Birgitte V Offersen

Summary

Affiliation: Aarhus University Hospital
Country: Denmark

Publications

  1. doi request reprint Is regional nodes radiotherapy an alternative to surgery?
    Birgitte Vrou Offersen
    Dept of Oncology, Aarhus University Hospital, Denmark Electronic address
    Breast 22:S118-28. 2013
  2. ncbi request reprint Patterns of angiogenesis in nonsmall-cell lung carcinoma
    B V Offersen
    Danish Cancer Society, Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    Cancer 91:1500-9. 2001
  3. doi request reprint Matrix metalloproteinase-9 measured in urine from bladder cancer patients is an independent prognostic marker of poor survival
    Birgitte V Offersen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    Acta Oncol 49:1283-7. 2010
  4. doi request reprint Accelerated partial breast irradiation as part of breast conserving therapy of early breast carcinoma: a systematic review
    Birgitte V Offersen
    Department of Oncology, Aarhus University Hospital, Aarhus C, Denmark
    Radiother Oncol 90:1-13. 2009
  5. ncbi request reprint Lack of association between level of Plasminogen Activator Inhibitor-1 and estimates of tumor angiogenesis in early breast cancer
    Birgitte Vrou Offersen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus C, Denmark
    Acta Oncol 46:782-91. 2007
  6. ncbi request reprint Urokinase plasminogen activator and plasminogen activator inhibitor type-1 in nonsmall-cell lung cancer: relation to prognosis and angiogenesis
    Birgitte Vrou Offersen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Nørrebrogade 44, Bld 5, DK 8000 Aarhus C, Denmark
    Lung Cancer 56:43-50. 2007
  7. ncbi request reprint Chalkley estimates of angiogenesis in early breast cancer--relevance to prognosis
    Birgitte V Offersen
    Danish Cancer Society, Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    Acta Oncol 41:695-703. 2002
  8. ncbi request reprint The prognostic relevance of estimates of proliferative activity in early breast cancer
    B V Offersen
    Danish Cancer Society, Department of Experimental Clinical Oncology, Aarhus, Denmark
    Histopathology 43:573-82. 2003
  9. pmc The myofibroblast is the predominant plasminogen activator inhibitor-1-expressing cell type in human breast carcinomas
    Birgitte Vrou Offersen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Nørrebrogade 44, Building 5, DK 8000 Aarhus C, Denmark
    Am J Pathol 163:1887-99. 2003
  10. ncbi request reprint Quantification of angiogenesis as a prognostic marker in human carcinomas: a critical evaluation of histopathological methods for estimation of vascular density
    B V Offersen
    Danish Cancer Society, Department of Experimental Clinical Oncology, Aarhus University Hospital, Nørrebrogade 44, Bld 5, DK 8000 Aarhus C, Denmark
    Eur J Cancer 39:881-90. 2003

