Jan Skrha

Summary

Affiliation: Charles University
Country: Czech Republic

Publications

  1. ncbi [Pathogenesis of type 1 and type 2 diabetes in 2011--the unifying model of glucoregulation disorder]
    J Skrha
    III interní klinika klinika endokrinologie a metabolizmu 1 lékarské fakulty UK a VFN Praha
    Vnitr Lek 57:949-53. 2011
  2. doi Lower plasma levels of glucose-dependent insulinotropic peptide (GIP) and pancreatic polypeptide (PP) in patients with ductal adenocarcinoma of the pancreas and their relation to the presence of impaired glucoregulation and weight loss
    Jan Skrha
    3rd Department of Internal Medicine and Laboratory for Endocrinology and Metabolism, Prague, Czechia Electronic address
    Pancreatology . 2016
  3. doi Glucose variability, HbA1c and microvascular complications
    Jan Skrha
    3rd Department of Internal Medicine, Laboratory for Endocrinology and Metabolism, 1st Faculty of Medicine, Charles University and General Faculty Hospital, U Nemocnice 1, 12808, Prague 2, Czech Republic
    Rev Endocr Metab Disord 17:103-10. 2016
  4. ncbi [Present and future of insulin treatment]
    J Skrha
    III Interní klinika 1 lékarské fakulty UK a VFN Praha
    Vnitr Lek 59:209-13. 2013
  5. ncbi [Education in medical specialties in the Czech Republic]
    J Skrha
    Univerzita Karlova v Praze, Lékarská fakulta, III Internií Klinika VFN
    Cas Lek Cesk 148:475-6. 2009
  6. ncbi Meal test for glucose-dependent insulinotropic peptide (GIP) in obese and type 2 diabetic patients
    J Skrha
    Third Department of Internal Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Physiol Res 59:749-55. 2010
  7. ncbi Insulin lispro improves postprandial glucose control in patients with diabetes mellitus
    J Skrha
    Third Department of Internal Medicine of First Medical Faculty, Charles University, Czech Republic
    Sb Lek 103:15-21. 2002
  8. ncbi [Changes in microcirculation and selected laboratory parameters in the early stages of diabetic microangiopathy]
    J Skrha
    III interni klinika 1 LF UK a VFN, Praha
    Cas Lek Cesk 140:370-4. 2001
  9. ncbi Effect of caloric restriction on oxidative markers
    Jan Skrha
    Laboratory for Endocrinology and Metabolism and 3rd Department of Internal Medicine, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
    Adv Clin Chem 47:223-47. 2009
  10. ncbi Oxidative stress and endothelium influenced by metformin in type 2 diabetes mellitus
    Jan Skrha
    Laboratory for Endocrinology and Metabolism, 3rd Department of Internal Medicine, First Faculty of Medicine, Charles University, U Nemocnice 1, 128 08 Prague 2, Czech Republic
    Eur J Clin Pharmacol 63:1107-14. 2007

Detail Information

Publications77

  1. ncbi [Pathogenesis of type 1 and type 2 diabetes in 2011--the unifying model of glucoregulation disorder]
    J Skrha
    III interní klinika klinika endokrinologie a metabolizmu 1 lékarské fakulty UK a VFN Praha
    Vnitr Lek 57:949-53. 2011
    ..The elucidation of the cause of changes in developed diabetes enables to suggest some perspective therapeutic approaches and/or preventive ways...
  2. doi Lower plasma levels of glucose-dependent insulinotropic peptide (GIP) and pancreatic polypeptide (PP) in patients with ductal adenocarcinoma of the pancreas and their relation to the presence of impaired glucoregulation and weight loss
    Jan Skrha
    3rd Department of Internal Medicine and Laboratory for Endocrinology and Metabolism, Prague, Czechia Electronic address
    Pancreatology . 2016
    ..The aim of this study was to determine plasma concentrations of selected gastrointestinal hormones in PDAC patients with and without diabetes and to compare them with levels found in Type 2 diabetic patients without cancer...
  3. doi Glucose variability, HbA1c and microvascular complications
    Jan Skrha
    3rd Department of Internal Medicine, Laboratory for Endocrinology and Metabolism, 1st Faculty of Medicine, Charles University and General Faculty Hospital, U Nemocnice 1, 12808, Prague 2, Czech Republic
    Rev Endocr Metab Disord 17:103-10. 2016
    ..It is concluded that randomized prospective follow-up trials could possibly help estimate whether short-term glucose variability should be considered as an independent risk factor for microvascular complications in diabetes. ..
  4. ncbi [Present and future of insulin treatment]
    J Skrha
    III Interní klinika 1 lékarské fakulty UK a VFN Praha
    Vnitr Lek 59:209-13. 2013
    ..Individualized insulin treatment is the basement for modern trends in diabetology...
