Zdenek Fisar

Summary

Affiliation: Charles University
Country: Czech Republic

Publications

  1. ncbi Effect of cannabinoids on platelet serotonin uptake
    Marie Velenovská
    Department of Psychiatry, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
    Addict Biol 12:158-66. 2007
  2. ncbi Statin-induced changes in mitochondrial respiration in blood platelets in rats and human with dyslipidemia
    J Vevera
    Department of Psychiatry, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic
    Physiol Res 65:777-788. 2016
  3. ncbi Mitochondrial Respiration in the Platelets of Patients with Alzheimer's Disease
    Zdenek Fisar
    Department of Psychiatry, First Faculty of Medicine, Charles University in Prague, Ke Karlovu 11, 120 00 Prague 2, Czech Republic
    Curr Alzheimer Res 13:930-41. 2016
  4. doi Drugs related to monoamine oxidase activity
    Zdenek Fisar
    Department of Psychiatry, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Ke Karlovu 11, 120 00 Prague 2, Czech Republic Electronic address
    Prog Neuropsychopharmacol Biol Psychiatry 69:112-24. 2016
  5. doi Cannabinoid-induced changes in respiration of brain mitochondria
    Zdenek Fisar
    Department of Psychiatry, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Ke Karlovu 11, Prague 2 120 00, Czech Republic Electronic address
    Toxicol Lett 231:62-71. 2014
  6. doi Cannabinoids and monoamine neurotransmission with focus on monoamine oxidase
    Zdenek Fisar
    Department of Psychiatry, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Ke Karlovu 11, 120 00 Prague 2, Czech Republic
    Prog Neuropsychopharmacol Biol Psychiatry 38:68-77. 2012
  7. ncbi Intracellular signalling pathways and mood disorders
    Z Fisar
    Charles University in Prague, First Faculty of Medicine and General University Hospital in Prague, Department of Psychiatry, Prague, Czech Republic
    Folia Biol (Praha) 56:135-48. 2010
  8. doi In vitro effects of acetylcholinesterase reactivators on monoamine oxidase activity
    Zdenek Fisar
    Department of Psychiatry, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Ke Karlovu 11, 120 00 Prague 2, Czech Republic
    Toxicol Lett 201:176-80. 2011
  9. ncbi Inhibition of monoamine oxidase activity by antidepressants and mood stabilizers
    Zdenek Fisar
    Department of Psychiatry, 1st Faculty of Medicine, Charles University, Ke Karlovu 11, 12808 Prague, Czech Republic
    Neuro Endocrinol Lett 31:645-56. 2010
  10. ncbi [Biochemical mechanisms of action of antidepressants]
    Zdenek Fisar
    Univerzita Karlova v Praze, 1 lékarská fakulta, Psychiatrická klinika VFN
    Cas Lek Cesk 150:531-40. 2011

