Pavel Vodicka

Summary

Affiliation: Academy of Sciences of the Czech Republic
Country: Czech Republic

Publications

  1. ncbi Association between genetic polymorphisms and biomarkers in styrene-exposed workers
    P Vodicka
    Institute of Experimental Medicine, Czech Academy of Sciences, Videnska 1083, 14220 Prague 4, Czech Republic
    Mutat Res 482:89-103. 2001
  2. ncbi Chromosomal damage and polymorphisms of DNA repair genes XRCC1 and XRCC3 in workers exposed to cytostatics
    L udovít Mušák
    Department of Medical Biology, Comenius University, Jessenius Faculty of Medicine Martin, Slovakia
    Neuro Endocrinol Lett 27:57-60. 2006
  3. doi Monitoring of dimethyl sulphate-induced N3-methyladenine, N7-methylguanine and O(6)-methylguanine DNA adducts using reversed-phase high performance liquid chromatography and mass spectrometry
    Jiri Chadt
    Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Videnska 1083, Prague 4, Czech Republic
    J Chromatogr B Analyt Technol Biomed Life Sci 867:43-8. 2008
  4. doi Chromosomal aberrations in tire plant workers and interaction with polymorphisms of biotransformation and DNA repair genes
    Ludovit Musak
    Department of Medical Biology, Comenius University Bratislava, Jessenius Faculty of Medicine, Mala Hora 4, 03754 Martin, Slovak Republic
    Mutat Res 641:36-42. 2008
  5. doi Modulation of DNA repair capacity and mRNA expression levels of XRCC1, hOGG1 and XPC genes in styrene-exposed workers
    Monika Hanova
    Institute of Experimental Medicine, Academy of Sciences of Czech Republic, Prague, Czech Republic
    Toxicol Appl Pharmacol 248:194-200. 2010
  6. doi DNA and chromosomal damage in medical workers exposed to anaesthetic gases assessed by the lymphocyte cytokinesis-block micronucleus (CBMN) assay. A critical review
    Pavel Vodicka
    Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Videnska 1083, 142 00 Prague, Czech Republic Institute of Biology and Medical Genetics, 1st Medical Faculty, Charles University, Albertov 4, 128 00 Prague, Czech Republic Biomedical Centre, Faculty of Medicine in Pilsen, Charles University in Prague, 323 00 Pilsen, Czech Republic Electronic address
    Mutat Res 770:26-34. 2016
  7. doi Polymorphisms in Non-coding RNA Genes and Their Targets Sites as Risk Factors of Sporadic Colorectal Cancer
    Pavel Vodicka
    Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Videnska 1083, 142 00, Prague, Czech Republic
    Adv Exp Med Biol 937:123-49. 2016
  8. doi Interactions of DNA repair gene variants modulate chromosomal aberrations in healthy subjects
    Pavel Vodicka
    Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, 14220 Prague, Czech Republic, Institute of Biology and Medical Genetics, 1st Faculty of Medicine, Charles University in Prague, 12800 Prague, Czech Republic, Biomedical Centre, Faculty of Medicine in Pilsen, Charles University in Prague, 32300 Pilsen, Czech Republic
    Carcinogenesis 36:1299-306. 2015
  9. doi Chromosomal damage among medical staff occupationally exposed to volatile anesthetics, antineoplastic drugs, and formaldehyde
    Ludovit Musak
    Department of Molecular Biology of Cancer, Institute of Experimental Medicine Academy of Sciences of the Czech Republic, Videnska 1083, 14200 Prague, Czech Republic
    Scand J Work Environ Health 39:618-30. 2013
  10. pmc Shared ancestral susceptibility to colorectal cancer and other nutrition related diseases
    Stefanie Huhn
    Department of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    BMC Med Genet 13:94. 2012

Detail Information

Publications56

  1. ncbi Association between genetic polymorphisms and biomarkers in styrene-exposed workers
    P Vodicka
    Institute of Experimental Medicine, Czech Academy of Sciences, Videnska 1083, 14220 Prague 4, Czech Republic
    Mutat Res 482:89-103. 2001
    ..In our study, styrene-specific DNA and haemoglobin adducts are under investigation. Completing these data with the results of genotyping of metabolising enzymes may provide a useful tool for individual genotoxic risk assessment...
