Michaela Pekarova

Summary

Affiliation: Institute of Biophysics
Country: Czech Republic

Publications

  1. doi request reprint The unique role of dietary L-arginine in the acceleration of peritoneal macrophage sensitivity to bacterial endotoxin
    Michaela Pekarova
    Institute of Biophysics, Academy of Sciences of the Czech Republic vvi, Brno, Czech Republic
    Immunol Res 56:73-84. 2013
  2. doi request reprint The crucial role of l-arginine in macrophage activation: What you need to know about it
    Michaela Pekarova
    Institute of Biophysics, Academy of Sciences of the Czech Republic, Kralovopolska 135, 612 65 Brno, Czech Republic Electronic address
    Life Sci 137:44-8. 2015
  3. doi request reprint Asymmetric dimethylarginine regulates the lipopolysaccharide-induced nitric oxide production in macrophages by suppressing the activation of NF-kappaB and iNOS expression
    Michaela Pekarova
    Institute of Biophysics, Academy of Sciences of the Czech Republic, Kralovopolska 135, 612 65 Brno, Czech Republic
    Eur J Pharmacol 713:68-77. 2013
  4. doi request reprint Asymmetric dimethyl arginine induces pulmonary vascular dysfunction via activation of signal transducer and activator of transcription 3 and stabilization of hypoxia-inducible factor 1-alpha
    Michaela Pekarova
    Institute of Biophysics, Academy of Sciences of the Czech Republic, v v i, Kralovopolska 135, 612 65 Brno, Czech Republic Electronic address
    Vascul Pharmacol 73:138-48. 2015
  5. pmc New role for L-arginine in regulation of inducible nitric-oxide-synthase-derived superoxide anion production in raw 264.7 macrophages
    Michaela Pekarova
    Institute of Biophysics, The Academy of Sciences of Czech Republic, Kralovopolska 135, 612 65 Brno, Czech Republic
    ScientificWorldJournal 11:2443-57. 2011
  6. doi request reprint The effect of lipid peroxidation products on reactive oxygen species formation and nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 macrophages
    Gabriela Ambrozova
    Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic
    Toxicol In Vitro 25:145-52. 2011
  7. ncbi request reprint The effect of uric acid on homocysteine-induced endothelial dysfunction in bovine aortic endothelial cells
    Ivana Papezikova
    Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic
    Neuro Endocrinol Lett 30:112-5. 2009
  8. doi request reprint Redox-sensitive regulation of macrophage-inducible nitric oxide synthase expression in vitro does not correlate with the failure of apocynin to prevent lung inflammation induced by endotoxin
    Daniela Viačková
    Institute of Biophysics, Academy of Sciences of the Czech Republic, Kralovopolska 135, CZ 612 65 Brno, Czech Republic
    Immunobiology 216:457-65. 2011
  9. doi request reprint The effects of H1-antihistamines on the nitric oxide production by RAW 264.7 cells with respect to their lipophilicity
    Jana Kralova
    Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic
    Int Immunopharmacol 9:990-5. 2009
  10. doi request reprint Effect of polyunsaturated fatty acids on the reactive oxygen and nitrogen species production by raw 264.7 macrophages
    Gabriela Ambrozova
    Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic
    Eur J Nutr 49:133-9. 2010

