George Sai Wah Tsao

Summary

Affiliation: University of Hong Kong
Country: China

Publications

  1. ncbi request reprint The biology of EBV infection in human epithelial cells
    Sai Wah Tsao
    Department of Anatomy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong, SAR, China
    Semin Cancer Biol 22:137-43. 2012
  2. pmc Efficient immortalization of primary nasopharyngeal epithelial cells for EBV infection study
    Yim Ling Yip
    Cancer Biology Laboratory, Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    PLoS ONE 8:e78395. 2013
  3. pmc Enhanced IL-6/IL-6R signaling promotes growth and malignant properties in EBV-infected premalignant and cancerous nasopharyngeal epithelial cells
    Guitao Zhang
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China
    PLoS ONE 8:e62284. 2013
  4. pmc Epstein-Barr virus-encoded latent membrane protein 1 impairs G2 checkpoint in human nasopharyngeal epithelial cells through defective Chk1 activation
    Wen Deng
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    PLoS ONE 7:e39095. 2012
  5. pmc Toll-like receptor 3 in Epstein-Barr virus-associated nasopharyngeal carcinomas: consistent expression and cytotoxic effects of its synthetic ligand poly(A:U) combined to a Smac-mimetic
    Benjamin Verillaud
    CNRS UMR 8126, Institut de Cancerologie Gustave Roussy, University Paris Sud 11, 39 rue Camille Desmoulins, 94805, Villejuif Cedex, France
    Infect Agent Cancer 7:36. 2012
  6. pmc Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells
    M C W Chan
    Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region of China
    Respir Res 6:135. 2005
  7. pmc Bear bile: dilemma of traditional medicinal use and animal protection
    Yibin Feng
    School of Chinese Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, PR China
    J Ethnobiol Ethnomed 5:2. 2009
  8. pmc MicroRNA let-7 suppresses nasopharyngeal carcinoma cells proliferation through downregulating c-Myc expression
    Thian Sze Wong
    Department of Surgery, Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China
    J Cancer Res Clin Oncol 137:415-22. 2011
  9. pmc Poly(I:C) induces intense expression of c-IAP2 and cooperates with an IAP inhibitor in induction of apoptosis in cancer cells
    Luc Friboulet
    Univ Paris Sud, CNRS UMR 8126 and Institut de Cancérologie Gustave Roussy, 39 rue Camille Desmoulins, F 94805 Villejuif, France
    BMC Cancer 10:327. 2010
  10. ncbi request reprint Establishment of two immortalized nasopharyngeal epithelial cell lines using SV40 large T and HPV16E6/E7 viral oncogenes
    Sai Wah Tsao
    Department of Anatomy, Faculty of Medicine, University of Hong Kong, New Medical Complex, 1st Floor, Laboratory Block, 21 Sassoon Road, Pokfulam, Hong Kong, China
    Biochim Biophys Acta 1590:150-8. 2002

Collaborators

Detail Information

Publications128 found, 100 shown here

  1. ncbi request reprint The biology of EBV infection in human epithelial cells
    Sai Wah Tsao
    Department of Anatomy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong, SAR, China
    Semin Cancer Biol 22:137-43. 2012
    ....
  2. pmc Efficient immortalization of primary nasopharyngeal epithelial cells for EBV infection study
    Yim Ling Yip
    Cancer Biology Laboratory, Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    PLoS ONE 8:e78395. 2013
    ..The establishment of an efficient method to immortalize primary nasopharyngeal epithelial cells will facilitate the investigation into the role of EBV infection in pathogenesis of nasopharyngeal carcinoma. ..
  3. pmc Enhanced IL-6/IL-6R signaling promotes growth and malignant properties in EBV-infected premalignant and cancerous nasopharyngeal epithelial cells
    Guitao Zhang
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China
    PLoS ONE 8:e62284. 2013
    ..Therefore, IL-6R overexpression, coupled with enhanced IL-6/STAT3 signaling may facilitate the malignant transformation of EBV-infected premalignant NPE cells into cancer cells, and enhance malignant properties of NPC cells...
  4. pmc Epstein-Barr virus-encoded latent membrane protein 1 impairs G2 checkpoint in human nasopharyngeal epithelial cells through defective Chk1 activation
    Wen Deng
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    PLoS ONE 7:e39095. 2012
    ..Elucidation of the mechanisms involved in LMP1-induced genomic instability in nasopharyngeal epithelial cells will shed lights on the understanding of role of EBV infection in NPC development...
  5. pmc Toll-like receptor 3 in Epstein-Barr virus-associated nasopharyngeal carcinomas: consistent expression and cytotoxic effects of its synthetic ligand poly(A:U) combined to a Smac-mimetic
    Benjamin Verillaud
    CNRS UMR 8126, Institut de Cancerologie Gustave Roussy, University Paris Sud 11, 39 rue Camille Desmoulins, 94805, Villejuif Cedex, France
    Infect Agent Cancer 7:36. 2012
    ....
  6. pmc Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells
    M C W Chan
    Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region of China
    Respir Res 6:135. 2005
    ..Since respiratory epithelial cells are the primary target cell for replication of influenza viruses, it is pertinent to investigate the cytokine induction profile of H5N1 viruses in these cells...
  7. pmc Bear bile: dilemma of traditional medicinal use and animal protection
    Yibin Feng
    School of Chinese Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, PR China
    J Ethnobiol Ethnomed 5:2. 2009
    ..We then discussed the strategy for stopping the trading of bear bile and issues of bear bile related to potential alternative candidates, existing problems in alternative research and work to be done in the future...
  8. pmc MicroRNA let-7 suppresses nasopharyngeal carcinoma cells proliferation through downregulating c-Myc expression
    Thian Sze Wong
    Department of Surgery, Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China
    J Cancer Res Clin Oncol 137:415-22. 2011
    ..This study aimed at evaluating the potential anti-proliferative effects of the microRNA let-7 family in nasopharyngeal carcinoma (NPC) cells. In addition, the association between let-7 suppression and DNA hypermethylation is examined...
