Francis K L Chan

Summary

Affiliation: The Chinese University of Hong Kong
Country: China

Publications

  1. doi request reprint Risks of Bleeding Recurrence and Cardiovascular Events With Continued Aspirin Use After Lower Gastrointestinal Hemorrhage
    Francis K L Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong Electronic address
    Gastroenterology 151:271-7. 2016
  2. doi request reprint Similar Efficacy of Proton-Pump Inhibitors vs H2-Receptor Antagonists in Reducing Risk of Upper Gastrointestinal Bleeding or Ulcers in High-Risk Users of Low-Dose Aspirin
    Francis K L Chan
    Department of Medicine and Therapeutics, Institute of Digestive Disease, The Chinese University of Hong Kong Electronic address
    Gastroenterology 152:105-110.e1. 2017
  3. pmc microRNA-139-5p exerts tumor suppressor function by targeting NOTCH1 in colorectal cancer
    Lijing Zhang
    Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Prince of Wales Hospital, Li Ka Shing Institute of Health Sciences, Shenzhen Research Institute, The Chinese University of Hong Kong, Sha Tin, Hong Kong, China
    Mol Cancer 13:124. 2014
  4. pmc Fibulin 1 is downregulated through promoter hypermethylation in gastric cancer
    Y Y Cheng
    Department of Medicine and Therapeutics, Institute of Digestive Disease, Faculty of Medicine, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China
    Br J Cancer 99:2083-7. 2008
  5. doi request reprint Effects of Helicobacter pylori infection on long-term risk of peptic ulcer bleeding in low-dose aspirin users
    Francis K L Chan
    Institute of Digestive Disease, Chinese University of Hong Kong, Hong Kong
    Gastroenterology 144:528-35. 2013
  6. doi request reprint Burden of nonsteroidal anti-inflammatory and antiplatelet drug use in Asia: a multidisciplinary working party report
    Francis Ka Leung Chan
    Institute of Digestive Disease, Chinese University of Hong Kong, Hong Kong
    Clin Gastroenterol Hepatol 10:753-60. 2012
  7. doi request reprint Editorial: single-tablet ibuprofen/double-dose famotidine for reduction of gastric and duodenal ulcers (REDUCE Trials): what can be reduced?
    Francis K L Chan
    Institute of Digestive Disease, Chinese University of Hong Kong, Hong Kong, China
    Am J Gastroenterol 107:387-8. 2012
  8. doi request reprint Anti-platelet therapy and managing ulcer risk
    Francis K L Chan
    Institute of Digestive Disease, Chinese University of Hong Kong, Hong Kong
    J Gastroenterol Hepatol 27:195-9. 2012
  9. pmc Lack of benefits for prevention of cardiovascular disease with aspirin therapy in type 2 diabetic patients--a longitudinal observational study
    Wilson Y Leung
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, PR China
    Cardiovasc Diabetol 8:57. 2009
  10. ncbi request reprint Does eradication of Helicobacter pylori impair healing of nonsteroidal anti-inflammatory drug associated bleeding peptic ulcers? A prospective randomized study
    F K Chan
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin
    Aliment Pharmacol Ther 12:1201-5. 1998

