Chi C Leung

Summary

Affiliation: Tuberculosis and Chest Service
Country: China

Publications

  1. ncbi Risk of active tuberculosis among schoolchildren in Hong Kong
    Chi Chiu Leung
    Tuberculosis and Chest Service, Department of Health, Hong Kong
    Arch Pediatr Adolesc Med 160:247-51. 2006
  2. ncbi Decline in prevalence of latent tuberculosis infection: is the waning of tuberculin reaction a factor?
    Chi Chiu Leung
    Am J Respir Crit Care Med 178:651-2; author reply 652-3. 2008
  3. doi Poor agreement between diagnostic tests for latent tuberculosis infection among HIV-infected persons in Hong Kong
    Chi Chiu Leung
    TB and Chest Service, Centre for Health Protection
    Respirology 21:1322-9. 2016
  4. doi Tuberculosis is associated with increased lung cancer mortality
    C C Leung
    Tuberculosis and Chest Service, Department of Health, Hong Kong SAR, China
    Int J Tuberc Lung Dis 17:687-92. 2013
  5. doi Obstructive lung disease does not increase lung cancer mortality among female never-smokers in Hong Kong
    C C Leung
    TB and Chest Service, Department of Health, Hong Kong, China
    Int J Tuberc Lung Dis 16:546-52. 2012
  6. doi Silicosis
    Chi Chiu Leung
    Tuberculosis and Chest Service, Centre for Health Protection, Department of Health, Hong Kong, China
    Lancet 379:2008-18. 2012
  7. doi A strong tuberculin reaction in primary school children predicts tuberculosis in adolescence
    Chi Chiu Leung
    Department of Health, Tuberculosis and Chest Service, Hong Kong, China
    Pediatr Infect Dis J 31:150-3. 2012
  8. doi Treatment of latent infection with Mycobacterium tuberculosis: update 2010
    C C Leung
    Tuberculosis and Chest Service, Dept of Health, Grantham Hospital, Hong Kong, China
    Eur Respir J 37:690-711. 2011
  9. doi T-Spot.TB outperforms tuberculin skin test in predicting tuberculosis disease
    Chi Chiu Leung
    Tuberculosis and Chest Service, Centre for Health Protection, Department of Health, Hong Kong, China
    Am J Respir Crit Care Med 182:834-40. 2010
  10. doi Passive smoking and tuberculosis
    Chi C Leung
    Department of Health, Hong Kong
    Arch Intern Med 170:287-92. 2010

Collaborators

Detail Information

Publications53

  1. ncbi Risk of active tuberculosis among schoolchildren in Hong Kong
    Chi Chiu Leung
    Tuberculosis and Chest Service, Department of Health, Hong Kong
    Arch Pediatr Adolesc Med 160:247-51. 2006
    ..To estimate the risk of active tuberculosis (TB) and its implication on preventive treatment among BCG-vaccinated schoolchildren...
  2. ncbi Decline in prevalence of latent tuberculosis infection: is the waning of tuberculin reaction a factor?
    Chi Chiu Leung
    Am J Respir Crit Care Med 178:651-2; author reply 652-3. 2008
  3. doi Poor agreement between diagnostic tests for latent tuberculosis infection among HIV-infected persons in Hong Kong
    Chi Chiu Leung
    TB and Chest Service, Centre for Health Protection
    Respirology 21:1322-9. 2016
    ..The tuberculin skin test (TST), T-Spot.TB (T-Spot) and QuantiFERON-TB Gold-In Tube (QFT) were compared in diagnosing latent tuberculosis infection (LTBI) among human immunodeficiency virus (HIV)-infected persons...
  4. doi Tuberculosis is associated with increased lung cancer mortality
    C C Leung
    Tuberculosis and Chest Service, Department of Health, Hong Kong SAR, China
    Int J Tuberc Lung Dis 17:687-92. 2013
    ..Elderly persons living in the community in Hong Kong...
  5. doi Obstructive lung disease does not increase lung cancer mortality among female never-smokers in Hong Kong
    C C Leung
    TB and Chest Service, Department of Health, Hong Kong, China
    Int J Tuberc Lung Dis 16:546-52. 2012
    ..High lung cancer mortality is observed among female never-smokers in Hong Kong...
