Genomes and Genes
Affiliation: University Hospital Center
- Physicians' perception, knowledge and awareness of cardiovascular risk factors and adherence to prevention guidelines: the PERCRO-DOC surveyZeljko Reiner
Department of Internal Medicine, University Hospital Center Zagreb, School of Medicine, University of Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia
Atherosclerosis 213:598-603. 2010..This study was designed to examine the physicians' knowledge and perception of CVD risk factors and perceived implementation of CVD prevention guidelines as well as barriers to their implementation...
- Lipid lowering drug therapy in patients with coronary heart disease from 24 European countries--Findings from the EUROASPIRE IV surveyZ Reiner
Department of Internal Medicine, University Hospital Center Zagreb, School of Medicine, University of Zagreb, Croatia Electronic address
Atherosclerosis 246:243-50. 2016....
- PCSK9 inhibitors--past, present and futureZeljko Reiner
a University Hospital Centre Zagreb, School of Medicine University of Zagreb, Department of Internal Medicine, Kispaticeva 12, Zagreb, Croatia 385 1 237 6041 385 1 238 8623
Expert Opin Drug Metab Toxicol 11:1517-21. 2015..Their use in statin-intolerant patients also raises questions, as the criteria for statin-intolerance are neither clear nor generally accepted. The presumed high cost of PCSK9 inhibitors might be an obstacle for their broader use...
- Resistance and intolerance to statinsZ Reiner
Department of Internal Medicine, University Hospital Centre Zagreb, School of Medicine, University of Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia Electronic address
Nutr Metab Cardiovasc Dis 24:1057-66. 2014..Some patients are statin-intolerant because they are unable to tolerate statin therapy at all or to tolerate a full therapeutic statin dose because of adverse effects, particularly myopathy and increased activity of liver enzymes...
- Lysosomal acid lipase deficiency--an under-recognized cause of dyslipidaemia and liver dysfunctionZeljko Reiner
University Hospital Center, School of Medicine, University of Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia Electronic address
Atherosclerosis 235:21-30. 2014..Finally, current management options are reviewed in light of the ongoing development of enzyme replacement therapy with sebelipase alfa (Synageva BioPharma Corp., Lexington, MA, USA), a recombinant human lysosomal acid lipase enzyme. ..
- Primary prevention of cardiovascular disease with statins in the elderlyZeljko Reiner
Department of Internal Medicine, University Hospital Centre Zagreb, School of Medicine, University of Zagreb, Kispaticeva 12, 10000, Zagreb, Croatia
Curr Atheroscler Rep 16:420. 2014....
- Treatment potential for dyslipidaemia management in patients with coronary heart disease across Europe: findings from the EUROASPIRE III surveyZeljko Reiner
Department of Internal Medicine, University Hospital Centre Zagreb, School of Medicine, University of Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia Electronic address
Atherosclerosis 231:300-7. 2013..The aim of this survey was to assess how dyslipidaemia is managed following a coronary event in different places in Europe...
- Managing the residual cardiovascular disease risk associated with HDL-cholesterol and triglycerides in statin-treated patients: a clinical updateZ Reiner
Department of Internal Medicine, University Hospital Center Zagreb, School of Medicine, University of Zagreb, Kispaticeva 12, 10 000 Zagreb, Croatia Electronic address
Nutr Metab Cardiovasc Dis 23:799-807. 2013....
- Prevalence and types of persistent dyslipidemia in patients treated with statinsZeljko Reiner
Zeljko Reiner, Department of Internal Medicine, University Hospital Centre Zagreb, School of Medicine, University of Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia
Croat Med J 54:339-45. 2013....
- Statins in the primary prevention of cardiovascular diseaseZeljko Reiner
Department of Internal Medicine, University Hospital Centre Zagreb, School of Medicine, University of Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia
Nat Rev Cardiol 10:453-64. 2013..In appropriately selected individuals, statins should also be used for primary prevention of ischaemic stroke and transient ischaemic attack...
- [Is hypertriglyceridaemia a risk factor for coronary heart disease?]Zeljko Reiner
Zavod za bolesti metabolizma, Klinika za unutrasnje bolesti Medicinskog fakulteta Sveucilista u Zagrebu, KBC Zagreb
Lijec Vjesn 134:105-11. 2012..If LDL cholesterol is elevated too, combination therapy is needed. Based upon recent studies in such patients a combination of a statin with fenofibrate and/or omega-3 fatty acids can be recommended...
