Carsten W Lederer

Summary

Affiliation: The Cyprus Institute of Neurology and Genetics
Country: Cyprus

Publications

  1. ncbi request reprint Motor protein KIFC5A interacts with Nubp1 and Nubp2, and is implicated in the regulation of centrosome duplication
    Andri Christodoulou
    Department of Biological Sciences, University of Cyprus and Cyprus Institute of Neurology and Genetics, PO Box 20537, 1678 Nicosia, Cyprus
    J Cell Sci 119:2035-47. 2006
  2. pmc Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosis
    Carsten W Lederer
    Department of Biological Sciences, University of Cyprus and Cyprus Institute of Neurology and Genetics, 1678 Nicosia, Cyprus
    BMC Genomics 8:26. 2007
  3. doi request reprint An electronic infrastructure for research and treatment of the thalassemias and other hemoglobinopathies: the Euro-mediterranean ITHANET project
    Carsten W Lederer
    Molecular Genetics Thalassaemia Department, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus
    Hemoglobin 33:163-76. 2009
  4. doi request reprint The nucleotide-binding proteins Nubp1 and Nubp2 are negative regulators of ciliogenesis
    Elena Kypri
    Department of Biological Sciences, University of Cyprus, University Avenue 1, 1678, Nicosia, Cyprus
    Cell Mol Life Sci 71:517-38. 2014
  5. ncbi request reprint Differential expression of molecular motors in the motor cortex of sporadic ALS
    Maria Pantelidou
    Department of Biological Sciences, University of Cyprus and Cyprus Institute of Neurology and Genetics, P O Box 20537, 1678 Nicosia, Cyprus
    Neurobiol Dis 26:577-89. 2007
  6. doi request reprint A novel family of katanin-like 2 protein isoforms (KATNAL2), interacting with nucleotide-binding proteins Nubp1 and Nubp2, are key regulators of different MT-based processes in mammalian cells
    Antonis Ververis
    Department of Biological Sciences, University of Cyprus, University Avenue 1, 1678, Nicosia, Cyprus
    Cell Mol Life Sci 73:163-84. 2016
  7. doi request reprint Compounds of the anthracycline family of antibiotics elevate human gamma-globin expression both in erythroid cultures and in a transgenic mouse model
    Pandelis Spyrou
    Molecular Genetics Thalassaemia Department, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus
    Blood Cells Mol Dis 44:100-6. 2010
  8. ncbi request reprint Amyotrophic lateral sclerosis--the tools of the trait
    Carsten W Lederer
    Department of Biological Sciences, University of Cyprus and Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus
    Biotechnol J 2:608-21. 2007
  9. doi request reprint Hb A2 Episkopi - a novel δ-globin chain variant [HBD:c.428C>T] in a family of mixed Cypriot-Lebanese descent
    Carsten W Lederer
    a Department of Molecular Genetics Thalassaemia, The Cyprus Institute of Neurology and Genetics, Cyprus and Cyprus School of Molecular Medicine, Nicosia, Cyprus
    Hematology . 2016
  10. doi request reprint Suitability of small diagnostic peripheral-blood samples for cell-therapy studies
    Coralea Stephanou
    Molecular Genetics Thalassaemia Department, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus Gene Expression and Therapy Group, King s College London, United Kingdom
    Cytotherapy 19:311-326. 2017

