Wei Zhang

Summary

Country: China

Publications

  1. doi request reprint Design, expression and characterization of a novel coexpression system of two antiarthritic molecules
    Wei Zhang
    Department of Translational Medicine, Beijing Institute of Basic Medical Sciences, Beijing 100850, China
    Appl Microbiol Biotechnol 97:6301-14. 2013
  2. doi request reprint Intraarticular gene transfer of SPRY2 suppresses adjuvant-induced arthritis in rats
    Wei Zhang
    Department of Translational Medicine, Beijing Institute of Basic Medical Sciences, 27 Taiping Road, Haidian District, Beijing, 100850, China
    Appl Microbiol Biotechnol 99:6727-35. 2015
  3. doi request reprint Sprouty2 suppresses the inflammatory responses in rheumatoid arthritis fibroblast-like synoviocytes through regulating the Raf/ERK and PTEN/AKT signals
    Wei Zhang
    Department of Translational Medicine, Beijing Institute of Basic Medical Sciences, 27 Taiping Road, Haidian District, Beijing 100850, China Electronic address
    Mol Immunol 67:532-9. 2015
  4. doi request reprint Whole-genome microRNA expression profiling identifies a 5-microRNA signature as a prognostic biomarker in Chinese patients with primary glioblastoma multiforme
    Wei Zhang
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
    Cancer 119:814-24. 2013
  5. doi request reprint Correlation of IDH1/2 mutation with clinicopathologic factors and prognosis in anaplastic gliomas: a report of 203 patients from China
    Chuan bao Zhang
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China
    J Cancer Res Clin Oncol 140:45-51. 2014
  6. pmc Significance of miR-196b in tumor-related epilepsy of patients with gliomas
    Gan You
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
    PLoS ONE 7:e46218. 2012
  7. pmc miR-181d: a predictive glioblastoma biomarker that downregulates MGMT expression
    Wei Zhang
    Department of Neurosurgery, Tiantan Hospital, Capital Medical University, Beijing, China
    Neuro Oncol 14:712-9. 2012
  8. ncbi request reprint [Long-term efficacy of Dermatophagoides pteronyssinus immunotherapy in patients with allergic rhinitis: a 3-year prospective study]
    Cheng shuo Wang
    Department of Otorhinolaryngology, Capital Medical University, Beijing Institute of Otorhinolaryngology, Beijing, China
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 47:804-8. 2012
  9. doi request reprint Intraarticular gene delivery of CTLA4-FasL suppresses experimental arthritis
    Wei Zhang
    Department of Translational Medicine, Beijing Institute of Basic Medical Sciences, Beijing 100850, China
    Int Immunol 24:379-88. 2012
  10. doi request reprint Clinical correlation of MGMT protein expression and promoter methylation in Chinese glioblastoma patients
    Kai Tang
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No 6 Tiantan Xili 100050, Dongcheng District, Beijing, China
    Med Oncol 29:1292-6. 2012

Collaborators

  • Tao Jiang
  • Wei Yan
  • Yu Wang
  • Xingyu Jiang
  • George F Gao
  • Fang Wang
  • Luo Zhang
  • Pei Yang
  • Zhao Shi Bao
  • Gan You
  • Chuan bao Zhang
  • Wenfu Zheng
  • Yanwei Liu
  • Ming Yang Li
  • Chuanbao Zhang
  • Zhuo Huang
  • Yi Sun
  • Zhaoxia Wang
  • Huimin Hu
  • Yan Wei Liu
  • Jiyun Yu
  • Renli Tian
  • Xiaotao Yin
  • Zhaoshi Bao
  • Bo Yuan
  • Yi Shi
  • Cheng shuo Wang
  • Yun Yuan
  • He Lv
  • Kun Yao
  • Zheng Wang
  • Jingying Zhu
  • Zhiyan Du
  • Xin Xin Cao
  • Hong Jun Wang
  • Wenwen Liu
  • Yu Jin
  • Lin Xi
  • Tanyu Hu
  • Hanning Wang
  • Daojun Hong
  • Xiao Liu
  • Shuang Ye
  • Jinquan Cai
  • Juan Zhao
  • Mingyang Li
  • Xiaoguang Qiu
  • Dao Bin Zhou
  • Kuiji Wang
  • Chen Wang