  9. pmc Poly(I:C) induces intense expression of c-IAP2 and cooperates with an IAP inhibitor in induction of apoptosis in cancer cells
    Luc Friboulet
    Univ Paris Sud, CNRS UMR 8126 and Institut de Cancérologie Gustave Roussy, 39 rue Camille Desmoulins, F 94805 Villejuif, France
    BMC Cancer 10:327. 2010
    ....
  10. ncbi request reprint Establishment of two immortalized nasopharyngeal epithelial cell lines using SV40 large T and HPV16E6/E7 viral oncogenes
    Sai Wah Tsao
    Department of Anatomy, Faculty of Medicine, University of Hong Kong, New Medical Complex, 1st Floor, Laboratory Block, 21 Sassoon Road, Pokfulam, Hong Kong, China
    Biochim Biophys Acta 1590:150-8. 2002
    ..The immortalized NP cell lines are non-tumorigenic and exhibit anchorage-dependent growth. These cell lines may provide a possible cell model system for studying the mechanisms involved in the tumorigenesis of NPC...
  11. ncbi request reprint The significance of LMP1 expression in nasopharyngeal carcinoma
    Sai Wah Tsao
    Department of Anatomy, Faculty of Medicine, University of Hong Kong, Hong Kong, PR China
    Semin Cancer Biol 12:473-87. 2002
    ..The frequent expression of LMP1 in undifferentiated nasopharyngeal carcinoma (NPC) points to a role for this viral oncoprotein as a key effector molecule in NPC pathogenesis...
  12. ncbi request reprint The association of E-cadherin expression and the methylation status of the E-cadherin gene in nasopharyngeal carcinoma cells
    S W Tsao
    Department of Anatomy, Faculty of Medicine, University of Hong Kong, Hong Kong, SAR, China
    Eur J Cancer 39:524-31. 2003
    ..Our results also suggest that reducing the methylation of the E-cad gene may be a potential therapeutic strategy for NPC...
  13. ncbi request reprint Immortalization of human prostate epithelial cells by HPV 16 E6/E7 open reading frames
    C K Choo
    Department of Pathology, University of Hong Kong, Hong Kong, China
    Prostate 40:150-8. 1999
    ..Here, we report our work on the immortalization of a human prostate epithelial cell line and show that it can be used as a model to study prostate tumorigenesis...
  14. ncbi request reprint Up-regulation of TRPM-2, MMP-7 and ID-1 during sex hormone-induced prostate carcinogenesis in the Noble rat
    X S Ouyang
    Department of Anatomy, Faculty of Medicine, Li Shu Fan Building, 5 Sassoon Road, University of Hong Kong, Hong Kong, SAR, China
    Carcinogenesis 22:965-73. 2001
    ..Our results provide the first evidence of up-regulation of TRPM-2, MMP-7 and Id-1 during sex hormone-induced prostate carcinogenesis and strongly suggest their association with the development of prostate cancer...
  15. doi request reprint Impact of G₂ checkpoint defect on centromeric instability
    W Deng
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China
    Oncogene 30:1281-9. 2011
    ..As there are multiple pathways leading to G(2) checkpoint defect, our finding offers a broad explanation for the common occurrence of centromeric aberrations in cancer cells...
  16. pmc Caspase activity is downregulated in choriocarcinoma: a cDNA array differential expression study
    P Y Fong
    Department of Pathology, University of Hong Kong, Pokfulam, Queen Mary Hospital, Hong Kong, China
    J Clin Pathol 59:179-83. 2006
    ..Placental trophoblast can be considered to be pseudomalignant tissue and the pathogenesis of gestational trophoblastic diseases remains to be clarified...
  17. ncbi request reprint Id helix-loop-helix proteins are differentially expressed in gestational trophoblastic disease
    W C Xue
    Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
    Histopathology 47:303-9. 2005
    ..To assess the expression of Id proteins in trophoblastic tissues and to correlate this with clinical parameters, proliferative and apoptotic indices as well as to related oncogene expression...
  18. ncbi request reprint Differential gene expression identified in complete hydatidiform mole by combining suppression subtractive hybridization and cDNA microarray
    H C Feng
    Department of Anatomy, The University of Hong Kong, Pokfulam, Queen Mary Hospital, Hong Kong, China
    Placenta 27:521-6. 2006
    ..0001) in 14 genotyped CHM when compared with 15 normal placentas. These candidate genes may contribute toward understanding the mechanism involved with the development and progression of CHM...
  19. pmc Id1 overexpression induces tetraploidization and multiple abnormal mitotic phenotypes by modulating aurora A
    Cornelia Man
    Department of Anatomy, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Mol Biol Cell 19:2389-401. 2008
    ....
  20. doi request reprint Overexpression of prostate stem cell antigen is associated with gestational trophoblastic neoplasia
    H C Feng
    Department of Anatomy, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Histopathology 52:167-74. 2008
    ..A proportion of patients with HM develop gestational trophoblastic neoplasia (GTN) requiring chemotherapy. The aim was to identify differentially expressed genes that are associated with development of GTN...
  21. ncbi request reprint Methylation status and expression of E-cadherin and cadherin-11 in gestational trophoblastic diseases
    W C Xue
    Department of Pathology, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Int J Gynecol Cancer 13:879-88. 2003
    ..Such differential expression was confirmed by western blot and semiquantitative RT-PCR. No obvious association was observed between the development of persistent trophoblastic disease with the expression of E-cadherin and cadherin-11...
