Country: Czech Republic
- Proteinases reduce metastatic dissemination and increase survival time in C57Bl6 mice with the Lewis lung carcinomaM Wald
Department of Surgery, 2nd Medical Faculty, Charles University, Prague, Czech Republic
Life Sci 63:PL237-43. 1998..None of the control animals survived for 100 days when the study was ended. The treated groups A, B and C showed survival rate 60%, 90% and 100% of animals, respectively, by 100 days...
- Mixture of trypsin, chymotrypsin and papain reduces formation of metastases and extends survival time of C57Bl6 mice with syngeneic melanoma B16M Wald
Department of Surgery, 2nd Medical School, Charles University, Prague, Czech Republic
Cancer Chemother Pharmacol 47:S16-22. 2001..The aim of the present study was to investigate the effect of a mixture of proteolytic enzymes (comprising trypsin, chymotrypsin and papain) on the metastatic model of syngeneic melanoma B16...
- Exogenous proteases confer a significant chemopreventive effect in experimental tumor modelsMartin Wald
Department of Surgery, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic
Integr Cancer Ther 7:295-310. 2008..In this article, details of the known mechanisms of systemic actions of enterally administered proteases are documented and their relationship with cancerogenesis is discussed...