  5. ncbi [Education in medical specialties in the Czech Republic]
    J Skrha
    Univerzita Karlova v Praze, Lékarská fakulta, III Internií Klinika VFN
    Cas Lek Cesk 148:475-6. 2009
    ..Resident positions becoming available just in this year were created as a part of the education system. Final design and stabilization of the whole system structure including financial support is proposed in the future...
  6. ncbi Meal test for glucose-dependent insulinotropic peptide (GIP) in obese and type 2 diabetic patients
    J Skrha
    Third Department of Internal Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Physiol Res 59:749-55. 2010
    ..Simple meal test could demonstrate impaired GIP secretion and delayed insulin secretion in Type 2 diabetic patients as compared to obese non-diabetic and non-obese healthy control individuals...
  7. ncbi Insulin lispro improves postprandial glucose control in patients with diabetes mellitus
    J Skrha
    Third Department of Internal Medicine of First Medical Faculty, Charles University, Czech Republic
    Sb Lek 103:15-21. 2002
    ..Therapy with insulin lispro was therefore associated with a significant improvement in postprandial blood glucose excursion control when compared with regular human insulin, without an increase in rate of hypoglycaemia...
  8. ncbi [Changes in microcirculation and selected laboratory parameters in the early stages of diabetic microangiopathy]
    J Skrha
    III interni klinika 1 LF UK a VFN, Praha
    Cas Lek Cesk 140:370-4. 2001
    ....
  9. ncbi Effect of caloric restriction on oxidative markers
    Jan Skrha
    Laboratory for Endocrinology and Metabolism and 3rd Department of Internal Medicine, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
    Adv Clin Chem 47:223-47. 2009
    ....
  10. ncbi Oxidative stress and endothelium influenced by metformin in type 2 diabetes mellitus
    Jan Skrha
    Laboratory for Endocrinology and Metabolism, 3rd Department of Internal Medicine, First Faculty of Medicine, Charles University, U Nemocnice 1, 128 08 Prague 2, Czech Republic
    Eur J Clin Pharmacol 63:1107-14. 2007
    ..Metformin may influence atherogenesis but the mechanisms are not well understood. A pilot study was undertaken to determine whether metformin administration is associated with changes in oxidative stress and endothelial function...
  11. ncbi [Pathogenesis of the connective tissue in diabetes]
    J Skrha
    III interní klinika 1 lékarskéfakulty UK a VFN, Praha
    Vnitr Lek 52:446-50. 2006
    ..Despite known pathogenic mechanisms in development of diabetic microangiopathy there are series of unresolved questions in the pathogenesis of diabetic skin disorders...
  12. ncbi Comparison of the insulin action parameters from hyperinsulinemic clamps with homeostasis model assessment and QUICKI indexes in subjects with different endocrine disorders
    Jan Skrha
    Third Department of Internal Medicine, First Faculty of Medicine, Charles University, 128 08 Prague 2, Czech Republic
    J Clin Endocrinol Metab 89:135-41. 2004
    ..The HOMA and QUICKI indexes do not offer the same information as glucose clamps in the rare cases with differently impaired peripheral or hepatic insulin action...
  13. ncbi [Pancreatic hormones and hormonal regulation of insulin secretion]
    J Skrha
    III interni klinika 1 LF UK a VFN, Praha
    Cas Lek Cesk 145:599-605. 2006
    ..Diabetes mellitus, similarly to disturbances of other hormones, can cause impaired regulation of insulin and other pancreatic hormones...
  14. ncbi Short-term very low calorie diet reduces oxidative stress in obese type 2 diabetic patients
    J Skrha
    Third Department of Internal Medicine, First Faculty of Medicine, Charles University, U Nemocnice 1, 128 08 Prague 2, Czech Republic
    Physiol Res 54:33-9. 2005
    ..Diabetes mellitus causes a greater resistance to the effects of a low calorie diet on oxidative stress...
  15. ncbi [Type 2 diabetes mellitus as a subclinical inflammation]
    Jan Skrha
    Univerzita Karlova v Praze, 1 lékarská fakulta, III interni klinika VFN
    Cas Lek Cesk 149:277-81. 2010
    ..The resulting subclinical inflammation is a consequence of defensive anti-inflammatory reactions. Such Type 2 diabetes conception brings various possibilities in the treatment and prevention...
  16. ncbi [Coeliac disease and diabetes]
    J Skrha
    III Interní klinika klinika endokrinologie a metabolismu 1 Iékarské fakulty UK a VFN Praha
    Vnitr Lek 57:375-7. 2011
    ..It may cause different complications if it would remain without treatment. Active screening of coeliac disease and similarly of autoimmune thyreopathy is therefore an integral part of examination in type 1 diabetic patients...
