Gang Xu

Summary

Affiliation: Tongji Medical College
Country: China

Publications

  1. pmc Role of Sema4C in TGF-β1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells
    Rui Zeng
    Division of Nephrology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People s Republic of China
    Nephrol Dial Transplant 26:1149-56. 2011
  2. pmc Cdc42-interacting protein-4 promotes TGF-Β1-induced epithelial-mesenchymal transition and extracellular matrix deposition in renal proximal tubular epithelial cells
    Shoujun Bai
    Devision of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
    Int J Biol Sci 8:859-69. 2012
  3. pmc Inhibition of PC cell-derived growth factor (PCDGF)/granulin-epithelin precursor (GEP) decreased cell proliferation and invasion through downregulation of cyclin D and CDK4 and inactivation of MMP-2
    Yulan Liu
    Cancer Biology Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China
    BMC Cancer 7:22. 2007
  4. doi request reprint Synergistic efficacy in human ovarian cancer cells by histone deacetylase inhibitor TSA and proteasome inhibitor PS-341
    Yong Fang
    Cancer Biology Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
    Cancer Invest 29:247-52. 2011
  5. doi request reprint HPV16/18 E5, a promising candidate for cervical cancer vaccines, affects SCPs, cell proliferation and cell cycle, and forms a potential network with E6 and E7
    Shujie Liao
    Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China
    Int J Mol Med 31:120-8. 2013
  6. doi request reprint Development and characterization of a novel method for the analysis of gene expression patterns in lymphatic endothelial cells derived from primary breast tissues
    Mingfu Wu
    Cancer Biology Research Center, Tongji Hospital, 430030 Wuhan, Hubei, People s Republic of China
    J Cancer Res Clin Oncol 136:863-72. 2010
  7. doi request reprint Reversal of the malignant phenotype of ovarian cancer A2780 cells through transfection with wild-type PTEN gene
    Huijuan Wu
    Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China
    Cancer Lett 271:205-14. 2008
  8. doi request reprint Implication of the Akt2/survivin pathway as a critical target in paclitaxel treatment in human ovarian cancer cells
    Danhui Weng
    Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China
    Cancer Lett 273:257-65. 2009
  9. doi request reprint Telmisartan but not valsartan inhibits TGF-beta-mediated accumulation of extracellular matrix via activation of PPARgamma
    Ying Yao
    Department of Nephrology, Huazhong University of Science and Technology, Wuhan 430030, China
    J Huazhong Univ Sci Technolog Med Sci 28:543-8. 2008
  10. doi request reprint Synergistic killing effect between vorinostat and target of CD146 in malignant cells
    Xiaoli Ma
    Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P R China
    Clin Cancer Res 16:5165-76. 2010

Collaborators

  • Ding Ma
  • Tao Zhu
  • Ying Yao
  • Min Han
  • Juncheng Wei
  • Gang Chen
  • Wei Wang
  • Yang Cao
  • Wei Li
  • Shixuan Wang
  • Jianfeng Zhou
  • Li Meng
  • Rui Zeng
  • Yunping Lu
  • Guangchang Pei
  • Mingfu Wu
  • Shujie Liao
  • Xi Xia
  • Xiaoli Ma
  • Zhiqiang Han
  • Hui Xing
  • Dongrui Deng
  • Shuang Li
  • Juan Yang
  • Lili Liu
  • Shoujun Bai
  • Xiaocheng Liu
  • Yong Fang
  • Peng Wu
  • Lanying You
  • Quanfu Ma
  • Daowen Wang
  • Xuefeng Jiang
  • Yanjie Weng
  • Xiaoyuan Huang
  • Danhui Weng
  • Xiaohong Song
  • Huijuan Wu
  • Yueqiang Li
  • Pei Kou
  • Qiaodan Zhou
  • Wenhui Liao
  • Yuan Tian
  • Xiangyang Bai
  • Shuwang Ge
  • Yun Luo
  • Jingyi Wu
  • Qinglei Gao
  • Beibei Wang
  • Danfeng Luo
  • Rui Wang
  • Wanhua Yang
  • Qian Zhang
  • Ying Zhang
  • Qiao Dan Zhou
  • Jiong Zhang
  • Yong Ning
  • Lin Chen
  • Song Rong
  • Yamin Zhang
  • Chuou Xu
