Aimin Xu

Summary

Affiliation: University of Hong Kong
Country: China

Publications

  1. ncbi request reprint Circulating adipocyte-fatty acid binding protein levels predict the development of the metabolic syndrome: a 5-year prospective study
    Aimin Xu
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Rd, Hong Kong, China
    Circulation 115:1537-43. 2007
  2. pmc Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice
    Aimin Xu
    Department of Medicine, Research Center of Heart, Brain, Hormone, and Healthy Aging, and Genome Research Center, University of Hong Kong, Hong Kong, China
    Proc Natl Acad Sci U S A 102:6086-91. 2005
  3. ncbi request reprint Adipocyte fatty acid-binding protein is a plasma biomarker closely associated with obesity and metabolic syndrome
    Aimin Xu
    Department of Medicine, University of Hong Kong, Hong Kong, China
    Clin Chem 52:405-13. 2006
  4. pmc Selective elevation of adiponectin production by the natural compounds derived from a medicinal herb alleviates insulin resistance and glucose intolerance in obese mice
    Aimin Xu
    Department of Medicine and Research Center for Heart, Brain, Hormones, and Healthy Aging, University of Hong Kong, Hong Kong
    Endocrinology 150:625-33. 2009
  5. ncbi request reprint Adiponectin ameliorates dyslipidemia induced by the human immunodeficiency virus protease inhibitor ritonavir in mice
    Aimin Xu
    Department of Medicine, The University of Hong Kong, L8 33A, New Laboratory Block, 21 Sassoon Road, Hong Kong, China
    Endocrinology 145:487-94. 2004
  6. ncbi request reprint Chronic treatment with growth hormone stimulates adiponectin gene expression in 3T3-L1 adipocytes
    Aimin Xu
    Department of Medicine, The University of Hong Kong, Hong Kong SAR, Hong Kong
    FEBS Lett 572:129-34. 2004
  7. ncbi request reprint Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes
    Aimin Xu
    Department of Medicine and Research Center of Heart, Brain, Hormone, and Healthy Aging, University of Hong Kong, Hong Kong, China
    J Biol Chem 280:18073-80. 2005
  8. pmc The effective fraction isolated from Radix Astragali alleviates glucose intolerance, insulin resistance and hypertriglyceridemia in db/db diabetic mice through its anti-inflammatory activity
    Ruby Lc Hoo
    Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Nutr Metab (Lond) 7:67. 2010
  9. doi request reprint Toll-like receptor 4 mutation protects obese mice against endothelial dysfunction by decreasing NADPH oxidase isoforms 1 and 4
    Chao Fan Liang
    Department of Pharmacology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong
    Arterioscler Thromb Vasc Biol 33:777-84. 2013
  10. ncbi request reprint Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans
    Yu Wang
    Genome Research Center and Department of Biochemistry, University of Hong Kong, Hong Kong, China
    Clin Chem 53:34-41. 2007

Collaborators

Detail Information

Publications108 found, 100 shown here

  1. ncbi request reprint Circulating adipocyte-fatty acid binding protein levels predict the development of the metabolic syndrome: a 5-year prospective study
    Aimin Xu
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Rd, Hong Kong, China
    Circulation 115:1537-43. 2007
    ..In the present study, we further evaluated the prospective association of A-FABP with the metabolic syndrome (MetS) as defined by the updated National Cholesterol Education Program criteria...
  2. pmc Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice
    Aimin Xu
    Department of Medicine, Research Center of Heart, Brain, Hormone, and Healthy Aging, and Genome Research Center, University of Hong Kong, Hong Kong, China
    Proc Natl Acad Sci U S A 102:6086-91. 2005
    ..These results collectively indicate that ANGPTL4 exerts distinct effects on glucose and lipid metabolism, and that its beneficial effect on glucose homeostasis might be useful for the treatment of diabetes...
  3. ncbi request reprint Adipocyte fatty acid-binding protein is a plasma biomarker closely associated with obesity and metabolic syndrome
    Aimin Xu
    Department of Medicine, University of Hong Kong, Hong Kong, China
    Clin Chem 52:405-13. 2006
    ..Mice with targeted disruption of the A-FABP gene exhibit a striking phenotype with strong protection from insulin resistance, hyperglycemia, and atherosclerosis. The clinical relevance of these findings remains to be confirmed...
  4. pmc Selective elevation of adiponectin production by the natural compounds derived from a medicinal herb alleviates insulin resistance and glucose intolerance in obese mice
    Aimin Xu
    Department of Medicine and Research Center for Heart, Brain, Hormones, and Healthy Aging, University of Hong Kong, Hong Kong
    Endocrinology 150:625-33. 2009
    ..The two natural compounds might provide the lead as a novel class of therapeutics for obesity-related diseases...
  5. ncbi request reprint Adiponectin ameliorates dyslipidemia induced by the human immunodeficiency virus protease inhibitor ritonavir in mice
    Aimin Xu
    Department of Medicine, The University of Hong Kong, L8 33A, New Laboratory Block, 21 Sassoon Road, Hong Kong, China
    Endocrinology 145:487-94. 2004
    ..These results suggest that hypoadiponectinemia is partly responsible for the metabolic disorders induced by HIV PIs, and adiponectin or its agonists might be useful for the treatment of these disorders...
  6. ncbi request reprint Chronic treatment with growth hormone stimulates adiponectin gene expression in 3T3-L1 adipocytes
    Aimin Xu
    Department of Medicine, The University of Hong Kong, Hong Kong SAR, Hong Kong
    FEBS Lett 572:129-34. 2004
    ....
