Qing Ye He

Summary

Affiliation: The University of Hong Kong
Country: China

Publications

  1. pmc Identification of Proteins Related to Nickel Homeostasis in Helicobater pylori by Immobilized Metal Affinity Chromatography and Two-Dimensional Gel Electrophoresis
    Xuesong Sun
    Institute of Life and Health Engineering, Jinan University, Guangzhou 510632, China
    Met Based Drugs 2008:289490. 2008
  2. ncbi request reprint Serological protein profiling of neuroblastoma by ProteinChip SELDI-TOF technology
    Qing Yu He
    Department of Chemistry, University of Hong Kong, Pokfulam, Hong Kong, China
    J Cell Biochem 95:165-72. 2005
  3. ncbi request reprint Proteomics in biomarker discovery and drug development
    Qing Yu He
    Department of Chemistry, University of Hong Kong, Pokfulam, Hong Kong, China
    J Cell Biochem 89:868-86. 2003
  4. ncbi request reprint Diverse proteomic alterations in gastric adenocarcinoma
    Qing Ye He
    Department of Chemistry, University of Hong Kong, China
    Proteomics 4:3276-87. 2004
  5. ncbi request reprint Identification of tumor-associated proteins in oral tongue squamous cell carcinoma by proteomics
    Qing Yu He
    Department of Chemistry, University of Hong Kong, Hong Kong, China
    Proteomics 4:271-8. 2004
  6. doi request reprint Proteomic identification of malignant transformation-related proteins in esophageal squamous cell carcinoma
    Yi Jun Qi
    Key Laboratory of Cellular and Molecular Immunology, Institute of Immunology, College of Medicine, Henan University, Keifeng, Henan 475000, China
    J Cell Biochem 104:1625-35. 2008
  7. ncbi request reprint Proteomics approach to illustrate drug action mechanisms
    Ying Wang
    Department of Chemistry, The University of Hong Kong, Pokfulam, Hong Kong, China
    Curr Drug Discov Technol 3:199-209. 2006
  8. ncbi request reprint Comparative proteomic analysis of esophageal squamous cell carcinoma
    Yijun Qi
    Laboratory for Cancer Research, College of Medicine, Zhengzhou University, Zhengzhou, China
    Proteomics 5:2960-71. 2005
  9. ncbi request reprint Synergistic effects of retinoic acid and tamoxifen on human breast cancer cells: proteomic characterization
    Ying Wang
    Department of Chemistry, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Exp Cell Res 313:357-68. 2007
  10. ncbi request reprint Toward the proteomic identification of biomarkers for the prediction of HBV related hepatocellular carcinoma
    Qing Yu He
    Department of Chemistry and Open Laboratory of Chemical Biology, University of Hong Kong, Hong Kong, China
    J Cell Biochem 103:740-52. 2008

Collaborators

  • Ruiguang Ge
  • Yi Ren
  • Suet Yi Leung
  • Jianqing Fan
  • B C Wong
  • John M Luk
  • Ying Wang
  • Jen Fu Chiu
  • Xuesong Sun
  • Ting Lei
  • Zhen Cai
  • Andy T Y Lau
  • Yuan Zhou
  • Hongzhe Sun
  • Yi Jun Qi
  • Chi Chun Wong
  • Lu Sheng Si
  • Sheng Xiong
  • Chun Nam Lok
  • Yijun Qi
  • Pei hui Yang
  • Yin Lau Lee
  • Jia Chen
  • Zongwei Cai
  • Ka Wing Cheng
  • Yuan Fang Ma
  • Yan Jie Li
  • Sai Ming Ngai
  • Yao Wu Du
  • Inderjeet Bhatia
  • Guang Chao Liu
  • George S W Tsao
  • Feng Chen
  • Ling Zhang
  • Pik To Cheung
  • Rong Chen
  • Paul Kwong Hang Tam
  • Chi Ming Ho
  • Chi Ming Che
  • Wing Yiu Yu
  • Dora L W Kwong
  • Lidong Wang
  • Jia Sen Xu
  • Will M Lee
  • Jeng Fu Chiu
  • William S B Yeung
  • Kai Fai Lee
  • Anthony Po Wing Yuen

