Frederic Colland

Summary

Publications

  1. ncbi Ubiquitin and cancer: from molecular targets and mechanisms to the clinic -- AACR Special Conference
    Frederic Colland
    Hybrigenics SA, 3 5 Impasse Reille, 75014 Paris, France
    IDrugs 9:179-81. 2006
  2. doi The therapeutic potential of deubiquitinating enzyme inhibitors
    Frederic Colland
    Hybrigenics SA, 3 5 Impasse Reille, 75014 Paris, France
    Biochem Soc Trans 38:137-43. 2010
  3. doi Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells
    Frederic Colland
    Hybrigenics Pharma, 75014 Paris, France
    Mol Cancer Ther 8:2286-95. 2009
  4. ncbi Integrating a functional proteomic approach into the target discovery process
    Frederic Colland
    Hybrigenics SA, 3 5 Impasse Reille, 75014 Paris, France
    Biochimie 86:625-32. 2004
  5. ncbi Combination of active and inactive siRNA targeting the mitotic kinesin Eg5 impairs silencing efficiency in several cancer cell lines
    Etienne Formstecher
    Hybrigenics SA, 75014 Paris, France
    Oligonucleotides 16:387-94. 2006
  6. doi Functional interaction between the ubiquitin-specific protease 25 and the SYK tyrosine kinase
    Michael Cholay
    Hybrigenics SA, 3 5 Impasse Reille 75014 Paris, France
    Exp Cell Res 316:667-75. 2010
  7. doi Discovery of specific inhibitors of human USP7/HAUSP deubiquitinating enzyme
    Celine Reverdy
    Hybrigenics Pharma, 3 5 Impasse Reille, 75014 Paris, France
    Chem Biol 19:467-77. 2012
  8. ncbi Targeting ubiquitin specific proteases for drug discovery
    Laurent Daviet
    Hybrigenics SA, 3 5 Impasse Reille, 75014 Paris, France
    Biochimie 90:270-83. 2008
  9. pmc Patented small molecule inhibitors in the ubiquitin proteasome system
    Philippe Guedat
    Hybrigenics SA, 3 5 Impasse Reille, 75014 Paris, France
    BMC Biochem 8:S14. 2007
  10. pmc Functional proteomics mapping of a human signaling pathway
    Frederic Colland
    Hybrigenics SA, 75014 Paris, France
    Genome Res 14:1324-32. 2004

Collaborators

Detail Information

Publications10

  1. ncbi Ubiquitin and cancer: from molecular targets and mechanisms to the clinic -- AACR Special Conference
    Frederic Colland
    Hybrigenics SA, 3 5 Impasse Reille, 75014 Paris, France
    IDrugs 9:179-81. 2006
  2. doi The therapeutic potential of deubiquitinating enzyme inhibitors
    Frederic Colland
    Hybrigenics SA, 3 5 Impasse Reille, 75014 Paris, France
    Biochem Soc Trans 38:137-43. 2010
    ..Advances in small molecule-based inhibitors specifically targeting DUBs are presented in this review...
  3. doi Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells
    Frederic Colland
    Hybrigenics Pharma, 75014 Paris, France
    Mol Cancer Ther 8:2286-95. 2009
    ..We thus report the identification of the first lead-like inhibitor against USP7, providing a structural basis for the development of new anticancer drugs...
  4. ncbi Integrating a functional proteomic approach into the target discovery process
    Frederic Colland
    Hybrigenics SA, 3 5 Impasse Reille, 75014 Paris, France
    Biochimie 86:625-32. 2004
    ....
  5. ncbi Combination of active and inactive siRNA targeting the mitotic kinesin Eg5 impairs silencing efficiency in several cancer cell lines
    Etienne Formstecher
    Hybrigenics SA, 75014 Paris, France
    Oligonucleotides 16:387-94. 2006
    ..Altogether, our results, which need to be confirmed with additional inactive siRNA, indicate that combination of siRNA may not increase but instead decrease silencing efficiency...
  6. doi Functional interaction between the ubiquitin-specific protease 25 and the SYK tyrosine kinase
    Michael Cholay
    Hybrigenics SA, 3 5 Impasse Reille 75014 Paris, France
    Exp Cell Res 316:667-75. 2010
    ..Moreover, we showed that SYK specifically phosphorylates USP25 and alters its cellular levels. This study thus uncovers a new SYK substrate and reveals a novel SYK function, namely the regulation of USP25 cellular levels...
  7. doi Discovery of specific inhibitors of human USP7/HAUSP deubiquitinating enzyme
    Celine Reverdy
    Hybrigenics Pharma, 3 5 Impasse Reille, 75014 Paris, France
    Chem Biol 19:467-77. 2012
    ..The data presented in this report provide proof of principle that USP7 inhibitors may be a valuable therapeutic for cancer. In addition, the discovery of such molecules offers interesting tools for studying deubiquitination...
  8. ncbi Targeting ubiquitin specific proteases for drug discovery
    Laurent Daviet
    Hybrigenics SA, 3 5 Impasse Reille, 75014 Paris, France
    Biochimie 90:270-83. 2008
    ..We will review here this class of enzymes from target validation to small molecule drug discovery...
  9. pmc Patented small molecule inhibitors in the ubiquitin proteasome system
    Philippe Guedat
    Hybrigenics SA, 3 5 Impasse Reille, 75014 Paris, France
    BMC Biochem 8:S14. 2007
    ..Publication history: Republished from Current BioData's Targeted Proteins database (TPdb; http://www.targetedproteinsdb.com)...
  10. pmc Functional proteomics mapping of a human signaling pathway
    Frederic Colland
    Hybrigenics SA, 75014 Paris, France
    Genome Res 14:1324-32. 2004
    ..Functional assays performed in mammalian cells including siRNA knock-down experiments identified eight novel proteins involved in Smad signaling, thus validating this integrated functional proteomics approach...