  6. doi Silicosis
    Chi Chiu Leung
    Tuberculosis and Chest Service, Centre for Health Protection, Department of Health, Hong Kong, China
    Lancet 379:2008-18. 2012
    ..Further efforts are needed for recognition and control of silica hazards, especially in developing countries...
  7. doi A strong tuberculin reaction in primary school children predicts tuberculosis in adolescence
    Chi Chiu Leung
    Department of Health, Tuberculosis and Chest Service, Hong Kong, China
    Pediatr Infect Dis J 31:150-3. 2012
    ..Children younger than 14 years of age appear to have a relatively low risk of tuberculosis (TB), but the risk of TB increases rapidly after 15 years of age to a secondary peak in young adulthood...
  8. doi Treatment of latent infection with Mycobacterium tuberculosis: update 2010
    C C Leung
    Tuberculosis and Chest Service, Dept of Health, Grantham Hospital, Hong Kong, China
    Eur Respir J 37:690-711. 2011
    ..A targeted approach is required to maximise cost-effectiveness. Each geographic region needs to set its own priority after taking into account available scientific data and local circumstances...
  9. doi T-Spot.TB outperforms tuberculin skin test in predicting tuberculosis disease
    Chi Chiu Leung
    Tuberculosis and Chest Service, Centre for Health Protection, Department of Health, Hong Kong, China
    Am J Respir Crit Care Med 182:834-40. 2010
    ..Silicosis is a well-recognized risk factor for tuberculosis (TB)...
  10. doi Passive smoking and tuberculosis
    Chi C Leung
    Department of Health, Hong Kong
    Arch Intern Med 170:287-92. 2010
    ..Increasing evidence has incriminated active smoking as a causal factor for tuberculosis (TB). However, the effect of secondhand tobacco smoke exposure on TB has not been similarly elucidated...
  11. doi Diabetic control and risk of tuberculosis: a cohort study
    Chi C Leung
    Tuberculosis and Chest Service, Department of Health, Hong Kong, People s Republic of China
    Am J Epidemiol 167:1486-94. 2008
    ..lt;7%), with adjusted hazard ratios of 3.11 (95% confidence interval: 1.63, 5.92), 3.08 (95% confidence interval: 1.44, 6.57), 3.63 (95% confidence interval: 1.79, 7.33), and 0.77 (95% confidence interval: 0.18, 3.35), respectively...
  12. ncbi Smoking and tuberculosis among silicotic patients
    C C Leung
    Tuberculosis and Chest Service, Centre for Health Protection, Department of Health, Grantham Hospital, Hong Kong, China
    Eur Respir J 29:745-50. 2007
    ..Smoking cessation may reduce 32.4% (95% CI: 6.5-54.0) of the risk. Smoking increases the risk of both tuberculosis infection and subsequent development of the disease among silicotic patients...
  13. ncbi Comparison of T-Spot.TB and tuberculin skin test among silicotic patients
    C C Leung
    Tuberculosis and Chest Service, Centre for Health Protection, Dept of Health, University of Hong Kong, China
    Eur Respir J 31:266-72. 2008
    ..T-Spot.TB is likely to perform better than tuberculin test in the screening of latent tuberculosis infection among silicotic subjects...
  14. ncbi Determinants of spirometric abnormalities among silicotic patients in Hong Kong
    Chi C Leung
    Department of Health Pneumoconiosis Clinic 4 F, Shaukiwan Jockey Club Clinic 8, Hong Kong
    Occup Med (Lond) 55:490-3. 2005
    ..Silicosis is the second commonest notified occupational disease in Hong Kong...
  15. ncbi Chest radiograph screening for tuberculosis in a Hong Kong prison
    C C Leung
    Department of Health, TB and Chest Service, 4 F Shaukiwan Jockey Club Clinic, Hong Kong, SAR, China
    Int J Tuberc Lung Dis 9:627-32. 2005
    ..Long-stay prisoners are not regularly screened for TB in Hong Kong...
  16. doi Choice of spirometric reference values for compensation assessment
    Chi Chiu Leung
    Pneumoconiosis Clinic, Centre for Health Protection, Department of Health, Hong Kong, China
    Respirology 14:865-72. 2009
    ..This study examined their relative performance in the compensational assessment of silicosis...