Detail Information

Publications37

  1. pmc Identification of Proteins Related to Nickel Homeostasis in Helicobater pylori by Immobilized Metal Affinity Chromatography and Two-Dimensional Gel Electrophoresis
    Xuesong Sun
    Institute of Life and Health Engineering, Jinan University, Guangzhou 510632, China
    Met Based Drugs 2008:289490. 2008
    ..The implication of these proteins in nickel homeostasis is discussed...
  2. ncbi request reprint Serological protein profiling of neuroblastoma by ProteinChip SELDI-TOF technology
    Qing Yu He
    Department of Chemistry, University of Hong Kong, Pokfulam, Hong Kong, China
    J Cell Biochem 95:165-72. 2005
    ..These results demonstrated the potential of serological biomarker identification for neuroblastoma by ProteinChip-SELDI technology...
  3. ncbi request reprint Proteomics in biomarker discovery and drug development
    Qing Yu He
    Department of Chemistry, University of Hong Kong, Pokfulam, Hong Kong, China
    J Cell Biochem 89:868-86. 2003
    ..This article provides a brief overview of the proteomic technologies and their application in biomarker discovery and drug development...
  4. ncbi request reprint Diverse proteomic alterations in gastric adenocarcinoma
    Qing Ye He
    Department of Chemistry, University of Hong Kong, China
    Proteomics 4:3276-87. 2004
    ....
  5. ncbi request reprint Identification of tumor-associated proteins in oral tongue squamous cell carcinoma by proteomics
    Qing Yu He
    Department of Chemistry, University of Hong Kong, Hong Kong, China
    Proteomics 4:271-8. 2004
    ..The potential of utilizing these tumor related proteins for screening cancer and monitoring recurrence warrants further investigation...
  6. doi request reprint Proteomic identification of malignant transformation-related proteins in esophageal squamous cell carcinoma
    Yi Jun Qi
    Key Laboratory of Cellular and Molecular Immunology, Institute of Immunology, College of Medicine, Henan University, Keifeng, Henan 475000, China
    J Cell Biochem 104:1625-35. 2008
    ..Expression pattern of annexin A2 was verified by Western blotting, immunocytochemistry and immunohistochemistry analysis. The implication of these protein alterations correlated to the esophageal malignant transformation is discussed...
  7. ncbi request reprint Proteomics approach to illustrate drug action mechanisms
    Ying Wang
    Department of Chemistry, The University of Hong Kong, Pokfulam, Hong Kong, China
    Curr Drug Discov Technol 3:199-209. 2006
    ....
  8. ncbi request reprint Comparative proteomic analysis of esophageal squamous cell carcinoma
    Yijun Qi
    Laboratory for Cancer Research, College of Medicine, Zhengzhou University, Zhengzhou, China
    Proteomics 5:2960-71. 2005
    ..These data may suggest that these proteins contribute to the multistage process of carcinogenesis, tumor progression, and invasiveness of ESCC...
  9. ncbi request reprint Synergistic effects of retinoic acid and tamoxifen on human breast cancer cells: proteomic characterization
    Ying Wang
    Department of Chemistry, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Exp Cell Res 313:357-68. 2007
    ..These results provide valuable insights into the mechanisms of RA and tamoxifen-induced TGFbeta signaling pathway in breast cancer cells...
  10. ncbi request reprint Toward the proteomic identification of biomarkers for the prediction of HBV related hepatocellular carcinoma
    Qing Yu He
    Department of Chemistry and Open Laboratory of Chemical Biology, University of Hong Kong, Hong Kong, China
    J Cell Biochem 103:740-52. 2008
    ..Given the fact that SAA is not a specific biomarker, further attempt is being made to identify the other two most discriminatory peaks to realize the possibility of using the predictive model for HCC surveillance and prediction...
  11. ncbi request reprint Proteomics of buccal squamous cell carcinoma: the involvement of multiple pathways in tumorigenesis
    Jia Chen
    Institute of Molecular Biology, University of Hong Kong, China
    Proteomics 4:2465-75. 2004
    ....
  12. ncbi request reprint Proteomic analysis of a preneoplastic phenotype in ovarian surface epithelial cells derived from prophylactic oophorectomies
    Qing Yu He
    Department of Chemistry, University of Hong Kong, Hong Kong Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, University of Hong Kong, Hong Kong
    Gynecol Oncol 98:68-76. 2005
    ..To study the pattern of protein expression associated with a predisposition to develop ovarian cancer...
  13. ncbi request reprint Application of proteomics in the study of tumor metastasis
    Zhen Cai
    Department of Surgery, The University of Hong Kong, Hong Kong, China
    Genomics Proteomics Bioinformatics 2:152-66. 2004
    ....
  14. ncbi request reprint Proteomic analysis of the mode of antibacterial action of silver nanoparticles
    Chun Nam Lok
    Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam, Hong Kong, China
