Kwok Yung Yuen

Summary

Affiliation: The University of Hong Kong
Country: China

Publications

  1. pmc Fatal anti-aquaporin-4 seropositive neuromyelitis optica spectrum disorder in tuberculosis
    Siddharth Sridhar
    Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Pokfulam, Hong Kong Special Administrative Region, China
    BMC Infect Dis 14:470. 2014
  2. pmc Metabolomics Analysis Reveals Specific Novel Tetrapeptide and Potential Anti-Inflammatory Metabolites in Pathogenic Aspergillus species
    Kim Chung Lee
    Department of Microbiology, The University of Hong Kong, Pokfulam, Hong Kong
    Int J Mol Sci 16:13850-67. 2015
  3. pmc Identification of specific metabolites in culture supernatant of Mycobacterium tuberculosis using metabolomics: exploration of potential biomarkers
    Susanna K P Lau
    State Key Laboratory of Emerging Infectious Diseases, Hong Kong, China Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, China Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, China Department of Microbiology, The University of Hong Kong, Hong Kong, China
    Emerg Microbes Infect 4:e6. 2015
  4. pmc Suboptimal Humoral Immune Response against Influenza A(H7N9) Virus Is Related to Its Internal Genes
    Andrew C Y Lee
    Department of Microbiology, The University of Hong Kong, Hong Kong, China
    Clin Vaccine Immunol 22:1235-43. 2015
  5. pmc Human H7N9 virus induces a more pronounced pro-inflammatory cytokine but an attenuated interferon response in human bronchial epithelial cells when compared with an epidemiologically-linked chicken H7N9 virus
    Kelvin K W To
    Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region, China
    Virol J 13:42. 2016
  6. pmc Metabolomic Profiling of Plasma from Patients with Tuberculosis by Use of Untargeted Mass Spectrometry Reveals Novel Biomarkers for Diagnosis
    Susanna K P Lau
    State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong Department of Microbiology, The University of Hong Kong, Hong Kong
    J Clin Microbiol 53:3750-9. 2015
  7. doi request reprint A novel astrovirus from dromedaries in the Middle East
    Patrick C Y Woo
    1 State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, PR China 4 Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, PR China 2 Department of Microbiology, The University of Hong Kong, Hong Kong, PR China 3 Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, PR China
    J Gen Virol 96:2697-707. 2015
  8. doi request reprint A six-year descriptive epidemiological study of human coronavirus infections in hospitalized patients in Hong Kong
    Cyril C Y Yip
    Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China
    Virol Sin 31:41-8. 2016
  9. pmc Minimal intervention for controlling nosocomial transmission of methicillin-resistant staphylococcus aureus in resource limited setting with high endemicity
    Vincent Chi Chung Cheng
    Department of Microbiology, Queen Mary Hospital, Hong Kong Special Administrative Region, China Infection Control Team, Queen Mary Hospital, Hong Kong Special Administrative Region, China
    PLoS ONE 9:e100493. 2014
  10. pmc Comparative genomic analysis of pre-epidemic and epidemic Zika virus strains for virological factors potentially associated with the rapidly expanding epidemic
    Zheng Zhu
    Department of Microbiology, The University of Hong Kong, Hong Kong, China
    Emerg Microbes Infect 5:e22. 2016

Collaborators

  • Patrick C Y Woo
  • Pak Leung Ho
  • James J Cai
  • Li Liu
  • Pui Hing Chau
  • Xuhua Xia
  • Joseph T Wu
  • Ka Hing Wong
  • Yi Guan
  • Can Li
  • Susanna K P Lau
  • Kelvin K W To
  • Jasper F W Chan
  • Kwok Hung Chan
  • Jasper Fuk Woo Chan
  • Honglin Chen
  • Vincent C C Cheng
  • Siddharth Sridhar
  • Ivan F N Hung
  • Vincent Chi Chung Cheng
  • Kelvin Kai Wang To
  • Cyril C Y Yip
  • Anna J X Zhang
  • Kim Chung Lee
  • Jie Zhou
  • Ching Wan Lam
  • Kenneth S M Li
  • Samson S Y Wong
  • Hin Chu
  • Jonathan H K Chen
  • Sally C Y Wong
  • Jonathan Hon Kwan Chen
  • Rachel Y Y Fan
  • Herman Tse
  • Hayes K H Luk
  • Candy C Y Lau
  • Wang Ngai Chow
  • Alan K L Tsang
  • Wenjun Song
  • Yi Huang
  • Sally Cheuk Ying Wong
  • Bo Jian Zheng
  • Iris W S Li
  • Hoi Wah Tsoi
  • Rodney A Lee
  • Garnet Kwan Yue Choi
  • Kong Hung Sze
  • Yu Lung Lau
  • Ivan Fan Ngai Hung
  • Min Zheng
  • Tuen Ching Chan
  • Shirly O T Curreem
  • Susanna Kar Pui Lau
  • Andrew C Y Lee
  • Tak Lun Que
  • Pui Wang
  • Siu Ying Lau
  • Dong Yan Jin
  • Josepha Wai Ming Tai
  • Carol S F Lam
  • Wing Cheong Yam
  • Rosana W S Poon
  • Jade L L Teng
  • Ming Wang
  • Lok Yee So
  • Zheng Zhu
  • Hanjun Zhao
  • Che Man Chan
  • Anna Jinxia Zhang
  • Tin Lun Wong
  • Chi Ching Tsang
  • Antonio H Y Ngan
  • Yin Ming Lui
  • Kah Meng Tee
  • Emily W T Tam
  • Andrea L Wu
  • Andy S F Chan
  • Richard Yi Tsun Kao
  • Deborah T Y Ho
  • Zhongshan Cheng
  • Alan Ka Lun Tsang
  • Akhee S Jahan
  • Kin Kui Lai
  • Ka Ching Lo
  • Patrick Li
  • Man Lung Yeung
  • Bobo Wing Yee Mok
  • Wai Lan Wu
  • Lanjuan Li
  • Xiaofeng Huang

Detail Information

Publications98

  1. pmc Fatal anti-aquaporin-4 seropositive neuromyelitis optica spectrum disorder in tuberculosis
    Siddharth Sridhar
    Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Pokfulam, Hong Kong Special Administrative Region, China
    BMC Infect Dis 14:470. 2014
    ..We report a fatal case of anti-aquaporin-4 antibody positive NMO spectrum disorder in a patient who was receiving treatment for pulmonary tuberculosis...
