Affiliation: University of Hong Kong
- Influenza H5N1 and H1N1 virus replication and innate immune responses in bronchial epithelial cells are influenced by the state of differentiationRenee W Y Chan
Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR, People s Republic of China
PLoS ONE 5:e8713. 2010..Since influenza infection in the bronchial epithelium will lead to tissue damage and associate with the epithelium regeneration, the data generated from the undifferentiated NHBE cultures may also be relevant to disease pathogenesis...
- Proinflammatory cytokine response and viral replication in mouse bone marrow derived macrophages infected with influenza H1N1 and H5N1 virusesRenee W Y Chan
Centre of Influenza Research and School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
PLoS ONE 7:e51057. 2012....
- Replication and pathogenesis of avian influenza A (H5N1) virus infection in polarised human bronchial and alveolar epitheliumM C W Chan
Centre of Influenza Research, School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
Hong Kong Med J 19:24-8. 2013..These viruses were potent inducers of cytokines and chemokines in primary human alveolar epithelial cells...
- Systems-level comparison of host responses induced by pandemic and seasonal influenza A H1N1 viruses in primary human type I-like alveolar epithelial cells in vitroSuki M Y Lee
Department of Microbiology, The University of Hong Kong, Hong Kong SAR, PR China
Respir Res 11:147. 2010..However a comprehensive gene expression profile of pdmH1N1 in relevant primary human cells in vitro has not been reported. Type I alveolar epithelial cells are a key target cell in pdmH1N1 pneumonia...
- Influenza H5N1 virus infection of polarized human alveolar epithelial cells and lung microvascular endothelial cellsMichael C W Chan
Departments of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, PR China
Respir Res 10:102. 2009..These are polarized cells and the polarity of influenza virus entry and egress as well as the secretion of cytokines and chemokines from the virus infected cells are likely to be central to the pathogenesis of human H5N1 disease...
- Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cellsM C W Chan
Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region of China
Respir Res 6:135. 2005..Since respiratory epithelial cells are the primary target cell for replication of influenza viruses, it is pertinent to investigate the cytokine induction profile of H5N1 viruses in these cells...