  • Meng Fu
  • Xiaoxia Peng
  • Hui Shen
  • Ling Chen
  • Ming Hui Duan
  • Ying Feng
  • Chengshuo Wang
  • Xiaoming Zhu
  • Jian Li
  • Guilin Li
  • Wei Wang
  • Yongping You
  • Jiangping Gao
  • Yuanji Xu
  • Jinqi Yan
  • Shouwei Li
  • Yu Bai
  • Ya Hua Liu
  • Yu Tao Gao
  • Chunsheng Kang
  • Li Jia Wang
  • Min Li
  • Jiashu Sun
  • Kai Tang
  • Dong Wang
  • Zhuo Wang
  • Li Ping Pan
  • Jianxun Qi
  • Ruimin Ma
  • Lusheng Song
  • Xiang Dong Wang
  • Jinghua Yan
  • Yan Zhao
  • Yu Hui Ouyang
  • Ruiqiang Ma
  • Chunling Xuan
  • Hongxia Zhu
  • Yeping Sun
  • Danhua Zhao
  • Liang Zhong

Detail Information

Publications69

  1. doi request reprint Design, expression and characterization of a novel coexpression system of two antiarthritic molecules
    Wei Zhang
    Department of Translational Medicine, Beijing Institute of Basic Medical Sciences, Beijing 100850, China
    Appl Microbiol Biotechnol 97:6301-14. 2013
    ..This study describes a single rAAV vector for production of two antiarthritic molecules antagonizing both TNF and T cells, which may serve as an attractive expression system for RA gene therapy. ..
  2. doi request reprint Intraarticular gene transfer of SPRY2 suppresses adjuvant-induced arthritis in rats
    Wei Zhang
    Department of Translational Medicine, Beijing Institute of Basic Medical Sciences, 27 Taiping Road, Haidian District, Beijing, 100850, China
    Appl Microbiol Biotechnol 99:6727-35. 2015
    ..Thus, the development of an immunoregulatory strategy based on SPRY2 may therefore have therapeutic potential in the treatment of RA...
  3. doi request reprint Sprouty2 suppresses the inflammatory responses in rheumatoid arthritis fibroblast-like synoviocytes through regulating the Raf/ERK and PTEN/AKT signals
    Wei Zhang
    Department of Translational Medicine, Beijing Institute of Basic Medical Sciences, 27 Taiping Road, Haidian District, Beijing 100850, China Electronic address
    Mol Immunol 67:532-9. 2015
    ....
  4. doi request reprint Whole-genome microRNA expression profiling identifies a 5-microRNA signature as a prognostic biomarker in Chinese patients with primary glioblastoma multiforme
    Wei Zhang
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
    Cancer 119:814-24. 2013
    ..The objective of this study was to identify a microRNA expression signature to improve outcome prediction for patients with primary GBM...
  5. doi request reprint Correlation of IDH1/2 mutation with clinicopathologic factors and prognosis in anaplastic gliomas: a report of 203 patients from China
    Chuan bao Zhang
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China
    J Cancer Res Clin Oncol 140:45-51. 2014
    ..We aimed to identify the mutation frequency of IDH genes in Chinese anaplastic glioma patients, the association of IDH gene mutation with other clinical and molecular pathological features and the prognostic value of it...
  6. pmc Significance of miR-196b in tumor-related epilepsy of patients with gliomas
    Gan You
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
    PLoS ONE 7:e46218. 2012
    ..The authors set out to correlate miR-196b expression in low-grade glioma patients with pre-operative seizures and post-operative seizure control...
  7. pmc miR-181d: a predictive glioblastoma biomarker that downregulates MGMT expression
    Wei Zhang
    Department of Neurosurgery, Tiantan Hospital, Capital Medical University, Beijing, China
    Neuro Oncol 14:712-9. 2012
    ..Together, these results suggest that miR-181d is a predictive biomarker for TMZ response and that its role is mediated, in part, by posttranscriptional regulation of MGMT...