  17. ncbi Initial experience on rifampin and pyrazinamide vs isoniazid in the treatment of latent tuberculosis infection among patients with silicosis in Hong Kong
    Chi Chiu Leung
    Tuberculosis Service, Department of Health, Pneumoconiosis Clinic, Grantham Hospital, 8 Chaiwan Road 4 F, Shaukiwan, Hong Kong, China
    Chest 124:2112-8. 2003
    ..To compare the adverse effects and treatment adherence between 2 months of rifampin plus pyrazinamide (2RZ) and 6 months of isoniazid (6H)...
  18. ncbi Smoking and tuberculosis among the elderly in Hong Kong
    Chi C Leung
    TB and Chest Service, Department of Community Medicine, The University of Hong Kong, China
    Am J Respir Crit Care Med 170:1027-33. 2004
    ..9-48.0%), 8.6% (95% CI, 3.3-15.1%), and 18.7% (95% CI, 7.7-30.4%) of the TB risk among males, females, and the entire cohort, respectively. Approximately 44.9% (95% CI, 20.7-64.6%) of the sex difference was attributable to smoking...
  19. ncbi Socio-economic factors and tuberculosis: a district-based ecological analysis in Hong Kong
    C C Leung
    TB and Chest Service, Department of Health, Hong Kong, China
    Int J Tuberc Lung Dis 8:958-64. 2004
    ..Relatively little is known about the impact of socio-economic factors on tuberculosis in a metropolitan city with high disease incidence...
  20. doi Lower lung cancer mortality in obesity
    Chi C Leung
    TB and Chest Service, Department of Health, Hong Kong, China, School of Public Health, The University of Hong Kong, Hong Kong, China
    Int J Epidemiol 40:174-82. 2011
    ..Malignancy is the leading cause of death in Hong Kong, and lung cancer tops the list of all cancer deaths...
  21. pmc Tuberculin response in BCG vaccinated schoolchildren and the estimation of annual risk of infection in Hong Kong
    C C Leung
    Tuberculosis Service and Chest Service, Department of Health, Hong Kong, China
    Thorax 60:124-9. 2005
    ..In Hong Kong there has been nearly universal neonatal BCG vaccination coverage since 1980...
  22. ncbi Seasonal pattern of tuberculosis in Hong Kong
    Chi Chiu Leung
    Tuberculosis and Chest Service, Department of Health, 8 Chaiwan Road 4 F, Shaukiwan, Hong Kong, China
    Int J Epidemiol 34:924-30. 2005
    ..Summer predominance of tuberculosis (TB) was reported previously in temperate regions. No consistent data were available for lower latitudes...
  23. ncbi Lower risk of tuberculosis in obesity
    Chi C Leung
    Tuberculosis and Chest Service, Department of Health, The University of Hong Kong, and Tuberculosis and Chest Unit, Grantham Hospital, Wanchai Chest Clinic, 99 Kennedy Rd, Wanchai, Hong Kong, China
    Arch Intern Med 167:1297-304. 2007
    ..The association with body mass index (BMI; calculated as weight in kilograms divided by the square of height in meters), as categorized by the Asian standards, was assessed with the control of other baseline characteristics...
  24. ncbi A nested case-control study on treatment-related risk factors for early relapse of tuberculosis
    Kwok C Chang
    Tuberculosis and Chest Service, Department of Health, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
    Am J Respir Crit Care Med 170:1124-30. 2004
    ..9-5.5%) for standard daily regimen; 0.5% (95% CI 0.1-2.6%) for extended thrice-weekly regimen; and 0.4% (95% CI 0.1-0.9%) for extended daily regimen. Further studies are required to reduce the risk of relapse under program settings...
  25. doi Hepatotoxicity of pyrazinamide: cohort and case-control analyses
    Kwok C Chang
    Tuberculosis and Chest Service, Centre for Health Protection, Department of Health, Hong Kong, China
    Am J Respir Crit Care Med 177:1391-6. 2008
    ..Relatively little is known about the hepatotoxicity of pyrazinamide...
