Tomas Kalina

Summary

Affiliation: Charles University
Country: Czech Republic

Publications

  1. pmc Myeloid antigens in childhood lymphoblastic leukemia: clinical data point to regulation of CD66c distinct from other myeloid antigens
    Tomas Kalina
    Department of Immunology, Charles University 2nd Medical School, Prague, Czech Republic
    BMC Cancer 5:38. 2005
  2. doi request reprint Profiling of polychromatic flow cytometry data on B-cells reveals patients' clusters in common variable immunodeficiency
    Tomas Kalina
    Department of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles University Prague and University Hospital Motol, Prague, Czech Republic
    Cytometry A 75:902-9. 2009
  3. doi request reprint Kinetics of dendritic cells reconstitution and costimulatory molecules expression after myeloablative allogeneic haematopoetic stem cell transplantation: implications for the development of acute graft-versus host disease
    Rudolf Horvath
    Institute of Immunology, Charles University, 2nd Faculty of Medicine, University Hospital Motol, Prague, Czech Republic
    Clin Immunol 131:60-9. 2009
  4. doi request reprint Appearance of CMV specific T-cells predicts fast resolution of viremia post hematopoietic Stem cell transplantation
    Ondrej Pelak
    Department of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles University Prague and University Hospital Motol, V Uvalu 84, 150 06, Prague, Czech Republic
    Cytometry B Clin Cytom . 2015
  5. ncbi request reprint TEL/AML1 and immunoreceptor gene rearrangements-which comes first?
    Jan Zuna
    CLIP Childhood Leukaemia Investigation Prague, 2nd Medical School, Charles University Prague, V Uvalu 84, Prague, Czech Republic
    Leuk Res 29:633-9. 2005
  6. doi request reprint Cytokines, growth, and environment factors in bone marrow plasma of acute lymphoblastic leukemia pediatric patients
    Martin Kovac
    CLIP Childhood Leukemia Investigation Prague, Department of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic
    Eur Cytokine Netw 25:8-13. 2014
  7. doi request reprint The adaptor protein NTAL enhances proximal signaling and potentiates corticosteroid-induced apoptosis in T-ALL
    Karel Svojgr
    CLIP Childhood Leukemia Investigation Prague, Prague, Czech Republic
    Exp Hematol 40:379-85. 2012
  8. doi request reprint An automated analysis of highly complex flow cytometry-based proteomic data
    Jan Stuchly
    Department of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles University Prague and University Hospital Motol, Prague, Czech Republic
    Cytometry A 81:120-9. 2012
  9. doi request reprint Detection of residual B precursor lymphoblastic leukemia by uniform gating flow cytometry
    Ester Mejstrikova
    CLIP Childhood Leukemia Investigation Prague, Prague, Czech Republic
    Pediatr Blood Cancer 54:62-70. 2010
  10. doi request reprint Low marginal zone-like B lymphocytes and natural antibodies characterize skewed B-lymphocyte subpopulations in del22q11 DiGeorge patients
    Adam Klocperk
    Department of Immunology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic Electronic address
    Clin Immunol 161:144-9. 2015