  2. pmc Metabolomics Analysis Reveals Specific Novel Tetrapeptide and Potential Anti-Inflammatory Metabolites in Pathogenic Aspergillus species
    Kim Chung Lee
    Department of Microbiology, The University of Hong Kong, Pokfulam, Hong Kong
    Int J Mol Sci 16:13850-67. 2015
    ....
  3. pmc Identification of specific metabolites in culture supernatant of Mycobacterium tuberculosis using metabolomics: exploration of potential biomarkers
    Susanna K P Lau
    State Key Laboratory of Emerging Infectious Diseases, Hong Kong, China Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, China Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, China Department of Microbiology, The University of Hong Kong, Hong Kong, China
    Emerg Microbes Infect 4:e6. 2015
    ..Studies on clinical samples from tuberculosis patients are required to explore for their potential role as diagnostic biomarkers. ..
  4. pmc Suboptimal Humoral Immune Response against Influenza A(H7N9) Virus Is Related to Its Internal Genes
    Andrew C Y Lee
    Department of Microbiology, The University of Hong Kong, Hong Kong, China
    Clin Vaccine Immunol 22:1235-43. 2015
    ..In conclusion, the internal genes of A(H7N9) virus can affect the humoral immune response against homologous viral surface proteins, which may also contribute to the virulence of A(H7N9) virus. ..
  5. pmc Human H7N9 virus induces a more pronounced pro-inflammatory cytokine but an attenuated interferon response in human bronchial epithelial cells when compared with an epidemiologically-linked chicken H7N9 virus
    Kelvin K W To
    Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region, China
    Virol J 13:42. 2016
    ..These two viruses were genetically highly similar. This study sought to use a human bronchial epithelial cell line model to infer the virulence of these H7N9 viruses in humans...
  6. pmc Metabolomic Profiling of Plasma from Patients with Tuberculosis by Use of Untargeted Mass Spectrometry Reveals Novel Biomarkers for Diagnosis
    Susanna K P Lau
    State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong Department of Microbiology, The University of Hong Kong, Hong Kong
    J Clin Microbiol 53:3750-9. 2015
    ..The present findings may offer insights into the pathogenesis and host response in TB...
  7. doi request reprint A novel astrovirus from dromedaries in the Middle East
    Patrick C Y Woo
    1 State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, PR China 4 Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, PR China 2 Department of Microbiology, The University of Hong Kong, Hong Kong, PR China 3 Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, PR China
    J Gen Virol 96:2697-707. 2015
    ..These results suggest that AstV is a novel species of the genus Mamastrovirus in the family Astroviridae. Further studies are important to understand the pathogenic potential of DcAstV. ..
  8. doi request reprint A six-year descriptive epidemiological study of human coronavirus infections in hospitalized patients in Hong Kong
    Cyril C Y Yip
    Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China
    Virol Sin 31:41-8. 2016
    ..09%) was significantly higher than that in the age group of 0-10 years (12/2529, 0.47%) (P < 0.05). These data provides new insight into the epidemiology of coronaviruses. ..
  9. pmc Minimal intervention for controlling nosocomial transmission of methicillin-resistant staphylococcus aureus in resource limited setting with high endemicity
    Vincent Chi Chung Cheng
    Department of Microbiology, Queen Mary Hospital, Hong Kong Special Administrative Region, China Infection Control Team, Queen Mary Hospital, Hong Kong Special Administrative Region, China
    PLoS ONE 9:e100493. 2014
    ..To control nosocomial transmission of methicillin-resistant Staphylococcus aureus (MRSA) in resource-limited healthcare setting with high endemicity...
  10. pmc Comparative genomic analysis of pre-epidemic and epidemic Zika virus strains for virological factors potentially associated with the rapidly expanding epidemic
    Zheng Zhu
    Department of Microbiology, The University of Hong Kong, Hong Kong, China
    Emerg Microbes Infect 5:e22. 2016
    ....
  11. pmc An A14U Substitution in the 3' Noncoding Region of the M Segment of Viral RNA Supports Replication of Influenza Virus with an NS1 Deletion by Modulating Alternative Splicing of M Segment mRNAs
    Min Zheng
    State Key Laboratory for Emerging Infectious Diseases, Department of Microbiology, and Research Center of Infection and Immunology, The University of Hong Kong, Hong Kong SAR, People s Republic of China Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The University of Hong Kong, Hong Kong SAR, People s Republic of China
    J Virol 89:10273-85. 2015
    ....
  12. doi request reprint Hemagglutinin of influenza A virus binds specifically to cell surface nucleolin and plays a role in virus internalization
    Che Man Chan
    State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China Department of Microbiology, The University of Hong Kong, Hong Kong, China Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, China
    Virology 494:78-88. 2016
    ..Overall, our findings identified a novel role of NCL in influenza virus life cycle and established NCL as one of the host cell surface proteins for the entry of influenza A virus...
  13. doi request reprint Ongoing transmission of avian influenza A viruses in Hong Kong despite very comprehensive poultry control measures: A prospective seroepidemiology study
    Kelvin K W To
    State Key Laboratory for Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, China Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, China Department of Microbiology, The University of Hong Kong, Hong Kong, China
    J Infect 72:207-13. 2016
    ..Stringent measures have been implemented in Hong Kong to prevent human infections due to avian influenza viruses (AIVs). Here, we report the seroprevalence of AIVs among high risk population...
  14. doi request reprint Immunogenicity of intradermal trivalent influenza vaccine with topical imiquimod: a double blind randomized controlled trial
    Ivan F N Hung
    State Key Laboratory for Emerging Infectious Diseases, Carol Yu s Centre for Infection and Division of Infectious Diseases Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region, China
    Clin Infect Dis 59:1246-55. 2014
    ..Imiquimod, a synthetic Toll-like receptor 7 agonist enhanced immunogenicity of influenza vaccine in a mouse model. We hypothesized that topical imiquimod before intradermal influenza vaccination (TIV) would produce similar effect in human...