  • Huan Zhou
  • Yong He
  • Caixia Li
  • Ping Liu
  • Qinghua Zhang
  • Chen Lu
  • Lei Huang
  • Qiong Li
  • Yin Chen
  • Rong Zou
  • Yunpin Lu
  • Shuangmei Ye
  • Mei Huang
  • Jia Liu
  • Ni Sima
  • Qian Xu
  • Yanling Liu
  • Lingfei Han
  • Ronghua Liu
  • Xiao Cheng Liu
  • Li Zhou
  • Youqing Liu
  • Duozhuang Tang
  • Juan Zhang
  • Xiangyi Ma
  • Jinhua Zhou
  • Rui Chen
  • Yan Liu
  • Ling Tu

Detail Information

Publications47

  1. pmc Role of Sema4C in TGF-β1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells
    Rui Zeng
    Division of Nephrology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People s Republic of China
    Nephrol Dial Transplant 26:1149-56. 2011
    ..Sema4C, a member of the semaphorin family, was found to be essential for the activation of p38 MAPK. However, the role of Sema4C in promoting TGF-β1-induced EMT is unclear...
  2. pmc Cdc42-interacting protein-4 promotes TGF-Β1-induced epithelial-mesenchymal transition and extracellular matrix deposition in renal proximal tubular epithelial cells
    Shoujun Bai
    Devision of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
    Int J Biol Sci 8:859-69. 2012
    ..Through this mechanism, CIP4 is capable of inducing ECM deposition and exacerbating progressive fibrosis in chronic renal failure...
  3. pmc Inhibition of PC cell-derived growth factor (PCDGF)/granulin-epithelin precursor (GEP) decreased cell proliferation and invasion through downregulation of cyclin D and CDK4 and inactivation of MMP-2
    Yulan Liu
    Cancer Biology Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China
    BMC Cancer 7:22. 2007
    ..In the present study we investigated whether and how PCDGF/GEP mediated cell proliferation and invasion in ovarian cancer...
  4. doi request reprint Synergistic efficacy in human ovarian cancer cells by histone deacetylase inhibitor TSA and proteasome inhibitor PS-341
    Yong Fang
    Cancer Biology Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
    Cancer Invest 29:247-52. 2011
    ..This demonstrated that TSA interacted synergistically with PS-341, which raised the possibility that combined the two drugs may represent a novel strategy in ovarian cancer...
  5. doi request reprint HPV16/18 E5, a promising candidate for cervical cancer vaccines, affects SCPs, cell proliferation and cell cycle, and forms a potential network with E6 and E7
    Shujie Liao
    Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China
    Int J Mol Med 31:120-8. 2013
    ..Therefore, HPV16/18 E5 plays a critical role in carcinogenesis and is a potential therapeutic target in CC treatment...
  6. doi request reprint Development and characterization of a novel method for the analysis of gene expression patterns in lymphatic endothelial cells derived from primary breast tissues
    Mingfu Wu
    Cancer Biology Research Center, Tongji Hospital, 430030 Wuhan, Hubei, People s Republic of China
    J Cancer Res Clin Oncol 136:863-72. 2010
    ..These findings also suggest that the LEC-specific genes Sema4C and C4orf7 may play an important role in the oncogenesis of human breast cancer...
  7. doi request reprint Reversal of the malignant phenotype of ovarian cancer A2780 cells through transfection with wild-type PTEN gene
    Huijuan Wu
    Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China
    Cancer Lett 271:205-14. 2008
    ....
  8. doi request reprint Implication of the Akt2/survivin pathway as a critical target in paclitaxel treatment in human ovarian cancer cells
    Danhui Weng
    Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China
    Cancer Lett 273:257-65. 2009
    ..In the present study, we investigated the role of the Akt2/survivin pathway in paclitaxel-induced resistance by a modified method to generate an effective shRNA vector...