    J Proteome Res 5:916-24. 2006
    ..Nano-Ag appear to be an efficient physicochemical system conferring antimicrobial silver activities...
  15. ncbi request reprint Proteomic approach to study the cytotoxicity of dioscin (saponin)
    Ying Wang
    Department of Chemistry and Open Laboratory of Chemical Biology, University of Hong Kong, Pokfulam, Hong Kong, PR China
    Proteomics 6:2422-32. 2006
    ..Current study of protein alterations in dioscin-treated HL-60 cells suggested that dioscin exerts cytotoxicity through multiple apoptosis-inducing pathways...
  16. ncbi request reprint Heparin chromatography to deplete high-abundance proteins for serum proteomics
    Ting Lei
    Institute of Cancer Research, School of Life Science and Technology, Xi an Jiaotong University, Xi an, China
    Clin Chim Acta 388:173-8. 2008
    ..A highly promising first step for most analytical approaches of serum is to deplete as many of the high-abundance proteins as possible...
  17. doi request reprint Proteomic analysis of neonatal mouse brain: evidence for hypoxia- and ischemia-induced dephosphorylation of collapsin response mediator proteins
    Yuan Zhou
    Department of Anatomy, The University of Hong Kong, Hong Kong
    J Proteome Res 7:2507-15. 2008
    ..Hypophosphorylated CRMPs might be implicated in the pathogenesis of HI-related neurological disorders...
  18. pmc A proteome analysis of the arsenite response in cultured lung cells: evidence for in vitro oxidative stress-induced apoptosis
    Andy T Y Lau
    Institute of Molecular Biology, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, People s Republic of China
    Biochem J 382:641-50. 2004
    ..Taken together, our results demonstrate that high levels of arsenite cause oxidative stress-induced apoptosis...
  19. doi request reprint Isolation of cytoplasmatic proteins from cultured cells for two-dimensional gel electrophoresis
    Ying Wang
    The University of Hong Kong, Hong Kong, China
    Methods Mol Biol 425:101-12. 2008
    ..Isolation of cytoplasmic proteins from cells is a necessary step for high resolution protein separation by two-dimensional gel electrophoresis (2DE) and specific proteomic analysis...
  20. doi request reprint Modulation of gold(III) porphyrin 1a-induced apoptosis by mitogen-activated protein kinase signaling pathways
    Ying Wang
    Department of Chemistry and Open Laboratory of Chemical Biology, The University of Hong Kong, Hong Kong SAR, China
    Biochem Pharmacol 75:1282-91. 2008
    ..These results suggested that gold(III) porphyrin 1a is a promising anticancer agent directed toward the mitochondria...
  21. doi request reprint Fractionation of proteins by heparin chromatography
    Sheng Xiong
    Jinan University, Guangzhou, China
    Methods Mol Biol 424:213-21. 2008
    ..As an example, the fractionation of fibroblast growth factors (FGFs) from the extract of mouse brain microvascular endothelial cells (MVEC) is now introduced to demonstrate the procedure of heparin chromatography...
  22. ncbi request reprint A proteomic approach for the identification of bismuth-binding proteins in Helicobacter pylori
    Ruiguang Ge
    Department of Chemistry and Open Laboratory of Chemical Biology, The University of Hong Kong, Pokfulam Road, Hong Kong, People s Republic of China
    J Biol Inorg Chem 12:831-42. 2007
    ..Our data suggest that the inhibition of proteases, modulation of cellular oxidative stress and interference with nickel homeostasis may be key processes underlying the molecular mechanism of bismuth's actions against H. pylori...
  23. ncbi request reprint Application of immobilized metal affinity chromatography in proteomics
    Xuesong Sun
    Department of Chemistry, University of Hong Kong, Pokfulam, Hong Kong
    Expert Rev Proteomics 2:649-57. 2005
    ..In the near future, newly developed IMAC integrated with other proteomic methods will greatly contribute to the revolution of expression, cell-mapping and structural proteomics...
  24. doi request reprint Comparative proteomic analysis of indioside D-triggered cell death in HeLa cells
    Chi Chun Wong
    School of Biological Sciences, Department of Anatomy, The University of Hong Kong, Hong Kong SAR, China
    J Proteome Res 7:2050-8. 2008
    ..These results suggest that indioside D induced apoptosis in HeLa cells via both intrinsic and extrinsic cell death pathways...
  25. ncbi request reprint Transferrin-mediated gold nanoparticle cellular uptake
    Pei hui Yang
    Department of Chemistry and Open Laboratory of Chemical Biology, University of Hong Kong, Hong Kong
    Bioconjug Chem 16:494-6. 2005
    ..This specific transferrin-mediated nanoparticle uptake was validated by confocal scanning imaging and transferrin competition experiments...
  26. ncbi request reprint The embryotrophic activity of oviductal cell-derived complement C3b and iC3b, a novel function of complement protein in reproduction
    Yin Lau Lee
