Jin Yang

Summary

Country: China

Publications

  1. doi request reprint Pharmacokinetic properties of S-adenosylmethionine after oral and intravenous administration of its tosylate disulfate salt: a multiple-dose, open-label, parallel-group study in healthy Chinese volunteers
    Jin Yang
    Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, People s Republic of China
    Clin Ther 31:311-20. 2009
  2. doi request reprint Factors limiting the extent of absolute bioavailability of pradefovir in rat
    Qingqing Xiao
    a Department of Clinical Pharmacy, China Pharmaceutical University, Nanjing, China
    Xenobiotica 46:913-21. 2016
  3. doi request reprint Food effect on the pharmacokinetics of entecavir from dispersible tablets following oral administration in healthy Chinese volunteers
    Qing Hua Zhang
    Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, P R China
    Arzneimittelforschung 60:640-4. 2010
  4. pmc A semi-physiologically based pharmacokinetic pharmacodynamic model for glycyrrhizin-induced pseudoaldosteronism and prediction of the dose limit causing hypokalemia in a virtual elderly population
    Ruijuan Xu
    Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China
    PLoS ONE 9:e114049. 2014
  5. doi request reprint Changes in pharmacokinetic profiles of acetaminophen and its glucuronide after pretreatment with combinations of N-acetylcysteine and either glycyrrhizin, silibinin or spironolactone in rat
    Ruijuan Xu
    Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China
    Xenobiotica 44:541-6. 2014
  6. doi request reprint Evaluation of drug-drug interaction between henagliflozin, a novel sodium-glucose co-transporter 2 inhibitor, and metformin in healthy Chinese males
    Liupeng Wang
    a Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, P R China
    Xenobiotica 46:703-8. 2016
  7. ncbi request reprint Evaluation of pharmacokinetic interactions between long-acting HIV-1 fusion inhibitor albuvirtide and lopinavir/ritonavir, in HIV-infected subjects, combined with clinical study and simulation results
    Wanqiu Yang
    a Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China
    Xenobiotica . 2016
  8. doi request reprint Physiologically based pharmacokinetics model predicts the lack of inhibition by repaglinide on the metabolism of pioglitazone
    Qingqing Xiao
    Department of Clinical Pharmacy, School of Pharmacy, China Pharmaceutical University, Nanjing, China
    Biopharm Drug Dispos 36:603-12. 2015
  9. doi request reprint Evaluation of change in the skin concentration of tazarotene and betamethasone dipropionate based on drug-drug interaction for transdermal drug delivery in miniature pig
    Biao Yu
    Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China
    Xenobiotica 45:380-4. 2015
  10. doi request reprint Prediction of warfarin maintenance dose in Han Chinese patients using a mechanistic model based on genetic and non-genetic factors
    Yuan Lu
    Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, No 24 Tongjiaxiang, Nanjing, 210009, China
    Clin Pharmacokinet 52:567-81. 2013

Collaborators

  • Ying Chen
  • Lu Shen
  • Min Zhang
  • Qian Wang
  • Ruijuan Xu
  • Qingqing Xiao
  • Wanqiu Yang
  • Xiaoquan Liu
  • Liupeng Wang
  • Dan Wang
  • Linwen Yuan
  • Biao Yu
  • Yuan Lu
  • Fang Liu
  • Andrew K Davey
  • Qing Hua Zhang
  • Haiyan Liu
  • Lin Chen
  • Yitao Ding
  • Chunyong Wu
  • Youqun Wang
  • Cheng Yao
  • Pengcheng Ma
  • Wei Qian
  • Liling Tang
  • Dingding Chen
  • Min Zang
  • Jing Zhang
  • Haiyan Zhang
  • Xueying Zhang
  • Jiping Wang
  • Ji Ping Wang
  • Ying He