Collaborators

Detail Information

Publications40

  1. ncbi Effect of cannabinoids on platelet serotonin uptake
    Marie Velenovská
    Department of Psychiatry, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
    Addict Biol 12:158-66. 2007
    ..A hypothesis was supported that lowered serotonin uptake may reflect a gender-related differences in effects of psychoactive cannabinoids...
  2. ncbi Statin-induced changes in mitochondrial respiration in blood platelets in rats and human with dyslipidemia
    J Vevera
    Department of Psychiatry, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic
    Physiol Res 65:777-788. 2016
    ..Both intact and permeabilized platelets can be used as a readily available biological model to study changes in cellular energy metabolism in patients treated with statins...
  3. ncbi Mitochondrial Respiration in the Platelets of Patients with Alzheimer's Disease
    Zdenek Fisar
    Department of Psychiatry, First Faculty of Medicine, Charles University in Prague, Ke Karlovu 11, 120 00 Prague 2, Czech Republic
    Curr Alzheimer Res 13:930-41. 2016
    ..Analyses of complex IV activity, the respiratory rates of intact platelets, and the capacity of the ETS in permeabilized platelets may enable the characterization of mitochondrial dysfunctions in the initial stage of AD. ..
  4. doi Drugs related to monoamine oxidase activity
    Zdenek Fisar
    Department of Psychiatry, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Ke Karlovu 11, 120 00 Prague 2, Czech Republic Electronic address
    Prog Neuropsychopharmacol Biol Psychiatry 69:112-24. 2016
    ....
  5. doi Cannabinoid-induced changes in respiration of brain mitochondria
    Zdenek Fisar
    Department of Psychiatry, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Ke Karlovu 11, Prague 2 120 00, Czech Republic Electronic address
    Toxicol Lett 231:62-71. 2014
    ..This model explains both the inhibitory effect of cannabinoids and the protective effect of the CB1 receptor inverse agonist. ..
  6. doi Cannabinoids and monoamine neurotransmission with focus on monoamine oxidase
    Zdenek Fisar
    Department of Psychiatry, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Ke Karlovu 11, 120 00 Prague 2, Czech Republic
    Prog Neuropsychopharmacol Biol Psychiatry 38:68-77. 2012
    ..Basic information is summarized in the paper about mechanisms of action of cannabinoids on monoaminergic systems, with a view to inhibition of monoamine oxidase...
  7. ncbi Intracellular signalling pathways and mood disorders
    Z Fisar
    Charles University in Prague, First Faculty of Medicine and General University Hospital in Prague, Department of Psychiatry, Prague, Czech Republic
    Folia Biol (Praha) 56:135-48. 2010
    ....
  8. doi In vitro effects of acetylcholinesterase reactivators on monoamine oxidase activity
    Zdenek Fisar
    Department of Psychiatry, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Ke Karlovu 11, 120 00 Prague 2, Czech Republic
    Toxicol Lett 201:176-80. 2011
    ..Because oximes concentrations effective for MAO inhibition could not be achieved in vivo at the cerebral level, we suppose that oximes investigated do not interfere with brain MAO at therapeutically relevant concentrations...
  9. ncbi Inhibition of monoamine oxidase activity by antidepressants and mood stabilizers
    Zdenek Fisar
    Department of Psychiatry, 1st Faculty of Medicine, Charles University, Ke Karlovu 11, 12808 Prague, Czech Republic
    Neuro Endocrinol Lett 31:645-56. 2010
    ..We investigated systematically in vitro effects of pharmacologically different antidepressants and mood stabilizers on MAO activity...
  10. ncbi [Biochemical mechanisms of action of antidepressants]
    Zdenek Fisar
    Univerzita Karlova v Praze, 1 lékarská fakulta, Psychiatrická klinika VFN
    Cas Lek Cesk 150:531-40. 2011
    ..Knowledge about biological markers of mood disorders and predictors of efficiency of pharmacotherapy is included also in relation to importance, potentialities and perspectives in the development of new antidepressants...
  11. ncbi Binding of imipramine to phospholipid bilayers using radioligand binding assay
    Z Fisar
    Department of Psychiatry, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
    Gen Physiol Biophys 23:77-99. 2004
    ..These results support the hypothesis suggesting that the lipid part of biological membranes plays a role in the mechanism of antidepressant action...
  12. doi Inhibition of monoamine oxidase activity by cannabinoids
    Zdenek Fisar
    Department of Psychiatry, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Ke Karlovu 11, 120 00, Prague 2, Czech Republic
    Naunyn Schmiedebergs Arch Pharmacol 381:563-72. 2010
    ..Decrease of MAO activity may play a role in some effects of cannabinoids on serotonergic, noradrenergic, and dopaminergic neurotransmission...
  13. ncbi Phytocannabinoids and endocannabinoids
    Zdenek Fisar
    Department of Psychiatry, 1st Faculty of Medicine, Charles University in Prague, Ke Karlovu 11, 128 01 Prague 2, Czech Republic
    Curr Drug Abuse Rev 2:51-75. 2009
    ....
  14. ncbi Distribution of antidepressants between plasma and red blood cells
    Zdenek Fisar
    Department of Psychiatry, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
    Neuro Endocrinol Lett 27:307-13. 2006
    ..The distribution of different antidepressants between plasma and red blood cells (RBCs) or between water and erythrocyte membranes (ghosts) has not been sufficiently compared so far...
  15. ncbi Effect of long-term administration of antidepressants on the lipid composition of brain plasma membranes