    Department of Obstetrics and Gynaecology, University of Hong Kong, Pokfulam Road, Hong Kong SAR, China
    J Biol Chem 279:12763-8. 2004
    ..In conclusion, the present data showed that the oviduct produced C3/C3b, which was converted to iC3b to stimulate embryo development...
  27. ncbi request reprint Proteomic technology and its biomedical applications
    Andy T Y Lau
    Institute of Molecular Biology, The University of Hong Kong, Hong Kong, China
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 35:965-75. 2003
    ..This review describes recent advances in proteomic technology and discusses the potential applications of proteomics in biomedical research...
  28. ncbi request reprint Serum biomarkers of hepatitis B virus infected liver inflammation: a proteomic study
    Qing Yu He
    Department of Chemistry, University of Hong Kong, Pokfulam, Hong Kong, China
    Proteomics 3:666-74. 2003
    ..These unique phenomena appear specific to HBV infection. A combination simultaneously considering the quantities and isoforms of these proteins could be a useful serum biomarker (or index) for HBV diagnosis and therapy...
  29. ncbi request reprint Cellular pharmacological properties of gold(III) porphyrin 1a, a potential anticancer drug lead
    Ying Wang
    Department of Chemistry and Open Laboratory of Chemical Biology, The University of Hong Kong, Hong Kong SAR, China
    Eur J Pharmacol 554:113-22. 2007
    ..Our results highlighted the potential of gold(III) porphyrin 1a as an anticancer drug...
  30. ncbi request reprint Proteomic characterization of the cytotoxic mechanism of gold (III) porphyrin 1a, a potential anticancer drug
    Ying Wang
    Department of Chemistry, The University of Hong Kong, Pokfulam, Hong Kong SAR, P R China
    Proteomics 6:131-42. 2006
    ..Our results indicated that multiple factors leading to apoptosis were involved in drug cytotoxicity in SUNE1 cells. The balance between pro-apoptotic and anti-apoptotic signals determined the final fate of cancer cells...
  31. ncbi request reprint The use of proteomics in the discovery of serum biomarkers from patients with severe acute respiratory syndrome
    Yi Ren
    Department of Surgery, The University of Hong Kong, Hong Kong, China
    Proteomics 4:3477-84. 2004
    ..These findings indicate that increased TF-alpha(1)-AT may be therapeutically relevant, and may also be a useful biological marker for the diagnosis of SARS...
  32. ncbi request reprint Proteomic analysis of chromium cytotoxicity in cultured rat lung epithelial cells
    Ting Lei
    Department of Pathology, School of Medicine, Xi an Jiaotong University, Xi an, China
    Proteomics 8:2420-9. 2008
    ..The current findings provided additional evidence in protein level to support the claim that ROS generated during the process of Cr(VI) reduction are involved in the Cr(VI)-induced toxicity and carcinogenesis...
  33. ncbi request reprint Dioscin (saponin)-induced generation of reactive oxygen species through mitochondria dysfunction: a proteomic-based study
    Ying Wang
    Department of Chemistry, The University of Hong Kong, Hong Kong SAR, People s Republic of China
    J Proteome Res 6:4703-10. 2007
    ..The current study provided detailed evidence to support that dioscin is capable of inducing apoptosis in mammalian cells, in which the mitochondria-initiated apoptosis pathway plays an important role...
  34. ncbi request reprint GoldIII porphyrin 1a induced apoptosis by mitochondrial death pathways related to reactive oxygen species
    Ying Wang
    Department of Chemistry, The University of Hong Kong, SAR, China
    Cancer Res 65:11553-64. 2005
    ..These results support a role for gold(III) porphyrin 1a as a promising anticancer drug lead and as a possible novel therapeutic agent directed toward the mitochondria...
  35. ncbi request reprint Proteomic analyses of arsenic-induced cell transformation with SELDI-TOF ProteinChip technology
    Qing Yu He
    Department of Chemistry, The University of Hong Kong, Hong Kong, China
    J Cell Biochem 88:1-8. 2003
    ..Identification and characterization of these proteins may reveal the molecular basis of As-induced cell transformation and provide insight into the mechanisms by which arsenic induces carcinogenesis...
  36. doi request reprint Fractionation of proteins by immobilized metal affinity chromatography
    Xuesong Sun
    The University of Hong Kong, Hong Kong, China
    Methods Mol Biol 424:205-12. 2008
    ..In the future, newly developed IMAC techniques integrated with other proteomic methods will significantly contribute to the further development of proteomics...
  37. doi request reprint Cytokeratin 8 silencing in human nasopharyngeal carcinoma cells leads to cisplatin sensitization
    Ying Wang
    Department of Chemistry, The University of Hong Kong, Hong Kong SAR, China
    Cancer Lett 265:188-96. 2008
    ..Our findings implicate an underlying molecular mechanism in which CK8 is required for cisplatin resistance...