  17. ncbi [Diagnostics and treatment of organic hyperinsulinism--experience in 105 cases]
    J Skrha
    III interni klinika 1 LF UK a VFN, U Nemocnice 1, 128 08 Praha 2
    Cas Lek Cesk 148:389-94. 2009
    ..Organic hyperinsulinism causes hypoglycaemia manifesting mainly in the fasting state. We summarize our experience with diagnosis and treatment of 105 patients with organic hyperinsulinism...
  18. ncbi Effect of simvastatin and fenofibrate on endothelium in Type 2 diabetes
    Jan Skrha
    Laboratory for Endocrinology and Metabolism, Faculty of Medicine 1, Czech Republic
    Eur J Pharmacol 493:183-9. 2004
    ..05) concentrations. We conclude that simvastatin and fenofibrate interact, by different mechanisms, with oxidative stress, a key factor in the modification of fibrinolysis and endothelial function in Type 2 diabetes...
  19. ncbi 2,3,7,8-TCDD exposure, endothelial dysfunction and impaired microvascular reactivity
    Daniela Pelclova
    Department of Occupational Medicine, 1st Medical Faculty, Charles University and General University Hospital, Na Bojisti 1, Prague, Czech Republic
    Hum Exp Toxicol 26:705-13. 2007
    ..77, P = 0.009) as well as the velocity of perfusion increase during TH (r = -0.68, P = 0.03) and TH% (r = -0.78, P = 0.008). Our data document the presence of endothelial dysfunction in TCDD-exposed men...
  20. ncbi Serum alpha-tocopherol and ascorbic acid concentrations in Type 1 and Type 2 diabetic patients with and without angiopathy
    Jan Skrha
    Laboratory for Endocrinology and Metabolism, Department of Internal Medicine 3, Faculty of Medicine 1, Charles University, Prague, Czech Republic
    Clin Chim Acta 329:103-8. 2003
    ....
  21. pmc Acute hyperglycemia does not impair microvascular reactivity and endothelial function during hyperinsulinemic isoglycemic and hyperglycemic clamp in type 1 diabetic patients
    Eva Horová
    3rd Department of Internal Medicine, 1st Faculty of Medicine, Charles University, U Nemocnice 1, 12800 Prague, Czech Republic
    Exp Diabetes Res 2012:851487. 2012
    ..The aim of this study was to evaluate the effect of acute glycemia increase on microvasculature and endothelium in Type 1 diabetes during hyperinsulinemic clamp...
  22. ncbi Comparison of insulin sensitivity in patients with insulinoma and obese Type 2 diabetes mellitus
    J Skrha
    Department of Internal Medicine 3, Faculty of Medicine 1, Charles University, Prague, Czech Republic
    Horm Metab Res 28:595-8. 1996
    ..We conclude that insulin resistance was caused by postreceptor changes in obese Type 2 diabetes, whereas a decreased insulin binding capacity together with post-receptor defect was present in insulinoma patients...
  23. ncbi Early detection of pancreatic cancer: impact of high-resolution imaging methods and biomarkers
    Premysl Fric
    Departments of aMedicine GastroenterologybPathologycSurgery, Military University HospitaldLaboratory of Endocrinology and MetabolismeInstitute of Biochemistry and Experimental OncologyfInstitute of Clinical Biochemistry and Laboratory Diagnostics, General University Hospital, 1st and 2nd Faculty of MedicinegDepartment of Medicine, 3rd Faculty of Medicine, Charles University, Prague, Czech Republic
    Eur J Gastroenterol Hepatol 28:e33-e43. 2016
    ..An early indication of HRIMs and biomarkers is a prerequisite for the diagnosis of a resectable PC. This publication reviews the recent contribution of HRIMs and biomarkers toward an early diagnosis of PC...
  24. doi Early pancreatic carcinogenesis - risk factors, early symptoms, and the impact of antidiabetic drugs
    Premysl Fric
    aDepartment of Medicine and Gastroenterology, Military University Hospital bLaboratory of Endocrinology and Metabolism cInstitute of Biochemistry and Experimental Oncology, General University Hospital, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
    Eur J Gastroenterol Hepatol 28:e19-25. 2016
    ..The correct evaluation of antidiabetic drugs and their interactions with other components of pancreatic carcinogenesis may influence the early diagnosis of PC. ..
