Marlene Jimenez-Del-Rio

Summary

Affiliation: Universidad de Antioquia
Country: Colombia

Publications

  1. pmc The bad, the good, and the ugly about oxidative stress
    Marlene Jimenez-Del-Rio
    School of Medicine, Medical Research Institute, Neuroscience Research Group, University of Antioquia UdeA, SIU, Calle 62 52 59, Building 1, Room 412, Medellín 1226, Colombia
    Oxid Med Cell Longev 2012:163913. 2012
  2. doi request reprint The effects of polyphenols on survival and locomotor activity in Drosophila melanogaster exposed to iron and paraquat
    M Jimenez-Del-Rio
    School of Medicine, Medical Research Institute, Neuroscience Research Group, University of Antioquia UdeA, Calle 62 52 59, Building 1, Room 412, Medellin, Colombia
    Neurochem Res 35:227-38. 2010
  3. doi request reprint Using paraquat to generate anion free radicals and hydrogen peroxide in in vitro: Antioxidant effect of vitamin E: A procedure to teach theoretical and experimental principles of reactive oxygen species biochemistry
    Marlene Jimenez-Del-Rio
    School of Medicine, Medical Research Institute, Neuroscience Research Group, University of Antioquia UdeA, Calle 62 52 59, Building 1, Laboratory 411 412 SIU Medellin, Colombia
    Biochem Mol Biol Educ 38:104-9. 2010
  4. doi request reprint Low doses of paraquat and polyphenols prolong life span and locomotor activity in knock-down parkin Drosophila melanogaster exposed to oxidative stress stimuli: implication in autosomal recessive juvenile parkinsonism
    Leonardo Bonilla-Ramirez
    School of Medicine, Medical Research Institute, Neuroscience Research Group, University of Antioquia UdeA, Medellin, Colombia
    Gene 512:355-63. 2013
  5. doi request reprint Glucose starvation induces apoptosis in a model of acute T leukemia dependent on caspase-3 and apoptosis-inducing factor: a therapeutic strategy
    Miguel Mendivil-Perez
    School of Medicine, Medical Research Institute, University of Antioquia, Medellin, Colombia
    Nutr Cancer 65:99-109. 2013
  6. pmc TPEN induces apoptosis independently of zinc chelator activity in a model of acute lymphoblastic leukemia and ex vivo acute leukemia cells through oxidative stress and mitochondria caspase-3- and AIF-dependent pathways
    Miguel Mendivil-Perez
    Medical Research Institute School of Medicine, University of Antioquia UdeA, Medellin, Colombia
    Oxid Med Cell Longev 2012:313275. 2012
  7. doi request reprint Life span and locomotor activity modification by glucose and polyphenols in Drosophila melanogaster chronically exposed to oxidative stress-stimuli: implications in Parkinson's disease
    Hector Flavio Ortega-Arellano
    School of Medicine, Medical Research Institute, Neuroscience Research Group, University of Antioquia, SIU, Medellin, Colombia
    Neurochem Res 36:1073-86. 2011
  8. doi request reprint Acute and chronic metal exposure impairs locomotion activity in Drosophila melanogaster: a model to study Parkinsonism
    Leonardo Bonilla-Ramirez
    School of Medicine, Medical Research Institute, Neuroscience Research Group, University of Antioquia UdeA, Calle 62 52 59, SIU, Medellin, Colombia
    Biometals 24:1045-57. 2011
  9. ncbi request reprint 17 beta-estradiol protects lymphocytes against dopamine and iron-induced apoptosis by a genomic-independent mechanism. Implication in Parkinson's disease
    M Jimenez Del Rio
    School of Medicine, University of Antioquia, Calle 62 52 72, P O Box 1226, Medellin, Colombia
    Gen Pharmacol 35:1-9. 2000
  10. doi request reprint The cannabinoid CP55,940 prolongs survival and improves locomotor activity in Drosophila melanogaster against paraquat: implications in Parkinson's disease
    M Jimenez-Del-Rio
    School of Medicine, Department of Internal Medicine, Neurosciences Research Program, University of Antioquia, Calle 62 52 59, Building 1, Room 412, SIU Medellin, Colombia
    Neurosci Res 61:404-11. 2008