  7. ncbi request reprint Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes
    Aimin Xu
    Department of Medicine and Research Center of Heart, Brain, Hormone, and Healthy Aging, University of Hong Kong, Hong Kong, China
    J Biol Chem 280:18073-80. 2005
    ....
  8. pmc The effective fraction isolated from Radix Astragali alleviates glucose intolerance, insulin resistance and hypertriglyceridemia in db/db diabetic mice through its anti-inflammatory activity
    Ruby Lc Hoo
    Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Nutr Metab (Lond) 7:67. 2010
    ..This study aims to isolate bioactive ingredients from the traditional Chinese herb Radix Astragali (Huangqi) that alleviate obesity-induced metabolic damage through inhibiting inflammation...
  9. doi request reprint Toll-like receptor 4 mutation protects obese mice against endothelial dysfunction by decreasing NADPH oxidase isoforms 1 and 4
    Chao Fan Liang
    Department of Pharmacology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong
    Arterioscler Thromb Vasc Biol 33:777-84. 2013
    ..To analyze the role of toll-like receptor 4 in modulating metabolism and endothelial function...
  10. ncbi request reprint Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans
    Yu Wang
    Genome Research Center and Department of Biochemistry, University of Hong Kong, Hong Kong, China
    Clin Chem 53:34-41. 2007
    ..Because lipocalin-2 is abundantly expressed in adipose tissue and liver, we investigated its relevance to obesity-related pathologies...
  11. doi request reprint Uncoupling protein-2 protects endothelial function in diet-induced obese mice
    Xiao Yu Tian
    Institute of Vascular Medicine, Hong Kong SAR, China
    Circ Res 110:1211-6. 2012
    ..UCP2 also regulates insulin secretion and action. However, the role of UCP2 in endothelial dysfunction associated with diabetes and obesity is unclear...
  12. doi request reprint Suppression of the Raf/MEK/ERK signaling cascade and inhibition of angiogenesis by the carboxyl terminus of angiopoietin-like protein 4
    Ying Hua Yang
    Department of Medicine, The University of Hong Kong, L8 40, New Laboratory Block, 21 Sassoon Road, Hong Kong
    Arterioscler Thromb Vasc Biol 28:835-40. 2008
    ..This study aimed to investigate the structural and cellular basis underlying the biological actions of Angptl4...
  13. doi request reprint Obesity susceptibility genetic variants identified from recent genome-wide association studies: implications in a chinese population
    Chloe Y Y Cheung
    Department of Medicine, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong
    J Clin Endocrinol Metab 95:1395-403. 2010
    ..Recent large-scale genome-wide association studies identified novel genetic variants associated with obesity and body mass index (BMI) in addition to the well-described FTO and MC4R genetic variants...
  14. pmc Lipocalin-2 deficiency attenuates insulin resistance associated with aging and obesity
    Ivy K M Law
    Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong, China
    Diabetes 59:872-82. 2010
    ..The present study investigates whether lipocalin-2 deficiency or replenishment with this adipokine has any impact on systemic insulin sensitivity and the underlying mechanisms...
  15. pmc APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice
    Yi Wang
    Department of Medicine, Division of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
    Diabetes 60:3044-54. 2011
    ..This study aimed to investigate the roles of the multidomain adaptor protein APPL1 in modulating vascular actions of insulin in mice and in endothelial cells...
  16. doi request reprint Serum fibroblast growth factor-21 levels are associated with carotid atherosclerosis independent of established cardiovascular risk factors
    Wing Sun Chow
    From the Department of Medicine W S C, A X, Y C W, A W K T, C H Y F, H F T, B M Y C, K S L L, Research Centre of Heart, Brain, Hormone, and Healthy Aging A X, A W K T, H F T, B M Y C, K S L L, and Department of Radiology S C W C, M T C, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    Arterioscler Thromb Vasc Biol 33:2454-9. 2013
    ..In this study, we examined the relationship between serum FGF21 levels and carotid intima-media thickness (IMT) in a large cohort of Southern Chinese subjects...
  17. pmc Adiponectin prevents diabetic premature senescence of endothelial progenitor cells and promotes endothelial repair by suppressing the p38 MAP kinase/p16INK4A signaling pathway
    Junlei Chang
    Department of Medicine, University of Hong Kong, Hong Kong, China
    Diabetes 59:2949-59. 2010
    ..The objective of this study was to investigate whether adiponectin plays a role in modulating the bioavailability of circulating EPCs and endothelial repair...
  18. ncbi request reprint Hypoadiponectinemia as a predictor for the development of hypertension: a 5-year prospective study
    Wing Sun Chow
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Rd, Hong Kong, People s Republic of China
    Hypertension 49:1455-61. 2007
    ..76; 95% CIs: 1.06 to 7.16; P=0.037 versus highest tertile). Our data suggest that hypoadiponectinaemia may be involved in the pathogenesis of hypertension in humans...
  19. doi request reprint Plasma concentration of pigment epithelium-derived factor is closely associated with blood pressure and predicts incident hypertension in Chinese: a 10-year prospective study
    Cheng Chen
    Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong
    Clin Endocrinol (Oxf) 76:506-13. 2012
    ..Here we investigated the relationship of plasma PEDF concentration with BP and incident hypertension in a 10-year prospective study...
  20. pmc Upregulation of UCP2 by adiponectin: the involvement of mitochondrial superoxide and hnRNP K
    Mingyan Zhou
    Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong, China
    PLoS ONE 7:e32349. 2012
    ..The present study was designed to investigate the cellular and molecular mechanisms underlying adiponectin-induced UCP2 expression...