  8. ncbi request reprint [Long-term efficacy of Dermatophagoides pteronyssinus immunotherapy in patients with allergic rhinitis: a 3-year prospective study]
    Cheng shuo Wang
    Department of Otorhinolaryngology, Capital Medical University, Beijing Institute of Otorhinolaryngology, Beijing, China
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 47:804-8. 2012
    ..To evaluate the long-term efficacy of subcutaneous immunotherapy with Dermatophagoides pteronyssinus (DerP) in patients with allergic rhinitis...
  9. doi request reprint Intraarticular gene delivery of CTLA4-FasL suppresses experimental arthritis
    Wei Zhang
    Department of Translational Medicine, Beijing Institute of Basic Medical Sciences, Beijing 100850, China
    Int Immunol 24:379-88. 2012
    ..Our results indicate that rAAV.CTLA4-FasL profoundly suppressed experimental model of RA, implicating the potential therapeutic applications for suppression of RA by local joint delivery of CTLA4-FasL...
  10. doi request reprint Clinical correlation of MGMT protein expression and promoter methylation in Chinese glioblastoma patients
    Kai Tang
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No 6 Tiantan Xili 100050, Dongcheng District, Beijing, China
    Med Oncol 29:1292-6. 2012
    ....
  11. doi request reprint [Protection of anisodamine on the mitochondrial injury induced by oxidative stress in swine with cardiac arrest]
    Ya Hua Liu
    Department of Emergency, The General Hospital of PLA, Beijing, China
    Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 25:290-3. 2013
    ....
  12. doi request reprint Management and survival rates in patients with glioma in China (2004-2010): a retrospective study from a single-institution
    Pei Yang
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No 6 Tiantan Xili, Dongcheng District, Beijing, 100050, China
    J Neurooncol 113:259-66. 2013
    ..Age, preoperative KPS, tumor grades, radiotherapy, chemotherapy and Ki-67 expression were significantly associated with clinical prognosis...
  13. doi request reprint BCL2A1 is a potential biomarker for postoperative seizure control in patients with low-grade gliomas
    Gan You
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
    CNS Neurosci Ther 19:882-8. 2013
    ..To identify molecular genetic factors that influence preoperative seizure occurrence and postoperative seizure control in patients with low-grade gliomas (LGGs)...
  14. doi request reprint Genome-wide DNA methylation profiling identifies ALDH1A3 promoter methylation as a prognostic predictor in G-CIMP- primary glioblastoma
    Wei Zhang
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
    Cancer Lett 328:120-5. 2013
    ..Taken together, our results defined prognosis-related methylation signatures systematically for the first time in G-CIMP- primary GBMs. ALDH1A3 promoter methylation conferred a favorable prognosis in G-CIMP- primary GBMs...
  15. pmc ALDH1A3: A Marker of Mesenchymal Phenotype in Gliomas Associated with Cell Invasion
    Wenlong Zhang
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
    PLoS ONE 10:e0142856. 2015
    ..In conclusion, ALDH1A3 can serve as a novel marker of Mes phenotype in gliomas with potential clinical prognostic value. The expression of ALDH1A3 is associated with tumor cell invasion. ..
  16. pmc Outcome of vulvar reconstruction in patients with advanced and recurrent vulvar malignancies
    Wei Zhang
    Departments of Obstetrics and Gynecology, Peking Union Medical College PUMC Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shuaifuyuan No 1, Dongcheng District, Beijing, 100730, China
    BMC Cancer 15:851. 2015
    ..The purpose of this study was to evaluate the outcomes of vulvar reconstruction using musculocutaneous/skin flaps in patients with advanced and recurrent vulvar malignancies...
  17. doi request reprint Prognostic value of a nine-gene signature in glioma patients based on mRNA expression profiling
    Zhao Shi Bao
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
    CNS Neurosci Ther 20:112-8. 2014
    ..Gliomas are the most common primary brain tumors in adults and a significant cause of cancer-related mortality. A 9-gene signature was identified as a novel prognostic model reflecting survival situation obviously in gliomas...
  18. ncbi request reprint [Expression and activity identification of a fusion protein for promoting adenovirus infection efficiency of dendritic cells]
    Renli Tian
    Department of Urology, General Hospital of PLA, Beijing 100853 Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing 100850, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 30:476-9, 484. 2014
    ..To construct a prokaryotic expression plasmid for CT40L, express the target protein in E. coli, purity the CT40L fusion protein and verify its antigenicity...
