Ana B Crujeiras

Summary

Publications

  1. doi request reprint Differential expression of oxidative stress and inflammation related genes in peripheral blood mononuclear cells in response to a low-calorie diet: a nutrigenomics study
    Ana B Crujeiras
    Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    OMICS 12:251-61. 2008
  2. doi request reprint Obesity and menopause modify the epigenomic profile of breast cancer.
    Ana B Crujeiras
    Endocr Relat Cancer 24:351-363. 2017
  3. doi request reprint Genome-wide DNA methylation pattern in visceral adipose tissue differentiates insulin-resistant from insulin-sensitive obese subjects
    A B Crujeiras
    Cancer Epigenetics and Biology Program PEBC, Bellvitge Biomedical Research Institute IDIBELL, L Hospitalet, Catalonia, Spain Laboratory of Molecular and Cellular Endocrinology, Instituto de Investigación Sanitaria IDIS, Complejo Hospitalario Universitario de Santiago CHUS and Santiago de Compostela University USC, Santiago de Compostela, Spain CIBER Fisiopatología de la Obesidad y la Nutrición CIBEROBN, Madrid, Spain Electronic address
    Transl Res 178:13-24.e5. 2016
  4. doi request reprint Association between circulating irisin levels and the promotion of insulin resistance during the weight maintenance period after a dietary weight-lowering program in obese patients
    Ana B Crujeiras
    Laboratory of Molecular and Cellular Endocrinology, Instituto de Investigación Sanitaria IDIS, Complejo Hospitalario Universitario de Santiago CHUS and Santiago de Compostela University USC, Santiago de Compostela, Spain Cancer Epigenetics and Biology Program PEBC, Bellvitge Biomedical Research Institute IDIBELL, Barcelona, Spain CIBER Fisiopatología de la Obesidad y la Nutrición CIBEROBN, Madrid, Spain Electronic address
    Metabolism 63:520-31. 2014
  5. doi request reprint Pre-treatment circulating leptin/ghrelin ratio as a non-invasive marker to identify patients likely to regain the lost weight after an energy restriction treatment
    A B Crujeiras
    Laboratory of Molecular and Cellular Endocrinology, Instituto de Investigacion Sanitaria, Complejo Hospitalario Universitario de Santiago CHUS and Santiago de Compostela University USC, C Choupana, S N, 15706, Santiago de Compostela, Spain
    J Endocrinol Invest 37:119-26. 2014
  6. doi request reprint Association of weight regain with specific methylation levels in the NPY and POMC promoters in leukocytes of obese men: a translational study
    Ana B Crujeiras
    Cancer Epigenetics and Biology Program PEBC, Bellvitge Biomedical Research Institute IDIBELL, Spain Laboratory of Molecular and Cellular Endocrinology, Instituto de Investigación Sanitaria IDIS, Complejo Hospitalario Universitario de Santiago CHUS, Santiago de Compostela University USC, Spain CIBER Fisiopatología de la Obesidad y la Nutrición CIBEROBN, Spain Electronic address
    Regul Pept 186:1-6. 2013
  7. doi request reprint Oxidative stress associated to dysfunctional adipose tissue: a potential link between obesity, type 2 diabetes mellitus and breast cancer
    A B Crujeiras
    Cancer Epigenetics and Biology Program PEBC, Bellvitge Biomedical Research Institute, Barcelona, Spain
    Free Radic Res 47:243-56. 2013
  8. doi request reprint Association of breast cancer and obesity in a homogeneous population from Spain
    A B Crujeiras
    Laboratory of Molecular and Cellular Endocrinology, Instituto de Investigacion Sanitaria, Complejo Hospitalario de Santiago de Compostela, Santiago de Compostela, Spain
    J Endocrinol Invest 35:681-5. 2012
  9. doi request reprint Tachyphylaxis effects on postprandial oxidative stress and mitochondrial-related gene expression in overweight subjects after a period of energy restriction
    Ana B Crujeiras
    Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    Eur J Nutr 48:341-7. 2009
  10. doi request reprint Weight regain after a diet-induced loss is predicted by higher baseline leptin and lower ghrelin plasma levels
    Ana B Crujeiras
    Laboratory of Molecular and Cellular Endocrinology, Instituto de Investigació n Sanitaria, Complejo Hospitalario de Santiago and Santiago de Compostela University, Santiago de Compostela, Spain
    J Clin Endocrinol Metab 95:5037-44. 2010

Collaborators

Detail Information

Publications32

  1. doi request reprint Differential expression of oxidative stress and inflammation related genes in peripheral blood mononuclear cells in response to a low-calorie diet: a nutrigenomics study
    Ana B Crujeiras
    Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    OMICS 12:251-61. 2008
    ..IL8 gene expression warrant further research as a putative novel biomarker of changes in body fat percentage in response to an LCD...