  21. doi request reprint Adiponectin is required for PPARγ-mediated improvement of endothelial function in diabetic mice
    Wing Tak Wong
    Institute of Vascular Medicine, Chinese University of Hong Kong, Hong Kong, China Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China
    Cell Metab 14:104-15. 2011
    ..Thus, the adipose tissue represents a promising target for treating diabetic vasculopathy...
  22. ncbi request reprint Hypoxia dysregulates the production of adiponectin and plasminogen activator inhibitor-1 independent of reactive oxygen species in adipocytes
    Baoying Chen
    Department of Medicine, University of Hong Kong, Hong Kong, China
    Biochem Biophys Res Commun 341:549-56. 2006
    ..These effects may contribute to hypoadiponectinemia and elevated PAI-1 levels in obesity, type 2 diabetes, and cardiovascular diseases...
  23. pmc Mitochondrial dysfunction contributes to the increased vulnerabilities of adiponectin knockout mice to liver injury
    Mingyan Zhou
    Department of Pharmacology, Institute of Molecular Technology for Drug Discovery and Synthesis, University of Hong Kong, Hong Kong, China
    Hepatology 48:1087-96. 2008
    ..Moreover, the effects of adiponectin on mitochondrial activities and on protection against endotoxin-induced liver injuries were significantly attenuated in UCP2 knockout mice...
  24. pmc The KCNJ11 E23K polymorphism and progression of glycaemia in Southern Chinese: a long-term prospective study
    Chloe Y Y Cheung
    Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong
    PLoS ONE 6:e28598. 2011
    ..The KCNJ11 E23K variant is associated with type 2 diabetes mellitus (T2DM) in cross-sectional studies, but conflicting findings have been reported from prospective studies...
  25. pmc Selective inactivation of c-Jun NH2-terminal kinase in adipose tissue protects against diet-induced obesity and improves insulin sensitivity in both liver and skeletal muscle in mice
    Xinmei Zhang
    Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong
    Diabetes 60:486-95. 2011
    ..In this study, we aimed to define the role of JNK activation in adipose tissue in the development of obesity-related insulin resistance...
  26. doi request reprint Rosiglitazone promotes fatty acyl CoA accumulation and excessive glycogen storage in livers of mice without adiponectin
    Mingyan Zhou
    Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong, China
    J Hepatol 53:1108-16. 2010
    ..Rosiglitazone treatment stimulates the production of adiponectin, an insulin-sensitizing adipokine with hepatoprotective functions. The present study aims to investigate the hepatic actions of rosiglitazone in mice without adiponectin...
  27. doi request reprint Plasma level of pigment epithelium-derived factor is independently associated with the development of the metabolic syndrome in Chinese men: a 10-year prospective study
    Cheng Chen
    Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
    J Clin Endocrinol Metab 95:5074-81. 2010
    ..Here we investigated whether circulating PEDF levels predicted the development of the metabolic syndrome (MetS) in a 10-yr prospective study...
  28. doi request reprint APPL1 potentiates insulin-mediated inhibition of hepatic glucose production and alleviates diabetes via Akt activation in mice
    Kenneth K Y Cheng
    Department of Medicine, The University of Hong Kong, Hong Kong
    Cell Metab 9:417-27. 2009
    ..These results suggest that the potentiating effects of APPL1 on insulin-stimulated suppression of hepatic glucose production are attributed to its ability in counteracting the inhibition of Akt activation by TRB3...
  29. doi request reprint Protective effects of histamine on Gq-mediated relaxation in regenerated endothelium
    Calvin K Chan
    Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong, China
    Am J Physiol Heart Circ Physiol 306:H286-90. 2014
    ....
  30. doi request reprint Pharmacological inhibition of adipocyte fatty acid binding protein alleviates both acute liver injury and non-alcoholic steatohepatitis in mice
    Ruby L C Hoo
    Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    J Hepatol 58:358-64. 2013
    ..Here, we investigated the role of A-FABP in both lipopolysaccaride (LPS)-induced acute liver injury and high fat high cholesterol (HFHC) diet-induced NAFLD in mice...
  31. doi request reprint Adiponectin stimulates Wnt inhibitory factor-1 expression through epigenetic regulations involving the transcription factor specificity protein 1
    Jing Liu
    Department of Pharmacology, Brain, Hormone and Healthy Aging, University of Hong Kong, Hong Kong, China
    Carcinogenesis 29:2195-202. 2008
    ..Taken together, these data suggest that ADN might elicit its antitumor activities at least partially through promoting WIF1 expressions...
  32. ncbi request reprint Serum adipocyte fatty acid binding protein as a new biomarker predicting the development of type 2 diabetes: a 10-year prospective study in a Chinese cohort
    Annette W K Tso
    Department of Medicine, University of Hong Kong, Hong Kong, China
    Diabetes Care 30:2667-72. 2007
    ..Here we investigated whether serum A-FABP levels could predict the development of diabetes in a 10-year prospective study...
  33. doi request reprint Genetic variants associated with persistent central obesity and the metabolic syndrome in a 12-year longitudinal study
    Chloe Y Y Cheung
    Department of Medicine, LKS Faculty of Medicine, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, SAR, China
    Eur J Endocrinol 164:381-8. 2011
    ..In this study, we investigate whether these SNPs could also predict the persistence of central obesity and MetS in subjects from the Hong Kong Cardiovascular Risk Factors Prevalence Study (CRISPS) cohort...
