Sheng Chen

Summary

Affiliation: The Hong Kong Polytechnic University
Country: China

Publications

  1. doi request reprint Ebselen as a potent covalent inhibitor of New Delhi metallo-β-lactamase (NDM-1)
    Jiachi Chiou
    Shenzhen Key Laboratory for Food Biological Safety Control, Food Safety and Technology Research Centre, The Hong Kong Polytechnic University, Shenzhen Research Institute, Shenzhen, P R China
    Chem Commun (Camb) 51:9543-6. 2015
  2. doi request reprint Solubility of the catalytic domains of Botulinum neurotoxin serotype E subtypes
    Sheng Chen
    Shenzhen Key Lab for Food Biological Safety Control, Food Safety and Technology Research Center, Hong Kong PolyU Shenzhen Research Institute, Shenzhen, PR China State Key Lab of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong Special Administrative Region Electronic address
    Protein Expr Purif 118:18-24. 2016
  3. pmc Characterization of a novel zinc transporter ZnuA acquired by Vibrio parahaemolyticus through horizontal gene transfer
    Ming Liu
    Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University Hong Kong, China Food Safety and Technology Research Center, Hong Kong PolyU Shen Zhen Research Institute Shenzhen, China
    Front Cell Infect Microbiol 3:61. 2013
  4. pmc Clinical uses of botulinum neurotoxins: current indications, limitations and future developments
    Sheng Chen
    Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong
    Toxins (Basel) 4:913-39. 2012
  5. pmc Molecular Characterization of Escherichia coli Strains Isolated from Retail Meat That Harbor blaCTX-M and fosA3 Genes
    Miaomiao Xie
    College of Animal Science and Technology, Nanjing Agriculture University, Nanjing, People s Republic of China Shenzhen Key Laboratory for Food Biological Safety Control, Food Safety and Technology Research Centre, The Hong Kong PolyU Shenzhen Research Institute, Shenzhen, People s Republic of China
    Antimicrob Agents Chemother 60:2450-5. 2016
  6. doi request reprint Engineering Clostridia Neurotoxins with elevated catalytic activity
    Jiubiao Guo
    Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong Special Administrative Region
    Toxicon 74:158-66. 2013
  7. pmc Mechanism of substrate recognition by the novel Botulinum Neurotoxin subtype F5
    Jiubiao Guo
    Shenzhen Key Lab for Food Biological Safety Control, Food Safety and Technology Research Center, Hong Kong PolyU Shen Zhen Research Institute, Shenzhen, P R China
    Sci Rep 6:19875. 2016
  8. doi request reprint Comparative characterization of botulinum neurotoxin subtypes F1 and F7 featuring differential substrate recognition and cleavage mechanisms
    Jiubiao Guo
    Shenzhen Key Lab for Food Biological Safety Control, Food Safety and Technology Research Center, Hong Kong PolyU Shen Zhen Research Institute, Shenzhen, PR China State Key Lab of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong
    Toxicon 111:77-85. 2016
  9. pmc Characterization of an IncA/C Multidrug Resistance Plasmid in Vibrio alginolyticus
    Lianwei Ye
    College of Animal Science and Technology, Nanjing Agriculture University, Nanjing, People s Republic of China Shenzhen Key Laboratory for Food Biological Safety Control, Food Safety and Technology Research Centre, The Hong Kong PolyU Shenzhen Research Institute, Shenzhen, People s Republic of China
    Antimicrob Agents Chemother 60:3232-5. 2016
