Xiuping Chen

Summary

Affiliation: University of Macau
Country: China

Publications

  1. ncbi request reprint Cryptotanshinone Induces Pro-death Autophagy through JNK Signaling Mediated by Reactive Oxygen Species Generation in Lung Cancer Cells
    Wenhui Hao
    Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Taipa, Macau, China
    Anticancer Agents Med Chem 16:593-600. 2016
  2. ncbi request reprint Cucurbitacin B induces DNA damage, G2/M phase arrest, and apoptosis mediated by reactive oxygen species (ROS) in leukemia K562 cells
    Jiajie Guo
    Institute of Chinese Medical Sciences, University of Macau, Av Padre Tomás Pereira S J, Taipa, Macau, China
    Anticancer Agents Med Chem 14:1146-53. 2014
  3. pmc Material basis of Chinese herbal formulas explored by combining pharmacokinetics with network pharmacology
    Lixia Pei
    Pharmacology Laboratory of Traditional Chinese Medicine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
    PLoS ONE 8:e57414. 2013
  4. doi request reprint Filling the gap between traditional Chinese medicine and modern medicine, are we heading to the right direction?
    Xiuping Chen
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao Electronic address
    Complement Ther Med 21:272-5. 2013
  5. doi request reprint Target network analysis of adiponectin, a multifaceted adipokine
    Xiuping Chen
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
    J Cell Biochem 114:1145-52. 2013
  6. ncbi request reprint [Inspirations from natural products based drug research and development for Chinese medicine research--analysis of natural products recoded in TTD]
    Xiu ping Chen
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China
    Yao Xue Xue Bao 47:1423-7. 2012
  7. ncbi request reprint Quinones derived from plant secondary metabolites as anti-cancer agents
    Jin Jian Lu
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
    Anticancer Agents Med Chem 13:456-63. 2013
  8. doi request reprint Adiponectin: a biomarker for rheumatoid arthritis?
    Xiuping Chen
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
    Cytokine Growth Factor Rev 24:83-9. 2013
  9. doi request reprint Biological activities and potential molecular targets of cucurbitacins: a focus on cancer
    Xiuping Chen
    State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, China
    Anticancer Drugs 23:777-87. 2012
  10. ncbi request reprint No protective effect of curcumin on hydrogen peroxide-induced cytotoxicity in HepG2 cells
    Xiuping Chen
    State Key Laboratory of Quality Research in Chinese Medicine, Macau 999078, China
    Pharmacol Rep 63:724-32. 2011

Collaborators

  • Yitao Wang
  • Chung Hang Leung
  • Dik Lung Ma
  • Hongwei Gao
  • Jin Zheng
  • Hong Zhu
  • Mingqing Huang
  • Ting Li
  • Ping Chen
  • Liao Cui
  • Kang Liu
  • Ailin Liu
  • Junfeng Zhang
  • Wei Guo
  • Ji Li
  • Feng Chen
  • Meiwan Chen
  • Wenwen Zhao
  • Jin Jian Lu
  • Jinjian Lu
  • Lixia Pei
  • Zhangfeng Zhong
  • Jiajie Guo
  • Wen Sun
  • Zengtao Xu
  • Guowen Ren
  • Guosheng Wu
  • Wen Tan
  • Zheng Hai Tang
  • Xiao Huang Xu
  • Wenhui Hao
  • Sheng Liu
  • Haitao Feng
  • Weiwei Luo
  • Yanan Niu
  • Guixin Ma
  • Qingwen Zhang
  • Jiaolin Bao
  • Yuanwu Bao
  • Chi Man Vivienne Fong
  • Chuanhong Wu
  • Shuhui Guo
  • Guo Sheng Wu
  • Xiudan Zhan
  • Lidian Chen
  • Yingbo Li
  • Yuanye Dang
  • Min Xia Su
  • Wen Xiang Cao
  • Xiao ming Jiang
  • Le Le Zhang
  • Chunxia Li
  • Zhao Yang Liu
  • Qin Wu
  • Xiaocong Pang
  • Wei Lin
  • Lijuan Liu
  • Shaojing Li
  • Xia Guo
  • Xuenong Zhang
  • Jingshan Shi
  • Wenxue Li
  • Tongye Sha
  • Lei Dong
  • Haixia Qi
  • Chunming Wang
  • Yiming Niu
  • Lixin Jia
  • Jiao Lin Bao
  • Wen Shan Xu
  • Xu Wei
  • Dejun Hu
  • Jingrong Cui