- The perception and knowledge of cardiovascular risk factors among medical studentsZeljko Reiner
Department of Internal Medicine, University Hospital Centre Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia
Croat Med J 53:278-84. 2012..To assess perceptions, knowledge, and awareness of cardiovascular disease (CVD) risk factors among medical students (freshmen and graduating students)...
- ESC/EAS Guidelines for the management of dyslipidaemias: the Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS)Zeljko Reiner
University Hospital Center Zagreb, School of Medicine, University of Zagreb, Salata 2, 10 000 Zagreb, Croatia
Eur Heart J 32:1769-818. 2011..g. general practitioners (GPs) and cardiologists] interested in CVD prevention, but also specialists from lipid clinics or metabolic units who are dealing with dyslipidaemias that are more difficult to classify and treat...
- Rice policosanol does not have any effects on blood coagulation factors in hypercholesterolemic patientsZeljko Reiner
Department of Internal Medicine, University Hospital Centre Zagreb, Zagreb, Croatia
Coll Antropol 31:1061-4. 2007..Plasma fibrinogen, factors VII, VIII, XII and XIII were measured before and after the treatment. Rice policosanol treatment did not change significantly neither fibrinogen nor factors VII, VIII, XII and XIII...
- Combined therapy in the treatment of dyslipidemiaZeljko Reiner
Department of Internal Medicine, University Hospital Center Zagreb, Zagreb, Croatia
Fundam Clin Pharmacol 24:19-28. 2010..However, it has to be stated that for most of these combination therapies data on cardiovascular outcomes are still lacking...
- Atherosclerosis of retinal arteries in men: role of serum lipoproteins and apoproteinsEugenia Tedeschi-Reiner
Department of Internal Medicine, Zagreb University Hospital Center, Kispaticeva 12, 10000 Zagreb, Croatia
Croat Med J 45:333-7. 2004....
- [Low HDL-cholesterol--an important risk factor for cardiovascular diseases]Zeljko Reiner
Zavod za bolesti metabolizma, Klinika za unutrasnje bolesti Medicinskog fakulteta Sveucilista u Zagrebu, Klinicki bolnicki centar Zagreb, Kispaticeva 12, 10000 Zagreb
Lijec Vjesn 133:111-6. 2011..Treatment options with fibrates, particularly fenofibrate, and niacin are discussed based upon published trials, as well as combination therapy with these medicines and other lipid-lowering drugs...
- Relation of atherosclerotic changes in retinal arteries to the extent of coronary artery diseaseEugenia Tedeschi-Reiner
Department of Ophthalmology, University Hospital Sestre Milosrdnice, Zagreb, Croatia
Am J Cardiol 96:1107-9. 2005..The extent and severity of retinal vessel atherosclerosis correlated strongly with the extent and severity of CAD. Thus, atherosclerotic changes in the retinal arteries may be a predictor of the extent of CAD...
- Treatment and secondary prevention of ischemic coronary events in Croatia (TASPIC-CRO study)Zeljko Reiner
Department of Internal Medicine, University Hospital Centre Zagreb, Croatia
Eur J Cardiovasc Prev Rehabil 13:646-54. 2006....
- Public perceptions of cardiovascular risk factors in Croatia: the PERCRO surveyZeljko Reiner
Department of Internal Medicine, University Hospital Center Zagreb, School of Medicine, University of Zagreb, Croatia
Prev Med 51:494-6. 2010..Since there are almost no data about the perceptions and attitudes of the general public concerning risk factors for cardiovascular diseases (CVD) this survey was performed...
- Changes in butyrylcholinesterase activity and serum lipids after oxprenolol and glibenclamide treatments in non-diabetic ratsVlasta Bradamante
Department of Pharmacology, School of Medicine, University of Zagreb, Croatia
Arzneimittelforschung 56:64-9. 2006..These results showed that the increase in BuChE activity might be the first sign of altered triglyceride and lipoprotein metabolism...
- Differences in risk factors for coronary heart disease in patients from continental and Mediterranean regions of CroatiaMijo Bergovec
Department of Internal Medicine, University Hospital Dubrava, Zagreb, Croatia
Wien Klin Wochenschr 120:684-92. 2008....
- Clinical study on the effect of simvastatin on paraoxonase activityDiana Muačević-Katanec
Zagreb University Hospital Center, Croatia
Arzneimittelforschung 57:647-53. 2007..The antioxidant properties of simvastatin, which play an important role in HDL protection from oxidation, could be the mechanism inducing the increase in PON1 activity...