  34. doi request reprint Association of genetic variants in the adiponectin gene with adiponectin level and hypertension in Hong Kong Chinese
    Kwok Leung Ong
    Department of Medicine, University of Hong Kong, Hong Kong
    Eur J Endocrinol 163:251-7. 2010
    ..We therefore investigated whether single-nucleotide polymorphisms (SNPs) in the adiponectin gene influenced plasma adiponectin level and whether they were associated with hypertension...
  35. doi request reprint Berberine prevents hyperglycemia-induced endothelial injury and enhances vasodilatation via adenosine monophosphate-activated protein kinase and endothelial nitric oxide synthase
    Yiqun Wang
    Department of Medicine, University of Hong Kong, L8 40, New Laboratory Block, 21 Sassoon Road, Hong Kong, China
    Cardiovasc Res 82:484-92. 2009
    ..The aim of the present study was to examine the protective effect of the alkaloid drug berberine against hyperglycemia-induced cellular injury and endothelial dysfunction...
  36. doi request reprint Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans
    Xinmei Zhang
    Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China
    Diabetes 57:1246-53. 2008
    ..This study aimed to investigate the relationship between its serum levels and various cardiometabolic parameters in humans...
  37. ncbi request reprint Adiponectin as a negative regulator in obesity-related mammary carcinogenesis
    Yu Wang
    Genome Research Center, University of Hong Kong, Hong Kong SAR, China
    Cell Res 17:280-2. 2007
  38. pmc Chronic administration of BMS309403 improves endothelial function in apolipoprotein E-deficient mice and in cultured human endothelial cells
    Mary Yk Lee
    Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Br J Pharmacol 162:1564-76. 2011
    ..Here, we investigate the contribution of A-FABP to the pathogenesis of endothelial dysfunction in the aorta of apolipoprotein E-deficient (ApoE(-/-) ) mice and in cultured human endothelial cells...
  39. doi request reprint Serum zinc-alpha2-glycoprotein correlates with adiposity, triglycerides, and the key components of the metabolic syndrome in Chinese subjects
    Dennis C Y Yeung
    Department of Medicine, The University of Hong Kong, Hong Kong SAR, China
    J Clin Endocrinol Metab 94:2531-6. 2009
    ..Animal studies have demonstrated the role of ZAG as a lipid-mobilizing factor involved in regulating lipid metabolism and adiposity. However, the clinical relevance of these findings remains to be established...
  40. doi request reprint Calcitriol restores renovascular function in estrogen-deficient rats through downregulation of cyclooxygenase-2 and the thromboxane-prostanoid receptor
    Jinghui Dong
    Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, and School of Biomedical Sciences, Hong Kong, China
    Kidney Int 84:54-63. 2013
    ..Calcitriol restores endothelial function through downregulating both signaling proteins during estrogen deficiency. ..
  41. doi request reprint N-Acetylcysteine and allopurinol up-regulated the Jak/STAT3 and PI3K/Akt pathways via adiponectin and attenuated myocardial postischemic injury in diabetes
    Tingting Wang
    Department of Anesthesiology, The University of Hong Kong, Hong Kong SAR, China
    Free Radic Biol Med 63:291-303. 2013
    ..In conclusion, NAC and ALP prevented diabetic MI/R injury through PI3K/Akt and Jak2/STAT3 and cardiac APN may serve as a mediator via AdipoR2 in this process. ..
  42. pmc APPL1 potentiates insulin secretion in pancreatic β cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in mice
    Kenneth K Y Cheng
    Department of Medicine, The University of Hong Kong, Hong Kong, China
    Proc Natl Acad Sci U S A 109:8919-24. 2012
    ....
  43. doi request reprint Dipeptidyl peptidase 4 inhibitor sitagliptin protects endothelial function in hypertension through a glucagon-like peptide 1-dependent mechanism
    Limei Liu
    Institute of Vascular Medicine and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China
    Hypertension 60:833-41. 2012
    ....
  44. pmc High plasma level of fibroblast growth factor 21 is an Independent predictor of type 2 diabetes: a 5.4-year population-based prospective study in Chinese subjects
    Cheng Chen
    Department of Medicine, University of Hong Kong, Hong Kong
    Diabetes Care 34:2113-5. 2011
    ..4-year, population-based, prospective study...
  45. pmc Lipocalin-2 deficiency prevents endothelial dysfunction associated with dietary obesity: role of cytochrome P450 2C inhibition
    Jacky T C Liu
    Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong
    Br J Pharmacol 165:520-31. 2012
    ..Augmented lipocalin-2 has been found in patients with cardiovascular abnormalities.The present study was designed to investigate the role of lipocalin-2 in regulating endothelial function and vascular reactivity...
  46. pmc Adiponectin haploinsufficiency promotes mammary tumor development in MMTV-PyVT mice by modulation of phosphatase and tensin homolog activities
    Janice B B Lam
    Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong, China
    PLoS ONE 4:e4968. 2009
    ..A negative association of adiponectin levels with breast cancer development has been demonstrated. However, the precise role of adiponectin deficiency in mammary carcinogenesis remains elusive...
  47. doi request reprint Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins
    Ivy K M Law
    Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong, China
    Proteomics 9:2444-56. 2009
    ..Taken together, the present study has identified a number of novel SIRT protein interacting partners, which might be critically involved in the anti-aging and metabolic regulatory activities of sirtuins...