  25. ncbi Influence of PPAR-alpha agonist fenofibrate on insulin sensitivity and selected adipose tissue-derived hormones in obese women with type 2 diabetes
    K Anderlova
    Third Department of Medicine, First Faculty of Medicine, Charles University, Praha, Czech Republic
    Physiol Res 56:579-86. 2007
    ..The lack of insulin-sensitizing effects of fenofibrate in humans relative to rodents could be due to a generally lower PPAR-alpha expression in human liver and muscle...
  26. doi Increased tissue and circulating levels of dipeptidyl peptidase-IV enzymatic activity in patients with pancreatic ductal adenocarcinoma
    Petr Busek
    Laboratory of Cancer Cell Biology, Institute of Biochemistry and Experimental Oncology, First Faculty of Medicine, Charles University in Prague, Czech Republic Electronic address
    Pancreatology 16:829-38. 2016
    ..The present study analyzes blood plasma levels and the quantity and localization of DPP-IV and FAP in PDAC tissues...
  27. ncbi Association of obesity, diabetes, serum lipids and blood pressure regulates insulin action
    G Sindelka
    Third Department of Internal Medicine, First Faculty of Medicine, Charles University Prague, Czech Republic
    Physiol Res 51:85-91. 2002
    ..54, p<0.001) and mean blood pressure (r = -0.38, p<0.01). From the multiple regression analysis we conclude that obesity may have even greater influence on the insulin action than diabetes mellitus itself...
  28. pmc Gene polymorphisms of superoxide dismutases and catalase in diabetes mellitus
    Milan Flekac
    3rd Dept, of Internal Medicine, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
    BMC Med Genet 9:30. 2008
    ..Protective role of scavenger enzymes may be deteriorated by oxidative stress. This study was undertaken to investigate the association between gene polymorphisms of selected antioxidant enzymes and vascular complications of DM...
  29. ncbi The effect of simvastatin and fenofibrate on the expression of leukocyte adhesion molecules and lipopolysaccharide receptor CD14 in type 2 diabetes mellitus
    Tomas Stulc
    3rd Department of Medicine, Charles University, Czech Republic
    Neuro Endocrinol Lett 33:73-7. 2012
    ..We have therefore compared the effect of simvastatin and fenofibrate on several leukocyte activation markers in diabetes patients...
  30. ncbi Biochemical markers of endothelial dysfunction in patients with endocrine and essential hypertension
    O Petrak
    Third Internal Department, First Faculty of Medicine, Charles University, General Faculty Hospital, Prague, Czech Republic
    Physiol Res 55:597-602. 2006
    ..No correlation between the biochemical markers of endothelial dysfunction and vasopressor substances activated in endocrine hypertension was found...
  31. ncbi Does the treatment of primary hyperaldosteronism influence glucose tolerance?
    B Strauch
    Third Department of Internal Medicine, First Faculty of Medicine, Charles University, U Nemocnice 1, 128 08 Prague 2, Czech Republic
    Physiol Res 52:503-6. 2003
    ..Mild worsening of glucose tolerance after treatment could be explained by an increase of the body mass index. These data, in accordance with our previous study, do not support the idea that PH is a secondary form of diabetes mellitus...
  32. doi Precursors of pancreatic cancer
    Premysl Fric
    aGastroenterology Unit, Department of Medicine, Military University Hospital bLaboratory of Endocrinology and Metabolism cInstitute of Biochemistry and Experimental Oncology, First Faculty of Medicine, General University Hospital, and Charles University, Prague, Czech Republic
    Eur J Gastroenterol Hepatol . 2016
    ..The publication surveys the present knowledge of individual precursors and their role in the early pancreatic carcinogenesis...
  33. pmc Comparison of Different Treatment Modalities for Type 1 Diabetes, Including Sensor-Augmented Insulin Regimens, in 52 Weeks of Follow-Up: A COMISAIR Study
    Jan Soupal
    1 3rd Department of Internal Medicine, 1st Faculty of Medicine, Charles University in Prague, Czech Republic
    Diabetes Technol Ther 18:532-8. 2016
    ....
  34. ncbi Can the atherosclerosis prevention targets be achieved in type 2 diabetes?
    Jan Skrha
    Department of Internal Medicine 3, Faculty of Medicine 1, Charles University, U Nemocnice 1, 12808 Prague 2, Czech Republic
    Diabetes Res Clin Pract 68:S48-51. 2005
    ..More aggressive drug treatment together with life style changes will be necessary to reach our goals in Type 2 diabetic patients...
  35. ncbi Advanced glycoxidation end products in chronic diseases-clinical chemistry and genetic background
    Marta Kalousova
    Institute of Clinical Chemistry and Laboratory Diagnostics, First Faculty of Medicine and General University Hospital, Charles University, Katerinska 32, 12108 Prague 2, Czech Republic
    Mutat Res 579:37-46. 2005
    ....