  22. ncbi request reprint Epstein-Barr virus latent membrane protein 1 (LMP1) upregulates Id1 expression in nasopharyngeal epithelial cells
    H M Li
    Department of Anatomy, The University of Hong Kong, 21 Sassoon Road, Hong Kong SAR, China
    Oncogene 23:4488-94. 2004
    ..Induction of Id1 by LMP1 may facilitate clonal expansion of premalignant nasopharyngeal epithelial cells infected with EBV and may promote their malignant transformation...
  23. ncbi request reprint Latent membrane protein 1 suppresses RASSF1A expression, disrupts microtubule structures and induces chromosomal aberrations in human epithelial cells
    C Man
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, People s Republic of China
    Oncogene 26:3069-80. 2007
    ..Downregulation of RASSF1A expression by LMP1 may facilitate its role in transformation of premalignant nasopharyngeal epithelial cells into cancer cells...
  24. pmc Effect of all-trans retinoic acid on tissue dynamics of choriocarcinoma cell lines: an organotypic model
    P M Chiu
    Department of Pathology, University of Hong Kong, Hong Kong, China
    J Clin Pathol 59:845-50. 2006
    ..All-trans retinoic acid (ATRA) is a natural vitamin A derivative that has a profound effect on the regulation of cell growth, differentiation and death...
  25. ncbi request reprint E-cadherin expression is commonly downregulated by CpG island hypermethylation in esophageal carcinoma cells
    H X Si
    Department of Anatomy, the University of Hongkong, Li Shu Fan Building, 5 Sassoon Road, Hong Kong SAR, PR China
    Cancer Lett 173:71-8. 2001
    ..Our results indicate that 5' CpG island methylation is common in esophageal carcinoma and may play an important role in downregulation of E-cadherin...
  26. ncbi request reprint Nonrandom chromosomal imbalances in human ovarian surface epithelial cells immortalized by HPV16-E6E7 viral oncogenes
    S W Tsao
    Department of Anatomy, Faculty of Medicine, University of Hong Kong, SAR, Hong Kong, China
    Cancer Genet Cytogenet 130:141-9. 2001
    ..Identification of nonrandom chromosomal imbalance in immortalized HOSE cells may facilitate the identification of specific chromosomes harboring genes involved in the immortalization of human ovarian surface epithelial cells...
  27. ncbi request reprint Down-regulation of Id-1 expression is associated with TGF beta 1-induced growth arrest in prostate epithelial cells
    M T Ling
    Department of Anatomy, Faculty of Medicine, 5 F, Li Shu Fan Building, 5 Sassoon Road, University of Hong Kong, Hong Kong, SAR, China
    Biochim Biophys Acta 1570:145-52. 2002
    ..Our results provide evidence for the first time that TGF beta 1 may be one of the upstream regulators of Id-1...
  28. ncbi request reprint Mechanism of differential sensitivity to cisplatin in nasopharyngeal carcinoma cells
    X Wang
    Department of Anatomy, Faculty of Medicine, University of Hong Kong, Pok Fu Lam Road, Hong Kong
    Anticancer Res 21:403-8. 2001
    ..Our results suggest that upregulation of Bax is associated with the sensitivity of these NPC cells to cisplatin...
  29. pmc LMP1 of Epstein-Barr virus induces proliferation of primary mouse embryonic fibroblasts and cooperatively transforms the cells with a p16-insensitive CDK4 oncogene
    X Yang
    Department of Microbiology, The University of Hong Kong, Hong Kong, People s Republic of China
    J Virol 74:883-91. 2000
    ..Our results provide the first evidence of the abilities of the LMP1 gene, acting alone, to effectively induce the proliferation of primary MEF cells and of its cooperativity with another cellular oncogene in transforming primary cells...
  30. ncbi request reprint Regulation of p63 expression in primary and immortalized nasopharyngeal epithelial cells
    Y L Yip
    Cancer Biology Laboratory, Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, P R China
    Int J Oncol 33:713-24. 2008
    ....
  31. ncbi request reprint Identification of downstream target genes of latent membrane protein 1 in nasopharyngeal carcinoma cells by suppression subtractive hybridization
    A Kwok Fung Lo
    Department of Anatomy, Faculty of Medicine, University of Hong Kong, PR China
    Biochim Biophys Acta 1520:131-40. 2001
    ..The expression profiles of differentially expressed genes identified in this study suggest a role of LMP1 in promotion of cell survival and facilitation of tumor invasion...
  32. doi request reprint Anti-angiogenic and tumor-suppressive roles of candidate tumor-suppressor gene, Fibulin-2, in nasopharyngeal carcinoma
    E W L Law
    Department of Clinical Oncology and Center for Cancer Research, University of Hong Kong, Pokfulam, Hong Kong SAR, PR China
    Oncogene 31:728-38. 2012
    ..This study provides compelling evidence that FBLN2S has an important tumor-suppressive and anti-angiogenic role in NPC...
  33. ncbi request reprint Sex hormone-induced mammary carcinogenesis in female Noble rats: detection of differentially expressed genes
    G Leung
    Department of Anatomy, Faculty of Medicine, University of Hong Kong, New Medical Complex, Pokfulam, Hong Kong, China
    Breast Cancer Res Treat 77:49-63. 2003
    ..The result of the present study provides some information on the molecular basis of this sex hormone-induced mammary carcinogenesis and the role of these proteins in tumor progression...
  34. ncbi request reprint Evidence of increased Id-1 expression and its role in cell proliferation in nasopharyngeal carcinoma cells
    Xianghong Wang
    Department of Anatomy, Faculty of Medicine, University of Hong Kong, Hong Kong, SAR, China
    Mol Carcinog 35:42-9. 2002
    ....
  35. ncbi request reprint Alterations of biologic properties and gene expression in nasopharyngeal epithelial cells by the Epstein-Barr virus-encoded latent membrane protein 1
    Angela Kwok Fung Lo
    Department of Anatomy, The University of Hong Kong, Hong Kong SAR, China
    Lab Invest 83:697-709. 2003
    ..The present study also indicates the activation of the Ras/MAPK pathway in LMP1-expressing cells, which may be involved in mediating some of the transforming effects of LMP1 observed in nasopharyngeal epithelial cells...
