Li Yang

Summary

Country: China

Publications

  1. pmc Impact of renal dysfunction on long-term outcomes of elderly patients with acute coronary syndrome: a longitudinal, prospective observational study
    Yuqi Liu
    Institute of Geriatric Cardiology, Chinese PLA General Hospital, Beijing 100853, China
    BMC Nephrol 15:78. 2014
  2. pmc Effects of nerve growth factor on the action potential duration and repolarizing currents in a rabbit model of myocardial infarction
    Yun Feng Lan
    Institute of Geriatric Cardiology of Chinese PLA General Hospital, 28 Fuxing Road, 100853 Beijing, China
    J Geriatr Cardiol 10:39-51. 2013
  3. pmc Hyperpolarization activated cation current (I(f)) in cardiac myocytes from pulmonary vein sleeves in the canine with atrial fibrillation
    Jia Yue Li
    Institute of Geriatric Cardiology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China
    J Geriatr Cardiol 9:366-74. 2012
  4. ncbi request reprint [Age-related changes in transient outward potassium current of rat ventricular myocyte]
    Yi cheng Fu
    Institute of Geriatric Cardiology, The PLA General Hospital, Beijing 100853, China
    Sheng Li Xue Bao 65:185-92. 2013
  5. pmc Voltage-dependent anion channel (VDAC) is involved in apoptosis of cell lines carrying the mitochondrial DNA mutation
    Liu Yuqi
    Institute of Geriatric Cardiology, Chinese PLA General Hospital, Beijing 100853, PR China
    BMC Med Genet 10:114. 2009
  6. ncbi request reprint Effects of imidapril on heterogeneity of action potential and calcium current of ventricular myocytes in infarcted rabbits
    Yang Li
    Institute of Geriatric Cardiology of Chinese PLA General Hospital, Beijing, China
    Acta Pharmacol Sin 25:1458-63. 2004
  7. ncbi request reprint [Effect of imidapril on the effective refractory period and sodium current of ventricular noninfarction zone in healed myocardial infarction]
    Yang Li
    Institute of Geriatric Cardiology of Chinese PLA General Hospital, Beijing 100853, China
    Yao Xue Xue Bao 40:654-8. 2005
  8. pmc Seven novel mutations in the long isoform of the USH2A gene in Chinese families with nonsyndromic retinitis pigmentosa and Usher syndrome Type II
    Wenjun Xu
    Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China
    Mol Vis 17:1537-52. 2011
  9. ncbi request reprint [Mitochondrial tRNAMet mutation in Chinese Han essential hypertensive individuals]
    Zong Bin Li
    Institute of Geriatric Cardiology, General Hospital of Chinese PLA, Beijing 100853, China
    Yi Chuan 33:601-6. 2011
  10. ncbi request reprint Association of HLA haplotype with keloids in Chinese Hans
    Wen sheng Lu
    Key Laboratory of Dermatology Anhui Medical University, Ministry of Education, China, Hefei 230022, Anhui, China
    Burns 37:794-9. 2011

Collaborators

Detail Information

Publications82

  1. pmc Impact of renal dysfunction on long-term outcomes of elderly patients with acute coronary syndrome: a longitudinal, prospective observational study
    Yuqi Liu
    Institute of Geriatric Cardiology, Chinese PLA General Hospital, Beijing 100853, China
    BMC Nephrol 15:78. 2014
    ..This study investigated the impact of renal dysfunction (RD) on long-term outcomes in elderly patients with acute coronary syndrome (ACS), and evaluated prognostic factors in elderly patients with ACS and RD...
  2. pmc Effects of nerve growth factor on the action potential duration and repolarizing currents in a rabbit model of myocardial infarction
    Yun Feng Lan
    Institute of Geriatric Cardiology of Chinese PLA General Hospital, 28 Fuxing Road, 100853 Beijing, China
    J Geriatr Cardiol 10:39-51. 2013
    ..To investigate the effect of nerve growth factor (NGF) on the action potential and potassium currents of non-infarcted myocardium in the myocardial infarcted rabbit model...
  3. pmc Hyperpolarization activated cation current (I(f)) in cardiac myocytes from pulmonary vein sleeves in the canine with atrial fibrillation
    Jia Yue Li
    Institute of Geriatric Cardiology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China
    J Geriatr Cardiol 9:366-74. 2012
    ..To investigate the characteristics of ectopic automaticity and cation current (I(f)) of cardiac myocytes from pulmonary vein sleeves (PVs) in canines with atrial fibrillation...
  4. ncbi request reprint [Age-related changes in transient outward potassium current of rat ventricular myocyte]
    Yi cheng Fu
    Institute of Geriatric Cardiology, The PLA General Hospital, Beijing 100853, China
    Sheng Li Xue Bao 65:185-92. 2013
    ..9%) than in the other two groups (127.5% and 125.8%). In conclusion, the results show that Ito of rat ventricular myocyte of aging heart has increased current density and decreased response to isoproterenol...