- A view at the future--a dynamical, protocol-based and computationally intensive approach in cardiovascular risk assessmentLjiljana Majnarić-Trtica
Department of Family Medicine, School of Medicine, J J Strossmayer University Osijek, Croatia
Coll Antropol 34:437-45. 2010..We tested this possibility on an example of hyperhomocysteinemia which is a well-known complex cardiovascular risk factor...
- Drug therapy of cardiovascular risk factors: guidelines versus reality in primary health care serviceBiserka Bergman Marković
Biserka Bergman Markovic, General Practice Office, Albaharijeva 4, 10000 Zagreb, Croatia
Croat Med J 46:984-9. 2005....
- Variants of ESR1, APOE, LPL and IL-6 loci in young healthy subjects: association with lipid status and obesityJadranka Sertic
Clinical Institute of Laboratory Diagnosis, Zagreb University Hospital Centre, Zagreb, Croatia
BMC Res Notes 2:203. 2009..Significant associations were found for: LPL genetic polymorphic variant and abdominal obesity (p = 0.013), APO epsilon4 allele and hypercholesterolemia (p = 0.003), and ESR1-TA long allele and hypercholesterolemia (p = 0.011)...
- A pilot Croatian survey of risk factor (CRO-SURF) management in patients with cardiovascular diseaseIvan Pećin
University of Zagreb, Zagreb University Hospital Center, Department of Internal Diseases, Zagreb, Croatia
Coll Antropol 36:369-73. 2012..It is a good and cost effective tool to collect data on CVD risk factors and their management. The results obtained by using it indicate that there is still a high prevalence of modifiable risk factors in Croatian patients with CHD...
- Interaction of genetic risk factors confers increased risk for metabolic syndrome: the role of peroxisome proliferator-activated receptor γTamara Bozina
1 Department of Medical Chemistry, Biochemistry and Clinical Chemistry, University of Zagreb School of Medicine, Zagreb, Croatia
Genet Test Mol Biomarkers 18:32-40. 2014....
- Risk factors for microvascular atherosclerotic changes in patients with type 2 diabetes mellitusIveta Simić
University of Zagreb, University Hospital Center Zagreb, Department of Internal Medicine, Zagreb, Croatia
Coll Antropol 37:783-7. 2013..Lipid-lowering treatment might have an impact on microvascular complications in patients with type 2 diabetes, irrespectively of their serum lipid levels...
- Effects of lipoprotein lipase and peroxisome proliferator-activated receptor-gamma gene variants on metabolic syndrome traitsTamara Bozina
University of Zagreb, School of Medicine, Department of Medical Chemistry, Biochemistry and Clinical Chemistry, Zagreb, Croatia
Coll Antropol 37:801-8. 2013..Since the interplay between PPARG and LPL gene and gender seems to be significant it could point to the personalized behavioural recommendations for prevention of metabolic and cardiovascular diseases...
- Abnormal systolic blood pressure during treadmill test and brachial artery flow-mediated vasodilatation impairmentJure Mirat
Department of Cardiology, General Hospital Sveti Duh, Zagreb, Croatia
Coll Antropol 31:517-22. 2007..In hypertensives with abnormal SBP(mtt) an additional impairment of FMD exists when compared to hypertensives with normal SBP(mtt). Abnormal SBP(mtt) should be taken into account in global cardiovascular risk assessment...
- Comorbidity, multimorbidity and personalized psychosomatic medicine: epigenetics rolling on the horizonMiro Jakovljevic
Department of Psychiatry, University Hospital Centre Zagreb, 10000 Zagreb, Croatia
Psychiatr Danub 22:184-9. 2010..The potential relevance of epigenetics for better understanding and more successful treatment of comorbidity and multimorbidity is described...
- Mental disorders, treatment response, mortality and serum cholesterol: a new holistic look at old dataMiro Jakovljevic
University Psychiatric Clinic Rebro, Clinical Hospital Centre Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia
Psychiatr Danub 19:270-81. 2007..Changes in serum cholesterol levels may have a direct impact on mental performance, behavior, treatment response, survival and expected lifetime duration...
- Lipoprotein(a) predicts progression of carotid artery intima-media thickening in patients with type 2 diabetes: A four-year follow-upJozo Boras
Department of Cardiology, Vuk Vrhovac University Hospital, Zagreb, Croatia
Wien Klin Wochenschr 122:159-64. 2010....
- The burden of hyperlipidaemia and diabetes in cardiovascular diseasesMarijan Merkler
Department of Internal Medicine, University Hospital Center, Zagreb, Croatia
Fundam Clin Pharmacol 21:1-3. 2007..Therefore, planning and implementing programmes for prevention of CVD, particularly for controlling risk factors like hyperlipidaemia and diabetes should be accorded high priority...