  2. ncbi Chromosomal damage and polymorphisms of DNA repair genes XRCC1 and XRCC3 in workers exposed to cytostatics
    L udovít Mušák
    Department of Medical Biology, Comenius University, Jessenius Faculty of Medicine Martin, Slovakia
    Neuro Endocrinol Lett 27:57-60. 2006
    ..Our study addresses relationships between chromosomal aberrations (CAs), chromosome (CSA), and chromatid (CTA) types and polymorphisms in DNA repair genes XRCC1 and XRCC3...
  3. doi Monitoring of dimethyl sulphate-induced N3-methyladenine, N7-methylguanine and O(6)-methylguanine DNA adducts using reversed-phase high performance liquid chromatography and mass spectrometry
    Jiri Chadt
    Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Videnska 1083, Prague 4, Czech Republic
    J Chromatogr B Analyt Technol Biomed Life Sci 867:43-8. 2008
    ..1), respectively. The application of the above-mentioned techniques provides a valuable contribution for simultaneous determination of methylated DNA adducts, and may represent a suitable approach for similar monitoring/screening studies...
  4. doi Chromosomal aberrations in tire plant workers and interaction with polymorphisms of biotransformation and DNA repair genes
    Ludovit Musak
    Department of Medical Biology, Comenius University Bratislava, Jessenius Faculty of Medicine, Mala Hora 4, 03754 Martin, Slovak Republic
    Mutat Res 641:36-42. 2008
    ..045). Present results show that exposed individuals in the tire production, who smoke, exhibit higher chromosomal aberrations frequencies, and the extent of chromosomal damage may additionally be modified by relevant polymorphisms...
  5. doi Modulation of DNA repair capacity and mRNA expression levels of XRCC1, hOGG1 and XPC genes in styrene-exposed workers
    Monika Hanova
    Institute of Experimental Medicine, Academy of Sciences of Czech Republic, Prague, Czech Republic
    Toxicol Appl Pharmacol 248:194-200. 2010
    ..However, negative correlations of SSBs and mRNA expression levels of XRCC1, hOGG1 and XPC with styrene exposure warrant further highly-targeted study...
  6. doi DNA and chromosomal damage in medical workers exposed to anaesthetic gases assessed by the lymphocyte cytokinesis-block micronucleus (CBMN) assay. A critical review
    Pavel Vodicka
    Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Videnska 1083, 142 00 Prague, Czech Republic Institute of Biology and Medical Genetics, 1st Medical Faculty, Charles University, Albertov 4, 128 00 Prague, Czech Republic Biomedical Centre, Faculty of Medicine in Pilsen, Charles University in Prague, 323 00 Pilsen, Czech Republic Electronic address
    Mutat Res 770:26-34. 2016
    ..The meta-analysis of mean MN frequency of combined studies confirmed this tendency (log mean ratio=0.56 [0.34-0.77]; P=3.51×10-7). Similar differences between the exposed and controls were also observed for other biomarkers...
  7. doi Polymorphisms in Non-coding RNA Genes and Their Targets Sites as Risk Factors of Sporadic Colorectal Cancer
    Pavel Vodicka
    Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Videnska 1083, 142 00, Prague, Czech Republic
    Adv Exp Med Biol 937:123-49. 2016
    ....
  8. doi Interactions of DNA repair gene variants modulate chromosomal aberrations in healthy subjects
    Pavel Vodicka
    Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, 14220 Prague, Czech Republic, Institute of Biology and Medical Genetics, 1st Faculty of Medicine, Charles University in Prague, 12800 Prague, Czech Republic, Biomedical Centre, Faculty of Medicine in Pilsen, Charles University in Prague, 32300 Pilsen, Czech Republic
    Carcinogenesis 36:1299-306. 2015
    ....
  9. doi Chromosomal damage among medical staff occupationally exposed to volatile anesthetics, antineoplastic drugs, and formaldehyde
    Ludovit Musak
    Department of Molecular Biology of Cancer, Institute of Experimental Medicine Academy of Sciences of the Czech Republic, Videnska 1083, 14200 Prague, Czech Republic
    Scand J Work Environ Health 39:618-30. 2013
    ....