  10. pmc Comparative Characterization of CTX-M-64 and CTX-M-14 Provides Insights into the Structure and Catalytic Activity of the CTX-M Class of Enzymes
    Dandan He
    College of Veterinary Medicine, Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, National Reference Laboratory of Veterinary Drug Residues SCAU, South China Agricultural University, Guangzhou, People s Republic of China Shenzhen Key Laboratory for Food Biological Safety Control, Food Safety and Technology Research Center, Hong Kong Polytechnic University, Shen Zhen Research Institute, Shenzhen, People s Republic of China
    Antimicrob Agents Chemother 60:6084-90. 2016

Collaborators

  • Ming Liu
  • Mo Yang
  • Yong Wang
  • Xuechen Li
  • Yanxiang Zhao
  • Edward Wai Chi Chan
  • Ruichao Li
  • Jiubiao Guo
  • Marcus Ho Yin Wong
  • Dachuan Lin
  • Jiachi Chiou
  • Miaomiao Xie
  • Dandan He
  • Kaichao Chen
  • Meiying Yan
  • Lianwei Ye
  • Yuanjie Zhou
  • Liqi Xie
  • Wen Yao
  • Zhiwei Zheng
  • Kathy Hiu Laam Po
  • Marcus H Wong
  • Lizhang Liu
  • Jian Hua Liu
  • Edward Wai-Chi Chan
  • Zhenling Zeng
  • Jingyu Shi
  • Edward Waichi Chan
  • Jinglin Wang
  • Qiong Ding
  • Aisi Fu
  • Jinfei Zhang
  • Xiaobo Liu
  • Jingzhang Lv
  • Edward W Chan
  • Zhiqiang Yang
  • Biao Kan
  • Shan Gao
  • Gongxun Bai
  • Tak Hang Chan
  • Lanping Liu
  • Kwok Yin Wong
  • Pui Kin So
  • Xiaojie Chen
  • Weiwei Ye
  • Shengbiao Wan
  • Jiang Tao
  • Bin Ji
  • Xuan Liu
  • Chunyu Chan
  • Kin Fai Chan
  • Li Zeng
  • Jianhua Hao
  • Kan Biao
  • Ci Xu
  • Song Lin
  • Thomas Yun Chung Leung
  • Xuehua Pan
  • Hoi Ying Wan

Detail Information

Publications44

  1. doi request reprint Ebselen as a potent covalent inhibitor of New Delhi metallo-β-lactamase (NDM-1)
    Jiachi Chiou
    Shenzhen Key Laboratory for Food Biological Safety Control, Food Safety and Technology Research Centre, The Hong Kong Polytechnic University, Shenzhen Research Institute, Shenzhen, P R China
    Chem Commun (Camb) 51:9543-6. 2015
    ....
  2. doi request reprint Solubility of the catalytic domains of Botulinum neurotoxin serotype E subtypes
    Sheng Chen
    Shenzhen Key Lab for Food Biological Safety Control, Food Safety and Technology Research Center, Hong Kong PolyU Shenzhen Research Institute, Shenzhen, PR China State Key Lab of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong Special Administrative Region Electronic address
    Protein Expr Purif 118:18-24. 2016
    ..In conclusion, this study generated a soluble and stable recombinant LC/E and provided insight into the structural components that govern the solubility and stability of the LCs of other BoNT serotypes and Tetanus toxin. ..
  3. pmc Characterization of a novel zinc transporter ZnuA acquired by Vibrio parahaemolyticus through horizontal gene transfer
    Ming Liu
    Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University Hong Kong, China Food Safety and Technology Research Center, Hong Kong PolyU Shen Zhen Research Institute Shenzhen, China
    Front Cell Infect Microbiol 3:61. 2013
    ..These results suggest that the horizontally acquired znuA subfamily gene, vpa1307, contributes to the fitness and virulence of Vibrio species. ..
  4. pmc Clinical uses of botulinum neurotoxins: current indications, limitations and future developments
    Sheng Chen
    Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong
    Toxins (Basel) 4:913-39. 2012
    ..Much research still needs to be done to improve and extend the medical uses of BoNTs...