  5. pmc Voltage-dependent anion channel (VDAC) is involved in apoptosis of cell lines carrying the mitochondrial DNA mutation
    Liu Yuqi
    Institute of Geriatric Cardiology, Chinese PLA General Hospital, Beijing 100853, PR China
    BMC Med Genet 10:114. 2009
    ..The mitochondrial voltage-dependent anion channel (VDAC) is increasingly implicated in the control of apoptosis. We have studied the effects the mitochondrial DNA (mtDNA) tRNAIle mutation on VDAC expression, localization, and apoptosis...
  6. ncbi request reprint Effects of imidapril on heterogeneity of action potential and calcium current of ventricular myocytes in infarcted rabbits
    Yang Li
    Institute of Geriatric Cardiology of Chinese PLA General Hospital, Beijing, China
    Acta Pharmacol Sin 25:1458-63. 2004
    ..To investigate the effects of chronic treatment with imidapril on the electrophysiologic heterogeneous change of the noninfarcted myocardium of rabbits after myocardial infarction and the mechanism of its antiarrhythmic efficacy...
  7. ncbi request reprint [Effect of imidapril on the effective refractory period and sodium current of ventricular noninfarction zone in healed myocardial infarction]
    Yang Li
    Institute of Geriatric Cardiology of Chinese PLA General Hospital, Beijing 100853, China
    Yao Xue Xue Bao 40:654-8. 2005
    ..To investigate the effects of imidapril (IMI) on effective refractory period (ERP) and sodium current (I(Na)) of myocytes in ventricular noninfarction zone of healed myocardial infarction (HMI) in rabbit models...
  8. pmc Seven novel mutations in the long isoform of the USH2A gene in Chinese families with nonsyndromic retinitis pigmentosa and Usher syndrome Type II
    Wenjun Xu
    Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China
    Mol Vis 17:1537-52. 2011
    ..To describe the clinical and genetic findings in one Chinese family with autosomal recessive retinitis pigmentosa (arRP) and in three unrelated Chinese families with Usher syndrome type II (USH2)...
  9. ncbi request reprint [Mitochondrial tRNAMet mutation in Chinese Han essential hypertensive individuals]
    Zong Bin Li
    Institute of Geriatric Cardiology, General Hospital of Chinese PLA, Beijing 100853, China
    Yi Chuan 33:601-6. 2011
    ....
  10. ncbi request reprint Association of HLA haplotype with keloids in Chinese Hans
    Wen sheng Lu
    Key Laboratory of Dermatology Anhui Medical University, Ministry of Education, China, Hefei 230022, Anhui, China
    Burns 37:794-9. 2011
    ..In addition, the association of certain HLA haplotypes with susceptibility to keloids would provide clues in choosing proper preventive strategies...
  11. ncbi request reprint [Cause and treatment of dysuria post trans-urethral resection of prostate]
    Zheng yan Tang
    Department of Urology, Xiangya Hospital, Central South University, Changsha 410008, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 31:601-3. 2006
    ..To evaluate the cause and treatment of dysuria post trans-urethral resection of prostate (TURP)...
  12. ncbi request reprint [Suppression of osteosarcoma in vitro by coexpression of antisense VEGF165 cDNA and thymidine kinase gene]
    Yan Wang
    Department of Pathology, Sun Yat sen Medical College, Sun Yat Sen University, Guangzhou 510089, China
    Zhonghua Bing Li Xue Za Zhi 36:190-5. 2007
    ..To investigate the effect of VEGF expression in osteosarcoma cell line and the target killing effect of HSV1-TK/GCV system on transfected osteosarcoma cells under hypoxia conditions...
  13. ncbi request reprint Using √°tuous Algorithm and Modulus Maximum Lines to Detect R-wave of ECG Signal
    Yang Li
    Key Lab of Biomechanics and Tissue Engineering under the State Education Ministry, Bioengineering, College, Chongqing University, 400044, China Email
    Conf Proc IEEE Eng Med Biol Soc 2:1270-3. 2005
    ..Experiment shows that, this method can easily realize the accurate orientation and real-time detection of R-wave. Due to its simplicity it could be feasible in a real-time testing or clinical heart rate screening...
  14. ncbi request reprint Inhibition of replication and infection of severe acute respiratory syndrome-associated coronavirus with plasmid-mediated interference RNA
    Bing Ni
    Institute of Immunology PLA, Third Military Medical University, Chongqing, China
    Antivir Ther 10:527-33. 2005
    ....
