Yu Sheng Cong

Summary

Publications

  1. pmc Cav-1 deletion impaired hematopoietic stem cell function
    L Bai
    Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medical Center, Peking Union Medical College, Beijing 100021, China
    Cell Death Dis 5:e1140. 2014
  2. pmc DDRGK1 regulates NF-κB activity by modulating IκBα stability
    Peng Xi
    Key Laboratory for Cell Proliferation and Regulation Biology of Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing, China
    PLoS ONE 8:e64231. 2013
  3. pmc Telomerase reverse transcriptase in the regulation of gene expression
    Junzhi Zhou
    Institute of Aging Research, Hangzhou Normal University School of Medicine, Hangzhou 310036, China
    BMB Rep 47:8-14. 2014
  4. doi request reprint Human telomerase reverse transcriptase regulates MMP expression independently of telomerase activity via NF-κB-dependent transcription
    Deqiang Ding
    2Institute of Aging Research, Hangzhou Normal University School of Medicine, Hangzhou, China
    FASEB J 27:4375-83. 2013
  5. doi request reprint Down-regulation of the cavin family proteins in breast cancer
    Lin Bai
    Key Lab of Cell Proliferation and Regulation Biology of the Ministry of Education, Institute of Cell Biology, Beijing Normal University, Beijing 100875, PR China
    J Cell Biochem 113:322-8. 2012
  6. doi request reprint Serine/threonine-protein phosphatase 2A physically interacts with human telomerase reverse transcriptase hTERT and regulates its subcellular distribution
    Peng Xi
    Key Laboratory for Cell Proliferation and Regulation Biology of Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing 100875, China
    J Cell Biochem 114:409-17. 2013
  7. pmc Regulation of cellular senescence by the essential caveolar component PTRF/Cavin-1
    Lin Bai
    Key Lab of Cell Proliferation and Regulation Biology of the Ministry of Education, Institute of Cell Biology, Beijing Normal University, 19 Xin Jie Kou Wai Avenue, Beijing 100875, China
    Cell Res 21:1088-101. 2011
  8. doi request reprint Implications of telomere-independent activities of telomerase reverse transcriptase in human cancer
    Deqiang Ding
    Institute of Aging Research, Hangzhou Normal University School of Medicine, Hangzhou, China
    FEBS J 280:3205-11. 2013
  9. pmc Endoplasmic reticulum stress activates telomerase
    Junzhi Zhou
    Institute of Aging Research, Hangzhou Normal University School of Medicine, Hangzhou, 310036, China Key Laboratory for Cell Proliferation and Regulation Biology of Ministry of Education, Beijing Normal University, Beijing, 100875, China
    Aging Cell 13:197-200. 2014
  10. doi request reprint Increased polymerase I and transcript release factor (Cavin-1) expression attenuates platelet-derived growth factor receptor signalling in senescent human fibroblasts
    Qian Li
    Key laboratory for Cell Proliferation and Regulation Biology of the Ministry of Education, Beijing Normal University, Beijing, China
    Clin Exp Pharmacol Physiol 41:169-73. 2014