  10. pmc Shared ancestral susceptibility to colorectal cancer and other nutrition related diseases
    Stefanie Huhn
    Department of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    BMC Med Genet 13:94. 2012
    ..A two-stage case-control study on CRC susceptibility was conducted to assess the influence of the ancestral alleles in the polymorphisms previously associated with nutrition-related complex diseases...
  11. pmc A gene-wide investigation on polymorphisms in the taste receptor 2R14 (TAS2R14) and susceptibility to colorectal cancer
    Daniele Campa
    German Cancer Research Center DKFZ, Heidelberg, Germany
    BMC Med Genet 11:88. 2010
    ..TAS2R14 is one of the better characterized members of the taste receptor family and has several polymorphic variants. Several substances that have been shown to activate TAS2R14 are powerful toxic and carcinogenic agents...
  12. pmc Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study
    Daniele Campa
    Genomic Epidemiology Group, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    BMC Gastroenterol 10:112. 2010
    ..Accumulating evidence also indicates a role of ghrelin in cancer development...
  13. doi Chromosomal damage in peripheral blood lymphocytes of newly diagnosed cancer patients and healthy controls
    Pavel Vodicka
    Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Science of Czech Republic, Videnska 1083, 14200 Prague 4, Czech Republic
    Carcinogenesis 31:1238-41. 2010
    ..However, studies on incident cancer patients are lacking; thus, we investigated chromosomal damage in newly diagnosed cancer patients and healthy individuals...
  14. ncbi Association of DNA repair polymorphisms with DNA repair functional outcomes in healthy human subjects
    Pavel Vodicka
    Institute of Experimental Medicine, Videnska 1083, 14200, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Carcinogenesis 28:657-64. 2007
    ..In summary, XRCC1 Arg399Gln and hOGG1 Ser326Cys polymorphisms seem to exert the predominant modulating effect on irradiation-specific DNA repair capacity and the capacity to repair DNA oxidative damage, respectively...
  15. ncbi Micronuclei, DNA single-strand breaks and DNA-repair activity in mice exposed to 1,3-butadiene by inhalation
    Pavel Vodicka
    Institute of Experimental Medicine, Academy of Sciences of Czech Republic, Videnska 1083, 14220 Prague 4, Czech Republic
    Mutat Res 608:49-57. 2006
    ..4 +/- 5.1 to 4.6 +/- 1.6 in the period following termination of the 1,3-butadiene exposure, while micronucleus frequencies in control animals were significantly lower (from 1.7 +/- 1.5 to 4.2 +/- 0.8)...
  16. ncbi 7-Alkylguanine adduct levels in urine, lungs and liver of mice exposed to styrene by inhalation
    Pavel Erik Vodicka
    Institute of Experimental Medicine, Academy of Sciences of Czech Republic, Videnska 1083, 14 220 Prague 4, Czech Republic
    Toxicol Appl Pharmacol 210:1-8. 2006
    ..5% of the total alkylation at N7 of guanine. The total styrene-specific 7-guanine alkylation accounts for about 1.0x10(-5)% of the total styrene uptake, while N1-adenine alkylation contributes to this percentage only negligibly...
  17. ncbi Markers of individual susceptibility and DNA repair rate in workers exposed to xenobiotics in a tire plant
    Pavel Vodicka
    Institute of Experimental Medicine, Academy of Science of Czech Republic, 14200 Prague, Czech Republic
    Environ Mol Mutagen 44:283-92. 2004
    ..097). The results from this study suggest the importance of evaluating markers of individual susceptibility, since they may modulate genotoxic effects induced by occupational exposure to xenobiotics...
  18. pmc Cytogenetic markers, DNA single-strand breaks, urinary metabolites, and DNA repair rates in styrene-exposed lamination workers
    Pavel Vodicka
    Institute of Experimental Medicine, Academy of Science of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    Environ Health Perspect 112:867-71. 2004
    ..The positive correlation between exposure parameters and DNA repair rates suggests that particular DNA repair pathways may be induced by styrene exposure...
  19. ncbi Genetic polymorphisms in DNA repair genes and possible links with DNA repair rates, chromosomal aberrations and single-strand breaks in DNA
    Pavel Vodicka
    Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Videnska 1083, 14200 Prague 4, Czech Republic
    Carcinogenesis 25:757-63. 2004
    ..9, P = 0.010) and XPC polymorphisms (F = 4.2, P = 0.046, MANOVA). Our results from this study suggest that markers of genotoxicity are associated with polymorphisms in genes encoding DNA repair enzymes...