  2. doi request reprint Obesity and menopause modify the epigenomic profile of breast cancer.
    Ana B Crujeiras
    Endocr Relat Cancer 24:351-363. 2017
    ..The ZNF577 methylation quantification is clearly relevant for the development of novel biomarkers of precision therapy in breast cancer...
  3. doi request reprint Genome-wide DNA methylation pattern in visceral adipose tissue differentiates insulin-resistant from insulin-sensitive obese subjects
    A B Crujeiras
    Cancer Epigenetics and Biology Program PEBC, Bellvitge Biomedical Research Institute IDIBELL, L Hospitalet, Catalonia, Spain Laboratory of Molecular and Cellular Endocrinology, Instituto de Investigación Sanitaria IDIS, Complejo Hospitalario Universitario de Santiago CHUS and Santiago de Compostela University USC, Santiago de Compostela, Spain CIBER Fisiopatología de la Obesidad y la Nutrición CIBEROBN, Madrid, Spain Electronic address
    Transl Res 178:13-24.e5. 2016
    ....
  4. doi request reprint Association between circulating irisin levels and the promotion of insulin resistance during the weight maintenance period after a dietary weight-lowering program in obese patients
    Ana B Crujeiras
    Laboratory of Molecular and Cellular Endocrinology, Instituto de Investigación Sanitaria IDIS, Complejo Hospitalario Universitario de Santiago CHUS and Santiago de Compostela University USC, Santiago de Compostela, Spain Cancer Epigenetics and Biology Program PEBC, Bellvitge Biomedical Research Institute IDIBELL, Barcelona, Spain CIBER Fisiopatología de la Obesidad y la Nutrición CIBEROBN, Madrid, Spain Electronic address
    Metabolism 63:520-31. 2014
    ..This study aimed to investigate the association between irisin and reduced insulin sensitivity induced by weight regain...
  5. doi request reprint Pre-treatment circulating leptin/ghrelin ratio as a non-invasive marker to identify patients likely to regain the lost weight after an energy restriction treatment
    A B Crujeiras
    Laboratory of Molecular and Cellular Endocrinology, Instituto de Investigacion Sanitaria, Complejo Hospitalario Universitario de Santiago CHUS and Santiago de Compostela University USC, C Choupana, S N, 15706, Santiago de Compostela, Spain
    J Endocrinol Invest 37:119-26. 2014
    ..Leptin and ghrelin appear to play a role in weight regain after a successful weight loss. The pre-treatment plasma levels of leptin/ghrelin ratio (L/G) could have power to predict this clinically relevant issue in the obesity treatment...
  6. doi request reprint Association of weight regain with specific methylation levels in the NPY and POMC promoters in leukocytes of obese men: a translational study
    Ana B Crujeiras
    Cancer Epigenetics and Biology Program PEBC, Bellvitge Biomedical Research Institute IDIBELL, Spain Laboratory of Molecular and Cellular Endocrinology, Instituto de Investigación Sanitaria IDIS, Complejo Hospitalario Universitario de Santiago CHUS, Santiago de Compostela University USC, Spain CIBER Fisiopatología de la Obesidad y la Nutrición CIBEROBN, Spain Electronic address
    Regul Pept 186:1-6. 2013
    ..Therefore, the study of leukocyte methylation levels reflects a putative epigenetic regulation of NPY and POMC, which might be implicated in the weight regain process and be used as biomarkers for predicting weight regain after dieting. ..
  7. doi request reprint Oxidative stress associated to dysfunctional adipose tissue: a potential link between obesity, type 2 diabetes mellitus and breast cancer
    A B Crujeiras
    Cancer Epigenetics and Biology Program PEBC, Bellvitge Biomedical Research Institute, Barcelona, Spain
    Free Radic Res 47:243-56. 2013
    ....