Collaborators

  • Juanita Bustamante
  • Carlos Velez-Pardo
  • Miguel Mendivil-Perez
  • Leonardo Bonilla-Ramirez
  • Hector Flavio Ortega-Arellano
  • Viviana Diaz-Aguirre
  • Angelica Rocio Bonilla-Porras
  • Cristian Ruiz-Moreno
  • Diana Quintero-Espinosa
  • Angelica R Bonilla-Porras
  • Isabel Cristina Avila-Gomez
  • Betty Lopez-Osorio
  • Vitelbina Núñez
  • Leidy Johana Vargas
  • Ligia Sierra-Garcia
  • M Jimenez Del Rio

Detail Information

Publications23

  1. pmc The bad, the good, and the ugly about oxidative stress
    Marlene Jimenez-Del-Rio
    School of Medicine, Medical Research Institute, Neuroscience Research Group, University of Antioquia UdeA, SIU, Calle 62 52 59, Building 1, Room 412, Medellín 1226, Colombia
    Oxid Med Cell Longev 2012:163913. 2012
    ..Finally, we will attempt to associate PD, cancer, and OS. This paper critically analyzes the evidence that support the "oxidative stress model" in neurodegeneration and cancer...
  2. doi request reprint The effects of polyphenols on survival and locomotor activity in Drosophila melanogaster exposed to iron and paraquat
    M Jimenez-Del-Rio
    School of Medicine, Medical Research Institute, Neuroscience Research Group, University of Antioquia UdeA, Calle 62 52 59, Building 1, Room 412, Medellin, Colombia
    Neurochem Res 35:227-38. 2010
    ..Our findings indicate that pure polyphenols might be potent neuroprotective agents for the treatment of PD against stressful stimuli...
  3. doi request reprint Using paraquat to generate anion free radicals and hydrogen peroxide in in vitro: Antioxidant effect of vitamin E: A procedure to teach theoretical and experimental principles of reactive oxygen species biochemistry
    Marlene Jimenez-Del-Rio
    School of Medicine, Medical Research Institute, Neuroscience Research Group, University of Antioquia UdeA, Calle 62 52 59, Building 1, Laboratory 411 412 SIU Medellin, Colombia
    Biochem Mol Biol Educ 38:104-9. 2010
    ....
  4. doi request reprint Low doses of paraquat and polyphenols prolong life span and locomotor activity in knock-down parkin Drosophila melanogaster exposed to oxidative stress stimuli: implication in autosomal recessive juvenile parkinsonism
    Leonardo Bonilla-Ramirez
    School of Medicine, Medical Research Institute, Neuroscience Research Group, University of Antioquia UdeA, Medellin, Colombia
    Gene 512:355-63. 2013
    ..Altogether our present results open new avenues for the screening, testing and development of novel antioxidant drugs against OS stimuli in neurodegenerative disorders...
  5. doi request reprint Glucose starvation induces apoptosis in a model of acute T leukemia dependent on caspase-3 and apoptosis-inducing factor: a therapeutic strategy
    Miguel Mendivil-Perez
    School of Medicine, Medical Research Institute, University of Antioquia, Medellin, Colombia
    Nutr Cancer 65:99-109. 2013
    ..001), but only vitamin E and glucose significantly rescued cells at 3 h of GS compared to control. Taken together these data suggest that glucose deprivation might efficiently eliminate leukemia cells via apoptosis...
  6. pmc TPEN induces apoptosis independently of zinc chelator activity in a model of acute lymphoblastic leukemia and ex vivo acute leukemia cells through oxidative stress and mitochondria caspase-3- and AIF-dependent pathways
    Miguel Mendivil-Perez
    Medical Research Institute School of Medicine, University of Antioquia UdeA, Medellin, Colombia
    Oxid Med Cell Longev 2012:313275. 2012
    ..Our data suggest that TPEN can be used as a potential therapeutic prooxidant agent against refractory leukemia. These data contribute to understanding the importance of oxidative stress in the treatment of ALL...
  7. doi request reprint Life span and locomotor activity modification by glucose and polyphenols in Drosophila melanogaster chronically exposed to oxidative stress-stimuli: implications in Parkinson's disease
    Hector Flavio Ortega-Arellano
    School of Medicine, Medical Research Institute, Neuroscience Research Group, University of Antioquia, SIU, Medellin, Colombia
    Neurochem Res 36:1073-86. 2011
    ..These findings altogether open new avenues for the screening, testing and development of novel antioxidant drugs against oxidative stress stimuli...
  8. doi request reprint Acute and chronic metal exposure impairs locomotion activity in Drosophila melanogaster: a model to study Parkinsonism