  48. pmc Hypoadiponectinemia as an independent predictor for the progression of carotid atherosclerosis: a 5-year prospective study
    Elaine Hui
    1 Department of Medicine, The University of Hong Kong, Hong Kong, China
    Metab Syndr Relat Disord 12:517-22. 2014
    ..In this 5-year prospective study, we examined the relationship between serum adiponectin and carotid intima media thickness (CIMT), a marker of subclinical atherosclerosis...
  49. pmc Elevated circulating adipocyte-fatty acid binding protein levels predict incident cardiovascular events in a community-based cohort: a 12-year prospective study
    Wing Sun Chow
    Department of Medicine, The University of Hong Kong, Hong Kong
    J Am Heart Assoc 2:e004176. 2013
    ..This study aimed to evaluate whether the 2 most abundant adipokines, adipocyte-fatty acid binding protein (A-FABP) and adiponectin, are independent risk factors predisposing to CVD...
  50. pmc Pro-inflammatory adipokines as predictors of incident cancers in a Chinese cohort of low obesity prevalence in Hong Kong
    Chun Yip Yeung
    Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong
    PLoS ONE 8:e78594. 2013
    ..Cytokines released from adipose tissues induce chronic low-grade inflammation, which may enhance cancer development. We investigated whether indices of obesity and circulating adipokine levels could predict incident cancer risk...
  51. doi request reprint Circadian rhythm of circulating fibroblast growth factor 21 is related to diurnal changes in fatty acids in humans
    Haoyong Yu
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China
    Clin Chem 57:691-700. 2011
    ..This study investigated the diurnal changes in circulating FGF21 concentrations and their association with other metabolic markers in both obese and lean individuals...
  52. pmc Serum fibroblast growth factor 19 levels are decreased in Chinese subjects with impaired fasting glucose and inversely associated with fasting plasma glucose levels
    Qichen Fang
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center of Diabetes, Shanghai, China
    Diabetes Care 36:2810-4. 2013
    ..This study investigated the change of FGF19 in prediabetes and newly diagnosed type 2 diabetes mellitus (T2DM) and explored the association of serum FGF19 levels with parameters of glucose metabolism in Chinese subjects...
  53. doi request reprint Toll-like receptor-4 mediates obesity-induced non-alcoholic steatohepatitis through activation of X-box binding protein-1 in mice
    Dewei Ye
    Department of Medicine, The University of Hong Kong, Hong Kong
    Gut 61:1058-67. 2012
    ..Non-alcoholic fatty liver disease is an obesity-related chronic liver disorder ranging from simple steatosis to non-alcoholic steatohepatitis (NASH), which may progress to liver fibrosis and cirrhosis...
  54. pmc A highly conserved motif within the NH2-terminal coiled-coil domain of angiopoietin-like protein 4 confers its inhibitory effects on lipoprotein lipase by disrupting the enzyme dimerization
    Ming Hon Yau
    Department of Medicine, Research Centre of Heart, Brain, Hormone and Healthy Aging, and Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong
    J Biol Chem 284:11942-52. 2009
    ....
  55. pmc Adipose tissue-specific inhibition of hypoxia-inducible factor 1{alpha} induces obesity and glucose intolerance by impeding energy expenditure in mice
    Xinmei Zhang
    Department of Medicine, University of Hong Kong, Hong Kong, China
    J Biol Chem 285:32869-77. 2010
    ..These findings support an indispensable role of HIF1α in maintaining the thermogenic functions of BAT, possibly through promoting angiogenesis and mitochondrial biogenesis in this tissue...
  56. ncbi request reprint Post-translational modifications of the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high molecular weight oligomeric complex
    Yu Wang
    Departments of Biochemistry and Medicine, Genome Research Centre, Faculty of Medicine Building, University of Hong Kong, 21 Sassoon Road, Hong Kong, China
    J Biol Chem 281:16391-400. 2006
    ....
  57. doi request reprint Calorie Restriction Prevents Metabolic Aging Caused by Abnormal SIRT1 Function in Adipose Tissues
    Cheng Xu
    State Key Laboratory of Pharmaceutical Biotechnology and Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong, China
    Diabetes 64:1576-90. 2015
    ....
  58. doi request reprint Fibroblast growth factor 21 protects against acetaminophen-induced hepatotoxicity by potentiating peroxisome proliferator-activated receptor coactivator protein-1α-mediated antioxidant capacity in mice
    Dewei Ye
    State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong, China Department of Medicine, University of Hong Kong, Hong Kong, China Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong, China
    Hepatology 60:977-89. 2014
    ....
  59. doi request reprint Adiponectin gene variants and the risk of coronary heart disease: a 16-year longitudinal study
    Chloe Y Y Cheung
    Department of MedicineDepartment of PsychiatryResearch Centre of HeartBrain, Hormone and Healthy AgingLi Ka Shing Faculty of MedicineCentre for Genomic Sciences, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, Hong KongCentre for Vascular ResearchUniversity of New South Wales, Sydney, New South Wales 2052, AustraliaDepartment of MedicineNorthwest Academic Centre, Western Hospital, The University of Melbourne, Melbourne, Victoria, Australia
    Eur J Endocrinol 171:107-15. 2014
    ....
  60. ncbi request reprint Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cells
    Kenneth K Y Cheng
    Department of Medicine, University of Hong Kong, Hong Kong, China
    Diabetes 56:1387-94. 2007
    ..Taken together, these results suggest that APPL1 acts as a common downstream effector of AdipoR1 and -R2, mediating adiponectin-evoked endothelial NO production and endothelium-dependent vasodilation...
