Ming Zhao

Summary

Country: China

Publications

  1. pmc RFX1 regulates CD70 and CD11a expression in lupus T cells by recruiting the histone methyltransferase SUV39H1
    Ming Zhao
    Department of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, NO, 139 Renmin Middle Rd, Changsha, Hunan 410011, PR China
    Arthritis Res Ther 12:R227. 2010
  2. ncbi request reprint Epigenetics and SLE: RFX1 downregulation causes CD11a and CD70 overexpression by altering epigenetic modifications in lupus CD4+ T cells
    Ming Zhao
    Department of Dermatology, Epigenetic Research Center, Second Xiangya Hospital, Central South University, 139 Renmin Middle Rd, Changsha, Hunan 410011, PR China
    J Autoimmun 35:58-69. 2010
  3. doi request reprint Inhibited expression of hematopoietic progenitor kinase 1 associated with loss of jumonji domain containing 3 promoter binding contributes to autoimmunity in systemic lupus erythematosus
    Qing Zhang
    Department of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, Hunan 410011, China
    J Autoimmun 37:180-9. 2011
  4. doi request reprint E4BP4 overexpression: a protective mechanism in CD4+ T cells from SLE patients
    Ming Zhao
    Department of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, Hunan, China
    J Autoimmun 41:152-60. 2013
  5. doi request reprint DNA demethylation of CD40l in CD4+ T cells from women with systemic sclerosis: a possible explanation for female susceptibility
    Xiaori Lian
    Department of Dermatology, Second Xiangya Hospital and Central South University, Changsha, China
    Arthritis Rheum 64:2338-45. 2012
  6. pmc A possible role of HMGB1 in DNA demethylation in CD4+ T cells from patients with systemic lupus erythematosus
    Yaping Li
    Department of Dermatology and Epigenetic Research Center, Key Laboratory of Diabetes Immunology of Ministry of Education, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China
    Clin Dev Immunol 2013:206298. 2013
  7. doi request reprint Whole-genome DNA methylation in skin lesions from patients with psoriasis vulgaris
    Peng Zhang
    Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, Second Xiangya Hospital, Central South University, 139 Renmin Middle Rd, Changsha, Hunan 410011, China
    J Autoimmun 41:17-24. 2013
  8. doi request reprint Aberrant histone modification in peripheral blood B cells from patients with systemic sclerosis
    Yaoyao Wang
    Department of Dermatology, Second Xiangya Hospital, Central South University, 139 Ren Min Road, Changsha 410011, China
    Clin Immunol 149:46-54. 2013
  9. doi request reprint Aberrant histone modifications in peripheral blood mononuclear cells from patients with Henoch-Schönlein purpura
    Shuangyan Luo
    Hunan Key Laboratory of Medical Epigenomics, Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China
    Clin Immunol 146:165-75. 2013
  10. pmc Hypomethylation of IL10 and IL13 promoters in CD4+ T cells of patients with systemic lupus erythematosus
    Ming Zhao
    Department of Dermatology, Epigenetic Research Center, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China
    J Biomed Biotechnol 2010:931018. 2010