  5. pmc Molecular Characterization of Escherichia coli Strains Isolated from Retail Meat That Harbor blaCTX-M and fosA3 Genes
    Miaomiao Xie
    College of Animal Science and Technology, Nanjing Agriculture University, Nanjing, People s Republic of China Shenzhen Key Laboratory for Food Biological Safety Control, Food Safety and Technology Research Centre, The Hong Kong PolyU Shenzhen Research Institute, Shenzhen, People s Republic of China
    Antimicrob Agents Chemother 60:2450-5. 2016
    ..colistrains in retail meats is a common event and that such strains may constitute an important reservoir ofblaCTX-Mgenes, which may be readily disseminated to other potential human pathogens. ..
  6. doi request reprint Engineering Clostridia Neurotoxins with elevated catalytic activity
    Jiubiao Guo
    Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong Special Administrative Region
    Toxicon 74:158-66. 2013
    ..The LC/B derivative with elevated activity has the potential to be developed into novel therapy to minimize the impact of immunoresistance during BoNT/B therapy. ..
  7. pmc Mechanism of substrate recognition by the novel Botulinum Neurotoxin subtype F5
    Jiubiao Guo
    Shenzhen Key Lab for Food Biological Safety Control, Food Safety and Technology Research Center, Hong Kong PolyU Shen Zhen Research Institute, Shenzhen, P R China
    Sci Rep 6:19875. 2016
    ..The study provides direct evidence of the evolutionary adaption of BoNT to recognize its substrate which is useful for effective antitoxin and inhibitor development. ..
  8. doi request reprint Comparative characterization of botulinum neurotoxin subtypes F1 and F7 featuring differential substrate recognition and cleavage mechanisms
    Jiubiao Guo
    Shenzhen Key Lab for Food Biological Safety Control, Food Safety and Technology Research Center, Hong Kong PolyU Shen Zhen Research Institute, Shenzhen, PR China State Key Lab of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong
    Toxicon 111:77-85. 2016
    ..Our findings provide insights into the distinct substrate recognition features of BoNT subtypes and useful information for therapy development for BoNT/F. ..
  9. pmc Characterization of an IncA/C Multidrug Resistance Plasmid in Vibrio alginolyticus
    Lianwei Ye
    College of Animal Science and Technology, Nanjing Agriculture University, Nanjing, People s Republic of China Shenzhen Key Laboratory for Food Biological Safety Control, Food Safety and Technology Research Centre, The Hong Kong PolyU Shenzhen Research Institute, Shenzhen, People s Republic of China
    Antimicrob Agents Chemother 60:3232-5. 2016
    ..Its backbone exhibited genetic homology to known IncA/C plasmids recoverable from members of the family Enterobacteriaceae, suggesting its possible origin in Enterobacteriaceae. ..
  10. pmc Comparative Characterization of CTX-M-64 and CTX-M-14 Provides Insights into the Structure and Catalytic Activity of the CTX-M Class of Enzymes
    Dandan He
    College of Veterinary Medicine, Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, National Reference Laboratory of Veterinary Drug Residues SCAU, South China Agricultural University, Guangzhou, People s Republic of China Shenzhen Key Laboratory for Food Biological Safety Control, Food Safety and Technology Research Center, Hong Kong Polytechnic University, Shen Zhen Research Institute, Shenzhen, People s Republic of China
    Antimicrob Agents Chemother 60:6084-90. 2016
    ..Our data confirmed that, in addition to the important residues located in the active site, residues distal to the active site also contribute to the catalytic activity of the enzyme through stabilizing its structural integrity. ..
  11. pmc Unique substrate recognition mechanism of the botulinum neurotoxin D light chain
    Jiubiao Guo
    From the Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China
    J Biol Chem 288:27881-7. 2013
    ..In conclusion, in this study, we identified a unique multistep substrate recognition mechanism by LC/D and provide insights for LC/D engineering and antitoxin development. ..
  12. pmc IncI1 Plasmids Carrying Various blaCTX-M Genes Contribute to Ceftriaxone Resistance in Salmonella enterica Serovar Enteritidis in China
    Marcus Ho Yin Wong
    State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong Shenzhen Key Laboratory for Food Biological Safety Control, Food Safety and Technology Research Centre, The Hong Kong PolyU Shenzhen Research Institute, Shenzhen, People s Republic of China
    Antimicrob Agents Chemother 60:982-9. 2016
    ....