  36. pmc Id-I stimulates cell proliferation through activation of EGFR in ovarian cancer cells
    X Zhang
    Cancer Biology Group, Department of Anatomy, The University of Hong Kong, 1 F, Faculty of Medicine Building, 21 Sassoon Road, Hong Kong
    Br J Cancer 91:2042-7. 2004
    ..Our findings also implicate that Id-1 may be a potential target for the development of novel strategies in the treatment of ovarian cancer...
  37. ncbi request reprint Molecular and cytogenetic changes involved in the immortalization of nasopharyngeal epithelial cells by telomerase
    H M Li
    Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Int J Cancer 119:1567-76. 2006
    ....
  38. ncbi request reprint Microtubule breakage is not a major mechanism for resolving end-to-end chromosome fusions generated by telomere dysfunction during the early process of immortalization
    W Deng
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China
    Chromosoma 116:557-68. 2007
    ..An important implication of this finding is that microtubule-kinetochore attachment is stronger than the chromosome structure...
  39. pmc Telomerase activation in nasopharyngeal carcinomas
    R Y Cheng
    Department of Anatomy, Faculty of Medicine, University of Hong Kong, Pokfulam
    Br J Cancer 77:456-60. 1998
    ..The high frequency of telomerase activation in stage I NPC (80% positive) suggests that it is an early event in tumour progression...
  40. ncbi request reprint Effect of p53 on centrosome amplification in prostate cancer cells
    X Ouyang
    Department od Anatomy, Faculty of Medicine, University of Hong Kong, SAR, PR China
    Biochim Biophys Acta 1541:212-20. 2001
    ..Our results indicate that p53 may play a role in the regulation of centrosome amplification and loss of p53 may be one of the mechanisms involving CIN in prostate cancer cells...
  41. ncbi request reprint Amplification and overexpression of aurora kinase A (AURKA) in immortalized human ovarian epithelial (HOSE) cells
    C M Chung
    Cancer Biology Laboratory, Department of Anatomy, Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Mol Carcinog 43:165-74. 2005
    ..Our study showed that amplification and overexpression of AURKA is a common and significant event during immortalization of HOSE cells and may represent an important premalignant change in ovarian carcinogenesis...
  42. doi request reprint Id-1 induces cell invasiveness in immortalized epithelial cells by regulating cadherin switching and Rho GTPases
    P Y Cheung
    Department of Anatomy, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    J Cell Biochem 112:157-68. 2011
    ..These data suggest that the Id-1-induced invasive potential may be regulated through the N-cadherin-RhoA axis and Rac1 activation...
  43. doi request reprint Regulation of RASSF1A in nasopharyngeal cells and its response to UV irradiation
    Vien H Y Lee
    School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, China
    Gene 443:55-63. 2009
    ..In summary, our data provided a simple model to explain the potential development of NPC, via silencing of the tumor suppressor RASSF1A by reduced bindings of activators Sp1 and Sp3 onto the GC-boxes in the core promoter of the gene...
  44. ncbi request reprint Latent membrane protein-1 of Epstein-Barr virus inhibits cell growth and induces sensitivity to cisplatin in nasopharyngeal carcinoma cells
    Yu Liu
    Department of Anatomy, Faculty of Medicine, University of Hong Kong, Hong Kong, People s Republic of China
    J Med Virol 66:63-9. 2002
    ..Alternatively, LMP1 alone may not be sufficient to facilitate nasopharyngeal carcinoma cell growth and additional oncogenic factors may be needed along with LMP1 in modulating the malignant property of nasopharyngeal carcinoma...
  45. ncbi request reprint Papillomavirus type 16 E6/E7 and human telomerase reverse transcriptase in esophageal cell immortalization and early transformation
    Hao Zhang
    Department of Medicine, University of Hong Kong, Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Cancer Lett 245:184-94. 2007
    ..In addition to supporting the role of HPV and telomerase in esophageal carcinogenesis, our cell lines may also be useful in vitro models for further studies of esophageal carcinogenesis...
  46. ncbi request reprint Establishment and characterization of a human non-small cell lung cancer cell line
    Amy Lai Shan Tai
    Department of Clinical Oncology, Faculty of Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, P R China
    Oncol Rep 13:1029-32. 2005
    ..This cell line may thus provide a useful cellular resource for studying the pathogenesis of SCC of the lung in the future...
  47. doi request reprint Preclinical evaluation of the AKT inhibitor MK-2206 in nasopharyngeal carcinoma cell lines
    Brigette B Y Ma
    State Key Laboratory in Oncology in South China, Sir Y K Pao Centre for Cancer, Department of Clinical Oncology, Cancer Drug Testing Unit, Hong Kong Cancer Institute, Chinese University of Hong Kong, Shatin, Hong Kong, China
    Invest New Drugs 31:567-75. 2013
    ..In summary, MK-2206 can inhibit growth and abrogate AKT and mTOR signaling in NPC cell lines. This agent is currently being evaluated in a phase II study in metastatic NPC...
  48. ncbi request reprint Anti-apoptotic role of BARF1 in gastric cancer cells
    Qi Wang
    Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Laboratory Block, 1 F, 21 Sassoon Road, Hong Kong, SAR, China
    Cancer Lett 238:90-103. 2006
    ..Our results suggest that BARF1 expression in gastric cancer cells may provide a protective role against apoptosis through an increased Bcl-2 to Bax ratio, thus promoting cancer cell survival...
  49. ncbi request reprint No effect of a high-fat diet on promotion of sex hormone-induced prostate and mammary carcinogenesis in the Noble rat model
    G Leung
    Department of Anatomy, Faculty of Medicine, University of Hong Kong, Hong Kong
    Br J Nutr 88:399-409. 2002
    ....