Collaborators

Detail Information

Publications22

  1. pmc Myeloid antigens in childhood lymphoblastic leukemia: clinical data point to regulation of CD66c distinct from other myeloid antigens
    Tomas Kalina
    Department of Immunology, Charles University 2nd Medical School, Prague, Czech Republic
    BMC Cancer 5:38. 2005
    ....
  2. doi request reprint Profiling of polychromatic flow cytometry data on B-cells reveals patients' clusters in common variable immunodeficiency
    Tomas Kalina
    Department of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles University Prague and University Hospital Motol, Prague, Czech Republic
    Cytometry A 75:902-9. 2009
    ....
  3. doi request reprint Kinetics of dendritic cells reconstitution and costimulatory molecules expression after myeloablative allogeneic haematopoetic stem cell transplantation: implications for the development of acute graft-versus host disease
    Rudolf Horvath
    Institute of Immunology, Charles University, 2nd Faculty of Medicine, University Hospital Motol, Prague, Czech Republic
    Clin Immunol 131:60-9. 2009
    ..This study reveals quantification of plasmacytoid and myeloid DCs as a potential biomarker for the prediction of acute GVHD development...
  4. doi request reprint Appearance of CMV specific T-cells predicts fast resolution of viremia post hematopoietic Stem cell transplantation
    Ondrej Pelak
    Department of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles University Prague and University Hospital Motol, V Uvalu 84, 150 06, Prague, Czech Republic
    Cytometry B Clin Cytom . 2015
    ....
  5. ncbi request reprint TEL/AML1 and immunoreceptor gene rearrangements-which comes first?
    Jan Zuna
    CLIP Childhood Leukaemia Investigation Prague, 2nd Medical School, Charles University Prague, V Uvalu 84, Prague, Czech Republic
    Leuk Res 29:633-9. 2005
    ..More mature immunogenotype of TEL/AML1-positive cases and changes in 37% of rearrangements between diagnosis and relapse suggest that in most cases the TEL/AML1 fusion is formed during immunoreceptor gene rearrangement process...
  6. doi request reprint Cytokines, growth, and environment factors in bone marrow plasma of acute lymphoblastic leukemia pediatric patients
    Martin Kovac
    CLIP Childhood Leukemia Investigation Prague, Department of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic
    Eur Cytokine Netw 25:8-13. 2014
    ..At the diagnosis of ALL, changes in the soluble microenvironment are detectable in BM plasma. These changes probably participate in the pathogenesis and/or result from the changes in the cell composition. ..
  7. doi request reprint The adaptor protein NTAL enhances proximal signaling and potentiates corticosteroid-induced apoptosis in T-ALL
    Karel Svojgr
    CLIP Childhood Leukemia Investigation Prague, Prague, Czech Republic
    Exp Hematol 40:379-85. 2012
    ..Higher ERK phosphorylation leads to enhanced cell death after TCR stimulation and increases cell sensitivity to methylprednisolone-induced cell death...
  8. doi request reprint An automated analysis of highly complex flow cytometry-based proteomic data
    Jan Stuchly
    Department of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles University Prague and University Hospital Motol, Prague, Czech Republic
    Cytometry A 81:120-9. 2012
    ..The approach presented here exemplifies how large-scale flow cytometry data analysis can be efficiently processed to employ flow cytometry as a high-content proteomics method...
  9. doi request reprint Detection of residual B precursor lymphoblastic leukemia by uniform gating flow cytometry
    Ester Mejstrikova
    CLIP Childhood Leukemia Investigation Prague, Prague, Czech Republic
    Pediatr Blood Cancer 54:62-70. 2010
    ..Flow cytometry (FC)-based RD detection is easy to perform, but interpretation requires expert analysis due to individual differences among patients...
  10. doi request reprint Low marginal zone-like B lymphocytes and natural antibodies characterize skewed B-lymphocyte subpopulations in del22q11 DiGeorge patients
    Adam Klocperk
    Department of Immunology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic Electronic address
    Clin Immunol 161:144-9. 2015
    ..Patients with DiGeorge syndrome suffer from T-lymphopenia. T-cells are important for the maturation and regulation of B-cell function. Our aim was to characterize the B-cell compartment in DiGeorge syndrome patients...
  11. pmc Prognosis of children with mixed phenotype acute leukemia treated on the basis of consistent immunophenotypic criteria
    Ester Mejstrikova
    CLIP Childhood Leukemia Investigation Prague Department of Pediatric Hematology and Oncology, Charles University, 2ndFaculty of Medicine and University Hospital Motol, Prague, Czech Republic
    Haematologica 95:928-35. 2010