  • Qiqi Wang
  • Wenshan Xu
  • Dongmei Dai
  • Xia Yuan
  • Jing Xie
  • Zhengming Qian
  • Lei Ma
  • Yiyi Ye
  • Xianghui Han
  • Jian Gong
  • Keyuan Zhou
  • Tie Wu

Detail Information

Publications49

  1. ncbi request reprint Cryptotanshinone Induces Pro-death Autophagy through JNK Signaling Mediated by Reactive Oxygen Species Generation in Lung Cancer Cells
    Wenhui Hao
    Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Taipa, Macau, China
    Anticancer Agents Med Chem 16:593-600. 2016
    ..3% in A549 xenograft nude mice, which was completely reversed by NAC (50 mg/kg) co-treatment. Our findings showed that CTS induced pro-death autophagy through activating JNK signaling mediated by increasing intracellular ROS production. ..
  2. ncbi request reprint Cucurbitacin B induces DNA damage, G2/M phase arrest, and apoptosis mediated by reactive oxygen species (ROS) in leukemia K562 cells
    Jiajie Guo
    Institute of Chinese Medical Sciences, University of Macau, Av Padre Tomás Pereira S J, Taipa, Macau, China
    Anticancer Agents Med Chem 14:1146-53. 2014
    ..Taken together, these results suggested that ROS mediated Cuc B-induced DNA damage, G2/M arrest, and apoptosis in K562 cells. This study provides novel mechanisms to better understand the underlying anti-cancer mechanisms of Cuc B. ..
  3. pmc Material basis of Chinese herbal formulas explored by combining pharmacokinetics with network pharmacology
    Lixia Pei
    Pharmacology Laboratory of Traditional Chinese Medicine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
    PLoS ONE 8:e57414. 2013
    ..The combination of PK with network pharmacology might be a potent method for exploring the material basis of TCM formulas...
  4. doi request reprint Filling the gap between traditional Chinese medicine and modern medicine, are we heading to the right direction?
    Xiuping Chen
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao Electronic address
    Complement Ther Med 21:272-5. 2013
    ..However, are we heading to the right direction?..
  5. doi request reprint Target network analysis of adiponectin, a multifaceted adipokine
    Xiuping Chen
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
    J Cell Biochem 114:1145-52. 2013
    ....
  6. ncbi request reprint [Inspirations from natural products based drug research and development for Chinese medicine research--analysis of natural products recoded in TTD]
    Xiu ping Chen
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China
    Yao Xue Xue Bao 47:1423-7. 2012
    ..This paper briefly introduces the TTD, analyzes the natural products derived drugs/compounds recorded in TTD, which we think might provide some inspiration for the innovation of TCM...
  7. ncbi request reprint Quinones derived from plant secondary metabolites as anti-cancer agents
    Jin Jian Lu
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
    Anticancer Agents Med Chem 13:456-63. 2013
    ..We intend to summarize their anti-cancer effects and investigate the mechanism of actions to promote the research and development of anti-cancer agents from quinones...
  8. doi request reprint Adiponectin: a biomarker for rheumatoid arthritis?
    Xiuping Chen
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
    Cytokine Growth Factor Rev 24:83-9. 2013
    ....
  9. doi request reprint Biological activities and potential molecular targets of cucurbitacins: a focus on cancer
    Xiuping Chen
    State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, China
    Anticancer Drugs 23:777-87. 2012
    ..The aim was to systematically analyze their bioactivities with an emphasis on their anticancer effects. Research and development has shed new insight into the beneficial properties of these compounds...