- Mitochondrial myopathy associated with a novel 5522G>A mutation in the mitochondrial tRNA(Trp) geneIvo Baric
Department of Paediatrics, University Hospital Centre Zagreb, Zagreb, Croatia
Eur J Hum Genet 21:871-5. 2013..The mutation was heteroplasmic with a mutational load between 88 and 99% in COX-negative fibres. This case contributes to the genetic heterogeneity of mitochondrial diseases caused by mutations in mitochondrial tRNA genes. ..
- Diabetic dyslipidemia or 'diabetes lipidus'?Diana Muačević-Katanec
Division for Metabolic Diseases, Department of Internal Medicine, University Hospital Center Zagreb and School of Medicine, Zagreb, Croatia
Expert Rev Cardiovasc Ther 9:341-8. 2011..As diabetes and the lipid metabolism disorder can be neither scrutinized nor treated separately, the authors query whether 'diabetes lipidus' would be a more appropriate term...
- Deletion polymorphism of the angiotensin I-converting enzyme gene in elderly patients with coronary heart diseaseBiserka Bergman Marković
Department of Family Medicine, Andrija Stampar School of Public Health, School of Medicine, University of Zagreb, Zagreb, Croatia
Coll Antropol 31:179-83. 2007..A weak, but increased risk of MI is associated with high frequency of DD genotype in the elderly. Strong correlation between ACE polymorphism and ACE plasma activities was demonstrated...
- Spontaneous perforation of the small intestine, a novel manifestation of classical homocystinuria in an adult with new cystathionine beta-synthetase gene mutationsDiana Muačević-Katanec
University of Zagreb, Zagreb University Hospital Center, Department of Internal Medicine, Division for Metabolic Diseases, Zagreb, Croatia
Coll Antropol 35:181-5. 2011..DNA analysis showed three detectable mutations in the cystathionine beta-synthetase gene, 1278T:c.833T>C, and two new mutations, V372G:c.1133T > G, and D520G:c.1558A > G in the aternatively spliced exon 15...
- Butyrylcholinesterase activity and plasma lipids in dexamethasone treated ratsAna Lucić Vrdoljak
Unit of Toxicology, Institute for Medical Research and Occupational Health, 10000 Zagreb, Croatia
Acta Pharm 55:177-85. 2005..Neither positive correlation between BuChE and triglycerides nor negative correlation between BuChE and HDL was found. Changes in lipid profile during DM treatment were not sex- and time-dependent...
- Mutation detection in Croatian patients with familial hypercholesterolemiaIvan Pećin
Department of Internal Medicine, University Hospital Center Zagreb, Croatia
Ann Hum Genet 77:22-30. 2013..HRM is a sensitive method for screening for mutations. While the causative mutation has been identified in 88% of these clinically defined FH patients, there appears to be a high degree of allelic heterogeneity in Croatian patients...
- Endogenous steroid sex hormones and atherosclerosis of retinal arteries in menEugenia Tedeschi-Reiner
Department of Opthalmology, University Hospital Sestre Milosrdnice, Zagreb, Croatia
Med Sci Monit 15:CR211-6. 2009..To our knowledge, there are no data on the effects of endogenous sex hormones on atherosclerosis of the retinal arteries in men, and the purpose of this study was to explore that association...
- Cytokines and growth factors in mostly atherosclerotic patients on hemodialysis determined by biochip array technologyJadranka Sertic
Department of Clinical Chemistry, Zagreb University School of Medicine, Zagreb, Croatia
Clin Chem Lab Med 45:1347-52. 2007....
- Thigh abscess as an extension of psoas abscess: the first manifestation of perforated appendiceal adenocarcinoma: case reportIgor Petrovic
Division of Abdominal Surgery, Clinical University Hospital Centre Zagreb, Kispaticeva 12, 10000, Zagreb, Croatia
Wien Klin Wochenschr 127:645-8. 2015..When upper leg abscess is suspected or proven abdominal examination is mandatory...
- Adverse effects of statins - myths and realityIveta Simić
University of Zagreb, School of Medicine, University Hospital Center Zagreb, Department of Internal Medicine, Division of Metabolic Disease, Zagreb, Kispaticeva 12, Croatia
Curr Pharm Des 21:1220-6. 2015..Systematic reviews and clinical guidelines suggest that the cardiovascular benefits of statins by far out-weight non-cardiovascular harms in patients with cardiovascular risk. ..
