W Y Chan

Summary

Affiliation: The Chinese University of Hong Kong
Country: China

Publications

  1. pmc Knee stability assessment on anterior cruciate ligament injury: Clinical and biomechanical approaches
    Mak Ham Lam
    Department of Orthopaedics and Traumatology, Prince of Wales Hospital, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, PR China
    Sports Med Arthrosc Rehabil Ther Technol 1:20. 2009
  2. pmc Dynamic expression of Dab2 in the mouse embryonic central nervous system
    Kwok Kuen Cheung
    Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, PR China
    BMC Dev Biol 8:76. 2008
  3. ncbi request reprint Receptor-mediated endocytosis of trichosanthin in choriocarcinoma cells
    Wood Yee Chan
    Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong
    Toxicology 186:191-203. 2003
  4. ncbi request reprint Substitution for natural musk in Pien Tze Huang does not affect its hepatoprotective activities
    W Y Chan
    Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Hum Exp Toxicol 23:35-47. 2004
  5. ncbi request reprint Cardiac neural crest of the mouse embryo: axial level of origin, migratory pathway and cell autonomy of the splotch (Sp2H) mutant effect
    Wood Yee Chan
    Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
    Development 131:3367-79. 2004
  6. ncbi request reprint Postnatal changes of vascular endothelial growth factor (VEGF) expression in the retinae of normal and hypertensive rats
    W Y Chan
    Department of Anatomy, The Chinese University of Hong Kong, Shatin, NT
    Life Sci 66:1615-25. 2000
  7. ncbi request reprint Apoptosis and Bcl-2 oncoprotein expression in the human fetal central nervous system
    W Y Chan
    Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin
    Anat Rec 252:165-75. 1998
  8. ncbi request reprint Epstein-Barr virus-associated gastric lymphomas are distinct from mucosa-associated lymphoid tissue-type lymphomas: genetic abnormalities of p53 gene
    W Y Chan
    Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT
    Diagn Mol Pathol 10:153-60. 2001
  9. ncbi request reprint Chromosome 11 copy number gains and Epstein-Barr virus-associated malignancies
    W Y Chan
    Department of Anatomical and Cellular Pathology Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT
    Diagn Mol Pathol 10:223-7. 2001
  10. pmc Consistent copy number gain in chromosome 12 in primary diffuse large cell lymphomas of the stomach
    W Y Chan
    Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Shatin, N T, Hong Kong
    Am J Pathol 152:11-6. 1998