  9. doi request reprint Telmisartan but not valsartan inhibits TGF-beta-mediated accumulation of extracellular matrix via activation of PPARgamma
    Ying Yao
    Department of Nephrology, Huazhong University of Science and Technology, Wuhan 430030, China
    J Huazhong Univ Sci Technolog Med Sci 28:543-8. 2008
    ..It may provide possibility that telmisartan works as a potential agent against diabetic nephropathy and hypertensive renal disease...
  10. doi request reprint Synergistic killing effect between vorinostat and target of CD146 in malignant cells
    Xiaoli Ma
    Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P R China
    Clin Cancer Res 16:5165-76. 2010
    ..Here, we sought to identify the potential protective reactions initiated by HDACi and determine whether targeting these reactions would enhance the antitumoral activity of HDACi...
  11. doi request reprint Selective targeting of HPV-16 E6/E7 in cervical cancer cells with a potent oncolytic adenovirus and its enhanced effect with radiotherapy in vitro and vivo
    Wei Wang
    Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China
    Cancer Lett 291:67-75. 2010
    ..These findings indicated the anti-tumoral efficacy of M6 on HPV16-positive cervical cancer cells and its synergic therapeutic application in radiation for cervical cancer...
  12. doi request reprint Hypoxia induced paclitaxel resistance in human ovarian cancers via hypoxia-inducible factor 1alpha
    Lei Huang
    Cancer Biology Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, 430030, Wuhan, Hubei, People s Republic of China
    J Cancer Res Clin Oncol 136:447-56. 2010
    ..To understand the relationship between hypoxia and chemoresistance, we investigated the potential role of hypoxia in the pathophysiology of chemoresistance, especially focusing on hypoxia-inducible factor 1alpha (HIF-1alpha)...
  13. doi request reprint Antisense Ki-67 cDNA transfection reverses the tumorigenicity and induces apoptosis in human breast cancer cells
    Rui Wang
    Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P R China
    Cancer Invest 26:830-5. 2008
    ..Our results suggested that antisense Ki-67 cDNA vector treatment might be an important potential option in the anticancer therapy...
  14. ncbi request reprint Isolation and characterization of lymphatic endothelial cells from human glossal lymphangioma
    Lanying You
    Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, P R China
    Oncol Rep 23:105-11. 2010
    ..They had the abilities of tube formation and differentiation in vitro, which provide a favorable cell model for further uncovering the pathogenesis of human lymphangiomas...
  15. doi request reprint Erbin inhibits TGF-β1-induced EMT in renal tubular epithelial cells through an ERK-dependent pathway
    Qiaodan Zhou
    Division of Nephrology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Wuhan, Hubei, People s Republic of China
    J Mol Med (Berl) 90:563-74. 2012
    ..However, in the absence of TGF-β1, Erbin failed to affect ERK activation and EMT process. These results suggest that Erbin is a negative feedback molecule induced by TGF-β1 and inhibits TGF-β1-induced EMT via ERK signaling pathway...
  16. doi request reprint A novel oncolytic adenovirus selectively silences the expression of tumor-associated STAT3 and exhibits potent antitumoral activity
    Zhiqiang Han
    Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
    Carcinogenesis 30:2014-22. 2009
    ..In summary, M4 has low toxicity and great potential as a therapeutic agent for different types of cancers...
  17. doi request reprint Identification of LIV1, a putative zinc transporter gene responsible for HDACi-induced apoptosis, using a functional gene screen approach
    Xiaoli Ma
    Cancer Biology Research Center, Tongji Hospital, Tongji Medical School, Huazhong University of Science and Technology, Wuhan, Hubai, China
    Mol Cancer Ther 8:3108-16. 2009
    ..As such, these findings highlight a novel mechanism underlying the action of HDACi that could be potentially useful in the clinical setting...