  10. ncbi request reprint No protective effect of curcumin on hydrogen peroxide-induced cytotoxicity in HepG2 cells
    Xiuping Chen
    State Key Laboratory of Quality Research in Chinese Medicine, Macau 999078, China
    Pharmacol Rep 63:724-32. 2011
    ..These results suggest that short pretreatment and subsequent longer co-treatment of low concentrations of curcumin showed no obvious protective effect on H₂O₂-induced HepG₂ cell injury...
  11. doi request reprint Anti-tumor potential of ethanol extract of Curcuma phaeocaulis Valeton against breast cancer cells
    Xiuping Chen
    State Key Laboratory of Quality Research in Chinese Medicine, Macau, China
    Phytomedicine 18:1238-43. 2011
    ..Cpv treatment also modulated several signaling transduction pathways. These results might provide some molecular basis for the anti-tumor activity of Curcuma phaeocaulis Valeton...
  12. pmc Anti-cancer natural products isolated from chinese medicinal herbs
    Wen Tan
    State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Av, Padre Toma s Pereira S, J, Taipa, Macao SAR, China
    Chin Med 6:27. 2011
    ..In particular, the discovery of the new use of artemisinin derivatives as excellent anti-cancer drugs is also reviewed...
  13. doi request reprint Adiponectin and breast cancer
    Xiuping Chen
    Institute of Chinese Medical Sciences, University of Macau, Av Padre Tomás Pereira S J, Taipa, Macau, China
    Med Oncol 28:1288-95. 2011
    ..However, more convincing evidence is needed to fully elucidate the exact role of adiponectin in breast cancer, since both its beneficial effects and possible mechanisms remain controversial...
  14. doi request reprint Furanodiene, a natural product, inhibits breast cancer growth both in vitro and in vivo
    Zhangfeng Zhong
    State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macau, China
    Cell Physiol Biochem 30:778-90. 2012
    ..H. Chen et C. Ling extract, which has a high furanodiene content, showed anti-cancer effects in breast cancer cells in vitro. The present study was designed to evaluate the in vitro and in vivo anti-cancer activity of furanodiene...
  15. doi request reprint Cucurbitacin E induces caspase-dependent apoptosis and protective autophagy mediated by ROS in lung cancer cells
    Guixin Ma
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao
    Chem Biol Interact 253:1-9. 2016
    ..Furthermore, CuE induced protective autophagy mediated by ROS through AKT/mTOR pathway. This study provides novel roles of ROS in the anticancer effect of CuE. ..
  16. ncbi request reprint Ganoderma lucidum extract induces G1 cell cycle arrest, and apoptosis in human breast cancer cells
    Guosheng Wu
    State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, China
    Am J Chin Med 40:631-42. 2012
    ..In conclusion, ESAC exerts anti-proliferation effects by inducing DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells...
  17. doi request reprint Psoralidin induced reactive oxygen species (ROS)-dependent DNA damage and protective autophagy mediated by NOX4 in breast cancer cells
    Guowen Ren
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
    Phytomedicine 23:939-47. 2016
    ..Psoralidin (PSO), a natural phenolic coumarin, was reported to have anti-cancer activities. PSO induced reactive oxygen species (ROS) generation in cancer cells. The role of ROS in its anti-cancer effect remains unclear...
  18. doi request reprint Germacrone inhibits the proliferation of breast cancer cell lines by inducing cell cycle arrest and promoting apoptosis
    Zhangfeng Zhong
    Institute of Chinese Medical Sciences, University of Macau, Av Padre Toma s Pereira S J, Taipa, Macau, 999078, China
    Eur J Pharmacol 667:50-5. 2011
    ..These results might provide some molecular basis for the anti-tumor activity of Rhizoma curcuma...
  19. doi request reprint Osimertinib induces autophagy and apoptosis via reactive oxygen species generation in non-small cell lung cancer cells
    Zheng Hai Tang
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
    Toxicol Appl Pharmacol 321:18-26. 2017
    ..Taken together, this is the first report that OSI induces an accompanied autophagy and the generation of ROS is critical for the OSI-induced autophagy, cell viability decrease, and apoptosis in NSCLC cells...