  36. ncbi Microvascular Reactivity and Endothelial Function in Type 2 Diabetic Patients with Hyperlipidemia Treated with Simvastatin: 3-year Follow-up
    M Prázný
    Charles University in Prague, First Faculty of Medicine, 3rd Department of Internal Medicine, Prague, Czech Republic
    Prague Med Rep 110:290-300. 2009
    ..56+/-30 PU, p<0.05, THmax 67+/-19, 81+/-37, 58+/-24 vs. 134+/-70 PU, p<0.01, PORHmax/t 2.0+/-1.4, 2.8+/-1.7, 1.9+/-1.3 vs. 7.7+/-7.4 PU/s, p<0.05, THmax/t 1.1+/-0.6, 1.0+/-0.4, 0.7+/-0.4 vs. 1.5+/-0.7 PU/s, p<0.05...
  37. ncbi Reduced microvascular perfusion and reactivity in adult GH deficient patients is restored by GH replacement
    V Hana
    Third Department of Internal Medicine, Faculty of Medicine I, Charles University, Prague, Czech Republic
    Eur J Endocrinol 147:333-7. 2002
    ..Changes in microcirculation and vascular reactivity could represent an early marker of developing vascular changes...
  38. ncbi Relationship between peripheral diabetic neuropathy and microvascular reactivity in patients with type 1 and type 2 diabetes mellitus -- neuropathy and microcirculation in diabetes
    Z Kasalova
    Department of Internal Medicine 3, Faculty of Medicine 1, Charles University, Prague, Czech Republic
    Exp Clin Endocrinol Diabetes 114:52-7. 2006
    ..We suppose that the pathogenesis of neuropathy and impaired microvascular reactivity may be differently influenced by metabolic factors in type 1 and type 2 diabetic patients...
  39. ncbi Paraoxonase 1 gene polymorphisms and enzyme activities in diabetes mellitus
    M Flekac
    Third Department of Internal Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Physiol Res 57:717-26. 2008
    ..The association of PON1 polymorphisms, lower PON1 activity and poorer diabetes control found in patients with macroangiopathy further support the idea of genetic factors contributing to the development of vascular disorders in diabetes...
  40. ncbi Impaired microvascular reactivity and endothelial function in patients with Cushing's syndrome: influence of arterial hypertension
    M Prázný
    Third Department of Internal Medicine, First Faculty of Medicine, Prague, Czech Republic
    Physiol Res 57:13-22. 2008
    ..4 PU.s(-1), p<0.05, and 0.95+/-0.6 vs. 1.8+/-1.1 PU.s(-1), p<0.05, respectively). The most pronounced impairment of microvascular reactivity was present in patients with combination of arterial hypertension and diabetes mellitus...
  41. ncbi [Laparoscopic diagnosis and treatment of organic hyperinsulinism--our first experience]
    J Svab
    I chirurgická klinika 1 LF UK a VFN, Praze
    Rozhl Chir 84:70-4. 2005
    ..3, 4). The operative time was 90 min. Drainage is necessary. CT guided drain in cavity of seroma is shown (Fig. 5)...
  42. ncbi The influence of nitric oxide synthase inhibitor L-NAME on bones of male rats with streptozotocin-induced diabetes
    P D Broulik
    Third Medical Department, First Faculty of Medicine, Charles University, U Nemocnice 1, 128 21 Prague 2, Czech Republic
    Physiol Res 52:729-34. 2003
    ..Inhibition of NO neither increased osteoclastic activity (TRAP) nor induced osteopenia in L-NAME-treated rats. This suggests a possibility that NO is not involved in the pathogenesis of diabetic osteopenia...
  43. ncbi [Changes in IGF-I levels and its binding proteins in diabetes mellitus and obesity]
    M Krsek
    III interni klinika 1 LF UK a VFN, Praha
    Cas Lek Cesk 142:216-9. 2003
    ..Present study was aimed to describe changes of its particular components in patients with type 1 and type 2 diabetic patients and patients with obesity...
  44. ncbi Microvascular reactivity in patients with hypercholesterolemia: effect of lipid lowering treatment
    T Stulc
    Third Department of Internal Medicine, U Nemocnice 1, Prague 2, Czech Republic
    Physiol Res 52:439-45. 2003
    ..These results suggest that microcirculation is not involved in the early vascular dysfunction induced by HLP and that MVR rather reflects changes which appear later in the course of the atherosclerotic disease...
  45. ncbi Serum leptin levels in patients with primary hyperaldosteronism before and after treatment: relationships to insulin sensitivity
    M Haluzik
    Third Department of Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic
    J Hum Hypertens 16:41-5. 2002
    ..Leptin is a protein hormone produced predominantly by adipocytes that plays a role in food intake regulation and a series of other physiological processes including blood pressure regulation...