  18. pmc Plexin-B1 silencing inhibits ovarian cancer cell migration and invasion
    Shuangmei Ye
    Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
    BMC Cancer 10:611. 2010
    ..In addition, the impact of Plexin-B1 expression on ovarian cancer cell proliferation, migration and invasion were investigated in vitro...
  19. pmc Lymphoma endothelium preferentially expresses Tim-3 and facilitates the progression of lymphoma by mediating immune evasion
    Xiaoyuan Huang
    Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China
    J Exp Med 207:505-20. 2010
    ..These findings highlight a novel molecular mechanism that is a potential target for enhancing the efficacy of tumor immunotherapy and controlling metastatic diseases...
  20. doi request reprint Short hairpin RNA targeting c-FLIP sensitizes human cervical adenocarcinoma Hela cells to chemotherapy and radiotherapy
    Aiyue Luo
    Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China
    Cancer Lett 271:323-32. 2008
    ....
  21. pmc Fenofibrate attenuated glucose-induced mesangial cells proliferation and extracellular matrix synthesis via PI3K/AKT and ERK1/2
    Rui Zeng
    Division of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
    PLoS ONE 8:e76836. 2013
    ..Such mechanisms may contribute to the favorable effects of treatment using fenofibrate in diabetic nephropathy. ..
  22. doi request reprint The preparation of human papillomavirus type 58 vaccine and exploring its biological activity and immunogenicity in vitro
    Dongrui Deng
    Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People s Republic of China
    Int J Gynecol Cancer 21:988-95. 2011
    ..Human papillomavirus (HPV) type 58 is the second most prevalent virus infection among Chinese women. To develop an HPV58 vaccine that combines both prophylactic and therapeutic functions, we generate a chimeric virus-like particle (cVLP)...
  23. pmc Mesenchymal stem cells as carriers and amplifiers in CRAd delivery to tumors
    Xi Xia
    Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China
    Mol Cancer 10:134. 2011
    ....
  24. doi request reprint Upregulated DJ-1 promotes renal tubular EMT by suppressing cytoplasmic PTEN expression and Akt activation
    Ying Yao
    Department of Nephrology, Huazhong University of Science and Technology, Wuhan, China
    J Huazhong Univ Sci Technolog Med Sci 31:469-75. 2011
    ..Contrarily, overexpression of PTEN protected HKC cells from TGF-β1-induced EMT. In conclusion, DJ-1 is upregulated in renal fibrosis and DJ-1 mediates EMT by suppressing cytoplasmic PTEN expression and Akt activation...
  25. doi request reprint Effect of tumor suppressor gene PTEN on the resistance to cisplatin in human ovarian cancer cell lines and related mechanisms
    Huijuan Wu
    Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China
    Cancer Lett 271:260-71. 2008
    ..Purpose: The aim of this study was to explore role of PTEN gene in chemosensitivity to cisplatin in human ovarian cancer cells and related mechanisms...
  26. ncbi request reprint Expression of TMEM87B interacting with the human papillomavirus type 18 E6 oncogene in the Hela cDNA library by a yeast two-hybrid system
    Shuang Li
    Department of Hematology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, People s Republic of China
    Oncol Rep 20:421-7. 2008
    ..It was indicated that the yeast two-hybrid system is efficient for screening interacting proteins. The novel gene TMEM87B may interact with HPV18 E6 and may be a potential oncogenesis target according to the bioinformatics analysis...
  27. doi request reprint TMTP1, a novel tumor-homing peptide specifically targeting metastasis
    Wanhua Yang
    Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People s Republic of China
    Clin Cancer Res 14:5494-502. 2008
    ..Methods used to detect metastasis, especially occult metastases, have received a great deal attention. In this study, a novel selective peptide was assessed for its specific binding to metastasis...
  28. doi request reprint Inhibition of Akt signaling by SN-38 induces apoptosis in cervical cancer
    Youqing Liu
    Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China
    Cancer Lett 274:47-53. 2009
    ..Our data suggested that SN-38 could induce apoptosis through a p53 pathway and that activation of p53 in response to S-38 is governed by Akt...