  15. pmc Avian influenza A H7N9 virus induces severe pneumonia in mice without prior adaptation and responds to a combination of zanamivir and COX-2 inhibitor
    Can Li
    Department of Microbiology, The University of Hong Kong, Hong Kong, China
    PLoS ONE 9:e107966. 2014
    ..Human infection caused by the avian influenza A H7N9 virus has a case-fatality rate of over 30%. Systematic study of the pathogenesis of avian H7N9 isolate and effective therapeutic strategies are needed...
  16. doi request reprint Recombinant influenza A virus hemagglutinin HA2 subunit protects mice against influenza A(H7N9) virus infection
    Kelvin K W To
    State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China
    Arch Virol 160:777-86. 2015
    ..This recombinant A(H7N9)-HA2 vaccine should be investigated as a complement to egg- or cell-based live attenuated or subunit influenza vaccines...
  17. doi request reprint Genetic diversity of Aspergillus species isolated from onychomycosis and Aspergillus hongkongensis sp. nov., with implications to antifungal susceptibility testing
    Chi Ching Tsang
    Department of Microbiology, The University of Hong Kong, Hong Kong
    Diagn Microbiol Infect Dis 84:125-34. 2016
    ..A diverse spectrum of Aspergillus species is associated with onychomycosis. Itraconazole and voriconazole are probably better drug options for Aspergillus onychomycosis. ..
  18. doi request reprint A systematic approach to novel virus discovery in emerging infectious disease outbreaks
    Siddharth Sridhar
    Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region, China
    J Mol Diagn 17:230-41. 2015
    ..A systematic approach that incorporates carefully chosen combinations of virus detection techniques is required for successful virus discovery. ..
  19. pmc First Report of Human Infection by Agromyces mediolanus, a Gram-Positive Organism Found in Soil
    Siddharth Sridhar
    Department of Microbiology, The University of Hong Kong, Hong Kong, China
    J Clin Microbiol 53:3377-9. 2015
    ..Rapid identification was possible by matrix-assisted laser desorption ionization-time of flight mass spectrometry. ..
  20. doi request reprint Topical imiquimod before intradermal trivalent influenza vaccine for protection against heterologous non-vaccine and antigenically drifted viruses: a single-centre, double-blind, randomised, controlled phase 2b/3 trial
    Ivan Fan Ngai Hung
    Carol Yu Centre for Infection and Division of Infectious Diseases, University of Hong Kong, Hong Kong Special Administrative Region, China Department of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China
    Lancet Infect Dis 16:209-18. 2016
    ..Pretreatment with topical imiquimod, a synthetic agonist of toll-like receptor 7, significantly improved the immunogenicity of influenza vaccination in elderly people. We aimed to clarify its effect in a younger age group...
  21. pmc Severe Acute Respiratory Syndrome (SARS) Coronavirus ORF8 Protein Is Acquired from SARS-Related Coronavirus from Greater Horseshoe Bats through Recombination
    Susanna K P Lau
    State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, China Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, China Department of Microbiology, The University of Hong Kong, Hong Kong, China
    J Virol 89:10532-47. 2015
    ..SARS-CoV ORF8 originated from SARSr-CoVs of greater horseshoe bats through recombination, which may be important for animal-to-human transmission...
  22. pmc Laboratory diagnosis of melioidosis: past, present and future
    Susanna K P Lau
    State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, China Department of Microbiology, The University of Hong Kong, Hong Kong, China
    Exp Biol Med (Maywood) 240:742-51. 2015
    ..thailandensis . Further studies using bacterial cultures and direct patient samples are required to evaluate the potential of metabolomics for improving diagnosis of melioidosis...
  23. pmc Discovery of a novel coronavirus, China Rattus coronavirus HKU24, from Norway rats supports the murine origin of Betacoronavirus 1 and has implications for the ancestor of Betacoronavirus lineage A
    Susanna K P Lau
    State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, China Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, China Department of Microbiology, The University of Hong Kong, Hong Kong, China
    J Virol 89:3076-92. 2015
    ..ChRCoV HKU24 may represent the murine origin of Betacoronavirus 1, and rodents are likely an important reservoir for ancestors of lineage A βCoVs...
  24. doi request reprint A novel dromedary camel enterovirus in the family Picornaviridae from dromedaries in the Middle East
    Patrick C Y Woo
    2Department of Microbiology, The University of Hong Kong, Hong Kong, PR China 3Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, PR China 1State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, PR China 4Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, PR China
    J Gen Virol 96:1723-31. 2015
    ..Further studies are important to understand the pathogenicity, epidemiology and genetic evolution of DcEV in this unique group of animals...
  25. pmc Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease
    Jasper F W Chan
    State Key Laboratory of Emerging Infectious Diseases and Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong Special Administrative Region, China Carol Yu Centre for Infection, Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region, China
    Clin Microbiol Rev 28:465-522. 2015
    ..They should be evaluated in suitable animal models before clinical trials. Developing an effective camel MERS-CoV vaccine and implementing appropriate infection control measures may control the continuing epidemic. ..
  26. doi request reprint Use of MALDI Biotyper plus ClinProTools mass spectra analysis for correct identification of Streptococcus pneumoniae and Streptococcus mitis/oralis
    Jonathan H K Chen
    Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China
    J Clin Pathol 68:652-6. 2015
    ..However, differentiation of S. pneumoniae from other Streptococcus mitis group organisms was found to be problematic using the Bruker MALDI Biotyper system...
  27. pmc High incidence of severe influenza among individuals over 50 years of age
    Anna J X Zhang
    Research Centre of Infection and Immunology, State Key Laboratory for Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Pokfulam Road, Pokfulam, Hong Kong Special Administrative Region, China
    Clin Vaccine Immunol 18:1918-24. 2011
    ....