  46. ncbi Comparison of laser-Doppler flowmetry with biochemical indicators of endothelial dysfunction related to early microangiopathy in Type 1 diabetic patients
    J Skrha
    Department of Internal Medicine 3, Faculty of Medicine 1, Charles University, U Nemocnice 1, 128 08 Prague, Czech Republic
    J Diabetes Complications 15:234-40. 2001
    ....
  47. ncbi [IGFBP-1 and its protective role in the pathogenesis of microangiopathy in type 1 diabetes mellitus]
    M Krsek
    III interni klinika 1 LF UK a VFN, Praha
    Cas Lek Cesk 140:234-7. 2001
    ..We studied the influence of this system on microvasculature in patients with type 1 diabetes with respect to the effect of IGFBP-1...
  48. ncbi The relationship between the IGF-I system and its binding proteins and microvascular reactivity in Type 1 diabetes mellitus
    M Krsek
    Third Department of Internal Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Physiol Res 51:379-85. 2002
    ..We conclude that the microvascular reactivity is impaired in Type 1 diabetes mellitus, but this impairment is not clearly dependent on the activity of the IGF-I system. It is probably only a complementary pathogenic factor...
  49. ncbi The influence of methylene blue and L-NAME on the development of streptozotocin-induced diabetes in rats
    M Haluzik
    IIIrd Department of Medicine, 1st Faculty of Medicine, Charles University, U Nemocnice 1, 128 08 Prague 2, Czech Republic
    Sb Lek 100:213-7. 1999
    ..The precise mechanism of this effect is not clear. We failed to demonstrate clear effect of methylene blue and/or L-NAME on oxidative stress development in diabetic rats...
  50. ncbi Impaired insulin action in primary hyperaldosteronism
    J Widimsky
    Third Internal Clinic, Faculty of Medicine, Charles University, Prague, Czech Republic
    Physiol Res 49:241-4. 2000
    ..We thus conclude that insulin resistance is also present in secondary forms of hypertension (primary hyperaldosteronism) which indicates the heterogeneity of impaired insulin action in patients with arterial hypertension...
  51. ncbi The relationship between serum levels of insulin-like growth factor-I and its binding proteins and microvascular function in acromegalic patients
    M Krsek
    Third Department of Internal Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Growth Horm IGF Res 12:54-9. 2002
    ..In addition, we found a significant relationship between the serum levels of IGFBP-1 and those of total and LDL cholesterol in the group of patients with hormonally active acromegaly...
  52. ncbi Screening for associated autoimmunity in type 1 diabetes mellitus with respect to diabetes control
    M Prázný
    Third Department of Internal Medicine, First Faculty of Medicine, Charles University, U Nemocnice 1, 128 08 Prague 2, Czech Republic
    Physiol Res 54:41-8. 2005
    ..We suggest the need for the follow-up of patients with positive autoantibodies because further deterioration of the respective organs can be expected...
  53. ncbi Treatment with the NO-synthase inhibitor, methylene blue, moderates the decrease in serum leptin concentration in streptozotocin-induced diabetes
    M Haluzik
    3 Medical Department, 1 Faculty of Medicine, Prague, Czech Republic
    Endocr Res 25:163-71. 1999
    ..We conclude that the drop of serum leptin levels in diabetic rats is probably mainly due to streptozotocin-induced insulin deficiency, which is partially attenuated by NO-synthase inhibitor treatment...
  54. ncbi Can primary hyperaldosteronism be considered as a specific form of diabetes mellitus?
    J Widimsky
    Third Internal Department, General Faculty Hospital, Charles University, Prague, Czech Republic
    Physiol Res 50:603-7. 2001
    ....
  55. doi Glycemic variability is higher in type 1 diabetes patients with microvascular complications irrespective of glycemic control
    Jan Soupal
    3rd Department of Internal Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Diabetes Technol Ther 16:198-203. 2014
    ..Our study assessed the relationship between microvascular complications (MVCs) and GV calculated from continuous glucose monitoring (CGM) data in type 1 diabetes patients...
  56. ncbi Insulin sensitivity in non-obese women with polycystic ovary syndrome during treatment with oral contraceptives containing low-androgenic progestin
    D Cibula
    Department of Obstetrics and Gynecology, Charles University, Apolinarska 18, Prague 2, 120 00, Czech Republic
    Hum Reprod 17:76-82. 2002
    ..The study aim was to investigate insulin action and androgen production during treatment with COC containing low-androgenic progestin...
  57. ncbi [Can hormonal contraceptives affect plasma levels of IGF-1 and IGFBP-1 in slim women with polycystic ovary syndrome?]
