Triantafyllos Stylianopoulos

Summary

Affiliation: University of Cyprus
Country: Cyprus

Publications

  1. pmc The Solid Mechanics of Cancer and Strategies for Improved Therapy
    Triantafyllos Stylianopoulos
    Mem ASME Cancer Biophysics Laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, 1678, Cyprus E Mail
    J Biomech Eng 139:. 2017
  2. pmc Hyaluronan-Derived Swelling of Solid Tumors, the Contribution of Collagen and Cancer Cells, and Implications for Cancer Therapy
    Chrysovalantis Voutouri
    Cancer Biophysics laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, Cyprus Electronic address
    Neoplasia 18:732-741. 2016
  3. pmc Towards Optimal Design of Cancer Nanomedicines: Multi-stage Nanoparticles for the Treatment of Solid Tumors
    Triantafyllos Stylianopoulos
    Cancer Biophysics laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, 1678, Nicosia, Cyprus
    Ann Biomed Eng 43:2291-300. 2015
  4. pmc Design considerations for nanotherapeutics in oncology
    Triantafyllos Stylianopoulos
    Cancer Biophysics laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, Cyprus Electronic address
    Nanomedicine 11:1893-907. 2015
  5. pmc Coevolution of solid stress and interstitial fluid pressure in tumors during progression: implications for vascular collapse
    Triantafyllos Stylianopoulos
    Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, Cyprus
    Cancer Res 73:3833-41. 2013
  6. pmc Cationic nanoparticles have superior transvascular flux into solid tumors: insights from a mathematical model
    Triantafyllos Stylianopoulos
    Department of Mechanical and Manufacturing Engineering, University of Cyprus, 1678, Nicosia, Cyprus
    Ann Biomed Eng 41:68-77. 2013
  7. doi request reprint Tensile mechanical properties and hydraulic permeabilities of electrospun cellulose acetate fiber meshes
    Triantafyllos Stylianopoulos
    Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia 1678, Cyprus
    J Biomed Mater Res B Appl Biomater 100:2222-30. 2012
  8. pmc Remodeling of extracellular matrix due to solid stress accumulation during tumor growth
    Athanassios P Pirentis
    a Cancer Biophysics Laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, Cyprus and
    Connect Tissue Res 56:345-54. 2015
  9. pmc Role of constitutive behavior and tumor-host mechanical interactions in the state of stress and growth of solid tumors
    Chrysovalantis Voutouri
    Cancer Biophysics laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, Cyprus
    PLoS ONE 9:e104717. 2014
  10. pmc Combining two strategies to improve perfusion and drug delivery in solid tumors
    Triantafyllos Stylianopoulos
    Department of Mechanical and Manufacturing Engineering, University of Cyprus, 1678 Nicosia, Cyprus
    Proc Natl Acad Sci U S A 110:18632-7. 2013

Collaborators

  • Dai Fukumura
  • Panagiotis Papageorgis
  • Chrysovalantis Voutouri
  • Fotios Mpekris
  • Stelios Angeli
  • Athanassios P Pirentis
  • Christiana Polydorou
  • Vasiliki Gkretsi
  • Andreani D Odysseos