  13. pmc IncFII Conjugative Plasmid-Mediated Transmission of blaNDM-1 Elements among Animal-Borne Escherichia coli Strains
    Dachuan Lin
    Shenzhen Key Laboratory for Food Biological Safety Control, Food Safety and Technology Research Center, Hong Kong PolyU Shen Zhen Research Institute, Shenzhen, People s Republic of China
    Antimicrob Agents Chemother 61:. 2017
    ..The blaNDM-1 gene can be incorporated into plasmids and stably inherited in animal-borne E. coli strains that can be maintained in animal gut microflora even without carbapenem selection pressure...
  14. pmc Complete Sequence of a F33:A-:B- Conjugative Plasmid Carrying the oqxAB, fosA3, and blaCTX-M-55 Elements from a Foodborne Escherichia coli Strain
    Marcus H Wong
    Shenzhen Key Laboratory for Food Biological Safety Control, Food Safety and Technology Research Centre, Shenzhen Research Institute, The Hong Kong Polytechnic UniversityShenzhen, China State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic UniversityKowloon, Hong Kong
    Front Microbiol 7:1729. 2016
    ..Dissemination of these plasmids may further compromise the effectiveness of current antimicrobial strategies...
  15. doi request reprint Genetic characterization of mcr-1-bearing plasmids to depict molecular mechanisms underlying dissemination of the colistin resistance determinant
    Ruichao Li
    Shenzhen Key Lab for Food Biological Safety Control, Food Safety and Technology Research Center, Hong Kong PolyU Shen Zhen Research Institute, Shenzhen, P R China
    J Antimicrob Chemother . 2016
    ..To analyse and compare mcr-1-bearing plasmids from animal Escherichia coli isolates, and to investigate potential mechanisms underlying dissemination of mcr-1...
  16. pmc Mutational Analysis of Quinolone Resistance Protein QnrVC7 Provides Novel Insights into the Structure-Activity Relationship of Qnr Proteins
    Kathy Hiu Laam Po
    Shenzhen Key Lab for Food Biological Safety Control, Food Safety and Technology Research Center, Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, People s Republic of China State Key Lab of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, People s Republic of China
    Antimicrob Agents Chemother 60:1939-42. 2016
    ..Some substitutions reduced the protective activity of QnrVC7, while some of them increased it. These findings advanced our understanding on the detailed structural organization and functional requirements of Qnr proteins. ..
  17. pmc Insights into the different catalytic activities of Clostridium neurotoxins
    Sheng Chen
    Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR
    Biochemistry 51:3941-7. 2012
    ..This analysis explains the molecular basis underlying the VAMP2 recognition and cleavage by LC/B and LC/T and provides insight that may extend the pharmacologic utility of these neurological reagents...
  18. pmc A Novel PCR-Based Approach for Accurate Identification of Vibrio parahaemolyticus
    Ruichao Li
    Shenzhen Key Lab for Food Biological Safety Control, Food Safety and Technology Research Center, Hong Kong PolyU Shen Zhen Research InstituteShenzhen, China State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic UniversityHung Hom, Hong Kong
    Front Microbiol 7:44. 2016
    ..parahaemolyticus detection and identification. ..
  19. doi request reprint Complete genetic analysis of plasmids carrying mcr-1 and other resistance genes in an Escherichia coli isolate of animal origin
    Ruichao Li
    Shenzhen Key Lab for Food Biological Safety Control, Food Safety and Technology Research Center, Hong Kong PolyU Shen Zhen Research Institute, Shenzhen, P R China
    J Antimicrob Chemother . 2016
    ..The ability of the mcr-1-bearing plasmid to undergo conjugation was also assessed. The mcr-1-bearing transposon Tn6330 was characterized by PCR and DNA sequencing...