    G Sindelka
    III interni klinika 1 LF UK a VFN, Praha
    Cas Lek Cesk 140:469-72. 2001
    ..The aim of our work was to determine effects of peroral contraceptives with low-androgen progestin on IGF system in PCOS patients and healthy woman controls...
  58. ncbi Glucose metabolism in a patient with insulinoma complicated by hyperosmolar non-ketotic state
    J Skrha
    Department of Internal Medicine 3, Faculty of Medicine, Charles University, Prague, Czechoslovakia
    Diabet Med 7:361-3. 1990
    ..The hyperosmolar state was induced by vomiting and dehydration during an acute urinary tract infection. Impairment of glucose metabolism was confirmed by the finding of reduced tissue sensitivity to insulin during a euglycaemic clamp...
  59. ncbi [Effect of insulin in hypertension with high and low levels of renin]
    G Sindelka
    III interni klinika 1 LF UK a VFN, Praha
    Cas Lek Cesk 140:205-8. 2001
    ..The aim of our study was to verify at the receptor and postreceptor levels the presence of insulin resistance in patients with high or low renin activity...
  60. ncbi Haemostasis, cytoadhesive molecules (sE-selectin and sICAM-1) and inflammatory markers in non-insulin dependent diabetes mellitus (NIDDM)
    J Kvasnicka
    Department of Clinical Haematology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
    Sb Lek 99:97-101. 1998
    ..According to these findings we suppose that an "inflammation" plays an important role in the evolution of atherosclerotic process at NIDDM together with the known influence of glucose and lipid metabolism pathology...
  61. ncbi N-acetyl-beta-glucosaminidase and albuminuria in acromegaly
    J Skrha
    Department of Internal Medicine 3, Faculty of Medicine, Charles University, Prague, Czechoslovakia
    Horm Metab Res 23:285-7. 1991
    ..Significant correlation was determined between urinary NAG activity and albuminuria of acromegalic patients (r = 0.84)...
  62. ncbi Comparison of the effects of atorvastatin or fenofibrate on nonlipid biochemical risk factors and the LDL particle size in subjects with combined hyperlipidemia
    Vojtech Melenovsky
    Third Department of Internal Medicine, General University Hospital, Charles University, Prague, Czech Republic
    Am Heart J 144:E6. 2002
    ..The aim of this study was to compare the effects of atorvastatin and fenofibrate on nonlipid biochemical risk factors and the low-density lipoprotein (LDL) particle size in subjects with CH...
  63. ncbi The effect of combination therapy with metformin and combined oral contraceptives (COC) versus COC alone on insulin sensitivity, hyperandrogenaemia, SHBG and lipids in PCOS patients
    D Cibula
    Department of Obstetrics and Gynecology, Charles University, Apolinarska 18, Prague 2, 120 00, Czech Republic
    Hum Reprod 20:180-4. 2005
    ..Neither oral contraceptives (COC) nor metformin are an optimal modality for the long-term treatment of polycystic ovary syndrome (PCOS). The aim of this study was to evaluate whether a combination of both is beneficial over COC monotherapy...
  64. ncbi Levels of circulating biomarkers at rest and after exercise in coronary artery disease patients
    V Danzig
    Second Department of Medicine, First Faculty of Medicine, General University Hospital, Charles University, Prague, Czech Republic
    Physiol Res 59:385-92. 2010
    ..MMP-9 and BNP increase significantly with exercise in both healthy individuals and CAD patients...
  65. ncbi Prediction of insulin sensitivity in nonobese women with polycystic ovary syndrome
    D Cibula
    Department of Obstetrics and Gynecology, Charles University, Praha 2, 120 00, Czech Republic
    J Clin Endocrinol Metab 87:5821-5. 2002
    ..The close relationship between insulin sensitivity and SHBG was documented by factor analysis and by its presence in all prediction models as the most significant (or even the single) predictor of the insulin sensitivity index...
  66. ncbi Advanced glycation end-products and advanced oxidation protein products in patients with diabetes mellitus
    M Kalousova
    First Institute of Medical Chemistry and Biochemistry, First Faculty of Medicine, Charles University, Katerinská Prague, Czech Republic
    Physiol Res 51:597-604. 2002
    ..Oxidative stress is increased in both types of DM, more in Type 2 where it contributes to the formation of glycoxidation products...
  67. ncbi Oxidative stress, inflammation and autoimmune reaction in type 1 and type 2 diabetes mellitus
    M Kalousova
    Institute of Medical Biochemistry, Charles University, and General Teaching Hospital, Prague, Czech Republic
    Prague Med Rep 105:21-8. 2004
    ..45, p<0.05). Oxidative stress and inflammation are more expressed in DM2 and they are partly related. In DM1, oxidative stress seems to be in closer link to autoimmune reaction than to inflammation...