  61. pmc Growth hormone induces hepatic production of fibroblast growth factor 21 through a mechanism dependent on lipolysis in adipocytes
    Wei Chen
    Department of Geriatrics, Hua Shan Hospital, Fudan University, Shanghai 200040, China
    J Biol Chem 286:34559-66. 2011
    ....
  62. pmc Adiponectin mediated MHC class II mismatched cardiac graft rejection in mice is IL-4 dependent
    Daxu Li
    Paediatric Surgery Division, Department of Surgery, The University of Hong Kong, Hong Kong SAR, China
    PLoS ONE 7:e48893. 2012
    ..Adiponectin regulates glucose and fatty-acid metabolism but its role in chronic graft rejection mediated by Th2 cytokines remains ill-defined...
  63. pmc Circulating levels of adipocyte and epidermal fatty acid-binding proteins in relation to nephropathy staging and macrovascular complications in type 2 diabetic patients
    Dennis C Y Yeung
    Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China
    Diabetes Care 32:132-4. 2009
    ..To investigate the relationships of serum adipocyte fatty acid-binding protein (A-FABP) and epidermal fatty acid-binding protein (E-FABP) with renal dysfunction and macrovascular complications in type 2 diabetic patients...
  64. doi request reprint Impact of combination therapy with amlodipine and atorvastatin on plasma adiponectin levels in hypertensive patients with coronary artery disease: combination therapy and adiponectin
    Mingfang Li
    Division of Cardiology, The University of Hong Kong, Hong Kong, China
    Postgrad Med 123:66-71. 2011
    ..The aim of this study was to investigate the impact of this combination therapy on plasma adiponectin levels...
  65. ncbi request reprint Protective roles of adiponectin in obesity-related fatty liver diseases: mechanisms and therapeutic implications
    Yu Wang
    Department of Pharmacology, University of Hong Kong, 21 Sassoon Road, Hong Kong, China
    Arq Bras Endocrinol Metabol 53:201-12. 2009
    ..This review aims to summarize recent advances on delineation of the structural, molecular and cellular mechanisms underlying the hepato-protective properties of adiponectin...
  66. ncbi request reprint Overexpression of angiopoietin-like protein 4 alters mitochondria activities and modulates methionine metabolic cycle in the liver tissues of db/db diabetic mice
    Yu Wang
    Genome Research Center, Faculty of Medicine Building, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong Special Administrative Region, China
    Mol Endocrinol 21:972-86. 2007
    ..In summary, our results suggest that ANGPTL4 might elicit its metabolic effects through modulating the mitochondria functions and methionine metabolic cycles in the liver tissue...
  67. doi request reprint Epidermal fatty-acid-binding protein: a new circulating biomarker associated with cardio-metabolic risk factors and carotid atherosclerosis
    Dennis C Y Yeung
    Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China
    Eur Heart J 29:2156-63. 2008
    ..Combined deficiency of E-FABP and A-FABP protects against the MetS and atherosclerosis in mice. This study investigated the association of serum E-FABP with cardio-metabolic risk factors and carotid atherosclerosis in humans...
  68. pmc Adipocyte fatty acid-binding protein modulates inflammatory responses in macrophages through a positive feedback loop involving c-Jun NH2-terminal kinases and activator protein-1
    Xiaoyan Hui
    Department of Medicine, Research Center of Heart, Brain, Hormone, and Healthy Aging, University of Hong Kong, Hong Kong
    J Biol Chem 285:10273-80. 2010
    ..These findings support the notion that pharmacological inhibition of A-FABP represents a valid strategy for treating inflammation-related disorders such as atherosclerosis...
  69. doi request reprint Bone morphogenic protein-4 impairs endothelial function through oxidative stress-dependent cyclooxygenase-2 upregulation: implications on hypertension
    Wing Tak Wong
    School of Biomedical Sciences, Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Circ Res 107:984-91. 2010
    ..Bone morphogenic protein (BMP)4 can stimulate superoxide production and exert proinflammatory effects on the endothelium. The underlying mechanisms of how BMP4 mediates endothelial dysfunction and hypertension remain elusive...
  70. pmc High glucose represses β-klotho expression and impairs fibroblast growth factor 21 action in mouse pancreatic islets: involvement of peroxisome proliferator-activated receptor γ signaling
    Wing Yan So
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
    Diabetes 62:3751-9. 2013
    ....
  71. pmc A-FABP and oxidative stress underlie the impairment of endothelium-dependent relaxations to serotonin and the intima-medial thickening in the porcine coronary artery with regenerated endothelium
    Calvin K Chan
    Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong, China
    ACS Chem Neurosci 4:122-9. 2013
    ..Thus, inhibition of either oxidative stress or A-FABP likely prevents both the selective dysfunction of G(i) protein mediated relaxation to serotonin and the neointimal thickening resulting from endothelial regeneration...
  72. doi request reprint Endothelium-selective activation of AMP-activated protein kinase prevents diabetes mellitus-induced impairment in vascular function and reendothelialization via induction of heme oxygenase-1 in mice
    Francois Y L Li
    Department of Medicine, University of Hong Kong, Hong Kong
    Circulation 126:1267-77. 2012
    ..The present study investigated whether endothelium-selective activation of AMPK prevents diabetes mellitus-induced endothelial damage and vascular dysfunction by improving reendothelialization in mice...