  8. doi request reprint Association of breast cancer and obesity in a homogeneous population from Spain
    A B Crujeiras
    Laboratory of Molecular and Cellular Endocrinology, Instituto de Investigacion Sanitaria, Complejo Hospitalario de Santiago de Compostela, Santiago de Compostela, Spain
    J Endocrinol Invest 35:681-5. 2012
    ..To evaluate for the first time in Spain if the association between obesity and breast cancer prognosis is similar to that reported in other countries with non Mediterranean dietary patterns...
  9. doi request reprint Tachyphylaxis effects on postprandial oxidative stress and mitochondrial-related gene expression in overweight subjects after a period of energy restriction
    Ana B Crujeiras
    Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    Eur J Nutr 48:341-7. 2009
    ..Postprandially induced oxidative stress can cause damage to mitochondrial components and initiate cellular degradative processes; which are related to obesity comorbidities...
  10. doi request reprint Weight regain after a diet-induced loss is predicted by higher baseline leptin and lower ghrelin plasma levels
    Ana B Crujeiras
    Laboratory of Molecular and Cellular Endocrinology, Instituto de Investigació n Sanitaria, Complejo Hospitalario de Santiago and Santiago de Compostela University, Santiago de Compostela, Spain
    J Clin Endocrinol Metab 95:5037-44. 2010
    ..Appetite-related hormones may play an important role in weight regain after obesity therapy...
  11. doi request reprint A nutrigenomic inflammation-related PBMC-based approach to predict the weight-loss regain in obese subjects
    Estibaliz Goyenechea
    Department of Nutrition and Food Science, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    Ann Nutr Metab 54:43-51. 2009
    ..We investigated the role of the proinflammatory status on weight changes in obese subjects receiving a low-calorie diet (LCD) and during the subsequent 6-month weight maintenance period...
  12. doi request reprint Expression of two inflammation-related genes (RIPK3 and RNF216) in mononuclear cells is associated with weight-loss regain in obese subjects
    Estibaliz Goyenechea
    Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Navarra, Spain
    J Nutrigenet Nutrigenomics 2:78-84. 2009
    ..We analyzed the expression of two interacting genes (RIPK3 and RNF216) in obese subjects receiving a low-calorie diet (LCD) and during the subsequent weight changes...
  13. ncbi request reprint A hypocaloric diet enriched in legumes specifically mitigates lipid peroxidation in obese subjects
    Ana B Crujeiras
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Free Radic Res 41:498-506. 2007
    ....
  14. doi request reprint Interaction Between Orexin-A and Sleep Quality in Females in Extreme Weight Conditions
    Sarah Sauchelli
    Department of Psychiatry, University Hospital of Bellvitge IDIBELL, Barcelona, Spain
    Eur Eat Disord Rev 24:510-517. 2016
    ..Our data confirm an interaction between elevated plasma orexin-A concentrations and poor sleep that contributes to fluctuations in body mass index. Copyright © 2016 John Wiley & Sons, Ltd and Eating Disorders Association...
  15. pmc Decision Making Impairment: A Shared Vulnerability in Obesity, Gambling Disorder and Substance Use Disorders?
    Nuria Mallorquí-Bagué
    Department of Psychiatry, University Hospital of Bellvitge IDIBELL, Barcelona, Spain
    PLoS ONE 11:e0163901. 2016
    ..The present study explores decision making in Substance use disorder (SUD), Gambling disorder (GD) and Obesity (OB) when assessed by Iowa Gambling Task (IGT) and compares them with healthy controls (HC)...
  16. doi request reprint Enhanced short-term improvement of insulin response to a low-caloric diet in obese carriers the Gly482Ser variant of the PGC-1alpha gene
    Estibaliz Goyenechea
    Department of Nutrition and Food Science, Physiology and Toxicology, University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain
    Diabetes Res Clin Pract 82:190-6. 2008
    ..The current study investigated the relationships of carrying this polymorphism with insulin resistance (IR) during a short-term weight-loss and the subsequent weight follow-up...