- [Familial hypercholesterolemia - do we think enough about this severe disease?]Ivan Pećin
Zavod za bolesti metabolizma, Klinika za unutarnje bolesti Medicinskog fakulteta, Klinicki bolnicki centar Zagreb
Lijec Vjesn 135:145-9. 2013..There is a need to increase the awareness of this disease in Croatia but also worldwide with one main goal: to early diagnose and prevent cardiovascular morbidity and mortality...
- [Croatian guidelines for nutrition in the elderly, part II--clinical nutrition]Zeljko Krznaric
Centar za klinicku prehranu i Zavod za gastroenterologiju i hepatologiju, Klinika za unutrasnje bolesti, KBC Zagreb, Kispaticeva 12, 10000 Zagreb
Lijec Vjesn 133:299-307. 2011....
- [A randomized, double-blind, placebo-controlled study of the antilipemic efficacy and tolerability of food supplement policosanol in patients with moderate hypercholesterolemia]Eugenia Tedeschi-Reiner
Klinika za unutrasnje bolesti Klinickog boirkog centra Zagreb Medicinskog fakulteta Sveufiligta u Zagrebu
Lijec Vjesn 127:273-9. 2005..It was well tolerated, with no drug-related effects on safety parameters such as serum aminotransferases, blood glucose, bilirubin, and CK, neither did it cause any clinical adverse reactions...
- [Should we begin with statin therapy in acute coronary syndrome?]Zeljko Reiner
Klinika za unutrasnje bolesti Klinicki bolnicki centar Zagreb Kispatićeva 12 10000 Zagreb, Hrvatska
Acta Med Croatica 58:147-50. 2004..Based upon the current knowledge, it might be concluded that patients hospitalized for ACS should be given a statin and the treatment should be initiated as soon as possible...
- [Lipoprotein disorders in chronic kidney failure, nephrotic syndrome and dialysis]Petar Kes
Zavod za dijalizu Klinickog bolnickog centra i Medicinskog fakulteta, Zagreb
Lijec Vjesn 124:372-7. 2002..The therapeutic approaches, which may be considered, include mainly dietary and life-style modifications, selective use of some technical components of dialysis systems, and the judicious prescriptions of lipid-lowering drugs...
- [Concomitant use of statins and cytochrome P 450 inhibitors in Croatia]Zeljko Reiner
Klinika za unutrasnje bolesti, Klinicki bolnicki centar Zagreb
Lijec Vjesn 127:65-8. 2005..This sex difference is, however, not statistically significant. Patients between 70 and 74 years of age taking statins are in Croatia at the highest risk of interactions because 8% of them take concomitantly cytochrome P 450 inhibitors...
- [Characteristics of hyperhomocysteinemia in dialysis patients]Vesna Lovcić
Centar za dijalizu, Odjel za internu medicinu, Opća bolnica Bjelovar, Bjelovar, Hrvatska
Acta Med Croatica 60:21-6. 2006..The aim of the study was to determine the prevalence of hyperhomocysteinemia and its relationship with other cardiovascular risk factors in dialysis patients...
- [Three-year-old boy--a homozygote for familiar hypercholesterolemia]Miroslav Dumic
Klinika za pedijatriju Rebro, Medicinski fakultet i KBC Zagreb
Lijec Vjesn 129:130-3. 2007..The boy has been treated with simvastatin and atorvastatin, but without reaching the treatment goals. LDL apheresis is planned as the treatment of choice for homozygous children with FH...
- European guidelines on cardiovascular disease prevention in clinical practice: executive summary: Fourth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (Constituted by rIan Graham
Department of Cardiology, Adelaide and Meath Hospital, Dublin, Ireland
Eur Heart J 28:2375-414. 2007
- [The effects of plant sterols on hypercholesterolemia]Zeljko Reiner
Klinika za unutrasnje bolesti KBC Zagreb
Lijec Vjesn 129:276-81. 2007..To achieve additional effects they can be combined with statin therapy, and this combination is also well tolerated and safe...
- Statins in heart failure - a failure?Zeljko Reiner
Nutr Metab Cardiovasc Dis 18:397-401. 2008
- [Effect of erythropoietin therapy on serum lipoprotein levels in patients on hemodialysis]Petar Kes
Zavod za nefrologiju i dijalizu, Klinika za unutarnje bolesti Klinicke bolnice Sestre milosrdnice, Zagreb
Lijec Vjesn 124:146-50. 2002..It could be concluded that long-term rHuEpo treatment is associated with an improvement in the lipid profile. These results suggest that the high incidence of cardiovascular diseases in HD patients might be reduced with rHuEpo therapy...