S L Ho

Summary

Affiliation: University of Hong Kong
Country: China

Publications

  1. pmc Mitochondrial uncoupling protein-2 (UCP2) mediates leptin protection against MPP+ toxicity in neuronal cells
    Philip Wing Lok Ho
    Division of Neurology, University Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, People s Republic of China
    Neurotox Res 17:332-43. 2010
  2. ncbi request reprint Cytochrome P4502D6 (debrisoquine 4-hydroxylase) and Parkinson's disease in Chinese and Caucasians
    S L Ho
    Division of Neurology, University Department of Medicine, University of Hong Kong, Hong Kong
    Eur J Neurol 6:323-9. 1999
  3. ncbi request reprint Estrogenic phenol and catechol metabolites of PCBs modulate catechol-O-methyltransferase expression via the estrogen receptor: potential contribution to cancer risk
    P W L Ho
    Division of Neurology, University Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Curr Drug Metab 9:304-9. 2008
  4. doi request reprint Neuromyelitis optica-IgG in idiopathic inflammatory demyelinating disorders amongst Hong Kong Chinese
    K H Chan
    University Department of Medicine, Research Center for Heart, Brain, Hormone and Healthy Aging, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Eur J Neurol 16:310-6. 2009
  5. doi request reprint Aquaporin-4 water channel expression by thymoma of patients with and without myasthenia gravis
    K H Chan
    University Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong
    J Neuroimmunol 227:178-84. 2010
  6. ncbi request reprint Oral perception and oral motor ability in edentulous patients with stroke and Parkinson's disease
    K C M Leung
    Oral Rehabilitation, Faculty of Dentistry, University of Hong Kong, Hong Kong
    J Oral Rehabil 29:497-503. 2002
  7. ncbi request reprint Effects of plasticisers and related compounds on the expression of the soluble form of catechol-O-methyltransferase in MCF-7 cells
    P W L Ho
    Division of Neurology, University Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Curr Drug Metab 9:276-9. 2008
  8. ncbi request reprint Nonthymoma early-onset- and late-onset-generalized myasthenia gravis--a retrospective hospital-based study
    K H Chan
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
    Clin Neurol Neurosurg 109:686-91. 2007
  9. ncbi request reprint Idiopathic inflammatory demyelinating disorders after acute transverse myelitis
    K H Chan
    Division of Neurology, University Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
    Eur J Neurol 13:862-8. 2006
  10. ncbi request reprint Myopia as a latent phenotype of a pleiotropic gene positively selected for facilitating neurocognitive development, and the effects of environmental factors in its expression
    W Mak
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, PR China
    Med Hypotheses 66:1209-15. 2006