  20. ncbi The role of various biomarkers in the evaluation of styrene genotoxicity
    P Vodicka
    Department of Genetic and Molecular Toxicology, Institute of Experimental Medicine, Academic of Science of Czech Republic, Videnska 1083, 14220 4, Prague, Czech Republic
    Cancer Detect Prev 27:275-84. 2003
    ..DNA repair capacity increased with the exposure, except for the group exposed to the highest styrene concentration. In this particular group, increased DNA repair capacity to remove oxidative DNA damage was found...
  21. ncbi DNA adducts, strand breaks and micronuclei in mice exposed to styrene by inhalation
    P Vodicka
    Institute of Experimental Medicine, Academy of Sciences of Czech Republic, Videnska 1083, 14220 4, Prague, Czech Republic
    Chem Biol Interact 137:213-27. 2001
    ..An interesting link has been found between DNA single-strand breaks in bone marrow and frequencies of micronuclei (r=0.721, P=0.028)...
  22. ncbi Spectrum of styrene-induced DNA adducts: the relationship to other biomarkers and prospects in human biomonitoring
    Pavel Vodicka
    Laboratory of Developmental and Genetic Toxicology, Institute of Experimental Medicine, Academic Sciences of the Czech Republic, Videnska 1083, 14220 4, Prague, Czech Republic
    Mutat Res 511:239-54. 2002
    ..Finally, we suggest a design of a population study, which may contribute to our understanding genotoxic events in the exposure either to single xenobiotic or complex mixture...
  23. ncbi New aspects in the biomonitoring of occupational exposure to styrene
    Pavel Vodicka
    Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Videnska 1083, 14220 Prague 4, Czech Republic
    Int Arch Occup Environ Health 75:S75-85. 2002
    ..Various styrene-induced DNA adducts (representing important integral measures of DNA damage) are discussed as potential powerful biomarkers of styrene exposure, with respect to DNA repair...
  24. ncbi Genetic polymorphisms and possible gene-gene interactions in metabolic and DNA repair genes: effects on DNA damage
    Alessio Naccarati
    Inst Exper Medicine, Acad Sci of the Czech Republic, Videnska 1083, 14200 Prague 4, Czech Republic
    Mutat Res 593:22-31. 2006
    ..In conclusion, our results suggest a relation between markers of genotoxicity and polymorphisms in genes coding for xenobiotic metabolizing and DNA repair enzymes as well as a modulating effect of combinations of these polymorphisms...
  25. doi DNA damage, DNA repair rates and mRNA expression levels of cell cycle genes (TP53, p21(CDKN1A), BCL2 and BAX) with respect to occupational exposure to styrene
    Monika Hanova
    Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Sciences of Czech Republic, Prague, Czech Republic
    Carcinogenesis 32:74-9. 2011
    ..044). Our study suggests a possible relationship between styrene exposure, DNA damage and transcript levels of key cell cycle genes...
  26. doi Differences in nucleotide excision repair capacity between newly diagnosed colorectal cancer patients and healthy controls
    Jana Slyskova
    Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Science of the Czech Republic, Videnska 1083, 14220 Prague, Czech Republic
    Mutagenesis 27:225-32. 2012
    ..Further, alterations in a complex multigene process like DNA repair may be better characterized by functional quantification of repair capacity than by quantification of individual genes transcripts or gene variants alone...
  27. doi DNA damage and nucleotide excision repair capacity in healthy individuals
    Jana Slyskova
    Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Science of the Czech Republic, Prague
    Environ Mol Mutagen 52:511-7. 2011
    ..048). Our results indicate the range of endogenous DNA single-strand breaks and capacity of NER in healthy volunteers as well as the role of potentially relevant confounders. Environ. Mol. Mutagen. 2011. © 2011 Wiley-Liss, Inc...
  28. doi MTHFR and MTRR genotype and haplotype analysis and colorectal cancer susceptibility in a case-control study from the Czech Republic
    Barbara Pardini
    Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Videnska 1083, 14200 Prague 4, Czech Republic
    Mutat Res 721:74-80. 2011
    ..For MTRR, additional studies on larger populations are needed to clarify the possible role of variation in this gene in colorectal carcinogenesis...