Collaborators

Detail Information

Publications34

  1. pmc Knee stability assessment on anterior cruciate ligament injury: Clinical and biomechanical approaches
    Mak Ham Lam
    Department of Orthopaedics and Traumatology, Prince of Wales Hospital, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, PR China
    Sports Med Arthrosc Rehabil Ther Technol 1:20. 2009
    ..Orthopaedic surgeons and scientists with related background are encouraged to understand knee biomechanics and stability assessment for ACL injury patients...
  2. pmc Dynamic expression of Dab2 in the mouse embryonic central nervous system
    Kwok Kuen Cheung
    Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, PR China
    BMC Dev Biol 8:76. 2008
    ..In this report, we have examined the localization of the Dab2 protein in the mouse embryonic central nervous system (CNS) at different developmental stages...
  3. ncbi request reprint Receptor-mediated endocytosis of trichosanthin in choriocarcinoma cells
    Wood Yee Chan
    Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong
    Toxicology 186:191-203. 2003
    ..The receptor-mediated uptake together with the specific intracellular routing of TCS may partly account for the differential vulnerability of the choriocarcinoma cell line towards the toxicity of TCS...
  4. ncbi request reprint Substitution for natural musk in Pien Tze Huang does not affect its hepatoprotective activities
    W Y Chan
    Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Hum Exp Toxicol 23:35-47. 2004
    ..It is also postulated that both formulations protect the liver through regulating signal transduction in the cell...
  5. ncbi request reprint Cardiac neural crest of the mouse embryo: axial level of origin, migratory pathway and cell autonomy of the splotch (Sp2H) mutant effect
    Wood Yee Chan
    Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
    Development 131:3367-79. 2004
    ..We conclude that the retardation of cardiac neural crest migration in splotch mutant embryos requires the genetic defect in both neural crest cells and their migratory environment...
  6. ncbi request reprint Postnatal changes of vascular endothelial growth factor (VEGF) expression in the retinae of normal and hypertensive rats
    W Y Chan
    Department of Anatomy, The Chinese University of Hong Kong, Shatin, NT
    Life Sci 66:1615-25. 2000
    ..It is speculated that the change of the VEGF protein expression pattern during the early phase of the development of hypertension may be related to the subsequent changes in the retinal vasculature of the hypertensive rat...
  7. ncbi request reprint Apoptosis and Bcl-2 oncoprotein expression in the human fetal central nervous system
    W Y Chan
    Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin
    Anat Rec 252:165-75. 1998
    ..Apoptosis and Bcl-2 oncoproteins are important for CNS development and, apart from being an apoptosis regulator, Bcl-2 oncoproteins may also have other roles to play during neural development...
  8. ncbi request reprint Epstein-Barr virus-associated gastric lymphomas are distinct from mucosa-associated lymphoid tissue-type lymphomas: genetic abnormalities of p53 gene
    W Y Chan
    Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT
    Diagn Mol Pathol 10:153-60. 2001
    ..These differences between the two groups suggest involvement of different carcinogens. Mutation of codon 242 has not been specifically associated with other tumors and may represent a mutational hot spot in the EBV-positive lymphomas...
  9. ncbi request reprint Chromosome 11 copy number gains and Epstein-Barr virus-associated malignancies
    W Y Chan
    Department of Anatomical and Cellular Pathology Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT
    Diagn Mol Pathol 10:223-7. 2001
    ..There seems to be differences between EBV-associated tumors of different locations, and between gastric carcinomas with and without EBV...
  10. pmc Consistent copy number gain in chromosome 12 in primary diffuse large cell lymphomas of the stomach
    W Y Chan
    Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Shatin, N T, Hong Kong
    Am J Pathol 152:11-6. 1998
    ..Our findings suggested that many DLCL were not derived from transformation of low grade MALT lymphomas...
  11. ncbi request reprint Elfin is expressed during early heart development
    M Kotaka
    Department of Biochemistry, The Chinese University of Hong Kong, Hong Kong
    J Cell Biochem 83:463-72. 2001
    ..Taken together, our experimental results suggest that Elfin may play an important role in myofibrillogenesis and heart development...
  12. ncbi request reprint Substance P and enkephalin containing fibers in the developing nucleus dorsalis of the human spinal cord
    D T Yew
    Department of Anatomy, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Neurosci Lett 312:87-90. 2001