  50. ncbi request reprint Utility of Epstein-Barr virus-encoded small RNA promoters for driving the expression of fusion transcripts harboring short hairpin RNAs
    E Y W Choy
    Department of Biochemistry, Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Gene Ther 15:191-202. 2008
    ....
  51. pmc Identification of a novel tumor transforming gene GAEC1 at 7q22 which encodes a nuclear protein and is frequently amplified and overexpressed in esophageal squamous cell carcinoma
    F B F Law
    Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Oncogene 26:5877-88. 2007
    ....
  52. pmc Co-expression of vascular endothelial growth factor (VEGF) and its receptors (flk-1 and flt-1) in hormone-induced mammary cancer in the Noble rat
    B Xie
    Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong
    Br J Cancer 81:1335-43. 1999
    ..The present study is the first report showing that VEGF may act as a growth stimulator for mammary cancer cells...
  53. ncbi request reprint Establishment and characterization of an immortalized human oviductal cell line
    Y L Lee
    Department of Obstetrics and Gynaecology, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Mol Reprod Dev 59:400-9. 2001
    ..0 +/- 2.07 microm vs. 83.9 +/- 5.23 microm). This immortalized cell line can be used as a continuous and stable in vitro system for the study of the oviductal embryotrophic activity. Mol. Reprod. Dev. 59: 400-409, 2001...
  54. ncbi request reprint Id-1 stimulates serum independent prostate cancer cell proliferation through inactivation of p16(INK4a)/pRB pathway
    Xue Song Ouyang
    Department of Anatomy, Faculty of Medicine, 5 F, Li Shu Fan Building, 5 Sassoon Road, University of Hong Kong, Hong Kong, SAR, China
    Carcinogenesis 23:721-5. 2002
    ..Given the fact that both Id-1 over-expression and inactivation of p16(INK4a)/pRB are common events in prostate cancer, our results provide a possible mechanism on the molecular basis of prostate carcinogenesis...
  55. ncbi request reprint Id-1 expression promotes cell survival through activation of NF-kappaB signalling pathway in prostate cancer cells
    Ming Tat Ling
    Cancer Biology Group, Department of Anatomy, Laboratory Block, Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, SAR, China
    Oncogene 22:4498-508. 2003
    ..Our findings also suggest a potential therapeutic strategy in which inactivation of Id-1 may lead to sensitization of prostate cancer cells to chemotherapeutic drug-induced apoptosis...
  56. ncbi request reprint Abnormal expression or mutation of TP53 and HPV in vulvar cancer
    H Y Ngan
    Department of Obstetrics and Gynaecology, University of Hong Kong
    Eur J Cancer 35:481-4. 1999
    ..Age was not found to be associated with HPV detection. However, the presence of HPV (71%) or absence of abnormal p53 expression (65%) were higher in tumours with VIN3, but were not correlated with dystrophy...
  57. ncbi request reprint Prevalence and predictive value of p53 mutation in patients with oesophageal squamous cell carcinomas: a prospective clinico-pathological study and survival analysis of 70 patients
    K Y Lam
    Department of Pathology, University of Hong Kong
    Int J Cancer 74:212-9. 1997
    ..p53 mutations also appear to play a role in predicting the survival of patients with stage III oesophageal squamous cell carcinomas...
  58. ncbi request reprint Id-1-induced Raf/MEK pathway activation is essential for its protective role against taxol-induced apoptosis in nasopharyngeal carcinoma cells
    Hiu Wing Cheung
    Cancer Biology Group, Department of Anatomy, The University of Hong Kong, Hong Kong
    Carcinogenesis 25:881-7. 2004
    ..Our evidence also indicates a novel treatment strategy to increase anticancer drug-induced apoptosis through inactivation of the Id-1 protein...
  59. ncbi request reprint Id-1 expression induces androgen-independent prostate cancer cell growth through activation of epidermal growth factor receptor (EGF-R)
    Ming Tat Ling
    Cancer Biology Group, Department of Anatomy, Central Laboratory of Institute of Molecular Technology for Drug Discovery and Synthesis, University of Hong Kong, 21 Sassoon Road, Hong Kong, SAR, China
    Carcinogenesis 25:517-25. 2004
    ..Inactivation of Id-1 may provide a potential therapeutic strategy leading to inhibition of androgen-independent prostate cancer cell growth...
  60. ncbi request reprint Telomerase assay and HPV 16/18 typing as adjunct to conventional cytological cervical cancer screening
    Hextan Y S Ngan
    Department of Obstetrics and Gynaecology, Queen Mary Hospital, University of Hong Kong, Hong Kong, China
    Tumour Biol 23:87-92. 2002
    ..This study aims at exploring the potential use of telomerase activity assay and typing of human papillomaviruses (HPV) 16 and 18 in improving the identification of high-grade cervical intraepithelial neoplasia (CIN)...
  61. doi request reprint Genetic alterations in a telomerase-immortalized human esophageal epithelial cell line: implications for carcinogenesis
    Pak Yan Cheung
    Cancer Biology Group, Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Cancer Lett 293:41-51. 2010
    ..Our data also revealed a novel positive regulation of p16(INK4a) on cyclin D1. These findings probably represent early crucial events and mechanisms in esophageal carcinogenesis...
  62. ncbi request reprint Id-1 modulates senescence and TGF-beta1 sensitivity in prostate epithelial cells
    Kaijun Di
    Cancer Biology Group, Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People s Republic of China
    Biol Cell 98:523-33. 2006
    ..Here, we investigated the role of Id-1 in cellular sensitivity to TGF-beta1...
  63. ncbi request reprint MAD2-induced sensitization to vincristine is associated with mitotic arrest and Raf/Bcl-2 phosphorylation in nasopharyngeal carcinoma cells
    Xianghong Wang
    Department of Anatomy, Faculty of Medicine, Hong Kong
    Oncogene 22:109-16. 2003
    ..Our data suggest a role for MAD2 in the sensitization of cancer cells to certain mitotic checkpoint-targeting anticancer drugs...