Detail Information

Publications21

  1. doi request reprint Is regional nodes radiotherapy an alternative to surgery?
    Birgitte Vrou Offersen
    Dept of Oncology, Aarhus University Hospital, Denmark Electronic address
    Breast 22:S118-28. 2013
    ..Also the issue of improved systemic adjuvant treatment will be discussed in relation to eventually no regional axillary treatment. ..
  2. ncbi request reprint Patterns of angiogenesis in nonsmall-cell lung carcinoma
    B V Offersen
    Danish Cancer Society, Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    Cancer 91:1500-9. 2001
    ....
  3. doi request reprint Matrix metalloproteinase-9 measured in urine from bladder cancer patients is an independent prognostic marker of poor survival
    Birgitte V Offersen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    Acta Oncol 49:1283-7. 2010
    ..The prognostic value of these measurements has never been investigated. Using this assay we have investigated the prognostic influence of total and active MMP-9 in urine from bladder cancer patients...
  4. doi request reprint Accelerated partial breast irradiation as part of breast conserving therapy of early breast carcinoma: a systematic review
    Birgitte V Offersen
    Department of Oncology, Aarhus University Hospital, Aarhus C, Denmark
    Radiother Oncol 90:1-13. 2009
    ..Patient selection for this therapy is pivotal and based on evidence from previous studies on patient/tumour characteristics and pattern of local recurrences we propose inclusion criteria for patients in APBI protocols...
  5. ncbi request reprint Lack of association between level of Plasminogen Activator Inhibitor-1 and estimates of tumor angiogenesis in early breast cancer
    Birgitte Vrou Offersen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus C, Denmark
    Acta Oncol 46:782-91. 2007
    ..This study confirms high PAI-1 or high Chalkley counts as markers of poor prognosis in breast cancer patients, and suggests that the prognostic impact of PAI-1 is independent of its supposed involvement in tumor angiogenesis...
  6. ncbi request reprint Urokinase plasminogen activator and plasminogen activator inhibitor type-1 in nonsmall-cell lung cancer: relation to prognosis and angiogenesis
    Birgitte Vrou Offersen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Nørrebrogade 44, Bld 5, DK 8000 Aarhus C, Denmark
    Lung Cancer 56:43-50. 2007
    ..We investigate whether uPA and PAI-1 are prognostic markers in NSCLC and whether they are related to angiogenesis...
  7. ncbi request reprint Chalkley estimates of angiogenesis in early breast cancer--relevance to prognosis
    Birgitte V Offersen
    Danish Cancer Society, Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    Acta Oncol 41:695-703. 2002
    ..Thus, in a univariate analysis it was found that high Chalkley estimates of angiogenesis indicated a poor prognosis, but high Chalkley estimates were independent prognostic markers only in node-positive patients...
  8. ncbi request reprint The prognostic relevance of estimates of proliferative activity in early breast cancer
    B V Offersen
    Danish Cancer Society, Department of Experimental Clinical Oncology, Aarhus, Denmark
    Histopathology 43:573-82. 2003
    ..This study investigates whether MIB-1 scores add additional prognostic impact when evaluated together with classical clinicopathological parameters at diagnosis in early breast cancer patients...
  9. pmc The myofibroblast is the predominant plasminogen activator inhibitor-1-expressing cell type in human breast carcinomas
    Birgitte Vrou Offersen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Nørrebrogade 44, Building 5, DK 8000 Aarhus C, Denmark
    Am J Pathol 163:1887-99. 2003
    ..In conclusion, we have provided a robust immunohistochemical procedure for detection of PAI-1 and shown that the majority of the PAI-1-expressing cells in invasive ductal breast carcinomas are myofibroblasts...
  10. ncbi request reprint Quantification of angiogenesis as a prognostic marker in human carcinomas: a critical evaluation of histopathological methods for estimation of vascular density
    B V Offersen
    Danish Cancer Society, Department of Experimental Clinical Oncology, Aarhus University Hospital, Nørrebrogade 44, Bld 5, DK 8000 Aarhus C, Denmark
    Eur J Cancer 39:881-90. 2003
    ....
  11. pmc Intense inflammation in bladder carcinoma is associated with angiogenesis and indicates good prognosis
    B V Offersen
    Department of Experimental Clinical Oncology, Danish Cancer Society, Aarhus University Hospital, Noerrebrogade 44, Bldg 5, DK 8000 Aarhus C, Denmark
    Br J Cancer 87:1422-30. 2002
    ..In conclusion, inflammation was significantly correlated to microvessel density, and areas of intense inflammation were an independent marker of good prognosis...
  12. ncbi request reprint Comparison of methods of microvascular staining and quantification in prostate carcinoma: relevance to prognosis
    Birgitte Vrou Offersen
    Department of Experimental Clinical Oncology, University Hospital of Aarhus, Denmark
    APMIS 110:177-85. 2002
    ..In conclusion, anti-CD34 antibodies are sensitive endothelial markers in prostate carcinoma, and the investigated counting methods are compatible. Moreover, high vascular scores seem to carry a poor prognosis...
  13. doi request reprint Importance of margin width in breast-conserving treatment of early breast cancer
    Anne Bodilsen
    Department of Breast and Endocrine Surgery, Aarhus University Hospital, Aarhus, Denmark
    J Surg Oncol 113:609-15. 2016
    ....
  14. doi request reprint The Influence of Repeat Surgery and Residual Disease on Recurrence After Breast-Conserving Surgery: A Danish Breast Cancer Cooperative Group Study
    Anne Bodilsen
    Department of Breast and Endocrine Surgery, Aarhus University Hospital, Aarhus, Denmark
    Ann Surg Oncol 22:S476-85. 2015
    ..This study aimed to identify factors associated with residual disease after repeat surgery and to determine their effect on ipsilateral breast tumor recurrence (IBTR) and survival...
  15. doi request reprint Pattern of relapse after breast conserving therapy, a study of 1519 early breast cancer patients treated in the Central Region of Denmark 2000-2009
    Anne Bodilsen
    a Department of Breast and Endocrine Surgery, Aarhus University Hospital, Denmark
    Acta Oncol 55:964-9. 2016
    ..The aim of the study was to investigating recurrence pattern and prognostic factors of recurrence in a population-based cohort...
  16. doi request reprint Quality assurance of conventional non-CT-based internal mammary lymph node irradiation in a prospective Danish Breast Cancer Cooperative Group trial: the DBCG-IMN study
    Lise B J Thorsen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    Acta Oncol 52:1526-34. 2013
    ..In the study, standard DBCG IMN-RT was provided only to patients with right-sided BC. We provide estimates of doses to IMNs and organs at risk (OARs) in patients treated with the non-CT-based RT techniques used during the DBCG-IMN study...
  17. doi request reprint CT-planned internal mammary node radiotherapy in the DBCG-IMN study: benefit versus potentially harmful effects
    Lise B J Thorsen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    Acta Oncol 53:1027-34. 2014
    ..This study estimates IMN doses and doses to organs at risk (OAR) in patients from the DBCG-IMN. Numbers needed to harm (NNH) if patients with left-sided breast cancer had received IMN-RT are compared to the number needed to treat (NNT)...
  18. ncbi request reprint Vitronectin in human breast carcinomas
    Mads Aaboe
    Laboratory for Cellular Protein Science, Department for Molecular Biology, Aarhus University, Gustav Wied s Vej 10C, DK 8000 C, Aarhus, Denmark
    Biochim Biophys Acta 1638:72-82. 2003
    ....
  19. pmc Microvessel density predicts survival in prostate cancer patients subjected to watchful waiting
    M Borre
    The Danish Cancer Society, Department of Experimental Clinical Oncology, University Hospital of Aarhus
    Br J Cancer 78:940-4. 1998
    ..0004), as well as in the clinically localized cancer population (P < 0.0001). These findings suggest that quantitation of angiogenesis reflects the spontaneous clinical outcome of prostate cancer...
  20. doi request reprint A comparison among HER2, TP53, PAI-1, angiogenesis, and proliferation activity as prognostic variables in tumours from 408 patients diagnosed with early breast cancer
    Birgitte Vrou Offersen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    Acta Oncol 47:618-32. 2008
    ..One hundred and sixty seven patients (41%) died from breast cancer...
  21. doi request reprint A comparison between p53 accumulation determined by immunohistochemistry and TP53 mutations as prognostic variables in tumours from breast cancer patients
    Jan Alsner
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    Acta Oncol 47:600-7. 2008
    ..To clarify their interrelationship and the importance of different TP53 mutation types, these markers were investigated in tumours from 630 patients with breast cancer...