  29. doi Polymorphisms in miRNA-binding sites of nucleotide excision repair genes and colorectal cancer risk
    Alessio Naccarati
    Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Prague, Czech Republic
    Carcinogenesis 33:1346-51. 2012
    ..Variation in miRNA target binding sites in the 3'untranslated region of NER genes may be important for modulating colorectal cancer risk, with a different relevance according to tumor location...
  30. doi Variations in mismatch repair genes and colorectal cancer risk and clinical outcome
    Veronika Vymetalkova
    Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Videnska 1083, 14200 Prague, Czech Republic, Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Katerinska 32, 12800 Prague, Czech Republic
    Mutagenesis 29:259-65. 2014
    ..03). No association with CRC risk was observed. We provide the first evidence that variations in potential miRNA target-binding sites in the 3'UTR of MMR genes may contribute to modulate CRC prognosis and predictivity of therapy. ..
  31. doi NBN 657del5 heterozygous mutations and colorectal cancer risk in the Czech Republic
    Barbara Pardini
    Institute of Experimental Medicine, Academy of Sciences of Czech Republic, Prague, Czech Republic
    Mutat Res 666:64-7. 2009
    ..The present results do not provide any evidence that the exceeding risk of CRC in this population is attributable to the high frequency of heterozygous carriage of the NBN 657del5...
  32. ncbi Styrene metabolism, genotoxicity, and potential carcinogenicity
    Pavel Vodicka
    Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Drug Metab Rev 38:805-53. 2006
    ....
  33. pmc Molecular characteristics of mismatch repair genes in sporadic colorectal tumors in Czech patients
    Veronika Polakova Vymetalkova
    Institute of Experimental Medicine Academy of Sciences of the Czech Republic, Prague, Czech Republic
    BMC Med Genet 15:17. 2014
    ..The present study aimed at characterizing of epigenetic and gene expression profiles of MMR genes in sporadic CRC patients from the Czech Republic, a country with one of the highest incidences of this cancer all over Europe...
  34. doi Association of serum bilirubin and promoter variations in HMOX1 and UGT1A1 genes with sporadic colorectal cancer
    Alena Jiraskova
    4th Department of Internal Medicine, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
    Int J Cancer 131:1549-55. 2012
    ..001). In conclusion, UGT1A1*28 allele carrier status might be a protective factor against the development of CRC in the male population, whereas low serum bilirubin levels are associated with an increased risk of CRC in both genders...
  35. doi Epigenome-wide analysis of DNA methylation reveals a rectal cancer-specific epigenomic signature
    Veronika Vymetalkova
    Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Epigenomics 8:1193-207. 2016
    ..The aim of the present study is to address a genome-wide search for novel methylation biomarkers in the rectal cancer (RC), as only scarce information on methylation profile is available...
  36. doi Structural chromosomal aberrations as potential risk markers in incident cancer patients
    Sona Vodenkova
    Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, 142 20 Prague, Czech Republic, Institute of Biology and Medical Genetics, 1st Faculty of Medicine, Charles University in Prague, 128 00 Prague, Czech Republic, Department of General Biology and Genetics, 3rd Faculty of Medicine, Charles University in Prague, 100 00 Prague, Czech Republic
    Mutagenesis 30:557-63. 2015
    ..Our study demonstrates that CAs serve as a predictive marker for breast and lung cancer, whereas only CTAs were elevated in incident CRC patients. ..
  37. doi Variation within 3'-UTRs of base excision repair genes and response to therapy in colorectal cancer patients: A potential modulation of microRNAs binding
    Barbara Pardini
    Authors Affiliations Human Genetics Foundation Torino Department of Medical Sciences, University of Turin, Turin Department of Biology, University of Pisa, Pisa Laboratory of Computational Oncology, Center for Integrated Biology CIBIO, University of Trento, Trento, Italy Department of Molecular Biology of Cancer, Institute of Experimental Medicine Departments of Surgery and Oncology, Thomayer Hospital Institute of Biology and Department of Medical Genetics and Department of Oncology, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Clin Cancer Res 19:6044-56. 2013
    ..SNPs in miRNA-binding sites may modulate the posttranscriptional regulation of gene expression operated by miRNAs and explain interindividual variability in BER capacity and response to 5-FU...