  64. doi request reprint Expression of Epstein-Barr virus-encoded LMP1 and hTERT extends the life span and immortalizes primary cultures of nasopharyngeal epithelial cells
    Yim Ling Yip
    Cancer Biology Laboratory, Li Ka Shing Faculty of Medicine, Department of Anatomy, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    J Med Virol 82:1711-23. 2010
    ....
  65. ncbi request reprint Significance of scheduling on the cytotoxicity of radiation and cisplatin combination treatment in nasopharyngeal carcinoma cells
    Xianghong Wang
    Department of Anatomy, University of Hong Kong, SAR, China
    Anticancer Drugs 13:957-64. 2002
    ..The differential cytotoxicity was partially explained by the alterations in cell cycle distribution. Our results indicate the importance of scheduling the radiation and cisplatin combination regimens on the survival of NPC cells...
  66. ncbi request reprint Identification of a novel function of TWIST, a bHLH protein, in the development of acquired taxol resistance in human cancer cells
    Xianghong Wang
    Cancer Biology Group, Department of Anatomy, Faculty of Medicine, University of Hong Kong, Hong Kong
    Oncogene 23:474-82. 2004
    ..Our evidence provides a therapeutic strategy to overcome acquired resistance through inactivation of TWIST expression in human cancer...
  67. ncbi request reprint Induction of senescent-like growth arrest as a new target in anticancer treatment
    Xianghong Wang
    Cancer Biology Laboratory, Department of Anatomy, Faculty of Medicine, University of Hong Kong, 21 Sassoon Road, Hong Kong, China
    Curr Cancer Drug Targets 3:153-9. 2003
    ..In addition, the possible factors and mechanisms involved in this process are also discussed. Finally, the implications on how senescent-like growth arrest might be exploited as a possible new target for anti-cancer drugs are addressed...
  68. ncbi request reprint Metastatic trophoblastic disease after an initial diagnosis of partial hydatidiform mole: genotyping and chromosome in situ hybridization analysis
    Annie N Y Cheung
    Department of Pathology, The University of Hong Kong, Hong Kong, China
    Cancer 100:1411-7. 2004
    ..Traditionally, it is believed that PHM carries a better prognosis and rarely develops metastasis. However, making a distinction between PHM and CHM using histologic criteria alone may be difficult...
  69. pmc A novel Hsp90 inhibitor AT13387 induces senescence in EBV-positive nasopharyngeal carcinoma cells and suppresses tumor formation
    King Chi Chan
    Department of Biology, Hong Kong Baptist University, Hong Kong, P, R, China
    Mol Cancer 12:128. 2013
    ..This study aimed to evaluate both the in vitro and in vivo antitumor effects of AT13387 in the EBV-positive NPC cell line C666-1...
  70. pmc Inhibition of c-Met downregulates TIGAR expression and reduces NADPH production leading to cell death
    V W Y Lui
    Cancer Signaling Laboratory, Department of Clinical Oncology, State Key Laboratory of Oncology in South China, Sir YK Pao Center for Cancer, Chinese University of Hong Kong, Hong Kong, China
    Oncogene 30:1127-34. 2011
    ..Our data provide the first evidence linking c-Met, TIGAR and NADPH regulation in human cancer cells suggesting that inhibition of a tyrosine kinase/TIGAR/NADPH cascade may have therapeutic applicability in human cancers...
  71. ncbi request reprint Identification of a tumor suppressive critical region mapping to 3p14.2 in esophageal squamous cell carcinoma and studies of a candidate tumor suppressor gene, ADAMTS9
    P H Y Lo
    Department of Biology and Center for Cancer Research, Hong Kong University of Science and Technology, Hong Kong, China
    Oncogene 26:148-57. 2007
    ..Thus, this study identifies and provides functional evidence for a CR associated with tumor suppression on 3p14.2 and provides the first evidence that ADAMTS9, mapping to this region, may contribute to esophageal cancer development...
  72. ncbi request reprint Human papillomavirus infection and loss of heterozygosity in esophageal squamous cell carcinoma
    Hua Xin Si
    Department of Anatomy, The University of Hong Kong, 21 Sassoon Road, Pokfulam Hong Kong SAR, China
    Cancer Lett 213:231-9. 2004
    ..Our results suggest that different genetic pathways of carcinogenesis may be associated with geographic differences in risk factors...
  73. ncbi request reprint Stable expression of EBERs in immortalized nasopharyngeal epithelial cells confers resistance to apoptotic stress
    Hing Lok Wong
    Cancer Biology Laboratory, Department of Anatomy, Faculty of Medicine, University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China
    Mol Carcinog 44:92-101. 2005
    ..Our results suggest that EBER expression may confer an apoptotic-resistant phenotype in immortalized nasopharyngeal epithelial cells...
  74. ncbi request reprint Id-1 activation of PI3K/Akt/NFkappaB signaling pathway and its significance in promoting survival of esophageal cancer cells
    Bin Li
    Cancer Biology Group, Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, SAR, China
    Carcinogenesis 28:2313-20. 2007
    ..Inactivation of Id-1 may provide us with a novel strategy to improve the treatment and survival of patients with esophageal cancer...
  75. ncbi request reprint Sequential cytogenetic and molecular cytogenetic characterization of an SV40T-immortalized nasopharyngeal cell line transformed by Epstein-Barr virus latent membrane protein-1 gene
    Hao Zhang
    Department of Anatomy, Faculty of Medicine, University of Hong Kong, 21, Sassoon Road, Hong Kong, China
    Cancer Genet Cytogenet 150:144-52. 2004
    ..Our observations suggest that serial transformation of NP cell lines might provide a useful in vitro model for the study of the multistep neoplastic transformation of NP cells...