    Z Fisar
    Department of Psychiatry, 1st Faculty of Medicine, Charles University, Ke Karlovu 11, 120 00 Prague 2, Czech Republic
    Gen Physiol Biophys 24:221-36. 2005
    ..Hypothesis was supported that changes in brain neurotransmission produced by antidepressants could be, at least partially, associated with adaptive changes in membrane cholesterol and phospholipids...
  16. ncbi Depression, antidepressants, and peripheral blood components
    Zdenek Fisar
    Department of Psychiatry, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
    Neuro Endocrinol Lett 29:17-28. 2008
    ....
  17. doi Platelet serotonin uptake in drug-naïve depressive patients before and after treatment with citalopram
    Zdenek Fisar
    Department of Psychiatry, 1st Faculty of Medicine, Charles University in Prague, Ke Karlovu 11, 128 01 Prague 2, Czech Republic
    Psychiatry Res 161:185-94. 2008
    ..The initial severity of depression was significantly negatively correlated with V(max), which supported a hypothesis that the initial severity of depressive disorder could be related to the lower V(max)...
  18. ncbi Interactions between tricyclic antidepressants and phospholipid bilayer membranes
    Z Fisar
    Department of Psychiatry, 1st Faculty of Medicine, Charles University, Ke Karlovu 11, 120 00 Prague 2, Czech Republic
    Gen Physiol Biophys 24:161-80. 2005
    ..The data supports the hypothesis under which TCAs could have effect on affective disorders partially via binding to the lipid part of the membrane and following changes of lipid-protein interactions...
  19. ncbi Cannabinoids and atherosclerosis
    Zdenek Fisar
    Charles University in Prague, First Faculty of Medicine, Department of Psychiatry, Prague, Czech Republic
    Prague Med Rep 110:5-12. 2009
    ..Basic information about function and role of the endocannabinoid system is summarized in the paper; possible therapeutic action of cannabinoids, effects on atherosclerosis specially, is described at the close...
  20. ncbi Effect of pharmacologically selective antidepressants on serotonin uptake in rat platelets
    Z Fisar
    Department of Psychiatry, 1st Faculty of Medicine, Charles University, Ke Karlovu 11, 120 00 Prague 2, Czech Republic
    Gen Physiol Biophys 24:113-28. 2005
    ..An increase in limiting membrane permeability for 5-HT could be included in the common adaptive effect of the long-term administration of antidepressants that differ in pharmacologic selectivity...
  21. ncbi In vitro effects of acetylcholinesterase inhibitors and reactivators on Complex I of electron transport chain
    Jana Hroudova
    Department of Psychiatry, 1st Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic
    Neuro Endocrinol Lett 32:259-63. 2011
    ..Various types of oximes reactivate AChE and are commonly used as antidotes against organophosphates (pesticides, nerve agents)...
  22. doi Synthesis and in vitro evaluation of 7-methoxy-N-(pent-4-enyl)-1,2,3,4-tetrahydroacridin-9-amine-new tacrine derivate with cholinergic properties
    Jan Korabecny
    Department of Pharmaceutical Chemistry and Drug Control, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic
    Bioorg Med Chem Lett 21:6563-6. 2011
    ..In this Letter, the synthesis, biological activity and molecular modelling of elimination by-product isolated during synthesis of 7-MEOTA based bis-alkylene linked compound is described...
  23. ncbi Plasma homocysteine in Alzheimer's disease with or without co-morbid depressive symptoms
    Eva Kitzlerova
    Department of Psychiatry, 1st Faculty of Medicine, Charles University Prague and General Teaching Hospital, Czech Republic
    Neuro Endocrinol Lett 35:42-9. 2014
    ..This study was designed to detect an association between plasma homocysteine and AD with or without co-morbid depressive symptoms...
  24. doi Mitochondrial respiration in blood platelets of depressive patients
    Jana Hroudova
    Department of Psychiatry, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Ke Karlovu 11, 121 08 Prague 2, Czech Republic Electronic address
    Mitochondrion 13:795-800. 2013
    ..The hypothesis that decreased mitochondrial respiratory rate participate in pathophysiology of depression was supported. ..
  25. ncbi Activities of respiratory chain complexes and citrate synthase influenced by pharmacologically different antidepressants and mood stabilizers
    Jana Hroudova
    Department of Psychiatry, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic
    Neuro Endocrinol Lett 31:336-42. 2010
    ..We investigated in vitro effects of pharmacologically different antidepressants and mood stabilizers on mitochondrial enzymes to discover, which mitochondrial functions could be involved in pathophysiology of mood disorders...
  26. pmc Plasma cortisol in Alzheimer's disease with or without depressive symptoms
    Martina Zverova
    Department of Psychiatry, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic
    Med Sci Monit 19:681-9. 2013
    ..The aim of this study was to investigate the association of plasma cortisol concentration with AD in presence or absence of comorbid depressive symptoms...
  27. doi Connectivity between mitochondrial functions and psychiatric disorders
    Jana Hroudova
    Department of Psychiatry, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic
    Psychiatry Clin Neurosci 65:130-41. 2011
    ....
  28. doi In vitro inhibition of mitochondrial respiratory rate by antidepressants
    Jana Hroudova