  19. pmc Upregulation of miR-196b confers a poor prognosis in glioblastoma patients via inducing a proliferative phenotype
    Ruimin Ma
    Laboratory Diagnosis Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
    PLoS ONE 7:e38096. 2012
    ..To explore the expression pattern, prognostic value and functional role of miR-196b in glioblastoma (GBM) patients using large cohorts...
  20. pmc CD3Z genetic polymorphism in immune response to hepatitis B vaccination in two independent Chinese populations
    Li Ping Pan
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China
    PLoS ONE 7:e35303. 2012
    ....
  21. doi request reprint Improved osmotic tolerance and ethanol production of ethanologenic Escherichia coli by IrrE, a global regulator of radiation-resistance of Deinococcus radiodurans
    Ruiqiang Ma
    College of Biological Sciences, China Agricultural University, Beijing, 100193, China
    Curr Microbiol 62:659-64. 2011
    ..Our results suggest that IrrE could potentially be used to improve osmotic stress tolerance and ethanol production in ethanologenic strains...
  22. pmc Glioblastoma with an oligodendroglioma component: distinct clinical behavior, genetic alterations, and outcome
    Yongzhi Wang
    Department of Neurosurgery, Beijing Tiantan Hospital, Beijing, China
    Neuro Oncol 14:518-25. 2012
    ..Presence of an oligodendroglial component may therefore be a useful classification and stratification variable in therapeutic trials of GBMs...
  23. pmc Low c-Met expression levels are prognostic for and predict the benefits of temozolomide chemotherapy in malignant gliomas
    Ming Yang Li
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China
    Sci Rep 6:21141. 2016
    ..Our results suggest that c-Met may serve as a potential predictive maker for clinical decision making. ..
  24. ncbi request reprint [Over-expression of human SPRY2 promotes the proliferation and survival of HEK293T cells]
    Jingying Zhu
    School of Life Science and Technology, Xinjiang University, Wulumuqi 830046 Department of Translational Medicine, Beijing Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing 100850, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 30:485-8. 2014
    ....
  25. pmc IDH mutation and MGMT promoter methylation in glioblastoma: results of a prospective registry
    Pei Yang
    Beijing Neurosurgical Institute, Capital Medical University, Beijing, China
    Oncotarget 6:40896-906. 2015
    ..The relative contribution of isocitrate dehydrogenase mutations (mIDH) and O6-methylguanine-DNA methyltransferase promoter methylation (methMGMT) as biomarkers in glioblastoma remain poorly understood...
  26. doi request reprint Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses
    Yi Shi
    Research Network of Immunity and Health, Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, China
    Science 342:243-7. 2013
    ..The structures of SH-H7N9 HA, AH-H7N9 HA, and its mutant in complex with either avian or human receptor analogs show how AH-H7N9 can bind human receptors while still retaining the avian receptor-binding property. ..
  27. pmc Identification of a 6-cytokine prognostic signature in patients with primary glioblastoma harboring M2 microglia/macrophage phenotype relevance
    Jinquan Cai
    Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China Chinese Glioma Cooperative Group CGCG, Beijing, China
    PLoS ONE 10:e0126022. 2015
    ..Interactions among these different cell types and pro-/anti-inflammatory cytokines may promote tumor development and progression...
  28. ncbi request reprint [Prokaryotic expression, purification and antigenicity identification of recombinant human survivin protein]
    Xiaotao Yin
    Department of Urology, General Hospital of PLA, Beijing, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 29:877-81. 2013
    ..To construct a prokaryotic expression plasmid pET28a-survivin, optimize the recombinant protein expression conditions in E.coli, and purify the survivin recombinant protein and identify its antigenicity...
  29. doi request reprint An airborne transmissible avian influenza H5 hemagglutinin seen at the atomic level
    Wei Zhang
    CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
    Science 340:1463-7. 2013
    ..Furthermore, the mutant HA possessed low affinities for both avian and human receptors. Our findings provide a structural and biophysical basis for the H5N1 adaptation to acquire human, but maintain avian, receptor-binding properties. ..