  15. pmc Proteome analysis of human gastric cardia adenocarcinoma by laser capture microdissection
    Yan Cheng
    Department of Gastroenterology, The Second Affiliated Hospital, Xi an Jiaotong University, Xi an, China
    BMC Cancer 7:191. 2007
    ..The incidence of gastric cardiac adenocarcinoma (GCA) has been increasing in the past two decades in China, but the molecular changes relating to carcinogenesis have not been well characterised...
  16. ncbi request reprint [AKAP82 expression in sperm in asthenospermia]
    Yang Li
    Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
    Zhonghua Nan Ke Xue 11:908-11. 2005
    ..To study the expression of AKAP82 which was one of A-kinase anchor proteins in sperm in asthenospermia...
  17. ncbi request reprint [The characteristics of retinitis pigmentosa with retinal vascular occlusion]
    Guang lu Wang
    Beijing Tongren Ophthalmic Center, Capital University of Medical Sciences, Beijing 100730, China
    Zhonghua Yan Ke Za Zhi 41:414-8. 2005
    ..To observe clinical features of Retinitis pigmentosa with retinal vascular occlusion and its prognosis...
  18. ncbi request reprint [Targeted inhibition of vascular endothelial growth factor (VEGF) expression in human osteosarcoma cell line by antisense VEGF165 cDNA promoted by hypoxia reaction element]
    Yan Wang
    Department of Pathology, Sun Yat sen Medical College, Sun Yat Sen University, Guangzhou 510089, China
    Zhonghua Bing Li Xue Za Zhi 34:588-91. 2005
    ....
  19. ncbi request reprint Catalpol modulates the expressions of Bcl-2 and Bax and attenuates apoptosis in gerbils after ischemic injury
    Dan Qing Li
    The Second Affiliated Hospital, Dalian Medical University, Dalian, Liaoning 116023, PR China
    Brain Res 1115:179-85. 2006
    ..All these suggested that catalpol could effectively inhibit apoptosis by modulating the expressions of Bcl-2 and Bax genes...
  20. ncbi request reprint [Incorporation of phosphatidylcholine into Escherichia coli membrane affects secretion of penicillin beta-lactamase]
    Xueli Cai
    Faculty of Life Sciences, Hubei University, Wuhan 430062, China
    Wei Sheng Wu Xue Bao 48:486-91. 2008
    ..5 mmol/L isopropy-beta-D-thiogalactoside (IPTG) for 4-8 hours at 37 degrees C...
  21. ncbi request reprint Derivation of embryonic stem cell line from frozen human embryos and neural differentiation
    Ji chun Tan
    Department of Medical Genetics, China Medical University, Shenyang, China
    Neuroreport 19:1451-5. 2008
    ..After the induction of cyclic AMP for 7 days, the neural progenitor cells had differentiated into neurons and glial cells...
  22. ncbi request reprint [Construction and identification of recombinant adenovirus vector expressing IkappaBalpha-IRES2-shCD40L]
    Xiao Ming Ding
    Department of Renal Transplantation, Center of Nephropathy, First Affiliated Hospital, Xi an Jiaotong University, Xi an 710061, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 26:416-9. 2010
    ..To construct adenovirus expressing vector secretory human CD40L extracellular domain (shCD40L) and IkappaBalpha...
  23. ncbi request reprint Multipotency of human neural stem cells from fetal striatum
    Yang Li
    Department of Cell Biology, Peking University Health Science Center, Beijing, China
    Neuroreport 19:1679-83. 2008
    ..The cellular nature of the human donor cells in chimeric tissues is, however, currently unknown, and further work will be done to identify what differentiated phenotypes have developed from the human cells...
  24. pmc Large novel deletions detected in Chinese families with aniridia: correlation between genotype and phenotype
    Xiaohui Zhang
    Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China
    Mol Vis 17:548-57. 2011
    ..To describe the clinical and genetic findings in two Chinese families with aniridia and other ocular abnormalities...
  25. pmc The association of a single nucleotide polymorphism in the promoter region of the LAMA1 gene with susceptibility to Chinese high myopia
    Yan Yan Zhao
    Eye Center of Beijing Tongren Hospital of Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Lab, Beijing, China
    Mol Vis 17:1003-10. 2011
    ..The purpose of this study was to determine if high myopia is associated with single nucleotide polymorphism (SNP) variants in LAMA1 in Chinese subjects...
  26. ncbi request reprint Voltage-dependent anion channel involved in the mitochondrial calcium cycle of cell lines carrying the mitochondrial DNA A4263G mutation
    Yuqi Liu
    Institute of Geriatric Cardiology, Chinese PLA General Hospital, Beijing 100853, China
    Biochem Biophys Res Commun 404:364-9. 2011
    ..We conclude that the mitochondrial VDAC is involved in both the increase of mitochondrial permeability to Ca(2+) and the decrease of mitochondrial membrane potential in cell lines carrying the mtDNA A4263G mutation...