  20. doi request reprint 2-Methoxy-6-acetyl-7-methyljuglone (MAM), a natural naphthoquinone, induces NO-dependent apoptosis and necroptosis by H2O2-dependent JNK activation in cancer cells
    Wen Sun
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
    Free Radic Biol Med 92:61-77. 2016
    ..In summary, a natural product MAM induced NO-dependent multiple forms of cell death in cancer cells mediated by H2O2-dependent JNK activation in cancer cells. GSH depletion might play an initial role in MAM-induced cytotoxicity. ..
  21. ncbi request reprint Solasodine Induces Apoptosis, Affects Autophagy, and Attenuates Metastasis in Ovarian Cancer Cells
    Xiao Huang Xu
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
    Planta Med . 2016
    ..This study could be used as a basis for further studies on the molecular mechanisms of the antiproliferation, apoptosis-inducing, autophagy-modifying, and antimetastatic activities of solasodine...
  22. doi request reprint Total Tanshinones-Induced Apoptosis and Autophagy Via Reactive Oxygen Species in Lung Cancer 95D Cells
    Hongwei Gao
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China
    Am J Chin Med 43:1265-79. 2015
    ..In conclusion, our findings showed that TDT-induced apoptosis and protective autophagy in 95D cells mediated by increasing intracellular ROS production. ..
  23. ncbi request reprint Ganoderma lucidum polysaccharides: immunomodulation and potential anti-tumor activities
    Zengtao Xu
    Institute of Chinese Medical Sciences, University of Macau, Macau, P R China
    Am J Chin Med 39:15-27. 2011
    ..However, many questions still need to be answered before both G. lucidum and GLPS can be widely accepted and used as anti-tumor agents...
  24. pmc PTEN Activation by DNA Damage Induces Protective Autophagy in Response to Cucurbitacin B in Hepatocellular Carcinoma Cells
    Yanan Niu
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Science, University of Macau, Macau
    Oxid Med Cell Longev 2016:4313204. 2016
    ..In summary, Cuc B induced DNA damage, apoptosis, and protective autophagy mediated by ROS. PTEN activation in response to DNA damage bridged DNA damage and prosurvival autophagy...
  25. pmc Cucurbitacin B induced ATM-mediated DNA damage causes G2/M cell cycle arrest in a ROS-dependent manner
    Jiajie Guo
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
    PLoS ONE 9:e88140. 2014
    ..These observations provide novel mechanisms and potential targets for better understanding of the anti-cancer mechanisms of cucurbitacins. ..
  26. doi request reprint Determination of bakkenolide A in rat plasma using liquid chromatography/tandem mass spectrometry and its application to a pharmacokinetic study
    Lixia Pei
    Pharmacology Laboratory of Traditional Chinese Medicine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China
    J Mass Spectrom 47:962-8. 2012
    ..8 ± 0.7 h. Based on the results, the oral bioavailability of BA in rats at 20 mg/kg is 15.7%...
  27. pmc Platycodin D potentiates proliferation inhibition and apoptosis induction upon AKT inhibition via feedback blockade in non-small cell lung cancer cells
    Ting Li
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
    Sci Rep 6:37997. 2016
    ..These findings also reveal the limitations of suppressing feedback-regulated pathways by monotherapy and establish a mechanistic rationale for a novel combination approach targeting AKT for the treatment of NSCLC...
  28. doi request reprint Chikusetsusaponin IVa methyl ester induces G1 cell cycle arrest, triggers apoptosis and inhibits migration and invasion in ovarian cancer cells
    Xin Chen
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
    Phytomedicine 23:1555-1565. 2016
    ..Panacis Japonici Rhizoma (PJR) is one of the most famous Chinese medical herbs that is known for exhibiting potential anti-cancer effects...
  29. ncbi request reprint Saponins from Chinese Medicines as Anticancer Agents
    Xiao Huang Xu
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
    Molecules 21:. 2016
    ..In addition, related signaling pathways and target proteins involved in the anticancer effects of saponins are also summarized in this work...