  17. doi request reprint Enduring Changes in Decision Making in Patients with Full Remission from Anorexia Nervosa
    Trevor Steward
    Department of Psychiatry, Bellvitge University Hospital IDIBELL, Barcelona, Spain
    Eur Eat Disord Rev 24:523-527. 2016
    ..However, little is known on how decision making in AN patients evolves in response to treatment or whether impairments are reversible...
  18. doi request reprint Longitudinal variation of circulating irisin after an energy restriction-induced weight loss and following weight regain in obese men and women
    Ana B Crujeiras
    Laboratory of Molecular and Cellular Endocrinology, Instituto de Investigación Sanitaria IDIS, Complejo Hospitalario Universitario de Santiago CHUS and Santiago de Compostela University USC, Santiago de Compostela, Spain Cancer Epigenetics and Biology Program PEBC, Bellvitge Biomedical Research Institute IDIBELL, Barcelona, Spain CIBER Fisiopatología de la Obesidad y la Nutrición CIBEROBN, Madrid, Spain
    Am J Hum Biol 26:198-207. 2014
    ..The objective of this work was to evaluate whether circulating human irisin levels are modulated by body size and changes in adiposity during an energy restriction treatment and the subsequent weight regain...
  19. ncbi request reprint A role for fruit content in energy-restricted diets in improving antioxidant status in obese women during weight loss
    Ana B Crujeiras
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Nutrition 22:593-9. 2006
    ..The aim of the present work was to estimate the ability of two hypocaloric diets with different fruit contents to improve antioxidant biomarkers related to lipid peroxidation in obese women...
  20. ncbi request reprint Obesity treatment by very low-calorie-ketogenic diet at two years: reduction in visceral fat and on the burden of disease
    Basilio Moreno
    Division of Endocrinology and Nutrition, Hospital G Universitario Gregorio Marañón, Madrid, Spain
    Endocrine 54:681-690. 2016
    ..the low-calorie diet group (350 months; p < 0.001). In conclusion, a very low-calorie-ketogenic diet was effective 24 months later, with a decrease in visceral adipose tissue and a reduction in the individual burden of disease...
  21. doi request reprint Plasma irisin depletion under energy restriction is associated with improvements in lipid profile in metabolic syndrome patients
    Rocío de la Iglesia
    Department of Nutrition, Food Science and Physiology, University of Navarra, Pamplona, Spain
    Clin Endocrinol (Oxf) 81:306-11. 2014
    ..This study aimed to evaluate the relationship between this hormone and the lipid profile of patients with metabolic syndrome (MetS) following a hypocaloric diet...
  22. ncbi request reprint Body composition changes after very low-calorie-ketogenic diet in obesity evaluated by three standardized methods
    Diego Gómez-Arbeláez
    Division of Endocrinology, Department of Medicine, Complejo Hospitalario Universitario de Santiago CHUS, Santiago de Compostela, Spain
    J Clin Endocrinol Metab . 2016
    ..A common concern when using low-calorie diets as a treatment for obesity is the reduction in fat-free mass, mostly muscular mass that occurs together with the fat mass loss, and the best methodologies to evaluate body composition changes...
  23. doi request reprint Food Addiction in Bulimia Nervosa: Clinical Correlates and Association with Response to a Brief Psychoeducational Intervention
    Ines Hilker
    Department of Psychiatry, University Hospital of Bellvitge IDIBELL, Barcelona, Spain
    Eur Eat Disord Rev 24:482-488. 2016
    ..Food addiction (FA) has been examined in different populations. Although high FA levels are associated with greater eating disorder severity, few studies have addressed how FA relates to treatment outcome...
  24. doi request reprint Orexin and sleep quality in anorexia nervosa: Clinical relevance and influence on treatment outcome
    Sarah Sauchelli
    Department of Psychiatry, University Hospital of Bellvitge IDIBELL, Barcelona, Spain Ciber Fisiopatologia Obesidad y Nutrición CIBERObn, Instituto Salud Carlos III, Madrid, Spain
    Psychoneuroendocrinology 65:102-8. 2016
    ..Little is known about the functioning of these peptides in anorexia nervosa (AN). The aims of the current study were to evaluate the extent to which orexin-A might be linked to sleep and treatment outcome in AN...