Collaborators

Detail Information

Publications30

  1. pmc RFX1 regulates CD70 and CD11a expression in lupus T cells by recruiting the histone methyltransferase SUV39H1
    Ming Zhao
    Department of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, NO, 139 Renmin Middle Rd, Changsha, Hunan 410011, PR China
    Arthritis Res Ther 12:R227. 2010
    ....
  2. ncbi request reprint Epigenetics and SLE: RFX1 downregulation causes CD11a and CD70 overexpression by altering epigenetic modifications in lupus CD4+ T cells
    Ming Zhao
    Department of Dermatology, Epigenetic Research Center, Second Xiangya Hospital, Central South University, 139 Renmin Middle Rd, Changsha, Hunan 410011, PR China
    J Autoimmun 35:58-69. 2010
    ..These findings reveal a crucial role for RFX1 in regulating the epigenetic status of T cells, and demonstrate that autoimmune responses in SLE are due in part to RFX1 downregulation...
  3. doi request reprint Inhibited expression of hematopoietic progenitor kinase 1 associated with loss of jumonji domain containing 3 promoter binding contributes to autoimmunity in systemic lupus erythematosus
    Qing Zhang
    Department of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, Hunan 410011, China
    J Autoimmun 37:180-9. 2011
    ..These findings suggest that HPK1 may serve as a novel target for effective SLE therapy...
  4. doi request reprint E4BP4 overexpression: a protective mechanism in CD4+ T cells from SLE patients
    Ming Zhao
    Department of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, Hunan, China
    J Autoimmun 41:152-60. 2013
    ..Furthermore, our data demonstrate that overexpression of E4BP4 initiates a protective mechanism in SLE CD4(+) T cells, which may be a promising target in the therapy for SLE...
  5. doi request reprint DNA demethylation of CD40l in CD4+ T cells from women with systemic sclerosis: a possible explanation for female susceptibility
    Xiaori Lian
    Department of Dermatology, Second Xiangya Hospital and Central South University, Changsha, China
    Arthritis Rheum 64:2338-45. 2012
    ..The aim of this study was to investigate the effect of DNA demethylation on CD40L expression in CD4+ T cells from female patients with SSc...
  6. pmc A possible role of HMGB1 in DNA demethylation in CD4+ T cells from patients with systemic lupus erythematosus
    Yaping Li
    Department of Dermatology and Epigenetic Research Center, Key Laboratory of Diabetes Immunology of Ministry of Education, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China
    Clin Dev Immunol 2013:206298. 2013
    ..A significant, positive correlation was found between HMGB1 mRNA and SLEDAI for SLE patients. Our data demonstrate that HMGB1 binds to Gadd45a and may be involved in DNA demethylation in CD4(+) T cells during lupus flare. ..
  7. doi request reprint Whole-genome DNA methylation in skin lesions from patients with psoriasis vulgaris
    Peng Zhang
    Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, Second Xiangya Hospital, Central South University, 139 Renmin Middle Rd, Changsha, Hunan 410011, China
    J Autoimmun 41:17-24. 2013
    ....
  8. doi request reprint Aberrant histone modification in peripheral blood B cells from patients with systemic sclerosis
    Yaoyao Wang
    Department of Dermatology, Second Xiangya Hospital, Central South University, 139 Ren Min Road, Changsha 410011, China
    Clin Immunol 149:46-54. 2013
    ..To investigate alterations in histone modifications in B cells and their role in the pathogenesis of systemic sclerosis (SSc)...
  9. doi request reprint Aberrant histone modifications in peripheral blood mononuclear cells from patients with Henoch-Schönlein purpura
    Shuangyan Luo
    Hunan Key Laboratory of Medical Epigenomics, Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China
    Clin Immunol 146:165-75. 2013
    ..These findings suggest that abnormal histone modifications are present in the PBMCs of patients with HSP, possibly contributing to the activation of pathological immune responses associated with HSP...
  10. pmc Hypomethylation of IL10 and IL13 promoters in CD4+ T cells of patients with systemic lupus erythematosus
    Ming Zhao
    Department of Dermatology, Epigenetic Research Center, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China
    J Biomed Biotechnol 2010:931018. 2010
    ..Together, our results show that promoter methylation is a determinant of IL10 and IL13 expression in CD4+ T cells, and we propose that DNA hypomethylation leads to IL10 and IL13 overexpression in SLE patients...