  30. doi request reprint Osthole inhibited TGF beta-induced epithelial-mesenchymal transition (EMT) by suppressing NF-κB mediated Snail activation in lung cancer A549 cells
    Haitao Feng
    a State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China
    Cell Adh Migr . 2017
    ..In conclusion, OST inhibited TGF-β1-induced EMT, adhesion, migration, and invasion through inactivation of NF-κB-Snail pathways in A549 cells. This study provides novel molecular mechanisms for the anti-metastatic effect of OST...
  31. doi request reprint Isocryptotanshinone, a STAT3 inhibitor, induces apoptosis and pro-death autophagy in A549 lung cancer cells
    Shuhui Guo
    a State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China
    J Drug Target 24:934-942. 2016
    ..These findings suggested that ICTS, a natural compound, is a potent STAT3 inhibitor. ICTS induced apoptosis and pro-death autophagy in A549 cells...
  32. ncbi request reprint Recent advances in breast cancer metastasis suppressor 1
    Xiuping Chen
    Institute of Chinese Medical Sciences, University of Macau, Macau, China
    Int J Biol Markers 26:1-8. 2011
    ..In this review, the authors provide an overview of its biology, function, action mechanism and pathological significance...
  33. doi request reprint A sensitive method for determination of platycodin d in rat plasma using liquid chromatography/tandem mass spectrometry and its application to a pharmacokinetic study
    Lixia Pei
    Pharmacology Laboratory of Traditional Chinese Medicine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
    Planta Med 78:244-51. 2012
    ..57 ± 0.70 h. Based on the results, the oral bioavailability of PD in rats at 10 mg/kg is 0.079 %...
  34. doi request reprint The anticancer properties of Salvia miltiorrhiza Bunge (Danshen): a systematic review
    Xiuping Chen
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
    Med Res Rev 34:768-94. 2014
    ....
  35. doi request reprint Celastrol induced DNA damage, cell cycle arrest, and apoptosis in human rheumatoid fibroblast-like synovial cells
    Zengtao Xu
    Department of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, China
    Am J Chin Med 41:615-28. 2013
    ..Collectively, we concluded that celastrol inhibits RA-FLS proliferation by inducing DNA damage, cell cycle arrest, and apoptosis in vitro, which might provide data for its application in RA treatment...
  36. doi request reprint Antidiabetic effect of the total polyphenolic acids fraction from Salvia miltiorrhiza Bunge in diabetic rats
    Mingqing Huang
    College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian Province 350108, China
    Phytother Res 26:944-8. 2012
    ..These results suggested that PAF has antidiabetic potential in vivo...
  37. doi request reprint 2',7'-Dichlorodihydrofluorescein as a fluorescent probe for reactive oxygen species measurement: Forty years of application and controversy
    Xiuping Chen
    Institute of Chinese Medical Sciences, University of Macau, Macau, PR China
    Free Radic Res 44:587-604. 2010
    ....
  38. pmc Tanshinones and diethyl blechnics with anti-inflammatory and anti-cancer activities from Salvia miltiorrhiza Bunge (Danshen)
    Hongwei Gao
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
    Sci Rep 6:33720. 2016
    ..In addition, the anti-cancer activity investigation indicated that most of isolated compounds exhibited cytotoxicity and the SAR analysis showed that the intact D ring was indispensable and unsaturated D ring played vital role...
  39. pmc Dihydrotanshinone I Attenuates Atherosclerosis in ApoE-Deficient Mice: Role of NOX4/NF-κB Mediated Lectin-Like Oxidized LDL Receptor-1 (LOX-1) of the Endothelium
    Wenwen Zhao
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau Macao, China
    Front Pharmacol 7:418. 2016
    ..This finding suggested that DHT might be used as a potential vascular protective candidate for the treatment of atherosclerosis...