Collaborators

Detail Information

Publications14

  1. pmc Cav-1 deletion impaired hematopoietic stem cell function
    L Bai
    Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medical Center, Peking Union Medical College, Beijing 100021, China
    Cell Death Dis 5:e1140. 2014
    ..Taken together, these data suggest that Cav-1-deficient cells impaired HSCs quiescence and induced environmental alterations, which limited HSCs self-renewal and function. ..
  2. pmc DDRGK1 regulates NF-κB activity by modulating IκBα stability
    Peng Xi
    Key Laboratory for Cell Proliferation and Regulation Biology of Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing, China
    PLoS ONE 8:e64231. 2013
    ..We further demonstrated that DDRGK1 interacts with IκBα and regulates its stability, thereby regulates the NF-κB transcriptional activity. Our findings identify DDRGK1 as an important regulator of the NF-κB pathway...
  3. pmc Telomerase reverse transcriptase in the regulation of gene expression
    Junzhi Zhou
    Institute of Aging Research, Hangzhou Normal University School of Medicine, Hangzhou 310036, China
    BMB Rep 47:8-14. 2014
    ..Several studies have shown a direct involvement of hTERT in gene transcription. This mini-review will focus on the role of hTERT in gene transcription regulation, and discuss its possible mechanisms...
  4. doi request reprint Human telomerase reverse transcriptase regulates MMP expression independently of telomerase activity via NF-κB-dependent transcription
    Deqiang Ding
    2Institute of Aging Research, Hangzhou Normal University School of Medicine, Hangzhou, China
    FASEB J 27:4375-83. 2013
    ..Together, these data reveal a telomere-independent role for telomerase as a transcriptional modulator of the NF-κB signaling pathway and a possible contributor to cancer development and progression...
  5. doi request reprint Down-regulation of the cavin family proteins in breast cancer
    Lin Bai
    Key Lab of Cell Proliferation and Regulation Biology of the Ministry of Education, Institute of Cell Biology, Beijing Normal University, Beijing 100875, PR China
    J Cell Biochem 113:322-8. 2012
    ..Thus, the caveolae is a potential therapeutic target and the expression of cavin family proteins could be a useful prognostic indicator of breast cancer progression...
  6. doi request reprint Serine/threonine-protein phosphatase 2A physically interacts with human telomerase reverse transcriptase hTERT and regulates its subcellular distribution
    Peng Xi
    Key Laboratory for Cell Proliferation and Regulation Biology of Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing 100875, China
    J Cell Biochem 114:409-17. 2013
    ..Together, these observations suggest that PP2A regulates hTERT subcellular localization, in addition to its inhibitory effects on telomerase activity...
  7. pmc Regulation of cellular senescence by the essential caveolar component PTRF/Cavin-1
    Lin Bai
    Key Lab of Cell Proliferation and Regulation Biology of the Ministry of Education, Institute of Cell Biology, Beijing Normal University, 19 Xin Jie Kou Wai Avenue, Beijing 100875, China
    Cell Res 21:1088-101. 2011
    ..Taken together, our findings identify PTRF as a novel regulator of cellular senescence that acts through the p53/p21 and caveolar pathways...
  8. doi request reprint Implications of telomere-independent activities of telomerase reverse transcriptase in human cancer
    Deqiang Ding
    Institute of Aging Research, Hangzhou Normal University School of Medicine, Hangzhou, China
    FEBS J 280:3205-11. 2013
    ....
  9. pmc Endoplasmic reticulum stress activates telomerase
    Junzhi Zhou
    Institute of Aging Research, Hangzhou Normal University School of Medicine, Hangzhou, 310036, China Key Laboratory for Cell Proliferation and Regulation Biology of Ministry of Education, Beijing Normal University, Beijing, 100875, China
    Aging Cell 13:197-200. 2014
    ..Our findings establish a functional link between ER stress and telomerase, both of which have important implications in the pathologies associated with aging and cancer. ..
  10. doi request reprint Increased polymerase I and transcript release factor (Cavin-1) expression attenuates platelet-derived growth factor receptor signalling in senescent human fibroblasts
    Qian Li
    Key laboratory for Cell Proliferation and Regulation Biology of the Ministry of Education, Beijing Normal University, Beijing, China
    Clin Exp Pharmacol Physiol 41:169-73. 2014
    ....
  11. doi request reprint Differential expression of oncogenic miRNAs in proliferating and senescent human fibroblasts
    Miao Wang
    Key Laboratory for Cell Proliferation and Regulation Biology of Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing, China
    Mol Cell Biochem 352:271-9. 2011
    ..It was further showed that inhibition of miR-17-5p and miR-20a by 2'-O-methyl antisense oligoribonucleotides resulted in the induction of senescent phenotypes in WI-38 cells...
  12. doi request reprint Telomerase reverse transcriptase activates the expression of vascular endothelial growth factor independent of telomerase activity
    Lili Zhou
    Key Laboratory for Cell Proliferation and Regulation Biology of Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, 19 Xin Jie Kou Wai Avenue, Beijing 100875, China
    Biochem Biophys Res Commun 386:739-43. 2009
    ..These results suggest that hTERT has non-telomeric activity in the regulation of gene expression and provide additional insights into the role of telomerase in aging and cancer...
  13. doi request reprint Lysophosphatidic acid activates telomerase in ovarian cancer cells through hypoxia-inducible factor-1alpha and the PI3K pathway
    Kun Yang
    Key Laboratory for Cell Proliferation and Regulation Biology of Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, 19 XinJieKouWai Avenue, Beijing 100875, China
    J Cell Biochem 105:1194-201. 2008
    ..Targeting human telomerase by LPA is potentially involved in its role of promoting tumor progression...
  14. pmc miR-127 regulates cell proliferation and senescence by targeting BCL6
    Jingwen Chen
    Key Laboratory for Cell Proliferation and Regulation Biology of Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing, China Institute of Aging Research, Hangzhou Normal University School of Medicine, Hangzhou, China
    PLoS ONE 8:e80266. 2013
    ..Over-expression of miR-127 or depletion of BCL6 inhibits breast cancer cell proliferation. Our data suggest that miR-127 may function as a tumor suppressor that modulates the oncogene BCL6...