  30. ncbi request reprint [Whole-genome messenger RNA profiling reveals genes involved in malignant progression of glioma]
    Pei Yang
    Department of Neurosurgery, Capital Medical University, Beijing, China
    Zhonghua Yi Xue Za Zhi 93:5-7. 2013
    ..To employ whole-genome messenger RNA profiling to identify the genes involved in malignant progression in glioma...
  31. doi request reprint Patients with primary diffuse large B-cell lymphoma of female genital tract have high risk of central nervous system relapse
    Xin Xin Cao
    Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China
    Ann Hematol 93:1001-5. 2014
    ..Central nervous system prophylaxis might be considered in addition to systemic chemotherapy for DLBCL of the female genital tract. ..
  32. doi request reprint Serum immunoglobulin free light chain and heavy/light chain measurements in POEMS syndrome
    Chen Wang
    Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China
    Ann Hematol 93:1201-6. 2014
    ..In summary, the overproduction of polyclonal immunoglobulin accounts for the high frequency of normal sFLC-R in patients with POEMS syndrome. The sHLC assay may provide unique information about this disorder. ..
  33. pmc Multidimensional analysis of gene expression reveals TGFB1I1-induced EMT contributes to malignant progression of astrocytomas
    Yanwei Liu
    Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China Chinese Glioma Cooperative Group CGCG, China
    Oncotarget 5:12593-606. 2014
    ..Studies in vitro and in vivo using TGF-β1 and TGFB1I1 shRNA demonstrated that TGFB1I1 is required for TGF-β stimulated EMT that contributes to malignant progression of astrocytomas. ..
  34. doi request reprint Severe sensory neuropathy in patients with adult-onset multiple acyl-CoA dehydrogenase deficiency
    Zhaoxia Wang
    Department of Neurology, Peking University First Hospital, Beijing, China
    Neuromuscul Disord 26:170-5. 2016
    ..Late-onset patients with ETFDH mutations can present with proximal muscle weakness and distal sensory neuropathy, which might be a new phenotypic variation, but the precise underlying pathogenesis remains to be elucidated. ..
  35. ncbi request reprint [A prospective study of adenosine triphosphate-tumor chemosensitivity assay directed chemotherapy in patients with recurrent ovarian cancer]
    Yu Tao Gao
    Department of Gynecologic Oncology, Chinese Academy of Medical Sciences, Beijing, China
    Zhonghua Fu Chan Ke Za Zhi 48:358-63. 2013
    ..To investigate the efficacy of adenosine triphosphate (ATP)-tumor chemosensitivity assay (TCA) directed chemotherapy in patients with recurrent epithelial ovarian cancer...
  36. doi request reprint Wharton's jelly-derived mesenchymal stem cells promote myocardial regeneration and cardiac repair after miniswine acute myocardial infarction
    Wei Zhang
    aTianjin Medical University Cardiovascular Clinical College bDepartment of Surgery, TEDA International Cardiovascular Hospital cAlliancells Institute of Stem Cells and Translational Regenerative Medicine Departments of dUltrasound eNuclear Medicine, TEDA International Cardiovascular Hospital fDepartment of Pathology, TEDA Hospital, Tianjin gPeking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
    Coron Artery Dis 24:549-58. 2013
    ..To investigate the therapeutic effects of Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) on myocardial regeneration and cardiac repair after acute myocardial infarction (AMI)...
  37. pmc Pattern of Venous Thromboembolism Occurrence in Gynecologic Malignancy: Incidence, Timing, and Distribution a 10-Year Retrospective Single-institutional Study
    Shuang Ye
    From the Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Medicine (Baltimore) 94:e2316. 2015
    ..The true incidence might have been under-estimated due to several reasons. The need for increased patient education and awareness of VTE is of importance. ..
  38. doi request reprint The genetic spectrum and the evaluation of CADASIL screening scale in Chinese patients with NOTCH3 mutations
    Xiao Liu
    Department of Neurology, Peking University First Hospital, Beijing, China
    J Neurol Sci 354:63-9. 2015
    ..The low sensitivity of CADASIL scale in our patients group indicated that the CADASIL scale should be refined according to the clinical characteristics of Chinese CADASIL patients when used in Chinese populations. ..
