Claus Graff

Summary

Affiliation: Aalborg University
Country: Denmark

Publications

  1. doi request reprint Identifying drug-induced repolarization abnormalities from distinct ECG patterns in congenital long QT syndrome: a study of sotalol effects on T-wave morphology
    Claus Graff
    Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
    Drug Saf 32:599-611. 2009
  2. doi request reprint Effects of bilastine on T-wave morphology and the QTc interval: a randomized, double-blind, placebo-controlled, thorough QTc study
    Claus Graff
    Medical Informatics Group, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
    Clin Drug Investig 32:339-51. 2012
  3. doi request reprint Quantitative analysis of T-wave morphology increases confidence in drug-induced cardiac repolarization abnormalities: evidence from the investigational IKr inhibitor Lu 35-138
    Claus Graff
    Department of Health Science and Technology, Center for Sensory Motor Interaction, Aalborg University, Aalborg, Denmark
    J Clin Pharmacol 49:1331-42. 2009
  4. doi request reprint Covariate analysis of QTc and T-wave morphology: new possibilities in the evaluation of drugs that affect cardiac repolarization
    C Graff
    Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
    Clin Pharmacol Ther 88:88-94. 2010
  5. doi request reprint New descriptors of T-wave morphology are independent of heart rate
    Mads P Andersen
    Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
    J Electrocardiol 41:557-61. 2008
  6. doi request reprint Assessing common classification methods for the identification of abnormal repolarization using indicators of T-wave morphology and QT interval
    Saeed Shakibfar
    Center for Sensory Motor Interaction, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
    Comput Biol Med 42:485-91. 2012
  7. doi request reprint The T-peak-T-end interval as a marker of repolarization abnormality: a comparison with the QT interval for five different drugs
    Tanveer A Bhuiyan
    Department of Health Science and Technology, Aalborg University, Frederik Bajers vej 7 C1, 9220, Aalborg, Denmark
    Clin Drug Investig 35:717-24. 2015
  8. doi request reprint Cardiac effects of sertindole and quetiapine: analysis of ECGs from a randomized double-blind study in patients with schizophrenia
    Jimmi Nielsen
    Aalborg University Hospital, Psychiatry, Aalborg, Denmark Department of Clinical Medicine, Aalborg University, Aalborg, Denmark Electronic address
    Eur Neuropsychopharmacol 25:303-11. 2015
  9. doi request reprint Minimal T-wave representation and its use in the assessment of drug arrhythmogenicity
    Saeed Shakibfar
    Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
    Ann Noninvasive Electrocardiol . 2016
  10. doi request reprint The cardiac safety of aripiprazole treatment in patients at high risk for torsade: a systematic review with a meta-analytic approach
    Christoffer Polcwiartek
    Department of Psychiatry, Aalborg University Hospital, Aalborg, Denmark
    Psychopharmacology (Berl) 232:3297-308. 2015