  28. doi request reprint Rapid reduction of viruria and stabilization of allograft function by fusidic acid in a renal transplant recipient with JC virus-associated nephropathy
    Jasper Fuk Woo Chan
    State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong Special Administrative Region, China
    Infection 43:577-81. 2015
    ..Further mechanistic and clinical studies are necessary to evaluate this treatment option for JCV-associated nephropathy. ..
  29. doi request reprint Proactive infection control measures to prevent nosocomial transmission of vancomycin-resistant enterococci in Hong Kong
    Vincent Chi Chung Cheng
    Department of Microbiology, Queen Mary Hospital, Hong Kong Special Administrative Region, China Infection Control Team, Queen Mary Hospital, Hong Kong Special Administrative Region, China
    J Formos Med Assoc 113:734-41. 2014
    ....
  30. pmc Decolonization of gastrointestinal carriage of vancomycin-resistant Enterococcus faecium: case series and review of literature
    Vincent C C Cheng
    Department of Microbiology, Queen Mary Hospital, Hong Kong Special Administrative Region, Hong Kong, China
    BMC Infect Dis 14:514. 2014
    ..Prolonged asymptomatic carriage of vancomycin-resistant enterococci (VRE) in the gastrointestinal tract and the lack of effective decolonization regimen perpetuate the endemicity of VRE in the healthcare settings...
  31. doi request reprint Characterization of the antigenicity of Cpl1, a surface protein of Cryptococcus neoformans var. neoformans
    Jian Piao Cai
    State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, University of Hong Kong, Hong Kong Special Administrative Region
    Mycologia 107:39-45. 2015
    ..neoformans var. neoformans and we showed by immunostaining that the Cpl1 protein was located on the surface. The Cpl1 protein is a specific surface protein of C. neoformans var. neoformans. ..
  32. pmc Epidemiology of human parechovirus, Aichi virus and salivirus in fecal samples from hospitalized children with gastroenteritis in Hong Kong
    Cyril C Y Yip
    Department of Microbiology, The University of Hong Kong, Hong Kong, Hong Kong
    Virol J 11:182. 2014
    ..The objective of this study was to investigate the prevalence and genetic diversity of HPeV, AiV and SalV in fecal samples from hospitalized children with gastroenteritis in Hong Kong...
  33. doi request reprint Lipid mediators of inflammation as novel plasma biomarkers to identify patients with bacteremia
    Kelvin K W To
    State Key Laboratory for Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, China Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, China Department of Microbiology, The University of Hong Kong, Hong Kong, China
    J Infect 70:433-44. 2015
    ..Rapid diagnostic tests for bacteremia are important for early treatment to improve clinical outcome. We sought to identify plasma biomarkers that can identify patients with bacteremia using an untargeted global metabolomic analysis...
  34. doi request reprint Ebola virus disease: a highly fatal infectious disease reemerging in West Africa
    Kelvin K W To
    State Key Laboratory for Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, China Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, China Department of Microbiology, The University of Hong Kong, Hong Kong, China
    Microbes Infect 17:84-97. 2015
    ..High viral loads in body fluids allow efficient transmission by contact. Lack of effective antivirals, vaccines and public health infrastructures in parts of Africa make it difficult to health workers to contain the outbreak. ..
  35. pmc Logistical feasibility and potential benefits of a population-wide passive-immunotherapy program during an influenza pandemic
    Joseph T Wu
    Department of Community Medicine and School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China
    Proc Natl Acad Sci U S A 107:3269-74. 2010
    ..As such, passive immunotherapy deserves more consideration by clinical researchers regarding its safety and efficacy as a treatment for severe cases of pandemic influenza...
  36. doi request reprint Retracted: outcome and immune reconstitution of HBV-specific immunity in patients with reactivation of occult HBV infection after alemtuzumab-containing chemotherapy regimen
    Chee Kin Hui
    Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Hong Kong, Special Administrative Region, China
    Hepatology 48:1-10. 2008
    ..Loss of HBsAg occurred after recovery of the CD4+T cell count and increased CD4+T cell reactivity against HBcAg 9 months after the end of chemotherapy...
  37. ncbi request reprint Accelerated evolutionary rate may be responsible for the emergence of lineage-specific genes in ascomycota
    James J Cai
    Department of Microbiology, Faculty of Medicine, University of Hong Kong, University Pathology Building, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong SAR, China
    J Mol Evol 63:1-11. 2006
    ..These analyses suggest that accelerated rates of gene evolution may be responsible for the emergence of apparently orphan genes...
  38. pmc Development and Evaluation of Novel Real-Time Reverse Transcription-PCR Assays with Locked Nucleic Acid Probes Targeting Leader Sequences of Human-Pathogenic Coronaviruses
    Jasper Fuk Woo Chan
    State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong Special Administrative Region, China Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region, China Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong Special Administrative Region, China Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong Special Administrative Region, China
    J Clin Microbiol 53:2722-6. 2015
    ..Analytical and clinical evaluations showed their noninferiority to a commercial multiplex PCR test for the detection of these coronaviruses. ..
  39. pmc Strategic measures for the control of surging antimicrobial resistance in Hong Kong and mainland of China
    Vincent C C Cheng
    Department of Microbiology, Queen Mary Hospital, Hong Kong, China Infection Control Team, Queen Mary Hospital, Hong Kong, China
    Emerg Microbes Infect 4:e8. 2015
    ..Transparency of surveillance data from each institute for public scrutiny provides an incentive for controlling antimicrobial resistance in healthcare settings at an administrative level. ..
  40. doi request reprint Pulmonary and extrapulmonary complications of human rhinovirus infection in critically ill patients
    Kelvin K W To
    State Key Laboratory for Emerging Infectious Diseases, The University of Hong Kong, Hong Kong Special Administrative Region Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong Special Administrative Region Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong Special Administrative Region Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region
    J Clin Virol 77:85-91. 2016
    ..Human rhinovirus (HRV) is frequently detected in patients with respiratory tract infection. However, the full clinical spectrum of HRV infection in critically ill patients is not well characterized...