  11. ncbi request reprint Inactivation of LARS2, located at the commonly deleted region 3p21.3, by both epigenetic and genetic mechanisms in nasopharyngeal carcinoma
    Wen Zhou
    Cancer Research Institute, Xiang Ya School of Medicine, Central South University, Changsha, China
    Acta Biochim Biophys Sin (Shanghai) 41:54-62. 2009
    ..5% of NP biopsies. Our data indicate that inactivation of LARS2 by both genetic and epigenetic mechanisms may be a common and important event in the carcinogenesis of NPC...
  12. doi request reprint Abnormal histone modifications in PBMCs from patients with psoriasis vulgaris
    Peng Zhang
    Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, Second Xiangya Hospital, Central South University, Changsha, China
    Eur J Dermatol 21:552-7. 2011
    ..We conclude that histone modifications are aberrant in the PBMCs of psoriasis vulgaris patients...
  13. doi request reprint Up-regulation of microRNA-210 induces immune dysfunction via targeting FOXP3 in CD4(+) T cells of psoriasis vulgaris
    Ming Zhao
    Department of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, 410011 Hunan, China
    Clin Immunol 150:22-30. 2014
    ..Our data demonstrates that increased miR-210 induces immune dysfunction via by FOXP3 in CD4(+) T cells from patients with PV. ..
  14. doi request reprint Hypomethylation and overexpression of CD70 (TNFSF7) in CD4+ T cells of patients with primary Sjögren's syndrome
    Heng Yin
    Department of Dermatology, Epigenetic Research Center, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, PR China
    J Dermatol Sci 59:198-203. 2010
    ..CD70 (TNFSF7), a B cell costimulatory molecule, is overexpressed in CD4(+) T cells from patients with systemic erythematosus lupus (SLE) due to the hypomethylation of its promoter...
  15. doi request reprint [Effect of total glucosides of peony on expression and DNA methylation status of ITGAL gene in CD4(+) T cells of systemic lupus erythematosus]
    Ming Zhao
    Department of Dermatology, Central South University, Changsha, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 37:463-8. 2012
    ..To investigate the effect of total glucosides of peony (TGP) on expression and DNA methylation status of ITGAL gene (CD11a) in CD4(+) T cells from patients with systemic lupus erythematosus (SLE)...
  16. doi request reprint Abnormal DNA methylation in CD4+ T cells from people with latent autoimmune diabetes in adults
    Yijun Li
    Department of Endocrinology, Key Laboratory of Diabetes Immunology, Institute of Metabolism and Endocrinology, Diabetes Center, Second Xiangya Hospital, Central South University, Ministry of Education, Changsha, Hunan 410011, China
    Diabetes Res Clin Pract 94:242-8. 2011
    ..DNA methylation levels are altered in CD4(+) T cells from LADA patients, which may contribute to disease onset and progression by affecting the expression of autoimmune-related genes...
  17. doi request reprint A proof-of-principle demonstration of a novel microarray-based method for quantifying DNA methylation levels
    Xiujuan Zhang
    Department of Dermatology, Epigenetic Research Center, Second Xiangya Hospital, Central South University, No 139 Renmin Middle Rd, Changsha, Hunan, 410011, People s Republic of China
    Mol Biotechnol 46:243-9. 2010
    ..These results indicate that our new microarray-based assay could prove to be a highly reliable, rapid, and cost effective diagnostic and prognostic test for SLE...
  18. doi request reprint [Construction of special reporter to detect DNA methylation regulatory activity in FCER1G gene promoter through patch-methylation]
    Yunsheng Liang
    Department of Dermatology, Central South University, Changsha, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 38:120-4. 2013
    ..To construct a special luciferase reporter to detect DNA methylation regulatory activity in FCER1G gene promoter regulatory element...
  19. doi request reprint Impaired DNA methylation and its mechanisms in CD4(+)T cells of systemic lupus erythematosus
    Yiqun Zhang
    Department of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenetics, Changsha, Hunan 410011, PR China
    J Autoimmun 41:92-9. 2013
    ..Possible mechanisms underlying these aberrancies are also discussed based on the reported literature and our own findings...
  20. pmc Overexpression of DNA damage-induced 45 α gene contributes to esophageal squamous cell cancer by promoter hypomethylation
    Bao Xiang Wang