  76. ncbi request reprint Mitotic arrest deficient 2 expression induces chemosensitization to a DNA-damaging agent, cisplatin, in nasopharyngeal carcinoma cells
    Hiu Wing Cheung
    Department of Anatomy, Faculty of Medicine, University of Hong Kong, Hong Kong, China
    Cancer Res 65:1450-8. 2005
    ..Our evidence further confirms the previous hypothesis that spindle checkpoint plays an important part in DNA damage-induced cell cycle arrest and suggests a novel role of MAD2 in cellular sensitivity to cisplatin...
  77. ncbi request reprint Physical status of HPV-16 in esophageal squamous cell carcinoma
    Hua Xin Si
    Department of Anatomy, The University of Hong Kong, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong SAR, PR China
    J Clin Virol 32:19-23. 2005
    ..Integration of viral DNA into host genome is essential for carcinogenesis since it promotes disruption of the HPV E2 gene, leading to abnormal expression of E6 and E7 oncoproteins...
  78. ncbi request reprint Cytogenetic and molecular genetic characterization of immortalized human ovarian surface epithelial cell lines: consistent loss of chromosome 13 and amplification of chromosome 20
    Yuesheng Jin
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China
    Gynecol Oncol 92:183-91. 2004
    ..This study aimed at identifying the genetic events involved in immortalization of ovarian epithelial cells, which might be important steps in ovarian carcinogenesis...
  79. doi request reprint Epstein-Barr virus infection in immortalized nasopharyngeal epithelial cells: regulation of infection and phenotypic characterization
    Chi Man Tsang
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    Int J Cancer 127:1570-83. 2010
    ..The establishment of a stable EBV infection model of premalignant nasopharyngeal epithelial cells will facilitate research investigation into the pathogenic role of EBV in NPC development...
  80. ncbi request reprint Molecular cloning and characterization of the zebrafish (Danio rerio) telomerase catalytic subunit (telomerase reverse transcriptase, TERT)
    Benson Wui Man Lau
    Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    J Mol Neurosci 34:63-75. 2008
    ..The expression of telomerase activity and TERT in retina implies that telomerase has functions other than the elongation of telomere. These findings could provide new insights on telomerase function in the nervous system...
  81. ncbi request reprint Expression of e-cadherin and beta-catenin in trophoblastic tissue in normal and pathological pregnancies
    H W Li
    Department of Anatomy, The University of Hong Kong, Pokulam, Hong Kong SAR, China
    Int J Gynecol Pathol 22:63-70. 2003
    ..Altered expression of E-cadherin and beta-catenin may play a role in the development of normal and pathological placentas...
  82. ncbi request reprint Minichromosome maintenance protein 7 expression in gestational trophoblastic disease: correlation with Ki67, PCNA and clinicopathological parameters
    W C Xue
    Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
    Histopathology 43:485-90. 2003
    ..To assess the proliferative activity of gestational trophoblastic disease (GTD) using one of the novel proliferation markers (MCM7) and to determine its prognostic value in hydatidiform mole (HM)...
  83. ncbi request reprint Berberine inhibits Rho GTPases and cell migration at low doses but induces G2 arrest and apoptosis at high doses in human cancer cells
    Chi Man Tsang
    Department of Anatomy, The University of Hong Kong, Pokfulam, Hong Kong, SAR, PR China
    Int J Mol Med 24:131-8. 2009
    ..The potential of berberine to inhibit cancer metastasis in cancer warrants further investigation...
  84. ncbi request reprint Establishment and characterization of a human first-trimester extravillous trophoblast cell line (TEV-1)
    Hui Chen Feng
    Department of Anatomy, The University of Hong Kong, Hong Kong, China
    J Soc Gynecol Investig 12:e21-32. 2005
    ..Research into the biology of human trophoblast invasion has been hampered by a lack of in vitro models. The aim of this study was to establish and characterize a human extravillous trophoblast cell line from the first-trimester placenta...
  85. doi request reprint Id-1 promotes tumorigenicity and metastasis of human esophageal cancer cells through activation of PI3K/AKT signaling pathway
    Bin Li
    Cancer Biology Group, Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Int J Cancer 125:2576-85. 2009
    ..In conclusion, our results provide the first evidence that Id-1 promotes tumorigenicity and metastasis of human esophageal cancer in vivo and that the PI3K inhibitor LY294002 can attenuate these effects...
  86. doi request reprint Functional characterization of THY1 as a tumor suppressor gene with antiinvasive activity in nasopharyngeal carcinoma
    Hong Lok Lung
    Department of Clinical Oncology, University of Hong Kong, Hong Kong, People s Republic of China
    Int J Cancer 127:304-12. 2010
    ..These findings suggest that THY1 is a TSG in NPC, which is involved in invasion and shows an association with tumor metastasis. Taken together, THY1 clearly plays an important functional role in tumor suppression in NPC...
  87. ncbi request reprint Id-1 promotes proliferation of p53-deficient esophageal cancer cells
    Cheuk Man Hui
    Cancer Biology Group, Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People s Republic of China
    Int J Cancer 119:508-14. 2006
    ....
  88. ncbi request reprint Epigenetic inactivation of CHFR in nasopharyngeal carcinoma through promoter methylation
    Hiu Wing Cheung
    Cancer Biology Group, Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong
    Mol Carcinog 43:237-45. 2005
    ..1% (22 out of 36) of primary NPC tumors while it was absent in non-malignant tissues. These findings suggest that downregulation of CHFR is a common event in NPC cells which may be due to hypermethylation of the gene promoter region...
  89. ncbi request reprint Characterization of a novel tumor-suppressor gene PLC delta 1 at 3p22 in esophageal squamous cell carcinoma
    Li Fu
    Department of Clinical Oncology, The University of Hong Kong, Pokfulam, Hong Kong, China
    Cancer Res 67:10720-6. 2007
    ..014), which was associated with its function in increasing cell adhesion and inhibiting cell mobility. Taken together, our results suggest that PLC delta 1 plays an important suppressive role in the development and progression of ESCC...