  41. pmc Middle East respiratory syndrome coronavirus infection: virus-host cell interactions and implications on pathogenesis
    Jie Zhou
    State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong Special Administrative Region, China
    Virol J 12:218. 2015
    ..More research findings on the pathogenesis of MERS and the tissue tropisms of MERS-CoV may help to improve the treatment and infection control of MERS. ..
  42. pmc Fatal systemic necrotizing infections associated with a novel paramyxovirus, anaconda paramyxovirus, in green anaconda juveniles
    Patrick C Y Woo
    State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong Department of Microbiology, The University of Hong Kong, Hong Kong Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong
    J Clin Microbiol 52:3614-23. 2014
    ..Epidemiological and genomic analyses suggested that the anaconda juveniles acquired the virus perinatally from the anaconda mother rather than from other reptiles in the park, with subsequent interanaconda juvenile transmission. ..
  43. pmc The biosynthetic pathway for a thousand-year-old natural food colorant and citrinin in Penicillium marneffei
    Patrick C Y Woo
    1 Department of Microbiology, The University of Hong Kong, Hong Kong 2 State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong 3 Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong 4 Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong
    Sci Rep 4:6728. 2014
    ..The present study on elucidation of the biosynthetic pathway of monascorubrin is a proof-of-the-concept study that serves as a cornerstone for future studies on monascorubrin biosynthesis pathway dissection in Monascus species. ..
  44. doi request reprint Cross-species transmission and emergence of novel viruses from birds
    Jasper Fuk Woo Chan
    State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, and Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong Special Administrative Region
    Curr Opin Virol 10:63-9. 2015
    ..A comprehensive avian virome will improve our understanding of birds' evolutionary dynamics. ..
  45. doi request reprint Metagenomic analysis of viromes of dromedary camel fecal samples reveals large number and high diversity of circoviruses and picobirnaviruses
    Patrick C Y Woo
    State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China Department of Microbiology, The University of Hong Kong, Hong Kong, China Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, China Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, China Electronic address
    Virology 471:117-25. 2014
    ..Further studies comparing the incidence of these viral families in healthy and sick dromedaries will reveal their pathogenic potential. ..
  46. doi request reprint Hospital Outbreak of Pulmonary and Cutaneous Zygomycosis due to Contaminated Linen Items From Substandard Laundry
    Vincent C C Cheng
    Department of Microbiology, Queen Mary Hospital Infection Control Unit, Queen Mary Hospital
    Clin Infect Dis 62:714-21. 2016
    ..Healthcare laundry-related infection is rare, and pulmonary zygomycosis due to contaminated hospital linens has never been reported...
  47. doi request reprint Host genes and influenza pathogenesis in humans: an emerging paradigm
    Kelvin Kai Wang To
    State Key Laboratory for Emerging Infectious Diseases, Carol Yu Centre for Infection, Research Centre of Infection and Immunology, Department of Microbiology, The University of Hong Kong, Hong Kong, China
    Curr Opin Virol 14:7-15. 2015
    ..Integration of knowledge from genetic and phenotypic studies is essential to identify important gene targets for treatment and prevention of influenza virus infection. ..
  48. pmc Identification of Novel Fusion Inhibitors of Influenza A Virus by Chemical Genetics
    Kin Kui Lai
    Department of Microbiology, HKU Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
    J Virol 90:2690-701. 2015
    ..Our study has offered concrete biological and mechanistic explorations for the strategic development of novel fusion inhibitors of influenza A viruses...
  49. doi request reprint Viral lung infections: epidemiology, virology, clinical features, and management of avian influenza A(H7N9)
    Kelvin K W To
    State Key Laboratory for Emerging Infectious Diseases, Carol Yu Centre for Infection, Research Centre of Infection and Immunology, Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region, China
    Curr Opin Pulm Med 20:225-32. 2014
    ..Here, we present the virological features relevant to clinical practice, and summarize the epidemiology, clinical findings, diagnosis, treatment, and preventive strategies of A(H7N9) infection...
  50. doi request reprint Circulating cytomegalic cells in a patient with advanced HIV presenting with cytomegalovirus rhinosinusitis
    Siddharth Sridhar
    Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong SAR, China
    J Clin Virol 65:87-9. 2015
    ..Furthermore, the detection of circulating cytomegalic cells is described--a rare finding with pathological and clinical significance in immunocompromised patients with CMV disease...
  51. doi request reprint Unique reassortant of influenza A(H7N9) virus associated with severe disease emerging in Hong Kong
    Kelvin Kai Wang To
    State Key Laboratory for Emerging Infectious Diseases, Hong Kong Special Administrative Region Carol Yu Centre for Infection, Hong Kong Special Administrative Region Research Centre of Infection and Immunology, Hong Kong Special Administrative Region Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region
    J Infect 69:60-8. 2014
    ..Human infections caused by avian influenza virus A(H7N9) re-emerged in late 2013. We reported the first Hong Kong patient without risk factors for severe A(H7N9) disease...
  52. doi request reprint Molecular diagnosis in clinical parasitology: when and why?
    Samson S Y Wong
    Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Pok Fu Lam, Hong Kong
    Exp Biol Med (Maywood) 239:1443-60. 2014
    ..Such tests can also be used for monitoring these recipients or highly immunosuppressed patients, so that early preemptive treatment can be given for reactivated parasitic infections while the parasitic burden is still low. ..
  53. doi request reprint Emergence in China of human disease due to avian influenza A(H10N8)--cause for concern?
    Kelvin K W To
    State Key Laboratory for Emerging Infectious Diseases, The University of Hong Kong, Hong Kong Special Administrative Region Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong Special Administrative Region Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong Special Administrative Region Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region
    J Infect 68:205-15. 2014
    ..Vigilant virological and serological surveillance for A(H10N8) in human, poultry and wild bird is important for following the trajectory of this emerging influenza virus. ..
  54. ncbi request reprint Proactive infection control measures to prevent nosocomial transmission of carbapenem-resistant Enterobacteriaceae in a non-endemic area
    Vincent Chi Chung Cheng
    Department of Microbiology, Queen Mary Hospital, Hong Kong, China Infection Control Team, Queen Mary Hospital, Hong Kong, China
    Chin Med J (Engl) 126:4504-9. 2013
    ....