Collaborators

Detail Information

Publications27

  1. pmc Mitochondrial uncoupling protein-2 (UCP2) mediates leptin protection against MPP+ toxicity in neuronal cells
    Philip Wing Lok Ho
    Division of Neurology, University Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, People s Republic of China
    Neurotox Res 17:332-43. 2010
    ..Interestingly, UCP2 knockdown increased UCP4 expression, but not of UCP5. Our findings show that leptin preserves cell survival by maintaining MMP and ATP levels mediated through UCP2 in MPP+-induced toxicity...
  2. ncbi request reprint Cytochrome P4502D6 (debrisoquine 4-hydroxylase) and Parkinson's disease in Chinese and Caucasians
    S L Ho
    Division of Neurology, University Department of Medicine, University of Hong Kong, Hong Kong
    Eur J Neurol 6:323-9. 1999
    ..All 69 of the sub-group of Chinese patients tested were homozygous for the wild-type allele at the G/A1934 polymorphic site. Neither the CYP2D6 allele nor haplotype was associated with PD in either ethnic group...
  3. ncbi request reprint Estrogenic phenol and catechol metabolites of PCBs modulate catechol-O-methyltransferase expression via the estrogen receptor: potential contribution to cancer risk
    P W L Ho
    Division of Neurology, University Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Curr Drug Metab 9:304-9. 2008
    ....
  4. doi request reprint Neuromyelitis optica-IgG in idiopathic inflammatory demyelinating disorders amongst Hong Kong Chinese
    K H Chan
    University Department of Medicine, Research Center for Heart, Brain, Hormone and Healthy Aging, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Eur J Neurol 16:310-6. 2009
    ..NMO-IgG, an autoantibody targeting aquaporin-4, is a marker for NMO. We studied the frequency and clinical relevance of NMO-IgG seropositivity in IIDD patients...
  5. doi request reprint Aquaporin-4 water channel expression by thymoma of patients with and without myasthenia gravis
    K H Chan
    University Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong
    J Neuroimmunol 227:178-84. 2010
    ..A significant proportion of NMO patients are seropositive for NMO-IgG, an autoantibody targeting aquaporin-4 (AQP4) water channel. Paraneoplastic NMO associated various tumors were recently reported...
  6. ncbi request reprint Oral perception and oral motor ability in edentulous patients with stroke and Parkinson's disease
    K C M Leung
    Oral Rehabilitation, Faculty of Dentistry, University of Hong Kong, Hong Kong
    J Oral Rehabil 29:497-503. 2002
    ..Edentulous patients with stroke should be encouraged to wear dentures during the rehabilitation phase as oral stereognosis is then less impaired...
  7. ncbi request reprint Effects of plasticisers and related compounds on the expression of the soluble form of catechol-O-methyltransferase in MCF-7 cells
    P W L Ho
    Division of Neurology, University Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Curr Drug Metab 9:276-9. 2008
    ..Assay of S-COMT protein levels represents a simple and convenient method of assessing the estrogenic potential of a compound...
  8. ncbi request reprint Nonthymoma early-onset- and late-onset-generalized myasthenia gravis--a retrospective hospital-based study
    K H Chan
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
    Clin Neurol Neurosurg 109:686-91. 2007
    ..Differences between nonthymoma early-onset and late-onset MG were reported. We studied the clinical and serological characteristics of nonthymoma AChR Ab-positive-generalized MG patients...
  9. ncbi request reprint Idiopathic inflammatory demyelinating disorders after acute transverse myelitis
    K H Chan
    Division of Neurology, University Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
    Eur J Neurol 13:862-8. 2006
    ..As long-term treatments for NMO are different from MS, early recognition of NMO and its variant is important for prevention of serious neurological deficits...
  10. ncbi request reprint Myopia as a latent phenotype of a pleiotropic gene positively selected for facilitating neurocognitive development, and the effects of environmental factors in its expression
    W Mak
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, PR China
    Med Hypotheses 66:1209-15. 2006
    ..The net gain in Darwinian fitness enables the pleiotropic gene to attain a high frequency in the human population, as reflected by our current prevalence of myopia...
  11. ncbi request reprint Cerebrospinal fluid to serum glucose ratio in non-hypoglycorrhachic neurological conditions
    W Mak
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong
    Hong Kong Med J 11:457-62. 2005
    ..To explore the relevance of cerebrospinal fluid to serum glucose ratio in non-hypoglycorrhachic conditions...
  12. ncbi request reprint Paraneoplastic motor neuropathy and inflammatory myopathy associated with nasopharyngeal carcinoma
    K H Chan
    University Department of Medicine, The University of Hong Kong, 4 F Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong, SAR, China
    J Neurooncol 81:93-6. 2007
  13. doi request reprint Whole exome sequencing identifies a novel mutation in the transglutaminase 6 gene for spinocerebellar ataxia in a Chinese family
    M Li
    Department of Psychiatry Centre for Reproduction, Development and Growth, University of Hong Kong, Hong Kong, China