  40. pmc Tert-butyl hydroperoxide (t-BHP) induced apoptosis and necroptosis in endothelial cells: Roles of NOX4 and mitochondrion
    Wenwen Zhao
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
    Redox Biol 11:524-534. 2017
    ..ROS derived from NADPH oxidase and mitochondria contributed to t-BHPL and t-BHPH-induced apoptosis and necroptosis, respectively...
  41. doi request reprint Cucurbitacin B induces DNA damage and autophagy mediated by reactive oxygen species (ROS) in MCF-7 breast cancer cells
    Guowen Ren
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
    J Nat Med 69:522-30. 2015
    ..Taken together, these results suggest that ROS-mediated Cuc-B-induced DNA damage and autophagy in MCF-7 cells, which provides new insights into the anticancer molecular mechanism of Cuc B. ..
  42. doi request reprint A sensitive method for determination of furanodiene in rat plasma using liquid chromatography/tandem mass spectrometry and its application to a pharmacokinetic study
    Lixia Pei
    Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
    Biomed Chromatogr 26:826-32. 2012
    ..1 h⋅ng/mL, and the elimination half-life was 2.40 ± 1.18 h. Based on this result, the oral bioavailability of furanodiene in rats at 10 mg/kg is 49.0%...
  43. doi request reprint Furanodiene, a natural small molecule suppresses metastatic breast cancer cell migration and invasion in vitro
    Zhangfeng Zhong
    University of Macau, Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, Avenue Padre Tomas Pereira Taipa, Macau 999078, China
    Eur J Pharmacol 737:1-10. 2014
    ..Our results suggested that furanodiene might be the primary contributor to the anti-cancer effects of volatile oil extracts, and it might be a good therapeutic target for highly metastatic breast cancer. ..
  44. pmc Cryptotanshinone inhibits oxidized LDL-induced adhesion molecule expression via ROS dependent NF-κB pathways
    Wenwen Zhao
    a State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
    Cell Adh Migr 10:248-58. 2016
    ..Results suggested that CPT inhibited ox-LDL-induced adhesion molecule expression by decreasing ROS and inhibiting the NF-κB pathways, which provides new insight into the anti-atherosclerotic mechanism of CPT. ..
  45. pmc Characterization of osimertinib (AZD9291)-resistant non-small cell lung cancer NCI-H1975/OSIR cell line
    Zheng Hai Tang
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
    Oncotarget 7:81598-81610. 2016
    ..Collectively, loss of EGFR could pose as one of the OSI-resistant mechanisms and navitoclax might be the candidate drug for OSI-resistant NSCLC patients...
  46. doi request reprint Baicalein Induces Beclin 1- and Extracellular Signal-Regulated Kinase-Dependent Autophagy in Ovarian Cancer Cells
    Ya fang Wang
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, P R China
    Am J Chin Med . 2017
    ..Taken together, these results suggest that BA induces Beclin 1- and ERK-dependent autophagy in ovarian cancer cells...
  47. doi request reprint Targeted depletion of tumour-associated macrophages by an alendronate-glucomannan conjugate for cancer immunotherapy
    Xiudan Zhan
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR, China
    Biomaterials 35:10046-57. 2014
    ..Taken together, these results demonstrate the potential of ALN-BSP as a safe and efficient tool targeted at direct depletion of TAMs for cancer immunotherapy...
  48. doi request reprint Adiponectin protects palmitic acid induced endothelial inflammation and insulin resistance via regulating ROS/IKKβ pathways
    Wenwen Zhao
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao
    Cytokine 88:167-176. 2016
    ..These results suggested that APN ameliorated endothelial inflammation and IR through ROS/IKKβ pathway. This study shed new insights into the mechanisms of APN's cardiovascular protective effect...
  49. doi request reprint Lipopolysaccharide induced LOX-1 expression via TLR4/MyD88/ROS activated p38MAPK-NF-κB pathway
    Wenwen Zhao
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
    Vascul Pharmacol 63:162-72. 2014
    ..In conclusion, our data suggested that LPS induces LOX-1 expression via TLR4/MyD88/ROS activated p38MAPK/NF-κB pathway in endothelial cells, which provides new regulatory mechanisms for LOX-1 expression. ..