  55. pmc A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses
    Hanjun Zhao
    Department of Microbiology, The University of Hong Kong, Hong Kong, China
    Sci Rep 6:22008. 2016
    ..This study has paved the avenue for developing new prophylactic and therapeutic agents with broad-spectrum antiviral activities. ..
  56. doi request reprint Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset
    Jasper Fuk Woo Chan
    State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong Special Administrative Region
    J Infect Dis 212:1904-13. 2015
    ..Lopinavir/ritonavir and interferon-β1b alone or in combination should be evaluated in clinical trials. MMF alone may worsen MERS and should not be used. ..
  57. pmc PExFInS: An Integrative Post-GWAS Explorer for Functional Indels and SNPs
    Zhongshan Cheng
    Department of Microbiology, The University of Hong Kong, Pokfulam Road, Hong Kong
    Sci Rep 5:17302. 2015
    ....
  58. pmc The K526R substitution in viral protein PB2 enhances the effects of E627K on influenza virus replication
    Wenjun Song
    1 State Key Laboratory for Emerging Infectious Diseases, Department of Microbiology, and the Research Center of Infection and Immunology, The University of Hong Kong, Hong Kong SAR, China 2 The Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou 310003, China
    Nat Commun 5:5509. 2014
    ..PB2-K526R interacts with nuclear export protein and our results suggest that it contributes to enhance replication for certain influenza virus subtypes, particularly in combination with 627K. ..
  59. pmc Toll-like receptor 7 agonist imiquimod in combination with influenza vaccine expedites and augments humoral immune responses against influenza A(H1N1)pdm09 virus infection in BALB/c mice
    Anna J X Zhang
    State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China
    Clin Vaccine Immunol 21:570-9. 2014
    ..The mechanisms of imiquimod-induced immune protection deserve further study. ..
  60. pmc First report of brain abscess caused by a satelliting phenotypic variant of Helcococcus kunzii
    Siddharth Sridhar
    Department of Microbiology, University of Hong Kong, Hong Kong Special Administrative Region, China
    J Clin Microbiol 52:370-3. 2014
    ..This is the first reported case of severe central nervous system infection due to H. kunzii and the first description of a satelliting phenotypic variant of this organism. ..
  61. doi request reprint Matrix-assisted laser desorption ionisation time-of-flight mass spectrometry for identification of clinically significant bacteria that are difficult to identify in clinical laboratories
    Susanna K P Lau
    State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China
    J Clin Pathol 67:361-6. 2014
    ..We aim to evaluate the usefulness of MALDI-TOF MS for identification of 'difficult-to-identify' bacterial isolates...
  62. doi request reprint Management of an incident of failed sterilization of surgical instruments in a dental clinic in Hong Kong
    Vincent Chi Chung Cheng
    Department of Microbiology, Queen Mary Hospital, Hong Kong Special Administrative Region, China Infection Control Team, Queen Mary Hospital, Hong Kong Special Administrative Region, China Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong Special Administrative Region, China
    J Formos Med Assoc 112:666-75. 2013
    ..We aim to illustrate the principles in performing such investigations and to highlight some of the important checkpoints in sterilization procedures...
  63. pmc Comparative analysis of complete genome sequences of three avian coronaviruses reveals a novel group 3c coronavirus
    Patrick C Y Woo
    Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    J Virol 83:908-17. 2009
    ..Further studies would be important to delineate whether the Asian leopard cat CoV was a result of interspecies jumping from birds, a situation analogous to that of bat and civet severe acute respiratory syndrome CoVs...
  64. pmc Comparative analysis of twelve genomes of three novel group 2c and group 2d coronaviruses reveals unique group and subgroup features
    Patrick C Y Woo
    State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
    J Virol 81:1574-85. 2007
    ..Further molecular epidemiological studies on coronaviruses in the bats of other countries, as well as in other animals, and complete genome sequencing will shed more light on coronavirus diversity and their evolutionary histories...
  65. ncbi request reprint Seasonal and tissue distribution of Laribacter hongkongensis, a novel bacterium associated with gastroenteritis, in retail freshwater fish in Hong Kong
    Susanna K P Lau
    Department of Microbiology, The University of Hong Kong, Hong Kong
    Int J Food Microbiol 113:62-6. 2007
    ..Proper handling of freshwater fish for cooking, especially the gills and gut, is recommended to prevent acquisition of L. hongkongensis, and other freshwater fish related infections...
  66. pmc Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats
    Susanna K P Lau
    Department of Microbiology, Research Centre of Infection and Immunology, State Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong Special Administrative Region, China
    Proc Natl Acad Sci U S A 102:14040-5. 2005
    ..Neutralizing antibody to human SARS-CoV also was detected in bats with lower viral loads. Precautions should be exercised in the handling of these animals...
  67. pmc Human parainfluenza virus 4 outbreak and the role of diagnostic tests
    Susanna K P Lau
    Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital
    J Clin Microbiol 43:4515-21. 2005
    ..To better define the epidemiology and clinical spectrum of disease of HPIV-4 infections, HPIV-4 should be included in the routine panels of respiratory virus detection on respiratory specimens...
  68. ncbi request reprint Alkanindiges hongkongensis sp. nov. A novel Alkanindiges species isolated from a patient with parotid abscess
    Patrick C Y Woo
    Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital Compound, Pokfulam Road, Hong Kong
    Syst Appl Microbiol 28:316-22. 2005
    ....
  69. pmc Catabacter hongkongensis gen. nov., sp. nov., isolated from blood cultures of patients from Hong Kong and Canada
    Susanna K P Lau
    Department of Microbiology, The University of Hong Kong, Hong Kong
    J Clin Microbiol 45:395-401. 2007
    ..hongkongensis. Further studies should be performed to ascertain the epidemiology and other disease associations of this bacterium...