  26. ncbi Dosing schedules of 6-month regimens and relapse for pulmonary tuberculosis
    Kwok C Chang
    Tuberculosis and Chest Service, Center for Health Protection, Department of Health Tuberculosis and Chest Unit, Grantham Hospital, Hong Kong, China
    Am J Respir Crit Care Med 174:1153-8. 2006
    ..The optimal approach for reducing tuberculosis relapse is open...
  27. ncbi Malignant mesothelioma in Hong Kong
    Kwok C Chang
    Tuberculosis and Chest Service, Department of Health, Hong Kong Pneumoconiosis Medical Board, Hong Kong
    Respir Med 100:75-82. 2006
    ..Asbestos consumption in Hong Kong rose in the 1970s and peaked in early 1980s and late 1990s. Hong Kong may encounter an epidemic of mesothelioma in the 2010s if effective occupational asbestos control measures are not in place...
  28. ncbi Tuberculosis in older people: a retrospective and comparative study from Hong Kong
    Chi C Leung
    Tuberculosis and Chest Service, Department of Health, Hong Kong, China
    J Am Geriatr Soc 50:1219-26. 2002
    ..To compare tuberculosis (TB) in older and younger patients...
  29. doi Smoking adversely affects treatment response, outcome and relapse in tuberculosis
    Chi C Leung
    TB and Chest Service, Dept of Health, Hong Kong, China
    Eur Respir J 45:738-45. 2015
    ..2%; ex-smokers: 7.2%). Smoking adversely affects baseline disease severity, bacteriological response, treatment outcome and relapse in tuberculosis. Smoking cessation likely reduces relapse and secondary transmission...
  30. ncbi Antituberculosis drugs and hepatotoxicity
    Wing Wai Yew
    Tuberculosis and Chest Unit, Grantham Hospital, Hong Kong, China
    Respirology 11:699-707. 2006
    ..Monitoring of liver chemistry is also required for those patients at risk of drug-induced hepatotoxicity...
  31. doi Systematic review of interferon-gamma release assays in tuberculosis: focus on likelihood ratios
    Kwok Chiu Chang
    Tuberculosis and Chest Service, Department of Health, Hong Kong SAR, China
    Thorax 65:271-6. 2010
    ..Clinical roles of QuantiFERON-TB Gold (QFT-G)/Gold in-Tube (QFT-G-IT) and T-SPOT.TB in tuberculosis require clarification...
  32. ncbi Tuberculin skin test reaction and body mass index in old age home residents in Hong Kong
    Moira Chan-Yeung
    Division of Respiratory Medicine, Department of Medicine, University of Hong Kong, Hong Kong, China
    J Am Geriatr Soc 55:1592-7. 2007
    ..To study the relationship between body mass index (BMI) and tuberculin skin test (TST) reaction in predicting the development of active tuberculosis (TB)...
  33. ncbi Prevalence of tuberculous infection and active tuberculosis in old age homes in Hong Kong
    Moira Chan-Yeung
    Respiratory Division, Department of Medicine, University of Hong Kong, Hong Kong, China
    J Am Geriatr Soc 54:1334-40. 2006
    ..To assess the prevalence of tuberculous infection and active tuberculosis (TB) in old age homes in Hong Kong and to determine whether there is institutional transmission in these homes...
  34. ncbi Update in tuberculosis 2006
    Wing Wai Yew
    Tuberculosis and Chest Unit, Grantham Hospital, Hong Kong, China
    Am J Respir Crit Care Med 175:541-6. 2007
  35. pmc The transmission dynamics of tuberculosis in a recently developed Chinese city
    Peng Wu
    Department of Community Medicine and School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    PLoS ONE 5:e10468. 2010
    ..We studied the transmission dynamics of TB in Hong Kong to explore the factors underlying recent trends in incidence...
  36. doi Update in tuberculosis 2007
    Wing Wai Yew
    Tuberculosis and Chest Unit, Grantham Hospital, Hong Kong, China
    Am J Respir Crit Care Med 177:479-85. 2008
  37. ncbi Update in tuberculosis 2005
    Wing Wai Yew
    Grantham Hospital Tuberculosis and Chest Unit, 125 Wong Chuk Hang Road, Hong Kong, China
    Am J Respir Crit Care Med 173:491-8. 2006
  38. ncbi Comparative roles of levofloxacin and ofloxacin in the treatment of multidrug-resistant tuberculosis: preliminary results of a retrospective study from Hong Kong
    Wing Wai Yew
    Tuberculosis and Chest Unit, Grantham Hospital, Hong Kong, China
    Chest 124:1476-81. 2003
    ..To compare levofloxacin and ofloxacin in the treatment of multidrug-resistant tuberculosis (MDR-TB)...