  25. doi request reprint Leptin resistance in obesity: An epigenetic landscape
    Ana B Crujeiras
    Laboratory of Molecular and Cellular Endocrinology, Instituto de Investigación Sanitaria IDIS, Complejo Hospitalario Universitario de Santiago CHUS and Santiago de Compostela University USC, Santiago de Compostela, Spain CIBER Fisiopatología de la Obesidad y la Nutrición CIBEROBN, Madrid, Spain
    Life Sci 140:57-63. 2015
    ....
  26. pmc The gastric CB1 receptor modulates ghrelin production through the mTOR pathway to regulate food intake
    Lucía L Senín
    Grupo Fisiopatologia Endocrina, Instituto de Investigación Sanitaria de Santiago de Compostela IDIS, Complexo Hospitalario Universitario de Santiago CHUS SERGAS, Santiago de Compostela, Spain CIBER Fisiopatología Obesidad y Nutrición CB06 03, Instituto de Salud Carlos III, Santiago de Compostela, Spain
    PLoS ONE 8:e80339. 2013
    ..In conclusion, to the best of our knowledge, the present work is the first to describe a CB1 receptor-mediated mechanism that influences gastric ghrelin secretion and food intake through the mTOR pathway. ..
  27. pmc Epigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancer
    Angel Díaz-Lagares
    Cancer Epigenetics and Biology Program PEBC, Bellvitge Biomedical Research Institute IDIBELL, L Hospitalet de Llobregat, 08908 Barcelona, Catalonia, Spain
    Proc Natl Acad Sci U S A 113:E7535-E7544. 2016
    ..The epigenetic loss of TP53TG1 therefore represents an altered event in an lncRNA that is linked to classical tumoral pathways, such as p53 signaling, but is also connected to regulatory networks of the cancer cell...
  28. pmc Changes in Body Composition in Anorexia Nervosa: Predictors of Recovery and Treatment Outcome
    Zaida Aguera
    Department of Psychiatry, University Hospital of Bellvitge IDIBELL, Barcelona, Spain
    PLoS ONE 10:e0143012. 2015
    ..Put succinctly, the best predictors of changes in BC were baseline BC values, which did not, however, seem to influence treatment outcome. ..
  29. pmc Modulation of Higher-Order Olfaction Components on Executive Functions in Humans
    Ana B Fagundo
    Department of Psychiatry, University Hospital of Bellvitge IDIBELL, Barcelona, Spain Ciber Fisiopatologia Obesidad y Nutrición CIBERObn, Instituto Salud Carlos III, Madrid, Spain
    PLoS ONE 10:e0130319. 2015
    ..These results robustly support the hypothesis that olfaction and executive measures have a common neural substrate in PFC and OFC, and suggest that olfaction might be a reliable cognitive marker in psychiatric and neurologic disorders. ..
  30. doi request reprint Obesity and the reproductive system disorders: epigenetics as a potential bridge
    Ana B Crujeiras
    Laboratory of Molecular and Cellular Endocrinology, Instituto de Investigación Sanitaria IDIS, Complejo Hospitalario Universitario de Santiago CHUS and Santiago de Compostela University USC, Santiago de Compostela, Spain Cancer Epigenetics and Biology Program PEBC, Bellvitge Biomedical Research Institute IDIBELL, Barcelona, Spain CIBER Fisiopatología de la Obesidad y la Nutrición CIBEROBN, Madrid, Spain
    Hum Reprod Update 21:249-61. 2015
    ....
  31. doi request reprint Comparison of a very low-calorie-ketogenic diet with a standard low-calorie diet in the treatment of obesity
    Basilio Moreno
    Division of Endocrinology and Nutrition, Hospital G Universitario Gregorio Marañón, Madrid, Spain
    Endocrine 47:793-805. 2014
    ..At one year follow-up in the group with VLCK diet, most of the patients loss more than 10 % of their initial weight and lean mass was well preserved...
  32. pmc The obestatin/GPR39 system is up-regulated by muscle injury and functions as an autocrine regenerative system
    Uxía Gurriarán-Rodríguez
    Area de Endocrinología Molecular y Celular, Instituto de Investigación Sanitaria de Santiago IDIS, Santiago de Compostela, Spain
    J Biol Chem 287:38379-89. 2012
    ..These data elucidate a novel mechanism whereby the obestatin/GPR39 system is coordinately regulated as part of the myogenic program and operates as an autocrine signal regulating skeletal myogenesis...