  70. doi request reprint The natural viral load profile of patients with pandemic 2009 influenza A(H1N1) and the effect of oseltamivir treatment
    Iris W Li
    Carol Yu Centre for Infection and Division of Infectious Diseases, Department of Microbiology, The University of Hong Kong, 4 F University Pathology Bldg, 102 Pokfulam Rd, Queen Mary Hospital, Hong Kong
    Chest 137:759-68. 2010
    ..The natural history of viral shedding from the upper respiratory tract of the new pandemic 2009 influenza A(H1N1) and the effect of oseltamivir treatment were uncertain...
  71. doi request reprint Antimicrobial resistance among uropathogens that cause acute uncomplicated cystitis in women in Hong Kong: a prospective multicenter study in 2006 to 2008
    Pak Leung Ho
    Department of Microbiology and Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong SAR, China
    Diagn Microbiol Infect Dis 66:87-93. 2010
    ..4-5.7; P = 0.003) and ciprofloxacin resistance (OR, 2.5; 95% CI, 1.1-5.8; P = 0.03). Knowledge of the resistance data and risk factors could inform better use of antibiotics for empiric therapy for acute uncomplicated cystitis...
  72. doi request reprint Emergence of enterovirus 71 "double-recombinant" strains belonging to a novel genotype D originating from southern China: first evidence for combination of intratypic and intertypic recombination events in EV71
    Cyril C Y Yip
    Department of Microbiology, The University of Hong Kong, Hong Kong, China
    Arch Virol 155:1413-24. 2010
    ..CA16 strains should also be classified into two genotypes. This represents the first evidence for a combination of intratypic and intertypic recombination in EV71 strains...
  73. ncbi request reprint The mitochondrial genome of the thermal dimorphic fungus Penicillium marneffei is more closely related to those of molds than yeasts
    Patrick C Y Woo
    Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong, PR China
    FEBS Lett 555:469-77. 2003
    ..Analysis of gene contents, gene orders, and gene sequences revealed that the mitochondrial genome of P. marneffei is more closely related to those of molds than yeasts...
  74. pmc Ecoepidemiology and complete genome comparison of different strains of severe acute respiratory syndrome-related Rhinolophus bat coronavirus in China reveal bats as a reservoir for acute, self-limiting infection that allows recombination events
    Susanna K P Lau
    State Key Laboratory of Emerging Infectious Diseases, Research Centre of Infection and Immunology, Department of Microbiology, The University of Hong Kong, Hong Kong, Hong Kong
    J Virol 84:2808-19. 2010
    ..Such frequent recombination, coupled with rapid evolution especially in ORF7b/ORF8 region, in these animals may have accounted for the cross-species transmission and emergence of SARS...
  75. pmc Leptotrichia hongkongensis sp. nov., a novel Leptotrichia species with the oral cavity as its natural reservoir
    Patrick C Y Woo
    State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China
    J Zhejiang Univ Sci B 11:391-401. 2010
    ..Based on phenotypic and genotypic characteristics, we propose a new species, Leptotrichia hongkongensis sp. nov., to describe this bacterium...
  76. pmc MBEToolbox: a MATLAB toolbox for sequence data analysis in molecular biology and evolution
    James J Cai
    Department of Microbiology, University of Hong Kong, Pokfulam, Hong Kong, China
    BMC Bioinformatics 6:64. 2005
    ..However, few functions are freely available in MATLAB to perform the sequence data analyses specifically required for molecular biology and evolution...
  77. ncbi request reprint Anaerospora hongkongensis gen. nov. sp. nov., a novel genus and species with ribosomal DNA operon heterogeneity isolated from an intravenous drug abuser with pseudobacteremia
    Patrick C Y Woo
    Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital Compound, Hong Kong
    Microbiol Immunol 49:31-9. 2005
    ..hippei and P. vibrioides. The G+C content of the bacterium (mean +/- SD) was 46.8 +/- 3.2%. For these reasons, a new genus and species, Anaerospora hongkongensis gen. nov. sp. nov., is proposed, for which HKU15T is the type strain...
  78. pmc Seronegative bacteremic melioidosis caused by Burkholderia pseudomallei with ambiguous biochemical profile: clinical importance of accurate identification by 16S rRNA gene and groEL gene sequencing
    Patrick C Y Woo
    Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
    J Clin Microbiol 41:3973-7. 2003
    ..Sequencing of the groEL gene showed that the isolate was B. pseudomallei. Proper identification of the bacterium in this study is crucial, since there would be a radical difference in the duration of antimicrobial therapy...
  79. doi request reprint Identification and complete genome analysis of three novel paramyxoviruses, Tuhoko virus 1, 2 and 3, in fruit bats from China
    Susanna K P Lau
    Department of Microbiology, The University of Hong Kong, Hong Kong, China
    Virology 404:106-16. 2010
    ..Analysis of phosphoprotein gene mRNA products confirmed mRNA editing. Antibodies to the viruses were detected in 48-60% of Leschenault's rousettes...
  80. pmc Clinical and molecular epidemiology of erythromycin-resistant beta-hemolytic lancefield group G streptococci causing bacteremia
    Patrick C Y Woo
    Department of Microbiology, The University of Hong Kong, Hong Kong
    J Clin Microbiol 41:5188-91. 2003
    ..The five isolates resistant to erythromycin but sensitive to clindamycin and one of those resistant to both erythromycin and clindamycin possessed mef genes...
  81. pmc Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia
    Patrick C Y Woo
    Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
    J Virol 79:884-95. 2005
    ..13 x 10(6) copies per ml, from a 35-year-old woman with pneumonia. Our data support the existence of a novel group 2 coronavirus associated with pneumonia in humans...
  82. pmc Increased genetic diversity of HIV-1 circulating in Hong Kong
    Jonathan Hon Kwan Chen
    Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, Special Administrative Region, China
    PLoS ONE 5:e12198. 2010
    ..Our study demonstrated the complex recombination of HIV-1 in Hong Kong and the need in developing surveillance system for tracking the distribution of new HIV-1 genetic variants...