  68. doi Serum microRNA-196 and microRNA-200 in pancreatic ductal adenocarcinoma of patients with diabetes mellitus
    Pavel Skrha
    2nd Department of Internal Medicine, 3rd Faculty of Medicine, Charles University, Faculty Hospital Kralovske Vinohrady, Prague, Czech Republic Electronic address
    Pancreatology 16:839-43. 2016
    ..Our aim was to compare expressions of 6 microRNAs (miRNAs) in patients with pancreatic ductal adenocarcinoma (PAC) and non-cancer patients, moreover according to the presence or absence of diabetes mellitus...
  69. ncbi The influence of n-3 polyunsaturated fatty acids and very low calorie diet during a short-term weight reducing regimen on weight loss and serum fatty acid composition in severely obese women
    M Kunesova
    Obesity Management Centre, Institute of Endocrinology, Charles University, Prague 1, Czech Republic
    Physiol Res 55:63-72. 2006
    ..595, p<0.008). The results suggest that long chain n-3 PUFA enhance weight loss in obese females treated by VLCD. Docosahexaenoate (22:6n-3) seems to be the active component...
  70. ncbi Pathogenesis of angiopathy in diabetes
    J Skrha
    Department of Internal Medicine 3, Faculty of Medicine 1, Charles University, Prague, Czech Republic
    Acta Diabetol 40:S324-9. 2003
    ..The latter represent advanced atherosclerosis when typical plaques are formed. Failure of protective scavenger mechanisms is one possible explanation of vessel wall pathology in diabetes...
  71. ncbi New methodology of influential point detection in regression model building for the prediction of metabolic clearance rate of glucose
    Milan Meloun
    Department of Analytical Chemistry, Faculty of Chemical Technology, Pardubice University, Pardubice, Czech Republic
    Clin Chem Lab Med 42:311-22. 2004
    ..MCRg reflects insulin sensitivity filtering-off the effect of blood glucose. The prediction of clamp parameters should enable us to avoid the demanding clamp examination, which is connected with a higher load and risk for patients...
  72. ncbi Cardiovascular disease in type 2 diabetics: epidemiology, risk factors and therapeutic modalities
    Mogher Khamaisi
    Diabetes Center, Department of Internal Medicine, Hadassah University Hospital, Jerusalem, Israel
    Isr Med Assoc J 5:801-6. 2003
    ....
  73. doi Insulin resistance and hyperinsulinemia: is hyperinsulinemia the cart or the horse?
    Michael H Shanik
    Division of Endocrinology, North Shore Long Island Jewish Health System, Lake Success, New York, USA
    Diabetes Care 31:S262-8. 2008
    ..5) Many patients with insulinoma who have elevated basal levels of insulin have reduced (but not absent) responsiveness to administered insulin. In summary, hyperinsulinemia is often both a result and a driver of insulin resistance...
  74. ncbi Hyperglycemia and its effect after acute myocardial infarction on cardiovascular outcomes in patients with Type 2 diabetes mellitus (HEART2D) Study design
    Zvonko Milicevic
    Eli Lilly and Company, Vienna, Austria
    J Diabetes Complications 19:80-7. 2005
    ..The HEART2D study seeks to determine the effect that PPBG control has on cardiovascular outcomes in patients who suffered an MI within the 21 days before study enrollment...
  75. ncbi Insulin sensitivity in women with polycystic ovary syndrome
    Jana Vrbikova
    Institute of Endocrinology, Charles University in Prague, 116 94 Czech Republic
    J Clin Endocrinol Metab 89:2942-5. 2004
    ..000008). We conclude that lean PCOS women are not more insulin resistant than healthy controls. Insulin hypersecretion, on the other hand, is present even in lean PCOS women...
  76. ncbi Oral sulodexide reduces albuminuria in microalbuminuric and macroalbuminuric type 1 and type 2 diabetic patients: the Di.N.A.S. randomized trial
    Giovanni Gambaro
    Department of Medical and Surgical Science, Division of Nephrology, University of Padua, Padua, Italy
    J Am Soc Nephrol 13:1615-25. 2002
    ..The effect on albuminuria is long-lasting and seemingly additive to the ACE inhibitory effect...
  77. ncbi Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial
    John A Dormandy
    Department of Clinical Vascular Research, Ingelby House, St Georges Hospital, Blackshaw Road, London SW17 0QT, UK
    Lancet 366:1279-89. 2005
    ..Our aim, therefore, was to ascertain whether pioglitazone reduces macrovascular morbidity and mortality in high-risk patients with type 2 diabetes...