  73. pmc Combined use of serum adiponectin and tumor necrosis factor-alpha receptor 2 levels was comparable to 2-hour post-load glucose in diabetes prediction
    Yu Cho Woo
    Department of Medicine, The University of Hong Kong, Pokfulam, Hong Kong
    PLoS ONE 7:e36868. 2012
    ..We evaluated the use of serum adiponectin, an anti-inflammatory adipokine, and several proinflammatory adipokines, as biomarkers of diabetes risk and whether they add to traditional risk factors in diabetes prediction...
  74. ncbi request reprint Resistin gene polymorphisms and progression of glycaemia in southern Chinese: a 5-year prospective study
    Jian Yu Xu
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Clin Endocrinol (Oxf) 66:211-7. 2007
    ..We evaluated, in a 5-year prospective study, whether RETN polymorphisms could predict the progression of glycaemia in southern Chinese...
  75. doi request reprint A gold(III) porphyrin complex with antitumor properties targets the Wnt/beta-catenin pathway
    Kim Hei Man Chow
    Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam, Hong Kong, China
    Cancer Res 70:329-37. 2010
    ..These data, in combination with computer modeling, suggest that gold-2a may represent a promising class of anticancer HDAC inhibitor preferentially targeting tumor cells with aberrant Wnt/beta-catenin signaling...
  76. ncbi request reprint Proteomic characterization of human serum proteins associated with the fat-derived hormone adiponectin
    Yu Wang
    Genome Research Center and Department of Biochemistry, University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, P R China
    Proteomics 6:3862-70. 2006
    ..These proteins might serve as the physiological-binding partners of adiponectin and regulate its bioavailability and biological activities...
  77. pmc Fibroblast growth factor 21 induces glucose transporter-1 expression through activation of the serum response factor/Ets-like protein-1 in adipocytes
    Xuan Ge
    Department of Medicine, University of Hong Kong, Hong Kong, China
    J Biol Chem 286:34533-41. 2011
    ..The impairment in this signaling pathway may contribute to FGF21 resistance in obese mice...
  78. pmc Hypoadiponectinemia is related to sympathetic activation and severity of obstructive sleep apnea
    Jamie C M Lam
    Department of Medicine, Queen Mary Hospital, Hong Kong, SAR China
    Sleep 31:1721-7. 2008
    ..This study investigated the relationship between serum adiponectin and sleep disordered breathing and its potential determinants...
  79. doi request reprint Lipopolysaccharide and hypoxia-induced HIF-1 activation in human gingival fibroblasts
    Jing Ping Li
    Faculty of Dentistry, The University of Hong Kong, 34 Hospital Rd, Hong Kong, China
    J Periodontol 83:816-24. 2012
    ..Here, evidence is provided that bacterial lipopolysaccharides (LPS) and cellular hypoxia, both associated with periodontitis, can individually, or in combination, lead to the accumulation and activation of HIF-1 in HGF in vitro...
  80. pmc N-acetylcysteine and allopurinol synergistically enhance cardiac adiponectin content and reduce myocardial reperfusion injury in diabetic rats
    Tingting Wang
    Department of Anaesthesiology, The University of Hong Kong, Hong Kong SAR, China
    PLoS ONE 6:e23967. 2011
    ..It is unknown whether or not antioxidant treatment with N-acetylcysteine (NAC) and/or allopurinol (ALP) can attenuate APN deficiency and myocardial ischemia reperfusion (MI/R) injury in the early stage of diabetes...
  81. ncbi request reprint Adiponectin modulates the glycogen synthase kinase-3beta/beta-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude mice
    Yu Wang
    Genome Research Center, University of Hong Kong, China
    Cancer Res 66:11462-70. 2006
    ..Taken together, these data support the role of adiponectin as a negative regulator of breast cancer development and also suggest that adiponectin might represent a novel therapeutic target for this disease...
  82. pmc Adiponectin and cardiovascular health: an update
    Xiaoyan Hui
    Department of Medicine, The University of Hong Kong, Hong Kong
    Br J Pharmacol 165:574-90. 2012
    ..It also discusses adiponectin-targeted drug discovery strategies for treating obesity, diabetes and CVD...
  83. ncbi request reprint Moderate wine consumption in the prevention of metabolic syndrome and its related medical complications
    Ling Liu
    Department of Medicine, The University of Hong Kong, L8 40, 21 Hong Kong
    Endocr Metab Immune Disord Drug Targets 8:89-98. 2008
    ....
  84. doi request reprint Vascular effects of adiponectin: molecular mechanisms and potential therapeutic intervention
    Weidong Zhu
    Department of Medicine, University of Hong Kong, Hong Kong, People s Republic of China
    Clin Sci (Lond) 114:361-74. 2008
    ....
  85. doi request reprint The decrement in circulating endothelial progenitor cells (EPCs) in type 2 diabetes is independent of the severity of the hypoadiponectemia
    Mingfang Li
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Diabetes Metab Res Rev 27:185-94. 2011
    ..Experimental studies suggest a potential link between hypoadiponectinaemia and the depletion of the EPC level. This study investigated the relationships between adiponectin level and EPC in patients with type 2 DM...
  86. doi request reprint PPAR-γ signaling and IL-5 inhibition together prevent chronic rejection of MHC Class II-mismatched cardiac grafts
    Yan Chen
    Division of Pediatric Surgery, Department of Surgery, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, SAR
    J Heart Lung Transplant 30:698-706. 2011
    ....
  87. ncbi request reprint Adiponectin inhibits cell proliferation by interacting with several growth factors in an oligomerization-dependent manner
    Yu Wang
    Genome Research Centre and the Departments of Biochemistry and Medicine, The University of Hong Kong, Hong Kong, China
    J Biol Chem 280:18341-7. 2005
    ....