  27. ncbi request reprint [Construction of pSG5/TRIF and its expression in Huh7 cells]
    Xue Ping Wang
    Institute of Geriatric Cardiology, General Hospital of PLA, Beijing 100853, China
    Nan Fang Yi Ke Da Xue Xue Bao 30:2498-501. 2010
    ..To construct the plasmid pSG5/TRIF and investigate its expression in Huh7 cells...
  28. ncbi request reprint Regulatory T-cell depletion synergizes with gp96-mediated cellular responses and antitumor activity
    Xiaoli Yan
    CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, No 1 West Beichen Road, Chaoyang District, Beijing 100101, China
    Cancer Immunol Immunother 60:1763-74. 2011
    ..Our results provide evidence that targeting Tregs may provide a more efficient strategy to potentiate gp96-mediated T-cell responses and enhance the antitumor efficiency of gp96-based therapeutic vaccine...
  29. ncbi request reprint Electrophysiological study of V535M hERG mutation of LQT2
    Chunyan Shao
    Institute of Geriatric Cardiology of Chinese PLA General Hospital, Beijing 100853, China
    J Huazhong Univ Sci Technolog Med Sci 31:741-8. 2011
    ..V535M hERG mutation demonstrated markedly decreased tail current densities, which suggests that V535M is a new loss-of-function mutation of hERG channel responsible for LQT2...
  30. pmc Are CD4+CD25-Foxp3+ cells in untreated new-onset lupus patients regulatory T cells?
    Hua xia Yang
    Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 41 Da Mu Cang Hu Tong Street, Beijing, 100032, China
    Arthritis Res Ther 11:R153. 2009
    ..However, little is known about the nature of this cell entity. The aim of this study was to explore the nature of abnormally increased CD4+CD25-Foxp3+ T cells in UNOL patients...
  31. ncbi request reprint Efficacy and antivascular effects of EphA2 reduction with an agonistic antibody in ovarian cancer
    Charles N Landen
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Natl Cancer Inst 98:1558-70. 2006
    ..We investigated the effects of reduced EphA2 levels on tumor growth and the tumor microenvironment in an orthotopic ovarian cancer model...
  32. ncbi request reprint Catalpol prevents the loss of CA1 hippocampal neurons and reduces working errors in gerbils after ischemia-reperfusion injury
    Dan Qing Li
    Department of Bioengineering, School of Environment and Life, Dalian University of Technology, Dalian, Liaoning 116023, People s Republic of China
    Toxicon 46:845-51. 2005
    ..All these indicated that catalpol was truly neuroprotective rather than simply delayed the onset of neuronal damage and might be of therapeutic value for the treatment of global cerebral ischemia...
  33. ncbi request reprint The changes of potassium currents in rabbit ventricle with healed myocardial infarction
    Nian Liu
    Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    J Huazhong Univ Sci Technolog Med Sci 24:128-31. 2004
    ....
  34. ncbi request reprint Matrine induces apoptosis in angiotensin II-stimulated hyperplasia of cardiac fibroblasts: effects on Bcl-2/Bax expression and caspase-3 activation
    Yang Li
    Department of Occupational and Environmental Health, School of Public Health, Wuhan University, Wuhan, China
    Basic Clin Pharmacol Toxicol 101:1-8. 2007
    ..The regulations of matrine on Bcl-2/Bax expression and caspase-3 activation may be the pro-apoptotic mechanisms involved...
  35. ncbi request reprint The experimental study of Cortex Eucommiae on meridian tropsim: the distribution study of aucubin in rat tissues
    Ye Zhao
    Biomedical Key Laboratory, Northwest University, 229 Taibai North Road, Xian 710069, PR China
    J Pharm Biomed Anal 46:368-73. 2008
    ..Lung, heart, spleen and testis were also detected to contain AU. The results closely conformed to the MT of CE and clearly demonstrated that AU was one of the material bases of the MT of CE...
  36. ncbi request reprint Effects of plasmid-based Stat3-specific short hairpin RNA and GRIM-19 on PC-3M tumor cell growth
    Ling Zhang
    Prostate Diseases Prevention and Treatment Research Center and Department of Pathophysiology, School of Basic Medicine, Jilin University, Changchun, PR China
    Clin Cancer Res 14:559-68. 2008
    ..To enhance the therapeutic efficacy of Stat3-specific shRNA, we applied a combination treatment involving gene associated with retinoid-IFN-induced mortality 19 (GRIM-19), another inhibitor of STAT3, along with shRNA...
  37. ncbi request reprint Prevalent expression of MHC class I chain-related molecule A in human osteosarcoma
    Shan ming Lu
    Department of Pathology, First Affiliated Hospital, Sun Yat Sen University, Guangdong, China
    Neoplasma 55:266-72. 2008
    ..Restoring the expression of NKG2D receptor on immune effector cells may contribute to a therapeutic strategy for human osteosarcoma...