  20. pmc IncHI2 Plasmids Are the Key Vectors Responsible for oqxAB Transmission among Salmonella Species
    Marcus Ho Yin Wong
    Shenzhen Key Laboratory for Food Biological Safety Control, Food Safety and Technology Research Centre, The Hong Kong PolyU Shenzhen Research Institute, Shenzhen, People s Republic of China
    Antimicrob Agents Chemother 60:6911-6915. 2016
    ....
  21. pmc Association of botulinum neurotoxin serotype A light chain with plasma membrane-bound SNAP-25
    Sheng Chen
    Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom Kowloon, Hong Kong
    J Biol Chem 286:15067-72. 2011
    ..These findings explain how LC/A associates with SNAP-25 on the plasma membrane and provide a basis for LC/A cleavage of SNAP-25 within the SNARE complex...
  22. pmc Genetic Characterization of a blaVEB-2-Carrying Plasmid in Vibrio parahaemolyticus
    Ruichao Li
    Shenzhen Key Laboratory for Food Biological Safety Control, Food Safety and Technology Research Centre, The Hong Kong PolyU Shenzhen Research Institute, Shenzhen, People s Republic of China
    Antimicrob Agents Chemother 60:6965-6968. 2016
    ..However, the plasmid contains resistance elements usually harbored by members of the family Enterobacteriaceae, suggesting that gene transfer events occurred and contributed to the formation of this multidrug resistance-encoding plasmid...
  23. doi request reprint Structure-based design, synthesis, and biological evaluation of isatin derivatives as potential glycosyltransferase inhibitors
    Yong Wang
    Department of Applied Biology and Chemical Technology and State Key Laboratory of Chirosciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China
    Chem Biol Drug Des 84:685-96. 2014
    ..Molecular docking study suggests a potential binding pocket of 4l in the GT domain of S. aureus PBP2. Taken together, compound 4l would provide a new scaffold for further development of potent GT inhibitors...
  24. pmc Dissemination of IncI2 Plasmids That Harbor the blaCTX-M Element among Clinical Salmonella Isolates
    Marcus Ho Yin Wong
    Shenzhen Key Laboratory for Food Biological Safety Control, Food Safety and Technology Research Centre, The Hong Kong PolyU Shenzhen Research Institute, Shenzhen, People s Republic of China State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong
    Antimicrob Agents Chemother 59:5026-8. 2015
    ..coli strains recovered from animals. This finding indicates that IncI2 plasmids harboring the blaCTX-M genes may undergo cross-species migration among potential bacterial pathogens, with E. coli as the major source of such elements. ..
  25. pmc Residues Distal to the Active Site Contribute to Enhanced Catalytic Activity of Variant and Hybrid β-Lactamases Derived from CTX-M-14 and CTX-M-15
    Dandan He
    College of Veterinary Medicine, Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, National Reference Laboratory of Veterinary Drug Residues SCAU, South China Agricultural University, Guangzhou, People s Republic of China Shenzhen Key Laboratory for Food Biological Safety Control, Food Safety and Technology Research Center, Hong Kong Polytechnic University, Shen Zhen Research Institute, Shenzhen, People s Republic of China State Key Laboratory of Chiroscience, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR
    Antimicrob Agents Chemother 59:5976-83. 2015
    ..These data indicate that residues distal to the active site of CTX-Ms contributed to their enhanced catalytic activities to ESCs. ..
  26. doi request reprint Isolation of carbapenem-resistant Pseudomonas spp. from food
    Marcus Ho Yin Wong
    Shenzhen Key Laboratory for Food Biological Safety Control, Food Safety and Technology Research Centre, The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, PR China State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong
    J Glob Antimicrob Resist 3:109-114. 2015
    ..Further selection of such carbapenem-resistant Pseudomonas spp. in the environment and the risk by which they are transmitted to clinical settings are of great public health concern...