  83. ncbi request reprint Laribacter hongkongensis: a potential cause of infectious diarrhea
    Patrick C Y Woo
    Department of Microbiology, The University of Hong Kong, China
    Diagn Microbiol Infect Dis 47:551-6. 2003
    ..More extensive epidemiologic studies should be carried out to ascertain the causative association between L. hongkongensis and diarrhea and to define the reservoir and modes of transmission of L. hongkongensis...
  84. ncbi request reprint Characterization of a novel insertion sequence, IS Bp1, in Burkholderia pseudomallei
    Patrick C Y Woo
    Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
    Arch Microbiol 177:267-73. 2002
    ..Using several insertion sequences and a combination of insertion-sequence-based and non-insertion-sequence-based methods such as ribotyping will probably increase the discriminatory power of molecular typing in B. pseudomallei...
  85. doi request reprint D225G mutation in hemagglutinin of pandemic influenza H1N1 (2009) virus enhances virulence in mice
    Bojian Zheng
    Department of Microbiology, The University of Hong Kong, Pokfulam, China
    Exp Biol Med (Maywood) 235:981-8. 2010
    ..The only consistent mutation in the genomes of viral clones obtained from dying mice was D225G substitution...
  86. doi request reprint Molecular epidemiology of methicillin-resistant Staphylococcus aureus in residential care homes for the elderly in Hong Kong
    Pak Leung Ho
    Division of Infectious Diseases, Department of Microbiology and Centre of Infection, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China
    Diagn Microbiol Infect Dis 61:135-42. 2008
    ..In contrast, HKU50 strains exhibit both multidrug resistance (MDR) (involving ciprofloxacin, erythromycin, and tetracycline, but not gentamicin) and non-MDR patterns...
  87. pmc Clinical and molecular epidemiology of human parainfluenza virus 4 infections in hong kong: subtype 4B as common as subtype 4A
    Susanna K P Lau
    Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong
    J Clin Microbiol 47:1549-52. 2009
    ..Patients with HPIV4 infection were mainly young children and immunocompromised adults. In contrast to the reported predominance of HPIV4A infection, molecular subtyping revealed that 15 (44%) cases were caused by HPIV4B...
  88. pmc CoVDB: a comprehensive database for comparative analysis of coronavirus genes and genomes
    Yi Huang
    Department of Microbiology, Research Centre of Infection and Immunology and State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong
    Nucleic Acids Res 36:D504-11. 2008
    ..With the annotated sequences in CoVDB, more specific blast search results can be generated for efficient downstream analysis...
  89. ncbi request reprint Cytosine deamination and selection of CpG suppressed clones are the two major independent biological forces that shape codon usage bias in coronaviruses
    Patrick C Y Woo
    State Key Laboratory of Emerging Infectious Diseases, Hong Kong Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong Department of Microbiology, The University of Hong Kong, Hong Kong
    Virology 369:431-42. 2007
    ..The underlying mechanism for the extreme codon usage bias, cytosine deamination and G+C content in CoV-HKU1 warrants further studies...
  90. pmc Clinical features and complete genome characterization of a distinct human rhinovirus (HRV) genetic cluster, probably representing a previously undetected HRV species, HRV-C, associated with acute respiratory illness in children
    Susanna K P Lau
    State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
    J Clin Microbiol 45:3655-64. 2007
    ..A newly identified HRV species, HRV-C, is circulating worldwide and is an important cause of febrile wheeze and asthmatic exacerbations in children requiring hospitalization...
  91. ncbi request reprint Characterization of a novel cryptic plasmid, pHLHK26, in Laribacter hongkongensis
    Patrick C Y Woo
    Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
    New Microbiol 30:139-47. 2007
    ....
  92. pmc First report of Tsukamurella keratitis: association between T. tyrosinosolvens and T. pulmonis and ophthalmologic infections
    Patrick C Y Woo
    State Key Laboratory of Emerging Infectious Diseases, Research Centre of Infection and Immunology, and Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
    J Clin Microbiol 47:1953-6. 2009
    ..One case was associated with trichiasis and the other with contact lens wear. The two isolates were identified as T. tyrosinosolvens and T. pulmonis, respectively, by phenotypic characterization and 16S rRNA sequencing...
  93. pmc Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection
    Vincent C C Cheng
    State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong Special Administrative Region, China
    Clin Microbiol Rev 20:660-94. 2007
    ....
  94. doi request reprint Lactobacillus rhamnosus hepatic abscess associated with Mirizzi syndrome: a case report and review of the literature
    Jasper F W Chan
    Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region, China
    Diagn Microbiol Infect Dis 66:94-7. 2010
    ..Literature on sporadic reports of Lactobacillus liver abscess is reviewed...
  95. ncbi request reprint Bats as a continuing source of emerging infections in humans
    Samson Wong
    Department of Microbiology, Research Centre of Infection and Immunology, The University of Hong Kong, 4 F University Pathology Building, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong
    Rev Med Virol 17:67-91. 2007
    ..A systematic survey of bats is warranted to better understand the ecology of these viruses...
  96. doi request reprint Viral load in patients infected with pandemic H1N1 2009 influenza A virus
    Kelvin K W To
    Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region, China
    J Med Virol 82:1-7. 2010
    ..Younger age was associated with prolonged shedding in the respiratory tract and higher viral load in the stool. Data from this quantitative analysis of viral shedding may have implications for formulating infection control measures...
  97. pmc Oseltamivir-resistant influenza A pandemic (H1N1) 2009 virus, Hong Kong, China
    Honglin Chen
    The University of Hong Kong, Hong Kong Special Administrative Region, People s Republic of China
    Emerg Infect Dis 15:1970-2. 2009
    ..Investigations showed a resistant virus with the neuraminidase (NA) 274Y genotype in quasi-species from a nasopharyngeal aspirate. Monitoring for the naturally occurring NA 274Y mutation in this virus is necessary...
  98. ncbi request reprint Single gene target bacterial identification. groEL gene sequencing for discriminating clinical isolates of Burkholderia pseudomallei and Burkholderia thailandensis
    Patrick C Y Woo
    Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
    Diagn Microbiol Infect Dis 44:143-9. 2002
    ....