  38. ncbi request reprint Mechanism of influenza A virus NS1 protein interaction with the p85beta, but not the p85alpha, subunit of phosphatidylinositol 3-kinase (PI3K) and up-regulation of PI3K activity
    Yang Li
    Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E3, Canada
    J Biol Chem 283:23397-409. 2008
    ..Finally, the mechanism by which binding of NS1 to p85beta regulates PI3K activity was discussed based on a predicted structural model of NS1-p85-p110 complex...
  39. ncbi request reprint Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma
    Premal H Thaker
    Department of Gynecologic Oncology, University of Texas U T M D Anderson Cancer Center, 1155 Herman Pressler, Unit 1362, Houston, Texas 77030, USA
    Nat Med 12:939-44. 2006
    ..These data also suggest that blocking ADRB-mediated angiogenesis could have therapeutic implications for the management of ovarian cancer...
  40. ncbi request reprint Sex difference in the repolarization currents of rabbit ventricular cells
    Yanfei Ruan
    Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    J Huazhong Univ Sci Technolog Med Sci 25:260-2. 2005
    ..L between male rabbits and female rabbits (P>0.05). The lower IK.tail of female rabbit myocytes may contribute to the longer repolarization and the higher incidence of drug-associated torsade de pointes...
  41. ncbi request reprint Protective effect of carvedilol on abnormality of L-type calcium current induced by oxygen free radical in cardiomyocytes
    Nian Liu
    Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    J Huazhong Univ Sci Technolog Med Sci 24:433-6. 2004
    ..It shows partly the possible mechanism of the special availability of carvedilol in chronic heart failure...
  42. ncbi request reprint Long-term effects of imidapril on calcium and potassium currents in rabbit left ventricular hypertrophic myocytes
    Yang Li
    Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Chin Med J (Engl) 116:1795-8. 2003
    ..To investigate the long-term effects of imidapril (IMI) on action potential and calcium and potassium currents in rabbit left ventricular hypertrophic myocytes...
  43. ncbi request reprint Effect of imidapril on heterogeneity of slow component of delayed rectifying K+ current in rabbit left ventricular hypertrophic myocytes
    Yang Li
    Department of Cardiology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong Science and Technology University, Wuhan 430030, China
    Acta Pharmacol Sin 24:681-6. 2003
    ..To investigate the transmural heterogeneous change of slow component of delayed rectifying potassium current in rabbit left ventricular hypertrophic myocytes and the effect of long-term treatment with imidapril (Imi)...
  44. ncbi request reprint T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities
    Gary Lee
    Tularik Inc, South San Francisco, California 94080, USA
    J Biol Chem 277:19649-57. 2002
    ..These results suggest that the activity of PPARgamma antagonists can be modulated by the availability and concentration of RXR agonists. T0070907 is a novel tool for the study of PPARgamma/RXRalpha heterodimer function...
  45. ncbi request reprint Effects of benzyltetrahydropalmatine on two components of the delayed rectifier K+ current in Guinea pig ventricular myocytes
    Yang Li
    Department of Cardiology, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, People s Republic of China
    Cardiovasc Drugs Ther 16:317-25. 2002
    ..It is concluded that BTHP prolonged the action potential duration with respect to its non-selective action on I(Kr) and I(Ks) in single guinea pig ventricular cell in a frequency-dependent fashion...
  46. ncbi request reprint Effect of lidocaine and amiodarone on transmural heterogeneity of ventricular repolarization in isolated rabbit hearts model of sustained global ischemia
    Binquan You
    Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    J Huazhong Univ Sci Technolog Med Sci 25:400-3. 2005
    ....
  47. pmc Focal adhesion kinase silencing augments docetaxel-mediated apoptosis in ovarian cancer cells
    Jyotsnabaran Halder
    Department of Gynecologic Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 11:8829-36. 2005
    ..Docetaxel causes cell death through induction of apoptosis; however, cell death characteristics for docetaxel have not yet been fully elucidated. We examined the role of focal adhesion kinase (FAK) cleavage in docetaxel-mediated apoptosis...
  48. ncbi request reprint Effects of benzyltetrahydropalmatine on the rapidly activating component of delayed rectifier potassium current in guinea pig ventricular myocytes
    Yang Li
    Department of Cardiology, Tongji Hospital, Wuhan 430030, China
    Yao Xue Xue Bao 37:603-7. 2002
    ..To investigate the effect of benzyltetrahydropalmatine (BTHP) on the rapidly activating component of delayed rectifier K+ current (Ikr) in single guinea pig ventricular myocytes...
  49. ncbi request reprint Huperzine A, a nootropic agent, inhibits fast transient potassium current in rat dissociated hippocampal neurons
    Yang Li
    State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 294 Tai Yuan Road, 200031, PR China
    Neurosci Lett 324:25-8. 2002
    ..The results suggest that HupA may act as a blocker at the external mouth of the A channel. The potential relevance of the inhibitory effect of HupA on IA to the treatment of Alzheimer's disease has been discussed...