  39. doi Genetic association between a chemokine gene CXCL-10 (IP-10, interferon gamma inducible protein 10) and susceptibility to tuberculosis
    Nelson Leung Sang Tang
    Department of Chemical Pathology, Faculty of Medicine, Chinese University of Hong Kong, Shatin, Hong Kong, China
    Clin Chim Acta 406:98-102. 2009
    ..These chemokines are components of innate immune response to respiratory tract pathogens. We examined the promoter variants of CXCL-10 and their role in predisposition to tuberculosis (TB)...
  40. pmc Comparison of intracellular cytokine flow cytometry and an enzyme immunoassay for evaluation of cellular immune response to active tuberculosis
    Wai Lin Leung
    Public Health Laboratory Services Branch, Centre for Health Protection, Department of Health, Hong Kong
    Clin Vaccine Immunol 16:344-51. 2009
    ..tuberculosis infection. Flow cytometry accurately locates the pool of immunological effector cells responsible for cytokine production during active TB. The ICC assay is an additional useful tool for the diagnosis of active TB...
  41. doi Management of multidrug-resistant tuberculosis: Update 2007
    Wing Wai Yew
    Tuberculosis and Chest Unit, Grantham Hospital, Hong Kong, China
    Respirology 13:21-46. 2008
    ..Furthermore, more attention needs to be focused on developing new drugs with potent bactericidal and sterilizing activities and low side-effects, and above all, drugs that are affordable for communities worldwide...
  42. ncbi Can the interferon-gamma release assay help diagnose active tuberculosis in the elderly?
    Chi Chiu Leung
    Chest 134:471. 2008
  43. ncbi Is the whole-blood gamma interferon assay better than the tuberculin skin test in predicting active tuberculosis?
    Chi Chiu Leung
    Am J Respir Crit Care Med 178:210-1; author reply 211. 2008
  44. doi Screening contacts of tuberculosis: overcoming obstacles with an old tool
    Chi Chiu Leung
    Am J Respir Crit Care Med 177:939-40. 2008
  45. ncbi Side effects of antituberculosis therapy
    Chi Chiu Leung
    Am J Respir Crit Care Med 169:1168-9; author reply 1169. 2004
  46. ncbi Further evidence for a link between silica dust and esophageal cancer
    Ignatius Tak Sun Yu
    Department of Community and Family Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
    Int J Cancer 114:479-83. 2005
    ..We believe that the excess risk of esophageal cancer mortality among caisson workers with silicosis could best be explained by the very heavy exposure to free silica dust in their working environment...
  47. ncbi Treatment of tuberculosis in HIV-infected patients: we need to know more
    David C Perlman
    Am J Respir Crit Care Med 175:1102-3. 2007
  48. ncbi Smoking and tuberculosis: infection, disease, and mortality
    Chi Chiu Leung
    Arch Intern Med 167:2008-9; author reply 2009. 2007
  49. pmc HIV-related TB and adverse drug events
    Chi Chiu Leung
    Thorax 62:923-4; author reply 924. 2007
  50. ncbi Study on twins: a good tool for infectious diseases?
    Chi Chiu Leung
    Am J Respir Crit Care Med 177:799-800. 2008
  51. ncbi Prognostic significance of early weight gain in underweight patients with tuberculosis
    Wing Wai Yew
    Am J Respir Crit Care Med 174:236-7. 2006
  52. ncbi Does metabolic syndrome cause obstructive sleep apnoea?
    Kwok Chiu Chang
    Respir Med 101:1043. 2007
  53. ncbi Lethal interaction: the colliding epidemics of tobacco and tuberculosis
    Madhukar Pai
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada
    Expert Rev Anti Infect Ther 5:385-91. 2007
    ..Since tobacco control will have multiple health benefits, it is likely to be a highly cost-effective intervention from a societal perspective...