  27. doi request reprint Molecular characterisation of a multidrug resistance conjugative plasmid from Vibrio parahaemolyticus
    Ming Liu
    Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong Food Safety and Technology Research Center, Hong Kong PolyU Shenzhen Research Institute, Shenzhen, PR China
    Int J Antimicrob Agents 42:575-9. 2013
    ..Transmission of this multidrug resistance conjugative plasmid among Vibrio spp. would compromise the effectiveness of Vibrio infection control and pose a huge threat to public health...
  28. pmc Increasing prevalence of ciprofloxacin-resistant food-borne Salmonella strains harboring multiple PMQR elements but not target gene mutations
    Dachuan Lin
    Food Safety and Technology Research Center, Hong Kong PolyU Shenzhen Research Institute, Shenzhen, P R China
    Sci Rep 5:14754. 2015
    ..To summarize, findings in this work suggested that PMQRs greatly facilitate development of fluoroquinolone resistance in Salmonella by abolishing the requirement of target gene mutations. ..
  29. pmc Emergence of clinical Salmonella enterica serovar Typhimurium isolates with concurrent resistance to ciprofloxacin, ceftriaxone, and azithromycin
    Marcus Ho Yin Wong
    Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, SAR Food Safety and Technology Research Center, Hong Kong PolyU Shenzhen Research Institute, Shenzhen, People s Republic of China
    Antimicrob Agents Chemother 58:3752-6. 2014
    ..The dissemination of resistance genes, such as those encoding ESBLs and the OqxAB pump, among Salmonella organisms will speed up the selection of XDR Salmonella, posing a huge threat to public health and Salmonella infection control...
  30. pmc Substrate-based inhibitors exhibiting excellent protective and therapeutic effects against Botulinum Neurotoxin A intoxication
    Jiubiao Guo
    Shenzhen Key Lab for Food Biological Safety Control, Food Safety and Technology Research Center, Hong Kong PolyU Shen Zhen Research Institute, Shenzhen, P R China
    Sci Rep 5:16981. 2015
    ....
  31. pmc Complete nucleotide sequence of a conjugative plasmid carrying bla(PER-1)
    Ruichao Li
    Shenzhen Key Lab for Food Biological Safety Control, Food Safety and Technology Research Center, Hong Kong PolyU Shen Zhen Research Institute, Shenzhen, People s Republic of China State Key Lab of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong
    Antimicrob Agents Chemother 59:3582-4. 2015
    ..A complex class 1 integron was identified together with ISCR1 and bla(PER-1) (ISCR1-bla(PER-1)-gst-abct-qacEΔ1-sul1), which was shown to form a circular intermediate playing an important role in the dissemination of bla(PER-1)...
  32. pmc First detection of AmpC β-lactamase bla(CMY-2) on a conjugative IncA/C plasmid in a Vibrio parahaemolyticus isolate of food origin
    Ruichao Li
    Shenzhen Key Lab for Food Biological Safety Control, Food Safety and Technology Research Center, Hong Kong PolyU Shenzhen Research Institute, Shenzhen, People s Republic of China State Key Lab of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong
    Antimicrob Agents Chemother 59:4106-11. 2015
    ..parahaemolyticus, thereby posing a potential threat to public health...
  33. pmc CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus
    Jiachi Chiou
    Shenzhen Key Lab for Food Biological Safety Control, Food Safety and Technology Research Center, Hong Kong PolyU Shen Zhen Research Institute, Shenzhen, People s Republic of China State Key Lab of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong
    Antimicrob Agents Chemother 59:3593-5. 2015
    ..Importantly, bla(CARB-17)-like genes were present in all 293 V. parahaemolyticus genome sequences available in GenBank and detectable in all 91 V. parahaemolyticus food isolates, further confirming the intrinsic nature of this gene...
  34. pmc Evolution and dissemination of OqxAB-like efflux pumps, an emerging quinolone resistance determinant among members of Enterobacteriaceae
    Marcus Ho Yin Wong
    Shenzhen Key Laboratory for Food Biological Safety Control, Food Safety and Technology Research Centre, Hong Kong PolyU Shenzhen Research Institute, Shenzhen, People s Republic of China State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong
    Antimicrob Agents Chemother 59:3290-7. 2015
    ....