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Motor protein KIFC5A interacts with Nubp1 and Nubp2, and is implicated in the regulation of centrosome duplication
    Andri Christodoulou
    Department of Biological Sciences, University of Cyprus and Cyprus Institute of Neurology and Genetics, PO Box 20537, 1678 Nicosia, Cyprus
    J Cell Sci 119:2035-47. 2006
    ..These results implicate KIFC5A and the Nubp proteins in a common regulatory pathway involved in the control of centrosome duplication in mammalian cells...
  2. pmc Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosis
    Carsten W Lederer
    Department of Biological Sciences, University of Cyprus and Cyprus Institute of Neurology and Genetics, 1678 Nicosia, Cyprus
    BMC Genomics 8:26. 2007
    ..Moreover, the human motor cortex, although critical to ALS pathology and physiologically altered in most forms of the disease, has not been screened systematically for therapeutic targets...
  3. doi request reprint An electronic infrastructure for research and treatment of the thalassemias and other hemoglobinopathies: the Euro-mediterranean ITHANET project
    Carsten W Lederer
    Molecular Genetics Thalassaemia Department, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus
    Hemoglobin 33:163-76. 2009
    ..The ITHANET Portal as a web-based tool born out of this experience amends some of the problems encountered and facilitates education and international exchange of data and expertise for hemoglobinopathies...
  4. doi request reprint The nucleotide-binding proteins Nubp1 and Nubp2 are negative regulators of ciliogenesis
    Elena Kypri
    Department of Biological Sciences, University of Cyprus, University Avenue 1, 1678, Nicosia, Cyprus
    Cell Mol Life Sci 71:517-38. 2014
    ..Our combined results for Nubp1, Nubp2, and KIFC5A and their striking effects on cilium formation suggest a central regulatory role for these proteins, likely involving CCT/TRiC chaperone activity, in ciliogenesis. ..
  5. ncbi request reprint Differential expression of molecular motors in the motor cortex of sporadic ALS
    Maria Pantelidou
    Department of Biological Sciences, University of Cyprus and Cyprus Institute of Neurology and Genetics, P O Box 20537, 1678 Nicosia, Cyprus
    Neurobiol Dis 26:577-89. 2007
    ..No mutations causing splicing defects or altering protein-coding sequences were identified in the genes of the three proteins. The present study implicates two motor proteins as possible candidates in SALS pathology...
  6. doi request reprint A novel family of katanin-like 2 protein isoforms (KATNAL2), interacting with nucleotide-binding proteins Nubp1 and Nubp2, are key regulators of different MT-based processes in mammalian cells
    Antonis Ververis
    Department of Biological Sciences, University of Cyprus, University Avenue 1, 1678, Nicosia, Cyprus
    Cell Mol Life Sci 73:163-84. 2016
    ..In conclusion, KATNAL2s are multitasking enzymes involved in the same cell type in critically important processes affecting cytokinesis, MT dynamics, and ciliogenesis and are also implicated in cell cycle progression. ..
  7. doi request reprint Compounds of the anthracycline family of antibiotics elevate human gamma-globin expression both in erythroid cultures and in a transgenic mouse model
    Pandelis Spyrou
    Molecular Genetics Thalassaemia Department, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus
    Blood Cells Mol Dis 44:100-6. 2010
    ..In parallel, future studies of the epigenetic effects of the five anthracyclines on the beta-globin locus will generate possible mechanistic leads on the regulation of the globin genes...
  8. ncbi request reprint Amyotrophic lateral sclerosis--the tools of the trait
    Carsten W Lederer
    Department of Biological Sciences, University of Cyprus and Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus
    Biotechnol J 2:608-21. 2007
    ..In combination with a further subcategorization of patients and the development of corresponding model systems for functional analyses, they will significantly influence the already changing face of ALS therapy...
  9. doi request reprint Hb A2 Episkopi - a novel δ-globin chain variant [HBD:c.428C>T] in a family of mixed Cypriot-Lebanese descent
    Carsten W Lederer
    a Department of Molecular Genetics Thalassaemia, The Cyprus Institute of Neurology and Genetics, Cyprus and Cyprus School of Molecular Medicine, Nicosia, Cyprus
    Hematology . 2016
    ..78-Mb sequence duplication on chromosome 1 (1q44) and developmental abnormalities...
  10. doi request reprint Suitability of small diagnostic peripheral-blood samples for cell-therapy studies
    Coralea Stephanou
    Molecular Genetics Thalassaemia Department, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus Gene Expression and Therapy Group, King s College London, United Kingdom
    Cytotherapy 19:311-326. 2017
    ..We propose that ubiquitous small-volume diagnostic samples represent a readily available and as yet untapped resource of primary patient-derived cells for cell- and gene-therapy studies...
  11. pmc The molecular spectrum and distribution of haemoglobinopathies in Cyprus: a 20-year retrospective study
    Petros Kountouris
    Molecular Genetics Thalassaemia, The Cyprus Institute of Neurology and Genetics, 6 International Airport Ave, 2370 Nicosia, Cyprus
    Sci Rep 6:26371. 2016
    ..Notably, several mutations are reported for the first time in the Cypriot population, whereas important differences are observed in the distribution of mutations across different districts of the island. ..
  12. pmc The nuclear ATPase/adenylate kinase hCINAP is recruited to perinucleolar caps generated upon RNA pol.II inhibition
    Anna Malekkou
    Department of Biological Sciences, University of Cyprus and Cyprus Institute of Neurology and Genetics, P O Box 20537, 1678 Nicosia, Cyprus
    FEBS Lett 584:4559-64. 2010
    ..In DNCs, hCINAP co-localizes with Paraspeckle Protein (PSP1) and also co-segregates with PSP1, and not coilin, in nuclear and nucleolar foci upon UV irradiation...