Detail Information

Publications14

  1. pmc The Solid Mechanics of Cancer and Strategies for Improved Therapy
    Triantafyllos Stylianopoulos
    Mem ASME Cancer Biophysics Laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, 1678, Cyprus E Mail
    J Biomech Eng 139:. 2017
    ..Finally, a continuum-level, mathematical framework to incorporate these types of solid stress is outlined...
  2. pmc Hyaluronan-Derived Swelling of Solid Tumors, the Contribution of Collagen and Cancer Cells, and Implications for Cancer Therapy
    Chrysovalantis Voutouri
    Cancer Biophysics laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, Cyprus Electronic address
    Neoplasia 18:732-741. 2016
    ..These results provide guidelines for emerging therapeutic strategies that target the tumor microenvironment to alleviate intratumoral stresses and improve vessel functionality and drug delivery...
  3. pmc Towards Optimal Design of Cancer Nanomedicines: Multi-stage Nanoparticles for the Treatment of Solid Tumors
    Triantafyllos Stylianopoulos
    Cancer Biophysics laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, 1678, Nicosia, Cyprus
    Ann Biomed Eng 43:2291-300. 2015
    ..Furthermore, our results suggest that smaller nanoparticles achieve better treatment outcome. ..
  4. pmc Design considerations for nanotherapeutics in oncology
    Triantafyllos Stylianopoulos
    Cancer Biophysics laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, Cyprus Electronic address
    Nanomedicine 11:1893-907. 2015
    ..Finally, we suggest specific design strategies that should optimize delivery to most solid tumors and discuss under what conditions active targeting would be beneficial...
  5. pmc Coevolution of solid stress and interstitial fluid pressure in tumors during progression: implications for vascular collapse
    Triantafyllos Stylianopoulos
    Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, Cyprus
    Cancer Res 73:3833-41. 2013
    ..Crucially, fluid pressure does not cause vessel compression of tumor vessels...
  6. pmc Cationic nanoparticles have superior transvascular flux into solid tumors: insights from a mathematical model
    Triantafyllos Stylianopoulos
    Department of Mechanical and Manufacturing Engineering, University of Cyprus, 1678, Nicosia, Cyprus
    Ann Biomed Eng 41:68-77. 2013
    ..Our model provides important guidelines for the optimal design of nanoparticle formulation for delivery to solid tumors...
  7. doi request reprint Tensile mechanical properties and hydraulic permeabilities of electrospun cellulose acetate fiber meshes
    Triantafyllos Stylianopoulos
    Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia 1678, Cyprus
    J Biomed Mater Res B Appl Biomater 100:2222-30. 2012
    ..In conclusion, polymer concentration, fiber alignment, and solvent have significant impact on the mechanical and fluid transport properties of electrospun cellulose acetate fiber meshes...
  8. pmc Remodeling of extracellular matrix due to solid stress accumulation during tumor growth
    Athanassios P Pirentis
    a Cancer Biophysics Laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, Cyprus and
    Connect Tissue Res 56:345-54. 2015
    ..This prediction is consistent with long-standing observations of tumor encapsulation and histologic sections that we performed, and it further corroborates the expansive growth hypothesis for the capsule formation. ..
  9. pmc Role of constitutive behavior and tumor-host mechanical interactions in the state of stress and growth of solid tumors
    Chrysovalantis Voutouri
    Cancer Biophysics laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, Cyprus
    PLoS ONE 9:e104717. 2014
    ....
  10. pmc Combining two strategies to improve perfusion and drug delivery in solid tumors
    Triantafyllos Stylianopoulos
    Department of Mechanical and Manufacturing Engineering, University of Cyprus, 1678 Nicosia, Cyprus
    Proc Natl Acad Sci U S A 110:18632-7. 2013
    ..g., pancreatic ductal adenocarcinomas). In the case of tumors with hyperpermeable and compressed vessels (e.g., subset of mammary carcinomas), the two strategies need to be combined for improved treatment outcomes. ..
  11. pmc Multistage nanoparticles for improved delivery into tumor tissue
    Triantafyllos Stylianopoulos
    Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, Cyprus
    Methods Enzymol 508:109-30. 2012
    ..Finally, we provide detailed experimental methods for the characterization of such nanoparticles...
  12. pmc Biphasic modeling of brain tumor biomechanics and response to radiation treatment
    Stelios Angeli
    Cancer Biophysics laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia 1678, Cyprus
    J Biomech 49:1524-31. 2016
    ..Our predictions relate to clinical symptoms of brain cancers and present useful tools for therapy planning. ..
  13. pmc Stress-mediated progression of solid tumors: effect of mechanical stress on tissue oxygenation, cancer cell proliferation, and drug delivery
    Fotios Mpekris
    Cancer Biophysics laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, P O Box 20537, 1678, Nicosia, Cyprus
    Biomech Model Mechanobiol 14:1391-402. 2015
    ..Finally, we demonstrated the applicability of our model to actual geometries, employing a breast tumor model derived from MR images. ..
  14. pmc Role of TGFβ in regulation of the tumor microenvironment and drug delivery (review)
    Panagiotis Papageorgis
    Cancer Biophysics laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia 1678, Cyprus
    Int J Oncol 46:933-43. 2015
    ..These findings provide new insights towards the significance of targeting TGFβ pathway to enhance personalized tumor treatment...