    Department of Psychiatry, Charles University in Prague and General University Hospital in Prague, Ke Karlovu 11, 120 00 Prague, Czech Republic
    Toxicol Lett 213:345-52. 2012
    ..Our findings suggest that mood stabilizers do not interfere with brain mitochondrial respiration, whereas direct mitochondrial targeting is involved in mechanisms of action of pharmacologically different antidepressants...
  29. ncbi Mitochondrial dysfunctions in bipolar disorder: effect of the disease and pharmacotherapy
    Tereza Cikánková
    First Faculty of Medicine, Charles University in Prague Department of Psychiatry Prague, Czech Republic
    CNS Neurol Disord Drug Targets . 2016
    ..Recent studies have also provided data about the positive effects of chronic treatment by mood stabilizers on mitochondrial functions...
  30. doi GSK3β, CREB, and BDNF in peripheral blood of patients with Alzheimer's disease and depression
    Jan Pláteník
    Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Katerinska 32, 121 08 Prague 2, Czech Republic
    Prog Neuropsychopharmacol Biol Psychiatry 50:83-93. 2014
    ....
  31. doi The effect of prolonged simvastatin application on serotonin uptake, membrane microviscosity and behavioral changes in the animal model
    Jan Vevera
    Department of Psychiatry, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Ke Karlovu 11, 120 00 Prague 2, Czech Republic
    Physiol Behav 158:112-20. 2016
    ..We also confirmed that such behavioral changes may be attributed to changes in serotonergic neurotransmission. ..
  32. doi Biological hypotheses and biomarkers of bipolar disorder
    Ekaterina Sigitova
    Department of Psychiatry, First Faculty of Medicine, Charles University and General University Hospital in Prague, Ke Karlovu 11, 120 00 Prague 2, Czech Republic
    Psychiatry Clin Neurosci . 2016
    ..Therapeutic hypotheses and mechanisms of the switch between depressive and manic state are discussed...
  33. ncbi In Vitro Effects of Cognitives and Nootropics on Mitochondrial Respiration and Monoamine Oxidase Activity
    Namrata Singh
    Department of Psychiatry, First Faculty of Medicine, Charles University and General University Hospital in Prague, Ke Karlovu 11, 120 00, Prague 2, Czech Republic
    Mol Neurobiol . 2016
    ..The results support the future research aimed at measuring the effects of currently used drugs or newly synthesized drugs on mitochondrial functioning in order to understand their mechanism of action...
  34. doi Progress in drug development for Alzheimer's disease: An overview in relation to mitochondrial energy metabolism
    Jana Hroudova
    Department of Psychiatry, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Ke Karlovu 11, 120 00 Prague 2, Czech Republic
    Eur J Med Chem 121:774-84. 2016
    ....
  35. doi Can chiroptical spectroscopy be used for the analysis of blood plasma?
    Michal Tatarkovič
    Department of Analytical Chemistry, Institute of Chemical Technology, Prague, Czech Republic
    Chirality 24:951-5. 2012
    ..Therefore, these methods can potentially be useful for following research in the development of new, noninvasive, and reliable screening methods of clinical diagnostics...
  36. doi Cannabinoid-Induced Changes in the Activity of Electron Transport Chain Complexes of Brain Mitochondria
    Namrata Singh
    Department of Psychiatry, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Ke Karlovu 11, 120 00, Prague 2, Czech Republic
    J Mol Neurosci 56:926-31. 2015
    ..Common inhibitory effect of cannabinoids on activity of complex II/III and IV confirmed a non-receptor-mediated mechanism of cannabinoid action on individual components of system of oxidative phosphorylation. ..
  37. pmc Mitochondrial dysfunctions in neurodegenerative diseases: relevance to Alzheimer's disease
    Jana Hroudova
    Department of Psychiatry, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Ke Karlovu 11, 120 00 Prague 2, Czech Republic
    Biomed Res Int 2014:175062. 2014
    ..Also, damaged function of electron transport chain complexes and interactions between pathological proteins and mitochondria are described for AD particularly and marginally for PD and HD. ..
  38. ncbi Cholesterol-lowering therapy evokes time-limited changes in serotonergic transmission
    Jan Vevera
    Psychiatric Clinic, First Faculty of Medicine of Charles University, Ke Karlovu 11, 120 00 Prague, Czech Republic
    Psychiatry Res 133:197-203. 2005
    ..A significant increase in SERT activity was detected only during the first month of simvastatin therapy. This finding suggests that within this period some patients could be vulnerable to depression, violence, or suicide...
  39. doi Synthesis and in vitro evaluation of N-(Bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a cholinesterase inhibitor with regard to Alzheimer's disease treatment
    Jan Korabecny
    Department of Pharmaceutical Chemistry and Drug Control, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic
    Molecules 15:8804-12. 2010
    ..Its inhibitory ability towards cholinesterases was determined and compared to tacrine (THA) and 9-amino-7-methoxy-1,2,3,4-tetrahydroacridine (7-MEOTA). The assessment of IC50 values revealed 1 as a weak inhibitor of both tested enzymes...
  40. doi Core/shell nanofibers with embedded liposomes as a drug delivery system
    Andrea Míčková
    Department of Biophysics, Second Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
    Biomacromolecules 13:952-62. 2012
    ..In conclusion, intact liposomes incorporated into nanofibers by coaxial electrospinning are very promising as a drug delivery system...