  50. ncbi request reprint Effects of benzyltetrahydropalmatine on potassium currents in guinea pig and rat ventricular myocytes
    Yang Li
    Department of Cardiology, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, China
    Acta Pharmacol Sin 23:612-6. 2002
    ....
  51. ncbi request reprint Songorine, a diterpenoid alkaloid of the genus Aconitum, is a novel GABA(A) receptor antagonist in rat brain
    Xiao Yan Zhao
    State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, PR China
    Neurosci Lett 337:33-6. 2003
    ..6 microM). The results suggest that songorine is a novel non-competitive antagonist at the GABA(A) receptor in rat brain...
  52. ncbi request reprint Feedback-mediated neuronal competition for survival cues regulates innervation of a target tissue
    Yang Li
    Program in Neuroscience and Neurobehavior al Disorders, Duke National University of Singapore Graduate Medical School, Singapore
    Bioessays 30:929-33. 2008
    ..The authors' model is inspired by the theory for pattern formation based on self-activation and lateral inhibition, proposed by Meinhardt and Gierer more than 30 years ago...
  53. ncbi request reprint Sequences within domain II of the urokinase receptor critical for differential ligand recognition
    Yang Li
    Department of Vascular Biology, Jerome H Holland Laboratory for the Biomedical Sciences, American Red Cross, Rockville, Maryland 20855, USA
    J Biol Chem 278:29925-32. 2003
    ..Altogether, our data demonstrated that uPAR D2 contains two distinct ligand binding sites for uPA and Vn. Such information will help us better understand the complex roles of uPAR in cell adhesion, migration, and tumor metastasis...
  54. ncbi request reprint [The expansion and biological characteristics of human mesenchymal stem cells]
    Dun Hua Zhou
    Department of Pediatrics, Second Hospital, Sun Yat Sen University, Guangzhou 510120, China
    Zhonghua Er Ke Za Zhi 41:607-10. 2003
    ..To enhance the clinical use of MSCs, the investigators studied the isolation and expansion of MSCs from adult bone marrow, fetal bone marrow and human umbilical cord blood, and investigated their biological identities...
  55. ncbi request reprint Structure-based discovery of potassium channel blockers from natural products: virtual screening and electrophysiological assay testing
    Hong Liu
    Center for Drug Discovery and Design, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 201203, Shanghai, People s Republic of China
    Chem Biol 10:1103-13. 2003
    ..Intracellular application of the four compounds had no effect on both the K(+) currents...
  56. ncbi request reprint Involvement of the PI 3-kinase signaling pathway in progression of colon adenocarcinoma
    Kianoush Khaleghpour
    Mammalian Cell Genetics, Biotechnology Research Institute, National Research Council of Canada, 6100 Royalmount Avenue, Montreal, Quebec H4P 2R2, Canada
    Carcinogenesis 25:241-8. 2004
    ..Hence, the components of the PI 3-kinase signaling pathway could serve as potential candidates for drug development in treatment of colon cancer...
  57. ncbi request reprint [The synthesis of MT in rat myocardial fibroblasts]
    Lin Gao
    Institute of Cardiovascular Research, Peking University First Hospital, Beijing 100034, China
    Beijing Da Xue Xue Bao 35:41-4. 2003
    ..To study the influence on the synthesis of metallothionein (MT) induced by lipopolysaccharide (LPS), basic fibroblast growth factor (bFGF), oxidized low-density lipoproteins (oxLDL) and ZnCl2 in rat myocardial fibroblasts...
  58. ncbi request reprint Huperzine A inhibits the sustained potassium current in rat dissociated hippocampal neurons
    Yang Li
    State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 294 Tai Yuan Road, Shanghai 200031, PR China
    Neurosci Lett 329:153-6. 2002
    ..HupA affected neither the steady-state inactivation of the current, nor its recovery from inactivation. The potential relevance of the inhibitory effect of HupA on the current to the treatment of Alzheimer's disease is discussed...
  59. ncbi request reprint The role of selectins and integrins in adenovirus vector-induced neutrophil recruitment to the liver
    Yang Li
    Gastrointestinal Research Group, Department of Medicine, University of Calgary, Calgary, Canada
    Eur J Immunol 32:3443-52. 2002
    ..In conclusion, adenovirus vectors induce rapid neutrophil-mediated inflammation in the post-sinusoidal venules by selectins and alpha(4)-integrin but surprisingly not by CD18...
  60. ncbi request reprint [Influence of protein kinase C on motility and acrosome reaction of sperm]
    Yang Li
    Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
    Zhonghua Nan Ke Xue 8:367-70. 2002
    ..It is proposed that PKC would be involved in the regulation of motility and acrosome reaction of sperm...