  90. ncbi request reprint Down-regulation and promoter methylation of tissue inhibitor of metalloproteinase 3 in choriocarcinoma
    Huichen Feng
    Department of Anatomy, The University of Hong Kong, 21 Sassoon Road, Hong Kong, China
    Gynecol Oncol 94:375-82. 2004
    ..To assess the differential gene expression in neoplastic and normal trophoblastic cells and evaluate the effect of methylation on tissue inhibitor of metalloproteinase 3 (TIMP3) expression in choriocarcinoma (CCA) cells...
  91. ncbi request reprint Viral load of HPV in esophageal squamous cell carcinoma
    Hua Xin Si
    Department of Anatomy, University of Hong Kong, Faculty of Medicine Building, 21 Sassoon Road, Hong Kong SAR, People s Republic of China
    Int J Cancer 103:496-500. 2003
    ..However, with the consistent detection of oncogenic HPVs in ESCC from some regions of China, the possibility of HPV infection being one of the multiple risk factors of ESCC in some geographic areas cannot be excluded...
  92. ncbi request reprint Curcumin alters the migratory phenotype of nasopharyngeal carcinoma cells through up-regulation of E-cadherin
    Thian Sze Wong
    Department of Surgery, University of Hong Kong Medical Center, Faculty of Medicine, The University of Hong Kong, China
    Anticancer Res 30:2851-6. 2010
    ..We hypothesized that suppressing NF-kappaB by curcumin could up-regulate E-cadherin expression in NPC cells...
  93. doi request reprint An RNA-directed nucleoside anti-metabolite, 1-(3-C-ethynyl-beta-d-ribo-pentofuranosyl)cytosine (ECyd), elicits antitumor effect via TP53-induced Glycolysis and Apoptosis Regulator (TIGAR) downregulation
    Vivian Wai Yan Lui
    Cancer Drug Testing Unit, State Key Laboratory in Oncology in Southern China, Sir Y K Pao Center for Cancer, Department of Clinical Oncology, Hong Kong Cancer Institute and Li Ka Shing Institute for Health Sciences, Chinese University of Hong Kong, Shatin, N T, Hong Kong, China
    Biochem Pharmacol 79:1772-80. 2010
    ..We demonstrated for the first time that an RNA-directed nucleoside analog, ECyd, exerts its antitumor activity via downregulation of a novel regulator of apoptosis, TIGAR. Moreover, ECyd may represent a novel therapy for NPC...
  94. pmc Effect of a qigong intervention program on telomerase activity and psychological stress in abused Chinese women: a randomized, wait-list controlled trial
    Agnes Tiwari
    School of Nursing, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 4 F, William M, W, Mong Block, 21 Sassoon Road, Pokfulam, Hong Kong
    BMC Complement Altern Med 14:300. 2014
    ....
  95. doi request reprint Chromodomain helicase/adenosine triphosphatase DNA binding protein 1-like (CHD1l) gene suppresses the nucleus-to-mitochondria translocation of nur77 to sustain hepatocellular carcinoma cell survival
    LeiLei Chen
    Department of Clinical Oncology, The University of Hong Kong, Pokfulam, Hong Kong, China
    Hepatology 50:122-9. 2009
    ..More importantly, we found that the inhibition of Nur77-mediated apoptosis by endogenous CHD1L is a critical biological cellular process in hepatocarcinogenesis...
  96. ncbi request reprint Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract
    J M Nicholls
    Department of Pathology, University of Hong Kong, Pok Fu Lam Road, Hong Kong SAR, China
    Nat Med 13:147-9. 2007
    ..We now demonstrate that ex vivo cultures of human nasopharyngeal, adenoid and tonsillar tissues can be infected with H5N1 viruses in spite of an apparent lack of these receptors...
  97. ncbi request reprint Over expression of ID-1 in prostate cancer
    X S Ouyang
    Cancer Biology Lab, Department of Anatomy, Faculty of Medicine, University of Hong Kong, Hong Kong, SAR, China
    J Urol 167:2598-602. 2002
    ..To test this hypothesis we analyzed Id-1 messenger RNA and protein expression by in situ hybridization and immunohistochemical study in human normal prostate, benign prostatic hyperplasia (BPH) and prostate cancer tissues...
  98. ncbi request reprint The effect of flutamide and tamoxifen on sex hormone-induced mammary carcinogenesis and pituitary adenoma
    G Leung
    Department of Anatomy, Faculty of Medicine, University of Hong Kong, China
    Breast Cancer Res Treat 72:153-62. 2002
    ..The animal model, in addition to mammary carcinogenesis, may be useful for investigation of anti-estrogen therapy in pituitary adenomas...
  99. doi request reprint Bauhinia variegata var. variegata trypsin inhibitor: from isolation to potential medicinal applications
    Evandro Fei Fang
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    Biochem Biophys Res Commun 396:806-11. 2010
    ..This may partially be contributed by its induction of cytokines and apoptotic bodies. These results unveil potential medicinal applications of BvvTI...
  100. doi request reprint Transforming growth factor beta1 promotes chromosomal instability in human papillomavirus 16 E6E7-infected cervical epithelial cells
    Wen Deng
    Department of Anatomy, The University of Hong Kong, Hong Kong, SAR, China
    Cancer Res 68:7200-9. 2008
    ..These results together suggest an important role of TGF-beta1 in the early process of cervical carcinogenesis...
  101. ncbi request reprint S-allylcysteine, a water-soluble garlic derivative, suppresses the growth of a human androgen-independent prostate cancer xenograft, CWR22R, under in vivo conditions
    Qingjun Chu
    Cancer Biology Group, Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
    BJU Int 99:925-32. 2007
    ....