  35. doi request reprint Molecular mechanisms of substrate recognition and specificity of botulinum neurotoxin serotype F
    Sheng Chen
    Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong
    Biochem J 433:277-84. 2011
    ..The understanding of the molecular mechanisms of LC/F substrate recognition provides insights into the development of antitoxins and engineering novel BoNTs to optimize current therapy and extend therapeutic interventions...
  36. doi request reprint Characterization of multidrug-resistant Proteus mirabilis isolated from chicken carcasses
    Marcus Ho Yin Wong
    Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, SAR
    Foodborne Pathog Dis 10:177-81. 2013
    ..The high-level of antimicrobial resistance of P. mirabilis isolated from food products may pose a potential threat to public health...
  37. doi request reprint A graphene oxide based fluorescence resonance energy transfer (FRET) biosensor for ultrasensitive detection of botulinum neurotoxin A (BoNT/A) enzymatic activity
    Jingyu Shi
    Interdisciplinary Division of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, PR China
    Biosens Bioelectron 65:238-44. 2015
    ..Based on fluorescence signal recovery measurement, the target BoNT-LcA was detected sensitively and selectively with the linear detection range from 1fg/mL to 1pg/mL. The limit of detection (LOD) for BoNT-LcA is around 1fg/mL. ..
  38. pmc Molecular mechanisms of substrate recognition and specificity of New Delhi metallo-β-lactamase
    Jiachi Chiou
    State Key Lab of Chiroscience, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR Food Safety and Technology Research Center, Hong Kong PolyU Shenzhen Research Institute, Shenzhen, People s Republic of China
    Antimicrob Agents Chemother 58:5372-8. 2014
    ..This study provides insights into the development of efficient inhibitors for NDM-1 and offers an efficient tactic with which to study the substrate specificities of other β-lactamases...
  39. pmc A novel adhesive factor contributing to the virulence of Vibrio parahaemolyticus
    Ming Liu
    Shenzhen Key Lab for Food Biological Safety Control, Food Safety and Technology Research Center, Hong Kong PolyU Shenzhen Research Institute, Shenzhen, China
    Sci Rep 5:14449. 2015
    ..Our finding suggested that VpadF is a major virulence factor of V. parahaemolyticus and a potential good candidate for V. parahaemolyticus infection control for both vaccine development and drug target. ..
  40. doi request reprint Exploration of endogenous substrate cleavage by various forms of botulinum neurotoxins
    Jiubiao Guo
    Shenzhen Key Lab for Food Biological Safety Control, Food Safety and Technology Research Center, Hong Kong PolyU Shen Zhen Research Institute, Shenzhen, PR China State Key Lab of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, PR China
    Toxicon 100:42-5. 2015
    ....
  41. pmc A simple, rapid and sensitive FRET assay for botulinum neurotoxin serotype B detection
    Jiubiao Guo
    Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR
    PLoS ONE 9:e114124. 2014
    ..Importantly, FVP-B showed the potential to be scaled up and used in high throughput screening of LC/B inhibitor. The currently developed FRET assay is one of the most economic and rapid FRET assays for LC/B detection. ..
  42. doi request reprint Expression and biochemical characterization of light chains of Botulinum neurotoxin subtypes F5 and F7
    Jiubiao Guo
    Shenzhen Key Lab for Food Biological Safety Control, Food Safety and Technology Research Center, Hong Kong PolyU Shenzhen Research Institute, Shenzhen, PR China State Key Lab of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong
    Protein Expr Purif 111:87-90. 2015
    ....
  43. doi request reprint Increasing prevalence of hydrogen sulfide negative Salmonella in retail meats
    Dachuan Lin
    Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong Special Administrative Region Food Safety and Technology Research Center, Hong Kong PolyU Shenzhen Research Institute, Shenzhen, PR China
    Food Microbiol 43:1-4. 2014
    ..Such finding warrants the development of an improved method for effective coverage of H2S negative Salmonella. ..