  39. doi request reprint Inhibition of ErbB2 by Herceptin reduces survivin expression via the ErbB2-beta-catenin/TCF4-survivin pathway in ErbB2-overexpressed breast cancer cells
    Hongxia Zhu
    Laboratory of Cell and Molecular Biology, State Key Laboratory of Molecular Oncology, Beijing, China
    Cancer Sci 101:1156-62. 2010
    ..This indicates that there may be a new cascade axis from ErbB2 to survivin...
  40. pmc Structural vaccinology: structure-based design of influenza A virus hemagglutinin subtype-specific subunit vaccines
    Chunling Xuan
    CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China
    Protein Cell 2:997-1005. 2011
    ..Together with recent reports on some similar HA globular head preparations we conclude that structure-based rational design of the HA globular head can be used for subtype-specific vaccines against influenza viruses...
  41. ncbi request reprint A strategy for depositing different types of cells in three dimensions to mimic tubular structures in tissues
    Bo Yuan
    National Center for NanoScience and Technology China, Beijing, China
    Adv Mater 24:890-6. 2012
    ..These layered tubes precisely mimic blood vessels and many other tubular structures, suggesting that they may be of great use in tissue engineering...
  42. pmc Integrated photonic emitter with a wide switching range of orbital angular momentum modes
    Yu Wang
    Department of Electronic Engineering, Tsinghua National Laboratory for Information Science and Technology, Tsinghua University, Beijing, China
    Sci Rep 6:22512. 2016
    ..Specifically, the dynamic switching of nine OAM modes (l = -4 ~ 4) with azimuthal polarization has been demonstrated by electrically controlled thermo-optic effect. ..
  43. pmc Induction of Germ Cell-like Cells from Porcine Induced Pluripotent Stem Cells
    Hanning Wang
    State Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, 100193, China
    Sci Rep 6:27256. 2016
    ..Overall, our study provides a feasible strategy for directing piPSCs to the germ cell fate and lays a foundation for exploring germ cell development mechanisms...
  44. pmc MicroRNA-142-3p Negatively Regulates Canonical Wnt Signaling Pathway
    Tanyu Hu
    CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China
    PLoS ONE 11:e0158432. 2016
    ..Thus, our findings highlight the inhibitory role of miR-142-3p in Wnt/β-catenin signaling, which help to understand the complex regulation of Wnt/β-catenin signaling...
  45. doi request reprint Whole-genome mRNA expression profiling identifies functional and prognostic signatures in patients with mesenchymal glioblastoma multiforme
    Zhao Shi Bao
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
    CNS Neurosci Ther 19:714-20. 2013
    ..The mesenchymal subtype, with a larger proportion, is considered a more lethal one. Clinical outcome prediction is required to better guide more personalized treatment for these patients...
  46. doi request reprint Mutational spectrum and clinical features in 35 unrelated mainland Chinese patients with GNE myopathy
    Juan Zhao
    Department of Neurology, Peking University First Hospital, Beijing, China
    J Neurol Sci 354:21-6. 2015
    ..There is phenotypic heterogeneity among patients with GNE myopathy, but muscle magnetic resonance imaging can be useful for differential diagnosis...
  47. doi request reprint Progress on molecular biomarkers and classification of malignant gliomas
    Chuanbao Zhang
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
    Front Med 7:150-6. 2013
    ..In this review, we summarize three distinctive biomarkers, three most commonly altered pathways, and three classifications based on microarray data in malignant gliomas...
  48. pmc SOCS3 promoter hypermethylation is a favorable prognosticator and a novel indicator for G-CIMP-positive GBM patients
    Ying Feng
    Department of Immunology, Institute of Basic Medical Sciences, Capital Medical University, Beijing, China
    PLoS ONE 9:e91829. 2014
    ..We explored the function of SOCS3 promoter hypermethylation in GBM cohorts, including analysis of the CpG island methylator phenotype (CIMP), when a large number of gene loci are simultaneously hypermethylated...