    ..The recent World Health Organization classification is simpler and could replace the EGIL scoring system after transformation into unambiguous guidelines...
  12. ncbi request reprint The identification of (ETV6)/RUNX1-regulated genes in lymphopoiesis using histone deacetylase inhibitors in ETV6/RUNX1-positive lymphoid leukemic cells
    Julia Starkova
    Childhood Leukaemia Investigation Prague, Department of Paediatric Haematology Oncology, 2nd Medical School, Charles University Prague, Prague, Czech Republic
    Clin Cancer Res 13:1726-35. 2007
    ..We wanted to show the regulatory effect of ETV6/RUNX1 and its reversibility by histone deacetylase inhibitors (HDACi), as well as to identify potential ETV6/RUNX1-regulated genes...
  13. doi request reprint Aberrantly expressed CEACAM6 is involved in the signaling leading to apoptosis of acute lymphoblastic leukemia cells
    Veronika Kanderová
    Department of Pediatric Hematology and Oncology, Charles University Prague, University Hospital Motol, Czech Republic
    Exp Hematol 38:653-660.e1. 2010
    ....
  14. doi request reprint Adaptor molecules expression in normal lymphopoiesis and in childhood leukemia
    Karel Svojgr
    CLIP Childhood Leukemia Investigation Prague, Czech Republic
    Immunol Lett 122:185-92. 2009
    ..Moreover, NTAL expression separates T lineage leukemias into two subgroups with good and poor response to initial prednisone therapy showing prognostic impact of this molecule in T-ALL...
  15. pmc Loss of B cells and their precursors is the most constant feature of GATA-2 deficiency in childhood myelodysplastic syndrome
    Michaela Novakova
    CLIP Department of Pediatric Hematology and Oncology, 2 Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic
    Haematologica 101:707-16. 2016
    ....
  16. doi request reprint Lymphocyte enrichment using CD81-targeted immunoaffinity matrix
    Ondrej Pelak
    CLIP Childhood Leukemia Investigation Prague, Department of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles University Prague and University Hospital Motol, Prague, Czech Republic
    Cytometry A . 2016
    ..They also stress the importance of the impurity removal to sensitively detect rare cell populations in unsupervised analysis. © 2016 International Society for Advancement of Cytometry...
  17. pmc Common Variable Immunodeficiency patients with a phenotypic profile of immunosenescence present with thrombocytopenia
    Jan Stuchly
    CLIP Childhood Leukemia Investigation Prague, Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic
    Sci Rep 7:39710. 2017
    ..We delineate a subgroup of CVID patients with activated and immunosenescent immunophenotype of lymphocytes and distinct set of clinical complications without common genetic background...
  18. pmc The TREC/KREC assay for the diagnosis and monitoring of patients with DiGeorge syndrome
    Eva Fronkova
    CLIP, Department of Paediatric Haematology Oncology, 2nd Medical School, Charles University Prague and University Hospital Motol, Prague, Czech Republic
    PLoS ONE 9:e114514. 2014
    ..Furthermore, we followed TREC/KREC levels in peripheral blood (PB) to monitor postnatal changes in lymphocyte production...
  19. doi request reprint Quality assessment program for EuroFlow protocols: summary results of four-year (2010-2013) quality assurance rounds
    Tomas Kalina
    CLIP Childhood Leukemia Investigation Prague and Department of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles University Prague and University Hospital Motol, Prague, Czech Republic
    Cytometry A 87:145-56. 2015
    ..It may be used to complement, but not replace, established proficiency tests. © 2014 International Society for Advancement of Cytometry. ..
  20. ncbi request reprint Unrelated partially matched lymphocyte infusions in a patient with complete DiGeorge/CHARGE syndrome
    Ales Janda
    Deptartment of Immunology, University Hospital Motol, Prague, Czech Republic
    Pediatr Transplant 11:441-7. 2007
    ..We believe that infusions of small doses of DLI from an unrelated donor represent a potentially helpful therapeutic option in patients with cDGS/CHARGE phenotype...
  21. ncbi request reprint CD27 expression in malignant and normal human B precursors: a confirmed phenomenon. Reply to Nilsson and colleagues
    Martina Vaskova
    Exp Hematol 34:573; author reply 574. 2006
  22. ncbi request reprint De novo generation of CD4 T cells against viruses present in the host during immune reconstitution
    Tomas Kalina
    Fred Hutchinson Cancer Research Center and the University of Washington School of Medicine, Seattle, WA, USA
    Blood 105:2410-4. 2005
    ..This finding provides a strong rationale to improve thymopoiesis in recipients of hematopoietic cell transplants and, perhaps, in other persons lacking de novo-generated CD4 T cells, such as AIDS patients and elderly persons...