    Leonardo Bonilla-Ramirez
    School of Medicine, Medical Research Institute, Neuroscience Research Group, University of Antioquia UdeA, Calle 62 52 59, SIU, Medellin, Colombia
    Biometals 24:1045-57. 2011
    ..melanogaster. Understanding therefore the effects of biometals in the Drosophila model may provide insights into the toxic effect of metal ions and more effective therapeutic approaches to Parkinsonism...
  9. ncbi request reprint 17 beta-estradiol protects lymphocytes against dopamine and iron-induced apoptosis by a genomic-independent mechanism. Implication in Parkinson's disease
    M Jimenez Del Rio
    School of Medicine, University of Antioquia, Calle 62 52 72, P O Box 1226, Medellin, Colombia
    Gen Pharmacol 35:1-9. 2000
    ..These findings may be particularly relevant to the potential approaches to rescue and prolong the survival of neurons by estrogens in patients with Parkinson's disease (PD)...
  10. doi request reprint The cannabinoid CP55,940 prolongs survival and improves locomotor activity in Drosophila melanogaster against paraquat: implications in Parkinson's disease
    M Jimenez-Del-Rio
    School of Medicine, Department of Internal Medicine, Neurosciences Research Program, University of Antioquia, Calle 62 52 59, Building 1, Room 412, SIU Medellin, Colombia
    Neurosci Res 61:404-11. 2008
    ..Therefore, cannabinoids may offer promising avenues for the design of molecules to prevent, delay, or ameliorate the treatment of population at high risk of suffering Parkinson disease...
  11. pmc Dmp53, basket and drICE gene knockdown and polyphenol gallic acid increase life span and locomotor activity in a Drosophila Parkinson's disease model
    Hector Flavio Ortega-Arellano
    Neuroscience Research Group, Medical Research Institute, Faculty of Medicine, University of Antioquia, Medellin, Colombia
    Genet Mol Biol 36:608-15. 2013
    ..We propose that a therapy with antioxidants and selectively "switching off" death genes in DAergic neurons could provide a means for pre-clinical PD individuals to significantly ameliorate their disease condition. ..
  12. ncbi request reprint Neuroprotective Effect of the LRRK2 Kinase Inhibitor PF-06447475 in Human Nerve-Like Differentiated Cells Exposed to Oxidative Stress Stimuli: Implications for Parkinson's Disease
    Miguel Mendivil-Perez
    Neuroscience Research Group, Medical Research Institute, Faculty of Medicine, University of Antioquia UdeA, Calle 70 No 52 21, and Calle 62 52 59, Building 1, Room 412, SIU Medellin, Colombia
    Neurochem Res 41:2675-2692. 2016
    ..Therefore, the pharmacological inhibition of LRRK2 might help to understand the OS-mediated kinase activation in PD neurodegenerative disorder...
  13. doi request reprint Doxorubicin induces apoptosis in Jurkat cells by mitochondria-dependent and mitochondria-independent mechanisms under normoxic and hypoxic conditions
    Miguel Mendivil-Perez
    Neuroscience Research Group, Medical Research Institute, Faculty of Medicine, University of Antioquia UdeA, Medellin, Colombia
    Anticancer Drugs 26:583-98. 2015
    ..e. mitochondria-caspase-3/AIF-dependent pathways) and through a direct DNA damage process. However, hypoxic conditions may reduce the effectiveness of dxr toxicity...
  14. doi request reprint Protective effects of the synthetic cannabinoids CP55,940 and JWH-015 on rat brain mitochondria upon paraquat exposure
    Carlos Velez-Pardo
    School of Medicine, Biomedical Research Institute, University of Antioquia, Medellin, Colombia
    Neurochem Res 35:1323-32. 2010
    ..Understanding the mechanistic action of cannabinoids on mitochondria might provide new insights into more effective therapeutic approaches for oxidative stress related disorders...
  15. pmc Response to rotenone is glucose-sensitive in a model of human acute lymphoblastic leukemia: involvement of oxidative stress mechanism, DJ-1, Parkin, and PINK-1 proteins
    Miguel Mendivil-Perez
    Neuroscience Research Group, Medical Research Institute, Faculty of Medicine, University of Antioquia UdeA, Calle 70 No 52 21 and Calle 62 No 52 59, Building 1, Room 412, Medellin, Colombia
    Oxid Med Cell Longev 2014:457154. 2014
    ..Our data suggest that combined therapy by using mitochondria-targeted damaging compounds and regulation of glucose (e.g., metformin) can efficiently terminate leukemia cells via apoptosis in hyperglycemic conditions...