Detail Information

Publications12

  1. doi request reprint Pharmacokinetic properties of S-adenosylmethionine after oral and intravenous administration of its tosylate disulfate salt: a multiple-dose, open-label, parallel-group study in healthy Chinese volunteers
    Jin Yang
    Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, People s Republic of China
    Clin Ther 31:311-20. 2009
    ..Despite being widely used as a dietary supplement with claimed benefits for numerous conditions, there is little information about the pharmacokinetic properties of exogenous SAMe...
  2. doi request reprint Factors limiting the extent of absolute bioavailability of pradefovir in rat
    Qingqing Xiao
    a Department of Clinical Pharmacy, China Pharmaceutical University, Nanjing, China
    Xenobiotica 46:913-21. 2016
    ..Activation of pradefovir mainly occurs in the liver. Low intestinal absorption was the main reason of low bioavailability of pradefovir in rats. The result was suggestive for the disposition of pradefovir in human intestine and liver. ..
  3. doi request reprint Food effect on the pharmacokinetics of entecavir from dispersible tablets following oral administration in healthy Chinese volunteers
    Qing Hua Zhang
    Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, P R China
    Arzneimittelforschung 60:640-4. 2010
    ..The aim of the present study was to assess the effect of food on the pharmacokinetics of entecavir (CAS 142217-69-4) from dispersible tablets...
  4. pmc A semi-physiologically based pharmacokinetic pharmacodynamic model for glycyrrhizin-induced pseudoaldosteronism and prediction of the dose limit causing hypokalemia in a virtual elderly population
    Ruijuan Xu
    Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China
    PLoS ONE 9:e114049. 2014
    ..The critical value of the dose limit was found to be 101 mg with a probability of 3.07%. ..
  5. doi request reprint Changes in pharmacokinetic profiles of acetaminophen and its glucuronide after pretreatment with combinations of N-acetylcysteine and either glycyrrhizin, silibinin or spironolactone in rat
    Ruijuan Xu
    Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China
    Xenobiotica 44:541-6. 2014
    ..3. Our results suggest that Mrp2 inhibitor GL should be discouraged with NAC to treat APAP hepatotoxicity. Such PK drug-drug interactions should be considered in the treatment of APAP-induced liver injury...
  6. doi request reprint Evaluation of drug-drug interaction between henagliflozin, a novel sodium-glucose co-transporter 2 inhibitor, and metformin in healthy Chinese males
    Liupeng Wang
    a Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, P R China
    Xenobiotica 46:703-8. 2016
    ..12; CI 1.02, 1.23). All monotherapies and combination therapy were well tolerated. 4. Henagliflozin can be co-administered with metformin without dose adjustment of either drug. ..
  7. ncbi request reprint Evaluation of pharmacokinetic interactions between long-acting HIV-1 fusion inhibitor albuvirtide and lopinavir/ritonavir, in HIV-infected subjects, combined with clinical study and simulation results
    Wanqiu Yang
    a Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China
    Xenobiotica . 2016
    ..So, a phase 3 clinical trial without dose adjustment is underway to validate their effectiveness and safety...
  8. doi request reprint Physiologically based pharmacokinetics model predicts the lack of inhibition by repaglinide on the metabolism of pioglitazone
    Qingqing Xiao
    Department of Clinical Pharmacy, School of Pharmacy, China Pharmaceutical University, Nanjing, China
    Biopharm Drug Dispos 36:603-12. 2015
    ..Repaglinide and pioglitazone are both CYP2C8 and CYP3A4 substrates. This study was to determine whether repaglinide has an inhibitory effect on the metabolism of pioglitazone in vitro, in silico and in vivo...
  9. doi request reprint Evaluation of change in the skin concentration of tazarotene and betamethasone dipropionate based on drug-drug interaction for transdermal drug delivery in miniature pig
    Biao Yu
    Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China
    Xenobiotica 45:380-4. 2015
    ..3. The results suggest that there was no significant drug-drug interaction trend between TZRT and BTMSDP in the process of transdermal permeation of combination cream into the stratum corneum and epidermis-dermis of mini-pigs...
  10. doi request reprint Prediction of warfarin maintenance dose in Han Chinese patients using a mechanistic model based on genetic and non-genetic factors
    Yuan Lu
    Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, No 24 Tongjiaxiang, Nanjing, 210009, China
    Clin Pharmacokinet 52:567-81. 2013
    ..The model incorporates demographic factors [sex, age, body weight (BW)] and the genetic polymorphisms of cytochrome P450 (CYP) 2C9 (CYP2C9) and vitamin K epoxide reductase complex subunit 1 (VKORC1)...
  11. pmc Acarbose bioequivalence: exploration of new pharmacodynamic parameters
    Min Zhang
    Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China
    AAPS J 14:345-51. 2012
    ..The acarbose test formulation can be initially considered to be bioequivalent to Glucobay®...
  12. doi request reprint Effects of glycyrrhizin on biliary transport and hepatic levels of glutathione in rats
    Ruijuan Xu
    Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China
    Biopharm Drug Dispos 33:235-45. 2012
    ..9% in the 20 µm GL group and by 60.5% in the 2 µm GL group. In conclusion, glycyrrhizin increases hepatic glutathione content possibly through inhibition of Mrp2 which then reduces the biliary excretion of glutathione...