  88. doi request reprint Adiponectin and adipocyte fatty acid binding protein in the pathogenesis of cardiovascular disease
    Aimin Xu
    Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong
    Am J Physiol Heart Circ Physiol 302:H1231-40. 2012
    ..Indeed, data from both animal studies and clinical investigations imply that these two adipokines are prognostic biomarkers for cardiovascular disease and even promising therapeutic targets for its treatment...
  89. ncbi request reprint Serum adiponectin is reduced in acromegaly and normalized after correction of growth hormone excess
    Karen Siu Ling Lam
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong
    J Clin Endocrinol Metab 89:5448-53. 2004
    ..Hypoadiponectinemia, reversible with GH-lowering therapies, may contribute to the increased insulin resistance and cardiovascular risk in patients with acromegaly...
  90. doi request reprint Post-translational modifications of adiponectin: mechanisms and functional implications
    Yu Wang
    Genome Research Center, University of Hong Kong, Hong Kong, China
    Biochem J 409:623-33. 2008
    ....
  91. ncbi request reprint Serum adiponectin is increased in advancing liver fibrosis and declines with reduction in fibrosis in chronic hepatitis B
    Chee Kin Hui
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China
    J Hepatol 47:191-202. 2007
    ..We studied the role of adiponectin in 2 chronic hepatitis B (CHB)-patient cohorts...
  92. doi request reprint Distinct changes in serum fibroblast growth factor 21 levels in different subtypes of diabetes
    Yang Xiao
    Diabetes Center, Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Key Laboratory of Diabetes Immunology, Ministry of Education, Central South University, Changsha, Hunan 410081, China
    J Clin Endocrinol Metab 97:E54-8. 2012
    ..This study aimed to investigate the association of serum FGF21 levels with type 1 diabetes, latent autoimmune diabetes in adults (LADA) and type 2 diabetes...
  93. doi request reprint Suppression of liver tumor growth and metastasis by adiponectin in nude mice through inhibition of tumor angiogenesis and downregulation of Rho kinase/IFN-inducible protein 10/matrix metalloproteinase 9 signaling
    Kwan Man
    Department of Surgery, The University of Hong Kong, Hong Kong, People s Republic of China
    Clin Cancer Res 16:967-77. 2010
    ..We aimed to investigate the effects of adiponectin on liver cancer growth and metastasis and explore the underlying mechanisms...
  94. ncbi request reprint Adiponectin: protection of the endothelium
    Karen S L Lam
    Department of Medicine and Research Centre of Heart, Brain, Hormone and Healthy Aging, Medical Faculty, University of Hong Kong, 21, Pokfulam, Hong Kong
    Curr Diab Rep 5:254-9. 2005
    ..The various mechanisms through which adiponectin may protect the endothelium, via its insulin-sensitizing, antiatherogenic, anti-inflammatory, and antioxidant properties, are reviewed...
  95. ncbi request reprint Identification and functional characterization of three novel human melanocortin-4 receptor gene variants in an obese Chinese population
    Rong Rong
    Department of Medicine, Li Ka Shing Medical Faculty, The University of Hong Kong, Pokfulam, Hong Kong, China
    Clin Endocrinol (Oxf) 65:198-205. 2006
    ..We studied the frequency of MC4R mutations in an obese southern Chinese population and the functional consequences of the novel variants identified...
  96. doi request reprint C-reactive protein is associated with obstructive sleep apnea independent of visceral obesity
    Macy Mei sze Lui
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong SAR, People s Republic of China
    Chest 135:950-6. 2009
    ..C-reactive protein (CRP) predicts atherosclerotic complications. Our study evaluates whether OSA is associated with an elevated CRP level, after elimination of known confounders including visceral obesity...
  97. pmc The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
    Aimin Xu
    School of Biological Sciences, University of Auckland, Auckland, New Zealand
    J Clin Invest 112:91-100. 2003
    ..These results demonstrate a novel mechanism of adiponectin action and suggest a potential clinical application of adiponectin and its agonists in the treatment of liver diseases...
  98. ncbi request reprint Identification of novel putative membrane proteins selectively expressed during adipose conversion of 3T3-L1 cells
    Aimin Xu
    The School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Biochem Biophys Res Commun 293:1161-7. 2002
    ....
  99. ncbi request reprint Proteomic analysis of adipocyte differentiation: Evidence that alpha2 macroglobulin is involved in the adipose conversion of 3T3 L1 preadipocytes
    Kai Luk Choi
    The School of Biological Sciences, University of Auckland, Auckland, New Zealand
    Proteomics 4:1840-8. 2004
    ....
  100. ncbi request reprint Globular and full-length forms of adiponectin mediate specific changes in glucose and fatty acid uptake and metabolism in cardiomyocytes
    Rengasamy Palanivel
    Department of Biology, York University, Toronto, Ontario, Canada M3J 1P3
    Cardiovasc Res 75:148-57. 2007
    ..Our aim was to investigate the regulation of glucose and fatty acid metabolism in cardiomyocytes by the globular (gAd) and full-length (fAd) forms of adiponectin...
  101. ncbi request reprint Proteomic and functional characterization of endogenous adiponectin purified from fetal bovine serum
    Yu Wang
    Center for Molecular Biodiscovery and School of Biological Sciences, University of Auckland, Auckland, New Zealand
    Proteomics 4:3933-42. 2004
    ..These results provide direct evidence that endogenous bovine adiponectin is a physiological hormone that can regulate lipid and glucose metabolism...