Collaborators

Detail Information

Publications18

  1. doi request reprint The unique role of dietary L-arginine in the acceleration of peritoneal macrophage sensitivity to bacterial endotoxin
    Michaela Pekarova
    Institute of Biophysics, Academy of Sciences of the Czech Republic vvi, Brno, Czech Republic
    Immunol Res 56:73-84. 2013
    ..Although macrophages are partially stimulated in the absence of extracellular L-arginine, the presence of this amino acid significantly accelerates the sensitivity of macrophages to bacterial endotoxin...
  2. doi request reprint The crucial role of l-arginine in macrophage activation: What you need to know about it
    Michaela Pekarova
    Institute of Biophysics, Academy of Sciences of the Czech Republic, Kralovopolska 135, 612 65 Brno, Czech Republic Electronic address
    Life Sci 137:44-8. 2015
    ....
  3. doi request reprint Asymmetric dimethylarginine regulates the lipopolysaccharide-induced nitric oxide production in macrophages by suppressing the activation of NF-kappaB and iNOS expression
    Michaela Pekarova
    Institute of Biophysics, Academy of Sciences of the Czech Republic, Kralovopolska 135, 612 65 Brno, Czech Republic
    Eur J Pharmacol 713:68-77. 2013
    ..In summary, L-NMMA and ADMA can mediate their effects on macrophage activation via regulation of intracellular signaling pathways, which can affect critical functions in activated macrophages...
  4. doi request reprint Asymmetric dimethyl arginine induces pulmonary vascular dysfunction via activation of signal transducer and activator of transcription 3 and stabilization of hypoxia-inducible factor 1-alpha
    Michaela Pekarova
    Institute of Biophysics, Academy of Sciences of the Czech Republic, v v i, Kralovopolska 135, 612 65 Brno, Czech Republic Electronic address
    Vascul Pharmacol 73:138-48. 2015
    ..Therefore this signaling pathway represents the potential pathway for future clinical interventions in PH. ..
  5. pmc New role for L-arginine in regulation of inducible nitric-oxide-synthase-derived superoxide anion production in raw 264.7 macrophages
    Michaela Pekarova
    Institute of Biophysics, The Academy of Sciences of Czech Republic, Kralovopolska 135, 612 65 Brno, Czech Republic
    ScientificWorldJournal 11:2443-57. 2011
    ..Moreover, we demonstrated, for the first time that increased concentrations of L-arginine further potentiate iNOS-dependent O(2) (∙-) formation in inflammatory macrophages...
  6. doi request reprint The effect of lipid peroxidation products on reactive oxygen species formation and nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 macrophages
    Gabriela Ambrozova
    Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic
    Toxicol In Vitro 25:145-52. 2011
    ..Also, changes in enzymatic pathways (especially NADPH-oxidase and nitric oxide synthase inhibition) and NO scavenging properties are included in the downregulation of reactive species formation...
  7. ncbi request reprint The effect of uric acid on homocysteine-induced endothelial dysfunction in bovine aortic endothelial cells
    Ivana Papezikova
    Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic
    Neuro Endocrinol Lett 30:112-5. 2009
    ..We have studied the effect of uric acid on intact endothelial cells as well as cells with homocysteine-induced endothelial dysfunction...
  8. doi request reprint Redox-sensitive regulation of macrophage-inducible nitric oxide synthase expression in vitro does not correlate with the failure of apocynin to prevent lung inflammation induced by endotoxin
    Daniela Viačková
    Institute of Biophysics, Academy of Sciences of the Czech Republic, Kralovopolska 135, CZ 612 65 Brno, Czech Republic
    Immunobiology 216:457-65. 2011
    ..In conclusion, our data suggest that the inhibitors of NADPH oxidase possess inhibitory potential against LPS-induced NO production by mouse macrophages; however, apocynin failed to reduce LPS-induced lung inflammation in mice...
  9. doi request reprint The effects of H1-antihistamines on the nitric oxide production by RAW 264.7 cells with respect to their lipophilicity
    Jana Kralova
    Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic
    Int Immunopharmacol 9:990-5. 2009
    ..In conclusion, as was shown in this study, the modulation of nitric oxide production could be caused by the downregulation of iNOS protein expression and/or the iNOS protein activity...
  10. doi request reprint Effect of polyunsaturated fatty acids on the reactive oxygen and nitrogen species production by raw 264.7 macrophages
    Gabriela Ambrozova
    Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic
    Eur J Nutr 49:133-9. 2010
    ..An oxidative burst of phagocytes accompanied by reactive oxygen species (ROS) and reactive nitrogen species (RNS) formation is one of the phagocyte functions that could be modulated by PUFAs...
  11. pmc Modulation of metabolic activity of phagocytes by antihistamines
    Antonin Lojek
    Institute of Biophysics, Academy of Sciences of the Czech Republic, Kralovopolska 135, 612 65 Brno, Czech Republic
    Interdiscip Toxicol 4:15-9. 2011
    ..Other antihistamines should be used, under pathological conditions accompanied by the overproduction of reactive oxygen species...
  12. ncbi request reprint The effect of aldose reductase inhibition by JMC-2004 on hyperglycemia-induced endothelial dysfunction
    Ivana Papezikova
    Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic
    Neuro Endocrinol Lett 29:775-8. 2008
    ..In this study, the effect of a novel ALR-2 inhibitor JMC-2004 on hyperglycemia-induced endothelial dysfunction was studied...
  13. pmc Nitro-oleic acid modulates classical and regulatory activation of macrophages and their involvement in pro-fibrotic responses
    Gabriela Ambrozova
    Institute of Biophysics, Academy of Sciences of the Czech Republic, Kralovopolska 135, 612 65 Brno, Czech Republic
    Free Radic Biol Med 90:252-60. 2016
    ....
  14. pmc The effects of dithiaden on nitric oxide production by RAW 264.7 cells
    Jana Kralova
    Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic
    Interdiscip Toxicol 1:214-7. 2008
    ..From this data it can be suggested that the inhibition effect of dithiaden on macrophage NO production is caused exclusively by the suppression of iNOS protein expression...
  15. ncbi request reprint The effect of different molecular weight hyaluronan on macrophage physiology
    Daniela Krejcova
    Academy of Sciences of the Czech Republic, Brno, Czech Republic
    Neuro Endocrinol Lett 30:106-11. 2009
    ..In contradiction, the biological effects of fragmented low molecular weight hyaluronan are suggested to be pro-angiogenic and pro-inflammatory...
  16. doi request reprint Continuous electrochemical monitoring of nitric oxide production in murine macrophage cell line RAW 264.7
    Michaela Pekarova
    Institute of Biophysics, Academy of Sciences of the Czech Republic, Kralovopolska 135, 612 65 Brno, Czech Republic
    Anal Bioanal Chem 394:1497-504. 2009
    ..7 cells was demonstrated by the immediate decrease in the signal due to NO as a response to the addition of iNOS inhibitor into the cell culture medium...
  17. doi request reprint Bone marrow-derived macrophages exclusively expressed caveolin-2: The role of inflammatory activators and hypoxia
    Michaela Maceckova
    Department of Animal Physiology and Immunology, Institute of Experimental Biology, Faculty of Science, Masaryk University, Kotlářská 267 2, 611 37 Brno, Czech Republic Institute of Biophysics, Academy of Sciences of the Czech Republic, Kralovopolska 135, 612 65 Brno, Czech Republic
    Immunobiology 220:1266-74. 2015
    ..We concluded that caveolin-2 is most probably involved in regulation of pro-inflammatory responses of BMDMs, triggered via activation of ERK1/2. ..
  18. doi request reprint ABC transporters affect the detection of intracellular oxidants by fluorescent probes
    Jirina Prochazkova
    Department of Animal Physiology and Immunology, Institute of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic
    Free Radic Res 45:779-87. 2011
    ..The activity of these transporters must be considered when employing fluorescent probes for the assessment of ROS production or mitochondrial membrane potential...