  49. ncbi request reprint Assembly of functional three-dimensional neuronal networks on a microchip
    Zhuo Huang
    Beijing Engineering Research Center for BioNanotechnology and CAS Key Lab for Biological, Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, 11 Beiyitiao, Zhongguancun, Beijing, 100190, P R China University of Chinese Academy of Sciences, Beijing, 100049, P R China
    Small 10:2530-6. 2014
    ..Spontaneous neuronal activities of the interconnected neuronal networks are also recorded. This approach shows promising applications in fundamental neuroscience, tissue engineering, and brain-machine interface. ..
  50. ncbi request reprint [Expression of human tumor necrosis factor receptor-Fc fusion protein and characterization of its biological activity]
    Zhiyan Du
    Department of Translational Medicine, Beijing Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing 100850, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 30:225-8. 2014
    ....
  51. pmc Molecular basis of the receptor binding specificity switch of the hemagglutinins from both the 1918 and 2009 pandemic influenza A viruses by a D225G substitution
    Wei Zhang
    CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
    J Virol 87:5949-58. 2013
    ..This is further confirmed by a D225E mutant that retains human receptor binding specificity with the salt bridge intact...
  52. pmc Identification of high risk anaplastic gliomas by a diagnostic and prognostic signature derived from mRNA expression profiling
    Chuan bao Zhang
    Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China
    Oncotarget 6:36643-51. 2015
    ..The two groups showed a high concordance with grade II and grade IV gliomas, respectively. The high risk group was more aggressive and complex. The three-gene signature showed diagnostic and prognostic value in anaplastic gliomas. ..
  53. pmc Co-expression of mitosis-regulating genes contributes to malignant progression and prognosis in oligodendrogliomas
    Yanwei Liu
    Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China
    Oncotarget 6:38257-69. 2015
    ..These data suggest that the co-expression of the six mitosis-regulating genes was associated with malignant progression and prognosis in ODs. ..
  54. doi request reprint A microfluidic flow-stretch chip for investigating blood vessel biomechanics
    Wenfu Zheng
    CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, 11 ZhongGuanCun BeiYiTiao, Beijing, 100190, China
    Lab Chip 12:3441-50. 2012
    ..The flow-stretch chip is a reliable tool for simulating the haemodynamic microenvironment...
  55. doi request reprint Microfluidic assay without blocking for rapid HIV screening and confirmation
    Lusheng Song
    CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, China
    Biomed Microdevices 14:631-40. 2012
    ..Methods like this one will find wide applications in clinical diagnosis and biochemical analysis based on the interactions between pairs of molecules...
  56. pmc Correlation of IDH1 mutation with clinicopathologic factors and prognosis in primary glioblastoma: a report of 118 patients from China
    Wei Yan
    Department of Neurosurgery, Capital Medical University, Beijing Tiantan Hospital, Beijing, China
    PLoS ONE 7:e30339. 2012
    ....
  57. ncbi request reprint Hypermethylation of testis derived transcript gene promoter significantly correlates with worse outcomes in glioblastoma patients
    Li Jia Wang
    Department of Immunology, Capital Medical University, Beijing, China
    Chin Med J (Engl) 126:2062-6. 2013
    ....
  58. doi request reprint A randomized controlled trial to assess adherence to allergic rhinitis treatment following a daily short message service (SMS) via the mobile phone
    Kuiji Wang
    Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China
    Int Arch Allergy Immunol 163:51-8. 2014
    ..However, data on the effects of SMS interventions to allergic rhinitis (AR) treatment is limited at present. We aimed to assess whether a daily SMS reminder could improve AR patients' adherence to medication and treatment outcomes...
  59. ncbi request reprint Neuronal networks: assembly of functional three-dimensional neuronal networks on a microchip (small 13/2014)
    Zhuo Huang
    Beijing Engineering Research Center for BioNanotechnology and CAS Key Lab for Biological, Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, 11 Beiyitiao, Zhongguancun, Beijing, 100190, P R China University of Chinese Academy of Sciences, Beijing, 100049, P R China
    Small 10:2736. 2014
    ..The structure shows spontaneous activities like those found in the brain. This approach shows promising applications in fundamental neuroscience, tissue engineering, and brain-machine interface. ..