  61. ncbi request reprint [Influence of dibutyryl cyclic adenosine monophosphate on motility of sperm]
    Yang Li
    Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
    Zhonghua Nan Ke Xue 8:398-400. 2002
    ..To investigate the influence of cAMP/PKA signal transduction on human sperm motility, and to study the effect of dibutyryl cyclic adenosine monophosphate dibutyryl cyclic adenosine monophosphate (dbcAMP) on human sperm motility in vitro...
  62. ncbi request reprint Experimental study on the mechanism of sex difference in the risk of torsade de pointes
    Yan fei Ruan
    Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Chin Med J (Engl) 117:538-41. 2004
    ..Consequently, we compared TdP incidence and TDR between male and female rabbit hearts in order to investigate the mechanism of sex difference in TdP risk in rabbits in vitro...
  63. ncbi request reprint Effect of autonomic nervous system on the transmural dispersion of ventricular repolarization in intact canine
    Cuntai Zhang
    Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030
    J Huazhong Univ Sci Technolog Med Sci 24:37-40. 2004
    ..Parasympathetic stimulation does not significantly affect the transmural dispersion of ventricular repolarization...
  64. ncbi request reprint Experimental study of the effect of autonomic nervous system on the transmural dispersion of ventricular repolarization under acute myocardial ischemia in vivo
    Cuntai Zhang
    Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030
    J Huazhong Univ Sci Technolog Med Sci 22:96-9. 2002
    ....
  65. ncbi request reprint Synaptic release of zinc from brain slices: factors governing release, imaging, and accurate calculation of concentration
    Christopher J Frederickson
    NeuroBioTex Inc, Galveston, TX 77550, USA
    J Neurosci Methods 154:19-29. 2006
    ..We show that common errors can cause up to a 3000-fold underestimation of the concentration of released zinc. The results should help bring consistency to the study of synaptic release of zinc...
  66. ncbi request reprint Cloning, expression, and identification of genes involved in the conversion of DL-2-amino-Delta2-thiazoline-4-carboxylic acid to L-cysteine via S-carbamyl-L-cysteine pathway in Pseudomonas sp. TS1138
    Yangsheng Yu
    Department of Microbiology, College of Life Sciences, Nankai University, Tianjin, P R China
    Biosci Biotechnol Biochem 70:2262-7. 2006
    ..These results suggest that tsB and tsC play important roles in the L-SCC pathway and L-cysteine biosynthesis in Pseudomonas sp. TS1138, and that they have potential applications in the industrial production of L-cysteine...
  67. pmc Oxidative modification of M-type K(+) channels as a mechanism of cytoprotective neuronal silencing
    Nikita Gamper
    Department of Physiology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    EMBO J 25:4996-5004. 2006
    ..Such blockade had no effect on survival of normoxic neurons. This work describes a novel pathway of M-channel regulation and suggests a role for M channels in protective neuronal silencing during oxidative stress...
  68. ncbi request reprint Application of surface-enhanced laser desorption/ionization time-of-flight-based serum proteomic array technique for the early diagnosis of prostate cancer
    Yu Zhuo Pan
    Research Center of Prostate Diseases, Department of Reproductive Pathophysiology, School of Basic Medicine, Jilin University, Changchun, China
    Asian J Androl 8:45-51. 2006
    ..To identify the serum biomarkers of prostate cancer (PCa) by protein chip and bioinformatics...
  69. ncbi request reprint Norepinephrine up-regulates the expression of vascular endothelial growth factor, matrix metalloproteinase (MMP)-2, and MMP-9 in nasopharyngeal carcinoma tumor cells
    Eric V Yang
    Department of Molecular Virology, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Cancer Res 66:10357-64. 2006
    ..The data suggest that catecholamine hormones produced by the sympathetic-adrenal medullary axis may affect NPC tumor progression, in part, through modulation of key angiogenic cytokines...
  70. ncbi request reprint The effects of histone deacetylase inhibitors on the induction of differentiation in chondrosarcoma cells
    Riku Sakimura
    Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka City, Japan
    Clin Cancer Res 13:275-82. 2007
    ..Histone acetylation and deacetylation play key roles in the regulation of chondrocytic differentiation. Here, we describe the antitumor effects of histone deacetylase (HDAC) inhibitors as differentiating reagents on chondrosarcomas...
  71. ncbi request reprint Discovering potassium channel blockers from synthetic compound database by using structure-based virtual screening in conjunction with electrophysiological assay
    Hong Liu
    Center for Drug Discovery and Design, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Zhangjiang Hi Tech Park, Shanghai 201203, PR China
    J Med Chem 50:83-93. 2007
    ..This study provides an alternative way of finding new blockers of voltage-gated K+ channels, while the techniques for high-throughput screening of K+ channel drugs remain in development...