  16. doi request reprint Purification of nasulysin-1: A new toxin from Porthidium nasutum snake venom that specifically induces apoptosis in leukemia cell model through caspase-3 and apoptosis-inducing factor activation
    Angelica Rocio Bonilla-Porras
    Neuroscience Research Group, Medical Research Institute, Faculty of Medicine, University of Antioquia, Calle 70 N 52 21, and Calle 62 52 59, Building 1, Room 412, SIU, P O Box 1226, Medellin, Colombia
    Toxicon 120:166-74. 2016
    ..Thus, these data warrant further investigation into the use of the metalloproteinase protein, nasulysin-1 as a potential therapeutic agent for treating leukemia. ..
  17. doi request reprint Fructose sensitizes Jurkat cells oxidative stress-induced apoptosis via caspase-dependent and caspase-independent mechanisms
    Viviana Diaz-Aguirre
    Neuroscience Research Group, Faculty of Medicine, Medical Research Institute, University of Antioquia UdeA, Calle 70 No 52 21 and Calle 62 52 59, Building 1, Room 412, SIU Medellin, Colombia
    Cell Biol Int 40:1162-1173. 2016
    ..e., aerobic glycolysis) to FRU metabolism (i.e., oxidative phosphorylation) after treatment with mitochondria-targeting molecules. These observations may help elucidate the cell death mechanism of leukemic cells cultured in FRU...
  18. doi request reprint Vitamin E synthetic derivate-TPGS-selectively induces apoptosis in jurkat t cells via oxidative stress signaling pathways: implications for acute lymphoblastic leukemia
    Cristian Ruiz-Moreno
    Neuroscience Research Group, Faculty of Medicine, Medical Research Institute, University of Antioquia, Calle 70 N 52 21, and Calle 62 52 59, Building 1, Room 412, SIU, P O Box 1226, Medellin, Colombia
    Apoptosis 21:1019-32. 2016
    ..In conclusion, TPGS selectively induces apoptosis in Jurkat cells through two independent but complementary H2O2-mediated signaling pathways. Our findings support the use of TPGS as a potential treatment for ALL. ..
  19. doi request reprint Knockdown transgenic Lrrk Drosophila resists paraquat-induced locomotor impairment and neurodegeneration: A therapeutic strategy for Parkinson's disease
    Diana Quintero-Espinosa
    Neuroscience Research Group, Medical Research Institute, Faculty of Medicine, University of Antioquia UdeA, Calle 70 No 52 21, and Calle 62 52 59, Building 1, Room 412 SIU Medellin, Colombia
    Brain Res . 2016
    ....
  20. doi request reprint Alzheimer's Disease, Drosophila melanogaster and Polyphenols
    Marlene Jimenez-Del-Rio
    Neuroscience Research Group, Medical Research Institute, Faculty of Medicine, University of Antioquia UdeA, SIU, Calle 70 No 52 21, and Calle 62 52 59, Building 1, Room 412, Medellin, Colombia
    Adv Exp Med Biol 863:21-53. 2015
    ..Here, we summarise data published within the past 16 years (1998-2014) on the molecular biology of AD and the use of polyphenols in the fly to understand the molecular actions and feasibility of these compounds in the treatment of AD...
  21. doi request reprint Distribution of APOE polymorphism in the "Paisa" population from northwest Colombia (Antioquia)
    Carlos Velez-Pardo
    Neuroscience Research Group, Medical Research Institute, Faculty of Medicine and
    Ann Hum Biol 42:195-8. 2015
    ....
  22. doi request reprint Effects of insulin-like growth factor-1 on rotenone-induced apoptosis in human lymphocyte cells
    Isabel Cristina Avila-Gomez
    School of Medicine, Medical Research Institute, Neuroscience Research Program, University of Antioquia, Medellin, Colombia
    Basic Clin Pharmacol Toxicol 106:53-61. 2010
    ..These data might contribute to understanding the role played by IGF-1 against oxidative stress stimuli...
  23. pmc Vitamin K3 and vitamin C alone or in combination induced apoptosis in leukemia cells by a similar oxidative stress signalling mechanism
    Angelica R Bonilla-Porras
    School of Medicine, Medical Research Institute, University of Antioquia UdeA, Calle 62 52 59, Building 1, Laboratory 411 412 SIU Medellin, Colombia
    Cancer Cell Int 11:19. 2011
    ..Secondary therapy-related acute lymphoblastic leukemia might emerge following chemotherapy and/or radiotherapy for primary malignancies. Therefore, other alternatives should be pursued to treat leukemia...