    ..Our results show that both SP- and ENK-positive fibers started to appear at around 10 weeks and a consistent pattern of immunoreactivity was established by around 26-30 weeks of gestation...
  13. pmc Accuracy of endoscopic ultrasonography in diagnosing ascites and predicting peritoneal metastases in gastric cancer patients
    Y T Lee
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin NT, Hong Kong, China
    Gut 54:1541-5. 2005
    ..Preoperative diagnosis of peritoneal metastases (PM) is difficult in patients with gastric cancer (GC)...
  14. pmc Sputum cytology of patients with severe acute respiratory syndrome (SARS)
    G M K Tse
    Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, Chinese University of Hong Kong, Ngan Shing Street, NT, Hong Kong ROC
    J Clin Pathol 57:256-9. 2004
    ..Severe acute respiratory syndrome (SARS) is a newly described form of atypical pneumonia linked to a novel coronavirus...
  15. ncbi request reprint Circulating Epstein-Barr virus DNA in the serum of patients with gastric carcinoma
    Y M Lo
    Department of Chemical Pathology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, People s Republic of China
    Clin Cancer Res 7:1856-9. 2001
    ..We investigated the detectability of EBV DNA in the serum of gastric carcinoma patients in Hong Kong. Previous data have shown that approximately 10% of gastric carcinomas in Hong Kong are associated with EBV...
  16. ncbi request reprint Circulating cell-free Epstein-Barr virus DNA levels in patients with EBV-associated lymphoid malignancies
    K I Lei
    Department of Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR
    Ann N Y Acad Sci 945:80-3. 2001
    ..Our aim was to update our results and to assess the role of the plasma EBV DNA levels as a molecular marker for disease monitoring in patients with EBV-associated lymphoid malignancies...
  17. doi request reprint Qianliguang (Senecio scandens) safety dilemma: dose is the key?
    Ge Lin
    Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR
    Planta Med 75:1107-11. 2009
    ..Therefore, appropriate dosage guidelines should be implemented for the herbal industry, for export/import retailers, and for herbal medicine practitioners to ensure the safe and beneficial use of these herbal medicines...
  18. ncbi request reprint Requirement of PPARalpha in maintaining phospholipid and triacylglycerol homeostasis during energy deprivation
    Susanna S T Lee
    Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    J Lipid Res 45:2025-37. 2004
    ..Taken together, these results show that PPARalpha plays an important role in regulation of fatty acid metabolism as well as phospholipid homeostasis during energy deprivation...
  19. ncbi request reprint The effect of Ginkgo biloba on the cerebellum of aging SAMP mouse--a TUNEL, bcl-2, and fMRI study
    Maria S M Wai
    Department of Anatomy, Chinese University of Hong Kong, Shatin, Hong Kong
    Microsc Res Tech 70:671-6. 2007
    ....
  20. ncbi request reprint Effect of Helicobacter pylori eradication on expression of cyclin D2 and p27 in gastric intestinal metaplasia
    J Yu
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong
    Aliment Pharmacol Ther 15:1505-11. 2001
    ..pylori-associated intestinal metaplasia. Eradication of H. pylori infection reverses the aberrant expression of cyclin D2 and p27 in intestinal metaplasia...
  21. ncbi request reprint Differential expression of calretinin, calbindin D28K and parvalbumin in the developing human cerebellum
    D T Yew
    Department of Anatomy, Faculty of Medicine, Chinese University of Hong Kong, Shatin, Hong Kong
    Brain Res Dev Brain Res 103:37-45. 1997
    ..A possible correlation between the developmentally regulated expression of the calcium-binding proteins and expression of different neurotransmitters during development is discussed...
  22. doi request reprint The mushroom ribosome-inactivating protein lyophyllin exerts deleterious effects on mouse embryonic development in vitro
    W Y Chan
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    Appl Microbiol Biotechnol 85:985-93. 2010
    ..This constitutes the first report on the teratogenicity of a mushroom RIP...
  23. ncbi request reprint Resistance to carbon tetrachloride-induced hepatotoxicity in mice which lack CYP2E1 expression
    F W Wong
    Department of Biochemistry, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Toxicol Appl Pharmacol 153:109-18. 1998
    ..These studies conclusively demonstrate that CYP2E1 is the major factor involved in the CCl4-induced hepatotoxicity in mice...
  24. doi request reprint Differential abilities of the mushroom ribosome-inactivating proteins hypsin and velutin to perturb normal development of cultured mouse embryos
    T B Ng
