorsen
    Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University Hospital, Skejby, DK 8200 Aarhus N, Denmark
    Mol Cell Proteomics 7:1214-24. 2008

Collaborators

Detail Information

Publications14

  1. pmc Tumor-specific usage of alternative transcription start sites in colorectal cancer identified by genome-wide exon array analysis
    Kasper Thorsen
    Department of Molecular Medicine, Aarhus University Hospital, Skejby, 8200 Aarhus N, Denmark
    BMC Genomics 12:505. 2011
    ..Aberrant expression patterns promoting carcinogenesis, however, may arise from alternative promoter usage...
  2. pmc Keratin23 (KRT23) knockdown decreases proliferation and affects the DNA damage response of colon cancer cells
    Karin Birkenkamp-Demtroder
    Department of Molecular Medicine MOMA, Aarhus University Hospital, Skejby, Aarhus N, Denmark
    PLoS ONE 8:e73593. 2013
    ..g. MRE11A, E2F1, RAD51 and BRCA1. Knockdown of KRT23 rendered colon cancer cells more sensitive to irradiation and reduced proliferation of the KRT23 depleted cells compared to irradiated control cells. ..
  3. pmc Alternative splicing of SLC39A14 in colorectal cancer is regulated by the Wnt pathway
    Kasper Thorsen
    Department of Molecular Medicine, Aarhus University Hospital, Skejby, DK 8200 Aarhus N, Denmark
    Mol Cell Proteomics 10:M110.002998. 2011
    ..In conclusion, alternative splicing of SLC39A14 was identified in colorectal tumors and found to be regulated by the Wnt pathway, most likely through regulation of SRPK1 and SRSF1...
  4. ncbi request reprint Frequent genomic loss at chr16p13.2 is associated with poor prognosis in colorectal cancer
    Claus Lindbjerg Andersen
    Department of Molecular Medicine MOMA, Aarhus University Hospital, Skejby, Aarhus N, Denmark
    Int J Cancer 129:1848-58. 2011
    ..The findings indicate that structural rearrangements involving chr16p13.2 are very frequent in colorectal neoplasia, often lead to homozygous deletion, and are associated with poor clinical outcome...
  5. doi request reprint MiRNA-362-3p induces cell cycle arrest through targeting of E2F1, USF2 and PTPN1 and is associated with recurrence of colorectal cancer
    Lise Lotte Christensen
    Department of Molecular Medicine, Aarhus University Hospital, Denmark
    Int J Cancer 133:67-78. 2013
    ..We conclude that miR-362-3p may be a novel prognostic marker in CRC, and hypothesize that the positive effects of augmented miR-362-3p expression may in part be mediated through the targets E2F1, USF2 and PTPN1...
  6. pmc Functional screening identifies miRNAs influencing apoptosis and proliferation in colorectal cancer
    Lise Lotte Christensen
    Colorectal Cancer Research Group, Department of Molecular Medicine MOMA, Aarhus University Hospital, University of Aarhus, Aarhus, Denmark
    PLoS ONE 9:e96767. 2014
    ..Finally, combining the functional screening with profiling of CRC tissue samples we identified clinically relevant miRNAs and miRNA targets in CRC. ..
  7. doi request reprint Identification and validation of highly frequent CpG island hypermethylation in colorectal adenomas and carcinomas
    Bodil Oster
    Department of Molecular Medicine, Aarhus University Hospital, Skejby, Denmark
    Int J Cancer 129:2855-66. 2011
    ..The hypermethylation changes often occurred already in adenomas, indicating that they may be used as biomarkers for early detection of CRC...
  8. ncbi request reprint Mutational context and diverse clonal development in early and late bladder cancer
    Iver Nordentoft
    Department of Molecular Medicine, Aarhus University Hospital, Brendstrupgaardsvej 100, 8200 Aarhus, Denmark
    Cell Rep 7:1649-63. 2014
    ..The ancestral clones contained Pik3ca/Kdm6a mutations and may reflect the field-disease mutations shared among later tumors. ..
  9. doi request reprint Non-CpG island promoter hypomethylation and miR-149 regulate the expression of SRPX2 in colorectal cancer
    Bodil Øster
    Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark
    Int J Cancer 132:2303-15. 2013
    ..The hypomethylation of SRPX2 is focal and not part of a large block. Furthermore, it often translates to an increased expression level, which may be modulated by miR-149...
  10. doi request reprint Alternative splicing in colon, bladder, and prostate cancer identified by exon array analysis
    Kasper Thorsen
    Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University Hospital, Skejby, DK 8200 Aarhus N, Denmark
    Mol Cell Proteomics 7:1214-24. 2008
    ....
  11. pmc Next-generation sequencing of RNA and DNA isolated from paired fresh-frozen and formalin-fixed paraffin-embedded samples of human cancer and normal tissue
    Jakob Hedegaard
    Department of Molecular Medicine MOMA, Molecular Diagnostic Laboratory, Aarhus University Hospital, Skejby, Aarhus, Denmark
    PLoS ONE 9:e98187. 2014
    ..Our results are promising and suggest that NGS can be used to study FFPE specimens in both prospective and retrospective archive-based studies in which FF specimens are not available. ..
  12. doi request reprint Quantitative proteomics of fractionated membrane and lumen exosome proteins from isogenic metastatic and nonmetastatic bladder cancer cells reveal differential expression of EMT factors
    Dennis Kjølhede Jeppesen
    Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark
    Proteomics 14:699-712. 2014
    ..Our proteomic approach may help identification of proteins in the membrane and lumen of exosomes potentially involved in the metastatic process. ..
  13. pmc Gene expression in skeletal muscle after an acute intravenous GH bolus in human subjects: identification of a mechanism regulating ANGPTL4
    Berthil F F Clasen
    Institute of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark
    J Lipid Res 54:1988-97. 2013
    ..This new concept implies that abundant supply of circulating FFA decreases the need for alternative triglyceride-derived FFA through distinct inhibition of LPL mediated by increased ANGPTL4 gene expression in human muscle...
  14. ncbi request reprint Clusterin expression in normal mucosa and colorectal cancer
    Claus Lindbjerg Andersen
    Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University Hospital, DK8200 Aarhus N, Denmark
    Mol Cell Proteomics 6:1039-48. 2007
    ..The cases with de novo synthesized Clusterin define a distinct subgroup of CRC that may be of clinical importance as anti-Clusterin therapeutics are now in clinical trials...