  38. ncbi Polymorphisms in microRNA binding sites of mucin genes as predictors of clinical outcome in colorectal cancer patients
    Veronika Vymetalkova
    Dept of Molecular Biology of Cancer, Institute of Experimental Medicine, Prague, Czech Republic
    Carcinogenesis . 2016
    ..0002) than those with the most common genotype.To our knowledge, this is the first study investigating miRSNPs potentially affecting miRNA binding to mucin genes and revealing their impact on CRC susceptibility or patient's survival...
  39. pmc Genotype and Haplotype Analyses of TP53 Gene in Breast Cancer Patients: Association with Risk and Clinical Outcomes
    Veronika Vymetalkova
    Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic Institute of Biology and Medical Genetics, First Faculty of Medicine Charles University, Prague, Czech Republic
    PLoS ONE 10:e0134463. 2015
    ..Rs1042522 polymorphism (even after applying the Dunn-Bonferroni correction for multiple testing) appears to be an independent prognostic marker in breast cancer patients...
  40. doi Post-treatment recovery of suboptimal DNA repair capacity and gene expression levels in colorectal cancer patients
    Jana Slyskova
    Institute of Experimental Medicine, ASCR, Prague, Czech Republic
    Mol Carcinog 54:769-78. 2015
    ..However, we identified a panel of blood DNA repair-related markers discerning acute stage of the disease from the remission period. In conclusion, our results support a model in which DNA repair is altered as a result of cancer...
  41. doi Inherited variability in a master regulator polymorphism (rs4846126) associates with survival in 5-FU treated colorectal cancer patients
    Barbara Pardini
    Human Genetics Foundation, Turin, Italy Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic Electronic address
    Mutat Res 766:7-13. 2014
    ..Treatment with 5-fluorouracil (5-FU) is known to improve survival in many cancers including colorectal cancer. Response to the treatment, overall survival and recurrence show inter-individual variation...
  42. doi Functional, genetic, and epigenetic aspects of base and nucleotide excision repair in colorectal carcinomas
    Jana Slyskova
    Institute of Experimental Medicine, and Institute of Biotechnology, Academy of Sciences, Czech Republic
    Clin Cancer Res 18:5878-87. 2012
    ..We, for the first time, evaluate both excision repair capacities in human colon biopsies to study their participation in colorectal tumorigenesis...
  43. ncbi Sporadic colorectal cancer and individual susceptibility: a review of the association studies investigating the role of DNA repair genetic polymorphisms
    Alessio Naccarati
    Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Mutat Res 635:118-45. 2007
    ..This gained experience shows that only carefully designed studies of a sufficient statistical power may resolve the relationships between polymorphisms and colorectal cancer risk...
  44. pmc The focus on sample quality: Influence of colon tissue collection on reliability of qPCR data
    Vlasta Korenkova
    Institute of Biotechnology, BIOCEV Centre, Czech Academy of Sciences, Prumyslova 595, 252 42, Vestec u Prahy, Czech Republic
    Sci Rep 6:29023. 2016
    ..PAXgene collection mode proved to be more easily implemented in the operating room and moreover the quality of RNA obtained from human colon tissues by this method is superior to the one obtained by snap freezing. ..
  45. doi Evaluation of tumor suppressor gene expressions and aberrant methylation in the colon of cancer-induced rats: a pilot study
    Veronika Polakova Vymetalkova
    Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Videnska 1083, 14200, Prague 4, Czech Republic
    Mol Biol Rep 40:5921-9. 2013
    ..In this study we addressed for the first time early functional alterations of tumor suppressor genes with underlying epigenetic mechanisms in experimentally induced CRC in rats...
  46. doi Gene expression variations: potentialities of master regulator polymorphisms in colorectal cancer risk
    Barbara Pardini
    Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Videnska 1083, 14220 Prague 4, Czech Republic
    Mutagenesis 27:161-7. 2012
    ..In the present work, we overview the potentialities to use results from GWAS and eQTL studies in the identification as well as investigation of master regulators in CRC susceptibility...