  72. ncbi request reprint Serum circulating human mRNA profiling and its utility for oral cancer detection
    Yang Li
    School of Dentistry and Dental Research Institute, Division of Head and Neck Surgery Otolaryngology, David Geffen School of Medicine University of California, Los Angeles, CA 90095, USA
    J Clin Oncol 24:1754-60. 2006
    ..Oral squamous cell carcinoma (OSCC) was selected as the proof-of-concept disease...
  73. ncbi request reprint Ribotoxic stress sensitizes glioblastoma cells to death receptor induced apoptosis: requirements for c-Jun NH2-terminal kinase and Bim
    Shuli Xia
    Kennedy Krieger Research Institute, Department of Neurology, School of Medicine, Johns Hopkins University, 707 N Broadway, Baltimore, MD 21205, USA
    Mol Cancer Res 5:783-92. 2007
    ..These findings show that anisomycin-induced ribotoxic stress sensitizes glioblastoma cells to death receptor-induced apoptosis via a specific mechanism requiring both JNK activation and Bim induction...
  74. ncbi request reprint Roles of palatine bone denudation repairing with free buccal or palatal mucosal graft on maxillary growth: an experimental study in rabbits
    Tian Meng
    Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, People s Republic of China
    Ann Plast Surg 59:323-8. 2007
    ..The results of this study demonstrate that palatal bone denudation repaired by free buccal or palatal mucosal graft might prevent maxillary deformity following cleft palate surgery...
  75. ncbi request reprint [Study on antioxidant activity of two major secoiridoid glucosides in the fruits of Ligustrum lucidum Ait]
    Yang Li
    Biology and Medicine Key Laboratory of Shaanxi Province, Northwest University, Xi an 710069, China
    Zhong Yao Cai 30:543-6. 2007
    ..It implied that the structure of secoiridoid glucoside was postitive to antioxidant activity. Otherwise, the results could promote the deep research of Furctus Ligustri Lucidi on antioxidant mechanism...
  76. pmc TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo
    Sachin Katyal
    Department Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    EMBO J 26:4720-31. 2007
    ..These data indicate that TDP1 is required for neural homeostasis, and reveal a widespread requisite for TDP1 function in response to acutely elevated levels of Top1-associated DNA strand breaks...
  77. ncbi request reprint Inhibition of experimental colon cancer metastasis by the GABA-receptor agonist nembutal
    Premal H Thaker
    Department of Gynecologic Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77230 1439, USA
    Cancer Biol Ther 4:753-8. 2005
    ..To the best of our knowledge, this is the first evidence that nembutal is a potent inhibitor of primary colon cancer and metastasis. These findings may have therapeutic implications for the treatment of colon and other cancers...
  78. ncbi request reprint Effects of volsartan on transmural heterogeneous changes of transient outward potassium currents in hypertrophic cardiomyocytes in rabbits
    Jianmin Xiao
    Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    J Huazhong Univ Sci Technolog Med Sci 24:437-40. 2004
    ..In conclusion, volsartan can inhibit the transmural heterogeneous changes of Ito in left ventricular hypertrophic cardiomyocytes in rabbit...
  79. ncbi request reprint In-vivo and in-vitro studies on the effect of Huang-Lian-Jie-Du-Tang on nimodipine transport across rat blood-brain barrier
    Dong Mei Zhang
    Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China
    J Pharm Pharmacol 59:1733-8. 2007
    ..Both the in-vivo and in-vitro experimental findings indicated that HLJDT pretreatment may alter the transport of nimodipine across rat BBB...
  80. ncbi request reprint Elucidation of signaling and functional activities of an orphan GPCR, GPR81
    Hongfei Ge
    Amgen, Inc, South San Francisco, CA 94080, USA
    J Lipid Res 49:797-803. 2008
    ..Hence, targeting GPR81 may lead to the development of a novel and effective therapy for dyslipidemia and a better side effect profile than nicotinic acid...
  81. ncbi request reprint Dual function for a unique site within the beta2I domain of integrin alphaMbeta2
    Driss Ehirchiou
    Department of Physiology, University of Maryland School of Medicine, Rockville, Maryland 20855, USA
    J Biol Chem 280:8324-31. 2005
    ..Altogether, our data demonstrate that inside-out signaling could modulate ligand binding directly by changing the ligand-binding pocket per se and/or indirectly by inducing multiple conformational changes within the receptor...
  82. ncbi request reprint Systemically transferred hematopoietic stem cells home to the subretinal space and express RPE-65 in a mouse model of retinal pigment epithelium damage
    Pelin Atmaca-Sonmez
    Department of Ophthalmology and Visual Sciences, University of Louisville, 301 E Muhammad Ali Blvd, Louisville, KY 40202, USA
    Exp Eye Res 83:1295-302. 2006
    ..Furthermore, the RPE-specific marker RPE-65 was expressed on adoptively transferred HSC in the denuded areas...