Collaborators

Detail Information

Publications14

  1. doi request reprint Identifying drug-induced repolarization abnormalities from distinct ECG patterns in congenital long QT syndrome: a study of sotalol effects on T-wave morphology
    Claus Graff
    Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
    Drug Saf 32:599-611. 2009
    ..This current is also inhibited in the congenital type 2 form of the long QT syndrome (LQT2). It is therefore possible that electrocardiographic LQT2 patterns might be used to identify abnormal repolarization patterns induced by drugs...
  2. doi request reprint Effects of bilastine on T-wave morphology and the QTc interval: a randomized, double-blind, placebo-controlled, thorough QTc study
    Claus Graff
    Medical Informatics Group, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
    Clin Drug Investig 32:339-51. 2012
    ....
  3. doi request reprint Quantitative analysis of T-wave morphology increases confidence in drug-induced cardiac repolarization abnormalities: evidence from the investigational IKr inhibitor Lu 35-138
    Claus Graff
    Department of Health Science and Technology, Center for Sensory Motor Interaction, Aalborg University, Aalborg, Denmark
    J Clin Pharmacol 49:1331-42. 2009
    ..As a covariate to the assessment of QT interval liability, MCS offered important additive information to the effect of Lu 35-138 on cardiac repolarization...
  4. doi request reprint Covariate analysis of QTc and T-wave morphology: new possibilities in the evaluation of drugs that affect cardiac repolarization
    C Graff
    Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
    Clin Pharmacol Ther 88:88-94. 2010
    ..one associated with a high risk and describes the added benefits of a T-wave MCS as a covariate to the assessment of the QTc interval...
  5. doi request reprint New descriptors of T-wave morphology are independent of heart rate
    Mads P Andersen
    Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
    J Electrocardiol 41:557-61. 2008
    ..42). Both the advanced T-wave descriptors (asymmetry, flatness, and others), ToTe intervals and TpTe intervals, were practically independent of heart rate (R(2) = 0-0.08), making heart rate correction unnecessary for these parameters...
  6. doi request reprint Assessing common classification methods for the identification of abnormal repolarization using indicators of T-wave morphology and QT interval
    Saeed Shakibfar
    Center for Sensory Motor Interaction, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
    Comput Biol Med 42:485-91. 2012
    ..Whether this is true in general with other ECG markers and other data sets is uncertain because the approach has not been tested in this setting...
  7. doi request reprint The T-peak-T-end interval as a marker of repolarization abnormality: a comparison with the QT interval for five different drugs
    Tanveer A Bhuiyan
    Department of Health Science and Technology, Aalborg University, Frederik Bajers vej 7 C1, 9220, Aalborg, Denmark
    Clin Drug Investig 35:717-24. 2015
    ..The T-peak to T-end (TpTe) interval has been suggested as an index of transmural dispersion and as a marker of drug-induced abnormal repolarization. In this study, we investigate the relation between TpTe and the QT interval...
  8. doi request reprint Cardiac effects of sertindole and quetiapine: analysis of ECGs from a randomized double-blind study in patients with schizophrenia
    Jimmi Nielsen
    Aalborg University Hospital, Psychiatry, Aalborg, Denmark Department of Clinical Medicine, Aalborg University, Aalborg, Denmark Electronic address
    Eur Neuropsychopharmacol 25:303-11. 2015
    ..Although, quetiapine (400-600mg) did not show worsening of repolarization measures some individual patients did experience significant worsening of repolarization. Clinical Trials NCT00654706...
  9. doi request reprint Minimal T-wave representation and its use in the assessment of drug arrhythmogenicity
    Saeed Shakibfar
    Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
    Ann Noninvasive Electrocardiol . 2016
    ..The majority of these techniques and algorithms use features that determine readily apparent characteristics of the T wave, such as duration, area, amplitude, and slopes...
  10. doi request reprint The cardiac safety of aripiprazole treatment in patients at high risk for torsade: a systematic review with a meta-analytic approach
    Christoffer Polcwiartek
    Department of Psychiatry, Aalborg University Hospital, Aalborg, Denmark
    Psychopharmacology (Berl) 232:3297-308. 2015
    ..Drug-induced Brugada syndrome (BrS) is also associated with SCD. Most SCDs occur in patients with additional cardiac risk factors...
  11. doi request reprint Assessing QT interval prolongation and its associated risks with antipsychotics
    Jimmi Nielsen
    Unit for Psychiatric Research, Aalborg Psychiatric Hospital, Aarhus University Hospital, Aalborg, Denmark
    CNS Drugs 25:473-90. 2011
    ....
  12. doi request reprint Cardiovascular safety of antipsychotics: a clinical overview
    Christoffer Polcwiartek
    a Department of Psychiatry, Aalborg University Hospital, Aalborg, Denmark
    Expert Opin Drug Saf 15:679-88. 2016
    ..Most antipsychotics have an unfavorable cardiovascular adverse effect profile, and SCD may occur even in patients with no cardiovascular risk factors...
  13. doi request reprint Preoperative Electrocardiogram Score for Predicting New-Onset Postoperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery
    Jiwei Gu
    Department of Cardiothoracic Surgery, Aalborg University Hospital, Aalborg, Denmark Department of Clinical Medicine, Aalborg University, Aalborg, Denmark Department of Cardiovascular Surgery, Heart Centre of General Hospital, Ningxia Medical University, Yinchuan, Ningxia, Peoples Republic of China Atrial Fibrillation Study Group, Aalborg University Hospital, Aalborg, Denmark Electronic address
    J Cardiothorac Vasc Anesth . 2016
    ..To investigate if electrocardiogram (ECG) markers from routine preoperative ECGs can be used in combination with clinical data to predict new-onset postoperative atrial fibrillation (POAF) following cardiac surgery...
  14. doi request reprint Unrecognised myocardial infarction in patients with schizophrenia
    Jimmi Nielsen
    1Department of Psychiatry, Aalborg University Hospital, Aalborg, Denmark
    Acta Neuropsychiatr 27:106-12. 2015
    ..Unrecognised or silent myocardial infarction (MI) occurs in ~30% of the population, but the rates of unrecognised MI in patients with schizophrenia have only been sparsely investigated...