  47. doi HOTAIR long non-coding RNA is a negative prognostic factor not only in primary tumors, but also in the blood of colorectal cancer patients
    Miroslav Svoboda
    Institute of Experimental Medicine, ASCR, Prague 14220, Czech Republic, Institute of Biology and Medical Genetics, First Medical Faculty, Charles University, Prague 12000, Czech Republic
    Carcinogenesis 35:1510-5. 2014
    ..Upregulated HOTAIR relative expression in primary tumors and in blood of CRC patients is associated with unfavorable prognosis. Our data suggest that HOTAIR blood levels may serve as potential surrogate prognostic marker in sporadic CRC...
  48. pmc Non-coding polymorphisms in nucleotide binding domain 1 in ABCC1 gene associate with transcript level and survival of patients with breast cancer
    Tereza Kunická
    Department of Toxicogenomics, National Institute of Public Health, Prague, Czech Republic 3rd Faculty of Medicine, Charles University, Prague, Czech Republic
    PLoS ONE 9:e101740. 2014
    ..This study aimed to explore tagged haplotype covering nucleotide binding domain 1 of ABCC1 in relation with corresponding transcript levels in tissues and clinical phenotype of breast cancer patients...
  49. doi Both genetic and dietary factors underlie individual differences in DNA damage levels and DNA repair capacity
    Jana Slyskova
    Department of Molecular Biology of Cancer, Institute of Experimental Medicine ASCR, Prague, Czech Republic Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic Electronic address
    DNA Repair (Amst) 16:66-73. 2014
    ..We have determined genetic and dietary factors that modulate DNA integrity. We propose that the positive health effect of fruit intake is partially mediated via DNA damage suppression and a simultaneous increase in DNA repair capacity. ..
  50. doi Polymorphisms within micro-RNA-binding sites and risk of sporadic colorectal cancer
    Debora Landi
    Dipartimento di Biologia, University of Pisa, Via Derna, 1, 56126 Pisa, Italy
    Carcinogenesis 29:579-84. 2008
    ..24-6.04, for the variant homozygotes] and INSR genes (OR = 1.94; 95% CI = 1.03-3.66, for the variant homozygotes). These results are the first reporting positive association between miRNA-binding SNPs sequences and cancer risk...
  51. ncbi A re-assessment of styrene-induced clastogenicity in mice in a subacute inhalation study
    Günter Engelhardt
    Product Safety, Regulations, Toxicology and Ecology, BASF Aktiengesellschaft, 67156 Ludwigshafen, Germany
    Arch Toxicol 77:56-61. 2003
    ..Under the experimental conditions used in the present investigation, there was no evidence of clastogenicity at any concentration or exposure interval...
  52. ncbi Assessment of biotransformation of the arene moiety of styrene in volunteers and occupationally exposed workers
    Paola Manini
    ISPESL Research Center at the University of Parma, Italy
    Toxicol Appl Pharmacol 189:160-9. 2003
    ..001) and possibly also to the dietary intake of styrene or 4-VP. Consequently, the use of 4-VP as a biomarker of styrene exposure is recommended for exposures exceeding 1 ppm...
  53. doi Could polymorphisms in ATP-binding cassette C3/multidrug resistance associated protein 3 (ABCC3/MRP3) modify colorectal cancer risk?
    Daniele Campa
    German Cancer Research Center, 69120 Heidelberg, Germany
    Eur J Cancer 44:854-7. 2008
    ..We did not find any significant association between the two ABCC3 polymorphisms and colorectal cancer risk...
  54. ncbi Insulin pathway related genes and risk of colorectal cancer: INSR promoter polymorphism shows a protective effect
    Sonali Pechlivanis
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Endocr Relat Cancer 14:733-40. 2007
    ..28, 95% CI 0.11-0.70). SNPs in the INS, IGFBPI, and IRS2 genes did not affect the risk of CRC. In conclusion, genetic variation in the insulin signaling pathway genes may affect the risk of CRC...
  55. doi PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome
    Barbara Schormair
    Institute of Human Genetics, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg 85764, Germany
    Nat Genet 40:946-8. 2008
    ..91 x 10(-10), odds ratio (OR) = 1.44; rs1975197, P(nominal/lambda corrected) = 5.81 x 10(-9), OR = 1.31). This work identifies PTPRD as the fourth genome-wide significant locus for RLS...