  60. pmc Adaptation of avian influenza A (H6N1) virus from avian to human receptor-binding preference
    Fei Wang
    College of Veterinary Medicine China Agricultural University, Beijing, China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences, Beijing, China
    EMBO J 34:1661-73. 2015
    ..Further structural analysis revealed how the P186L substitution in the receptor-binding site of HA determines the receptor-binding preference change. We conclude that the human-infecting H6N1 evolved into a human receptor preference. ..
  61. doi request reprint Stress-induced self-assembly of complex three dimensional structures by elastic membranes
    Yu Jin
    CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Centre of Nanoscience and Technology, 11 Beiyitiao, Zhongguancun, Haidian District, Beijing 100190, China
    Small 9:2410-4. 2013
    ..Narrow PDMS strips are used instead of the whole PDMS top layer, thus obtaining tubes made of the bottom polymer. ..
  62. doi request reprint Outcome of vulvar reconstruction by anterolateral thigh flap in patients with advanced and recurrent vulvar malignancy
    Wei Zhang
    Department of Obstetrics and Gynecology, Peking Union Medical College PUMC Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    J Surg Oncol 111:985-91. 2015
    ..To evaluate the outcomes of vulvar reconstruction using anterolateral thigh (ALT) flaps in patients with advanced and recurrent vulvar malignancies...
  63. doi request reprint Lipid profiling of human plasma from peritoneal dialysis patients using an improved 2D (NP/RP) LC-QToF MS method
    Min Li
    Beijing National Laboratory for Molecular Sciences, Institute of Analytical Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China
    Anal Bioanal Chem 405:6629-38. 2013
    ..The discovery of 30 potential biomarkers would be helpful to the malnutrition, inflammation, and atherosclerosis syndrome investigation. ..
  64. doi request reprint In silico characterization of the functional and structural modules of the hemagglutinin protein from the swine-origin influenza virus A (H1N1)-2009
    Yeping Sun
    CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China
    Sci China Life Sci 53:633-42. 2010
    ..These results are critical for understanding the pathogenicity of the virus and host immune response against the virus...
  65. doi request reprint Upregulation of interleukin-35 subunits in regulatory T cells in a murine model of allergic rhinitis
    Hui Shen
    Department of Otolaryngology, Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China
    ORL J Otorhinolaryngol Relat Spec 76:237-47. 2014
    ..We investigated the regulatory roles of interleukin (IL)-35, an immunosuppressive cytokine expressed by CD4(+)CD25(+)Foxp3(+) Treg cells, in a murine model of AR...
  66. doi request reprint Precise control of cell adhesion by combination of surface chemistry and soft lithography
    Wenfu Zheng
    National Center for Nanoscience and Technology, Beijing, China
    Adv Healthc Mater 2:95-108. 2013
    ..Recent advances in the manipulation of cell adhesion by the combination of surface chemistry and soft lithography will also be highlighted...
  67. doi request reprint Mutation status of somatic EGFR and KRAS genes in Chinese patients with prostate cancer (PCa)
    Meng Fu
    Department of Urology, Beijing Friendship Hospital, Capital Medical University, No 95 Yong an Road, Xicheng District, Beijing, 100050, China
    Virchows Arch 464:575-81. 2014
    ..We contend that accurate profiling of the mutation status of EGFR and KRAS could improve prognostic stratification, and we suggest a potential anti-EGFR therapy for patients with PCa with EGFR mutations...
  68. pmc Self-organizing circuit assembly through spatiotemporally coordinated neuronal migration within geometric constraints
    Yi Sun
    Chinese Academy of Sciences Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, China
    PLoS ONE 6:e28156. 2011
    ..How geometric constraints of the patterns regulate neuronal migration and circuit assembly of neurons within the patterns remains unexplored...
  69. ncbi request reprint [Comparative study on cluster and conventional immunotherapy with Dermatophagoides pteronyssinus in patients with allergic rhinitis]
    Cheng shuo Wang
    Department of Otorhinolaryngology Head and Neck Surgery, Capital Medical University, Beijing, China
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 46:981-5. 2011
    ..To compare the efficacy and safety of a 6-week cluster schedule of specific immunotherapy with that of a 14-week conventional schedule for the treatment of subjects with persistent allergic rhinitis (AR)...