    Department of Cardiothoracic Surgery, Second Xiangya Hospital of Central South University, Changsha, Hunan, PR China
    J Exp Clin Cancer Res 31:11. 2012
    ....
  21. doi request reprint Demethylation of TNFSF7 contributes to CD70 overexpression in CD4+ T cells from patients with systemic sclerosis
    Hongyan Jiang
    Department of Dermatology, Second Xiangya Hospital, Central South University, 139 Ren Min Road, Changsha 410011, China
    Clin Immunol 143:39-44. 2012
    ..These findings suggest that demethylation of CD70 promoter region contributes to the overexpression of CD70 in CD4+ T cells and may contribute to autoimmune response in SSc...
  22. doi request reprint Epigenetics, autoimmunity and hematologic malignancies: a comprehensive review
    Owen Ngalamika
    Department of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenetics, 139 Renmin Middle Rd, Changsha, Hunan 410011, PR China
    J Autoimmun 39:451-65. 2012
    ..Indeed, defining the factors that determine epigenetic alterations and their relationships to immune homeostasis will be a challenge greater or even equal to the human genome project...
  23. doi request reprint Epigallocatechin-3-gallate inhibits homocysteine-induced apoptosis of endothelial cells by demethylation of the DDAH2 gene
    Bi kui Zhang
    Department of Pharmaceutics, The Third Xiangya Hospital, Central South University, Changsha, China
    Planta Med 79:1715-9. 2013
    ..This research suggests that modulating the epigenetic processes might be a novel plausible way for treatment of atherosclerosis...
  24. doi request reprint [DNA methylation status of miR-126 and its host gene EGFL7 in CD4+ T cells from patients with systemic lupus erythematosus]
    Yunsheng Liang
    Hunan Key Laboratory of Medical Epigenomics, Changsha 410078 Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha 410011, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 38:793-7. 2013
    ..05). Conclusion: The upregulation of miR-126 and its host gene EGFL7 expression in CD4+ T cells from SLE is associated with the hypomethylation of the EGFL7 promoter. ..
  25. ncbi request reprint Homocysteine-induced hypermethylation of DDAH2 promoter contributes to apoptosis of endothelial cells
    Su Jie Jia
    Department of Pharmaceutics, The Third Xiangya Hospital, Central South University, Changsha, China
    Pharmazie 68:282-6. 2013
    ..In conclusion, hypermethylation of DDAH2 contributes to Hcy induced apoptosis of ECs. Modulating DNA methylation status of DDAH2 promoter may be a potential strategy for treatment of endothelial dysfunction...
  26. ncbi request reprint [Histone H3 acetylation of tumor necrosis factor-alpha and cyclooxygenase-2 in patients with type 2 diabetes]
    Can Hou
    Department of Endocrinology, Central South University, Changsha, Hunan, China
    Zhonghua Yi Xue Za Zhi 91:1805-8. 2011
    ....
  27. doi request reprint DNA demethylation of the perforin promoter in CD4(+) T cells from patients with subacute cutaneous lupus erythematosus
    Yongqi Luo
    Department of Dermatology, Epigenetic Research Center, Second Xiangya Hospital, Central South University, Changsha, PR China
    J Dermatol Sci 56:33-6. 2009
    ..However, it is unknown whether aberrant expression and methylation of perforin occur in CD4(+) T cells from patients with subacute cutaneous lupus erythematosus (SCLE)...
  28. doi request reprint Construction of Gadd45a expression plasmid and its expression in human T cells
    Yaping Li
    Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha 410011, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 36:398-404. 2011
    ..To construct Gadd45a expression plasmid and induce its expression in human T cells...
  29. doi request reprint Total glucosides of paeony induces regulatory CD4(+)CD25(+) T cells by increasing Foxp3 demethylation in lupus CD4(+) T cells
    Ming Zhao
    Department of Dermatology, Second Xiangya Hospital, Central South University Hunan Key Laboratory of Medical Epigenomics, Changsha, Hunan, China
    Clin Immunol 143:180-7. 2012
    ....
  30. ncbi request reprint Genetic and epigenetic alterations of LTF at 3p21.3 in nasopharyngeal carcinoma
    Hong Mei Yi
    Cancer Research Institute, Xiang Ya School of Medicine, Central South University, Changsha, Hunan, P R China
    Oncol Res 16:261-72. 2006
    ..In conclusion, our data indicate that two-hit silencing of LTF through genetic and epigenetic changes may be a common and important event in the carcinogenesis of NPC...