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    Toxicol In Vitro 24:1250-7. 2010
    ..In contrast, velutin did not exert any adverse influence on mouse development...
  25. ncbi request reprint Gastric choriocarcinoma shows characteristics of adenocarcinoma and gestational choriocarcinoma: a comparative genomic hybridization and fluorescence in situ hybridization study
    A Y Liu
    Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT
    Diagn Mol Pathol 10:161-5. 2001
    ..The authors believe this is the first interphase cytogenetics study on this rare tumor, and that the results support the theory that gastric choriocarcinoma arises from alternate differentiation pathways of adenocarcinoma...
  26. ncbi request reprint Imatinib (STI-571) heals a gastrocutaneous fistula resulting from a malignant gastric stromal tumor
    Enders K W Ng
    Department of Surgery, The Chinese University of Hong Kong, China
    Gastric Cancer 6:122-6. 2003
    ..Follow-up computed tonography (CT) scan 3 months later confirmed significant tumor reduction, and the patient has experienced no side effects from the treatment..
  27. doi request reprint Identification and characterization of a novel CXC chemokine in xenograft tumor induced by mas-overexpressing cells
    Wen Zhen Lin
    Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    Int J Cancer 125:1316-27. 2009
    ..Importantly, a novel CXC chemokine, TIF, was identified in the xenograft tumor tissues...
  28. pmc Structure of the influenza virus A H5N1 nucleoprotein: implications for RNA binding, oligomerization, and vaccine design
    Andy Ka Leung Ng
    Department of Biochemistry and Center for Protein Science and Crystallography, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    FASEB J 22:3638-47. 2008
    ..Our study of H5N1 NP provides insight into the oligomerization interface and the RNA-binding groove, which are attractive drug targets, and it identifies the epitopes that might be used for universal vaccine development...
  29. ncbi request reprint Pien Tze Huang protects the liver against carbon tetrachloride-induced damage
    Kenneth K H Lee
    Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, People s Republic of China
    Pharmacol Toxicol 91:185-92. 2002
    ..We thus postulate that the ability of Pien Tze Huang to protect the liver from damage is attained through its ability to modulate the activity of these important signal transduction pathways...
  30. ncbi request reprint Early postnatal sound exposure induces lasting neuronal changes in the inferior colliculus of senescence accelerated mice (SAMP8): a morphometric study on GABAergic neurons and NMDA expression
    Dietrich Ernst Lorke
    Institute of Neuroanatomy, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Cell Mol Neurobiol 23:143-64. 2003
    ..g., increased NMDAepsilon1 expression after 53 dB and elevated GABA expression after both 53 and 65 dB, are not merely explicable by accelerated aging...
  31. ncbi request reprint Development of catecholaminergic neurons in the human medulla oblongata
    Dietrich E Lorke
    Department of Neuroanatomy, Institute of Anatomy, University Hospital Eppendorf, Martinistr 52 D 20246 Hamburg, Germany
    Life Sci 73:1315-31. 2003
    ..Our results indicate that CA neurons in the human medulla, which are presumably involved in the control of ventilation and blood pressure, though generated rather early during development, mature relatively late...
  32. ncbi request reprint Partial neuroprotective effect of pretreatment with tanshinone IIA on neonatal hypoxia-ischemia brain damage
    Wen Jie Xia
    The Institute of Chinese Medicine, The Chinese University of Hong Kong
    Pediatr Res 58:784-90. 2005
    ..Further studies are required to elucidate whether rescue treatment with tanshinone IIA is effective and to determine whether its protective effect is also associated with secondary cooling of the brain...
  33. ncbi request reprint Expression of ARVCF in the human ganglionic eminence during fetal development
    Norbert Ulfig
    Neuroembryonic Research Laboratory, Department of Anatomy, University of Rostock, Rostock, Germany
    Dev Neurosci 26:38-44. 2004
    ..Our results implicate a very close association of ARVCF with migrating neurons from the GE...
  34. ncbi request reprint Expression patterns of PSA-NCAM in the human ganglionic eminence and its vicinity: role of PSA-NCAM in neuronal migration and axonal growth?
    Norbert Ulfig
    Neuroembryonic Research Laboratory, Department of Anatomy, University of Rostock, Rostock, Germany
    Cells Tissues Organs 177:229-36. 2004
    ..Our results suggest a close relationship between PSA-NCAM expression and neuronal migration (over short distances) and transitory axonal projections (target recognition and axonal fasciculation) in the region of the GE...