  29. doi request reprint Role of protein kinase C in advanced glycation end products-induced epithelial-mesenchymal transition in renal proximal tubular epithelial cells
    Shuwang Ge
    Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
    J Huazhong Univ Sci Technolog Med Sci 29:281-5. 2009
    ..High expression of Vimentin, phosphorylated beta-catenin, and TGF-beta1 induced by AGE-BSA may be mediated via the activation of PKC signal transduction pathway...
  30. doi request reprint CD4+ T Lymphocytes, especially Th2 cells, contribute to the progress of renal fibrosis
    Lili Liu
    Division of Nephrology, Department of Internal Medicine, Tongji Hospital, PR China
    Am J Nephrol 36:386-96. 2012
    ..But the role of CD4+ T lymphocytes in renal fibrosis is controversial and its cellular mechanism needs to be further investigated...
  31. pmc Renal interstitial infiltration and tertiary lymphoid organ neogenesis in IgA nephropathy
    Guangchang Pei
    Division of Nephrology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
    Clin J Am Soc Nephrol 9:255-64. 2014
    ..This prospective study was performed to determine the characteristics of renal interstitial infiltration and tertiary lymphoid organ (TLO) neogenesis in a cohort of Chinese patients with IgAN...
  32. pmc Biliverdin reductase mediates hypoxia-induced EMT via PI3-kinase and Akt
    Rui Zeng
    Division of Nephrology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, Hubei, People s Republic of China
    J Am Soc Nephrol 19:380-7. 2008
    ..In conclusion, biliverdin reductase mediates hypoxia-induced EMT through a PI3K/Akt-dependent pathway...
  33. doi request reprint Erbin interacts with Sema4C and inhibits Sema4C-induced epithelial-mesenchymal transition in HK2 cells
    Qiao Dan Zhou
    Department of Nephrology, Huazhong University of Science and Technology, Wuhan, 430030, China
    J Huazhong Univ Sci Technolog Med Sci 33:672-9. 2013
    ..In contrast, Erbin specific siRNA promoted EMT induced by Sema4C. Taken together, these results suggest that Erbin can interact with Sema4C, and co-expression of Erbin blocks the process of Sema4C-induced EMT. ..
  34. ncbi request reprint Effective penetration of cell-permeable peptide mimic of tyrosine residue 654 domain of beta-catenin into human renal tubular epithelial cells
    Rui Zeng
    Division of Nephrology, Department of Internal Medicine, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, 430030, China
    J Huazhong Univ Sci Technolog Med Sci 27:630-4. 2007
    ..It is concluded that a cell-permeable peptides mimic of tyrosine residue 654 domain of beta-catenin was successfully obtained, which may provide a useful reagent for interfering the human renal tubular epithelial-mesenchymal transition...
  35. ncbi request reprint Antisense-Snail transfer inhibits tumor metastasis by inducing E-cadherin expression
    Ali Zhang
    Cancer Biology Research Center, Tongji Hospital, Wuhan, Hubei 430040, China
    Anticancer Res 28:621-8. 2008
    ..These findings suggest that Snail plays a critical role in EMT and subsequent invasiveness. Snail inhibition may serve as a promising target for therapeutic strategies to prevent tumor metastasis...
  36. ncbi request reprint Biodistribution and kinetics of the novel selective oncolytic adenovirus M1 after systemic administration
    Xiaoyuan Huang
    Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People s Republic of China
    Mol Cancer Ther 7:1624-32. 2008
    ..Therefore, i.v. administration of M1 could prolong the survival time of tumor-bearing mice...
  37. doi request reprint PPARgamma agonists inhibit TGF-beta-PKA signaling in glomerulosclerosis
    Rong Zou
    Department of Nephrology, Wuhan Integrated TCM and Western Medicine Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Acta Pharmacol Sin 31:43-50. 2010
    ..To study the probable mechanisms of the anti-glomerulosclerosis effects induced by peroxisome proliferator-activated receptor gamma (PPARgamma) agonists in rat intraglomerular mesangial cells (MCs)...