    Clin Genet 83:269-73. 2013
    ..This study also shows that whole exome sequencing of a small number of affected individuals, leveraged on bioinformatics analysis, can be an efficient strategy for identifying causative mutations in rare Mendelian disorders...
  14. ncbi request reprint Clinical phenotypes of a large Chinese multigenerational kindred with autosomal dominant familial ALS due to Ile149Thr SOD1 gene mutation
    Gardian C Y Fong
    Division of Neurology, University Department of Medicine, University of Hong Kong, Hong Kong
    Amyotroph Lateral Scler 7:142-9. 2006
    ..Follow-up of the family will be helpful to explore any potential disease markers...
  15. doi request reprint Visit-to-visit systolic blood pressure variability predicts all-cause and cardiovascular mortality after lacunar infarct
    K K Lau
    Neurology Division, Department of Medicine, University of Hong Kong, Hong Kong, China
    Eur J Neurol 21:319-25. 2014
    ..The prognostic implications of outpatient clinic visit-to-visit BPV amongst patients with lacunar infarction are nevertheless unknown...
  16. ncbi request reprint Reversible paraneoplastic neuropathy associated with T-cell large granular lymphocyte leukemia
    W Y Au
    University Department of Medicine, Queen Mary Hospital, Pokfulam Road, Hong Kong
    Neurology 63:588-9. 2004
  17. ncbi request reprint An epidemiological study of motor neuron disease in Hong Kong
    G C Y Fong
    Department of Medicine, Queen Mary Hospital, Hong Kong
    Amyotroph Lateral Scler Other Motor Neuron Disord 6:164-8. 2005
    ..A territory-wide prospective epidemiological study is indicated...
  18. doi request reprint Garlic intake is an independent predictor of endothelial function in patients with ischemic stroke
    K K Lau
    Division of Neurology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China
    J Nutr Health Aging 17:600-4. 2013
    ..To investigate the effects of garlic on endothelial function in patients with ischemic stroke (ISS)...
  19. ncbi request reprint Mah-jong-induced seizures: case reports and review of twenty-three patients
    Richard S K Chang
    Department of Medicine, Queen Mary Hospital, Hong Kong
    Hong Kong Med J 13:314-8. 2007
    ..The pathophysiological mechanism underlying mah-jong-induced seizures may be different from the other cognition-associated reflex epileptic phenomena...
  20. ncbi request reprint Oral stereognosis in stroke and Parkinson's disease: a comparison of partially dentate and edentulous individuals
    E H Pow
    Oral Rehabilitation, Faculty of Dentistry, University of Hong Kong, Hong Kong
    Clin Oral Investig 5:112-7. 2001
    ..Partially dentate stroke patients are less likely to have impaired oral stereognosis than edentulous stroke patients...
  21. ncbi request reprint The impact of molecular biology on clinical neurology
    W Mak
    Division of Neurology, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    Hong Kong Med J 7:40-9. 2001
    ....
  22. doi request reprint Clinical outcome of relapsing remitting multiple sclerosis among Hong Kong Chinese
    K H Chan
    University Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
    Clin Neurol Neurosurg 113:617-22. 2011
    ..Clinical outcome of Chinese relapsing remitting multiple sclerosis (RRMS) patients is uncertain...
  23. ncbi request reprint Prose memory in patients with idiopathic Parkinson's disease
    Tatia M C Lee
    Neuropsychology Laboratory, Department of Psychology, The University of Hong Kong, Pokfulam Road, Hong Kong, Hong Kong, China
    Parkinsonism Relat Disord 11:453-8. 2005
    ..Very few studies have examined the comprehensive profile of prose memory deficits that challenges people with PD...
  24. ncbi request reprint Induction of unspliced c-fos messenger RNA in rodent brain by kainic acid and lipopolysaccharide
    Z Feng
    Division of Neurology, University Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Neurosci Lett 305:17-20. 2001
    ..Furthermore, tyrosine kinase and protein phosphatase inhibitors alter the preponderance of c-fos transcripts following LPS treatment...
  25. ncbi request reprint A possible explanation for the racial difference in distribution of large-arterial cerebrovascular disease: ancestral European settlers evolved genetic resistance to atherosclerosis, but confined to the intracranial arteries
    W Mak
    University Department of Medicine, Queen Mary Hospital, 4 F Professorial Block, Hong Kong, PR China
    Med Hypotheses 65:637-48. 2005
    ..Alternatively, if the mediator of this anti-atherogenic mechanism can be identified and applied therapeutically, we will have an ultimate mean to prevent atherosclerosis...
  26. ncbi request reprint Human catechol-O-methyltransferase down-regulation by estradiol
    H Jiang
    Division of Neurology, University Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, PR China
    Neuropharmacology 45:1011-8. 2003
    ..Our findings may explain the lower of COMT activity in women compared to that in men, and, in part, the beneficial effects of E2 therapy in post-menopausal Parkinson's disease patients...
  27. ncbi request reprint A case of ocular myasthenia gravis and Miller-Fisher syndrome
    W Mak
    Neurodiagnostic Unit, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, People s Republic of China
    Hosp Med 66:116-7. 2005