  38. ncbi request reprint Production and verification of human papillomavirus type 18 vaccine in vitro
    Shujie Liao
    Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei 430030, P R China
    Oncol Rep 20:211-7. 2008
    ..Furthermore, the ELISPOT results support the hypothesis that the cell-mediated immunity generated by HPV18 L1-VLP may cross-type among high-risk HPV types...
  39. doi request reprint Comparative genomics and function analysis on BI1 family
    Jinhua Zhou
    Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, Wuhan, Hubei, PR China
    Comput Biol Chem 32:159-62. 2008
    ..They share multiple motifs and transcriptional factors within the promoter and the coding regions. They may represent regulators of cell death pathways, which are concluded from structure conservation of BI1 family...
  40. pmc Delivery of recombinant adeno-associated virus-mediated human tissue kallikrein for therapy of chronic renal failure in rats
    Ling Tu
    Institute of Hypertension and Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Hum Gene Ther 19:318-30. 2008
    ....
  41. pmc Administration of dexamethasone protects mice against ischemia/reperfusion induced renal injury by suppressing PI3K/AKT signaling
    Jiong Zhang
    Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, Hubei, People s Republic of China
    Int J Clin Exp Pathol 6:2366-75. 2013
    ..All together, our data support that dexamethasone could be a good alternative therapy for prevention and treatment of IR-induced renal injury in the clinical practice. ..
  42. doi request reprint Dominant contribution of malignant endothelial cells to endotheliopoiesis in chronic myeloid leukemia
    Jingyi Wu
    Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P R China
    Exp Hematol 37:87-91. 2009
    ..The current study sought to determine CML-derived endotheliopoiesis in patients with CML...
  43. ncbi request reprint Galectin-9 ameliorates anti-GBM glomerulonephritis by inhibiting Th1 and Th17 immune responses in mice
    Qian Zhang
    Division of Nephrology, Dept of Internal Medicine, Tongji Hospital, Huazhong Univ of Science and Technology, 1095 Jiefang Ave, Wuhan 430030, Hubei, People s Republic of China
    Am J Physiol Renal Physiol 306:F822-32. 2014
    ..In conclusion, the protective role of Gal-9 in anti-GBM GN is associated with the inhibition of Th1 and Th17 cell-mediated immune responses and enhanced Th2 immunity in the kidney. ..
  44. pmc Cytochrome P450 epoxygenase CYP2J2 attenuates nephropathy in streptozotocin-induced diabetic mice
    Guangzhi Chen
    Department of Internal Medicine and Gene Therapy Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, Wuhan 430030, People s Republic of China
    Prostaglandins Other Lipid Mediat 96:63-71. 2011
    ..These findings highlight the beneficial roles of the CYP epoxygenase-EET system in the pathogenesis of diabetic nephropathy...
  45. doi request reprint Prevalence and risk factors associated with chronic kidney disease in a Uygur adult population from Urumqi
    Chen Lu
    Department of Nephrology, Huazhong University of Science and Technology, Wuhan, China
    J Huazhong Univ Sci Technolog Med Sci 30:604-10. 2010
    ..05%. The high prevalence and low awareness of CKD in this population suggest an urgent need for CKD prevention programs in Uygur people...
  46. ncbi request reprint Overexpression of vimentin contributes to prostate cancer invasion and metastasis via src regulation
    Juncheng Wei
    Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P R China
    Anticancer Res 28:327-34. 2008
    ..Vimentin promotes tumor cell invasiveness and the targeting of vimentin/C-src may be a promising strategy for preventing or blocking prostate cancer metastasis...
  47. pmc TJ0711, a novel vasodilatory β-blocker, protects SHR rats against hypertension induced renal injury
    Juan Yang
    Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030, China
    Am J Transl Res 5:279-90. 2013
    ..Together, our data suggest that TJ0711 possesses higher potency for renoprotection while manifesting the similar effect on hypertension therapy as Carvedilol...