Collaborators

Detail Information

Publications133 found, 100 shown here

  1. doi request reprint Risks of Bleeding Recurrence and Cardiovascular Events With Continued Aspirin Use After Lower Gastrointestinal Hemorrhage
    Francis K L Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong Electronic address
    Gastroenterology 151:271-7. 2016
    ..We assessed the long-term risks of recurrent lower GI bleeding and serious cardiovascular outcomes after aspirin-associated lower GI bleeding...
  2. doi request reprint Similar Efficacy of Proton-Pump Inhibitors vs H2-Receptor Antagonists in Reducing Risk of Upper Gastrointestinal Bleeding or Ulcers in High-Risk Users of Low-Dose Aspirin
    Francis K L Chan
    Department of Medicine and Therapeutics, Institute of Digestive Disease, The Chinese University of Hong Kong Electronic address
    Gastroenterology 152:105-110.e1. 2017
    ..We performed a double-blind randomized trial to compare the effects of a proton pump inhibitor (PPI) vs a H2RA antagonist in preventing recurrent upper GI bleeding and ulcers in high-risk aspirin users...
  3. pmc microRNA-139-5p exerts tumor suppressor function by targeting NOTCH1 in colorectal cancer
    Lijing Zhang
    Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Prince of Wales Hospital, Li Ka Shing Institute of Health Sciences, Shenzhen Research Institute, The Chinese University of Hong Kong, Sha Tin, Hong Kong, China
    Mol Cancer 13:124. 2014
    ..miR-139-5p was identified to be significantly down-regulated in colon tumor tissues by miRNA array. We aimed to clarify its biological function, molecular mechanisms and direct target gene in colorectal cancer (CRC)...
  4. pmc Fibulin 1 is downregulated through promoter hypermethylation in gastric cancer
    Y Y Cheng
    Department of Medicine and Therapeutics, Institute of Digestive Disease, Faculty of Medicine, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China
    Br J Cancer 99:2083-7. 2008
    ..Ectopic expression of FBLN1 led to the growth inhibition of gastric cancer cells through the induction of apoptosis. In summary, FBLN1 was identified as a novel candidate TSG epigenetically downregulated in gastric cancer...
  5. doi request reprint Effects of Helicobacter pylori infection on long-term risk of peptic ulcer bleeding in low-dose aspirin users
    Francis K L Chan
    Institute of Digestive Disease, Chinese University of Hong Kong, Hong Kong
    Gastroenterology 144:528-35. 2013
    ..However, it is not clear whether this strategy affects long-term risk of ulcer bleeding. We assessed the utility of testing ASA users with a high risk of ulcer bleeding for H pylori infection...
  6. doi request reprint Burden of nonsteroidal anti-inflammatory and antiplatelet drug use in Asia: a multidisciplinary working party report
    Francis Ka Leung Chan
    Institute of Digestive Disease, Chinese University of Hong Kong, Hong Kong
    Clin Gastroenterol Hepatol 10:753-60. 2012
    ..We established a working group to examine the burden of atherothrombotic and musculoskeletal diseases in Asia and made recommendations for safer prescribing of nonsteroidal anti-inflammatory drugs (NSAIDs) and low-dose aspirin...
  7. doi request reprint Editorial: single-tablet ibuprofen/double-dose famotidine for reduction of gastric and duodenal ulcers (REDUCE Trials): what can be reduced?
    Francis K L Chan
    Institute of Digestive Disease, Chinese University of Hong Kong, Hong Kong, China
    Am J Gastroenterol 107:387-8. 2012
    ..How the study findings may influence clinical practice deserves further consideration...
  8. doi request reprint Anti-platelet therapy and managing ulcer risk
    Francis K L Chan
    Institute of Digestive Disease, Chinese University of Hong Kong, Hong Kong
    J Gastroenterol Hepatol 27:195-9. 2012
    ..In the future, management of patients on dual anti-platelet therapy needs to be individualized according to their thrombotic and bleeding risks...
  9. pmc Lack of benefits for prevention of cardiovascular disease with aspirin therapy in type 2 diabetic patients--a longitudinal observational study
    Wilson Y Leung
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, PR China
    Cardiovasc Diabetol 8:57. 2009
    ..This study examined the benefit and harm of low-dose aspirin (daily dose < 300 mg) in patients with type 2 diabetes...
  10. ncbi request reprint Does eradication of Helicobacter pylori impair healing of nonsteroidal anti-inflammatory drug associated bleeding peptic ulcers? A prospective randomized study
    F K Chan
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin
    Aliment Pharmacol Ther 12:1201-5. 1998
    ..We investigated the effects of H. pylori eradication on the healing of NSAID-associated bleeding peptic ulcers...
  11. ncbi request reprint Protein-losing enteropathy in congestive heart failure: diagnosis by means of a simple method
    F K Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong
    Hepatogastroenterology 46:1816-8. 1999
    ..The use of this simple and non-invasive diagnostic technique in protein-losing enteropathy is discussed...
  12. ncbi request reprint Salvage therapies after failure of Helicobacter pylori eradication with ranitidine bismuth citrate-based therapies
    F K Chan
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong
    Aliment Pharmacol Ther 14:91-5. 2000
    ..Salvage therapies after initial Helicobacter pylori eradication failure of ranitidine bismuth citrate (RBC)-based regimens remain undefined...
  13. ncbi request reprint Randomized trial of low-dose misoprostol and naproxen vs. nabumetone to prevent recurrent upper gastrointestinal haemorrhage in users of non-steroidal anti-inflammatory drugs
    F K Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong
    Aliment Pharmacol Ther 15:19-24. 2001
    ..Prophylactic misoprostol or non-steroidal anti-inflammatory drugs (NSAIDs) with low gastric toxicity (nabumetone) has been shown to reduce mucosal injury...
  14. ncbi request reprint Expression and cellular localization of COX-1 and -2 in Helicobacter pylori gastritis
    F K Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong
    Aliment Pharmacol Ther 15:187-93. 2001
    ..There are conflicting reports on the expression of cyclooxygenase in Helicobacter pylori infection...
  15. ncbi request reprint Preventing recurrent upper gastrointestinal bleeding in patients with Helicobacter pylori infection who are taking low-dose aspirin or naproxen
    F K Chan
    Department of Medicine, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin
    N Engl J Med 344:967-73. 2001
    ..It is uncertain whether infection with Helicobacter pylori is a risk factor for bleeding in such patients...
  16. ncbi request reprint Helicobacter pylori and nonsteroidal anti-inflammatory drugs
    F K Chan
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong, China
    Gastroenterol Clin North Am 30:937-52. 2001
    ..Given the significant role of H. pylori in the latter condition, screen-and-treat H. pylori might be a useful strategy for the prevention of ulcer complications in high-risk patients receiving low-dose aspirin in the future...
  17. ncbi request reprint Helicobacter pylori, NSAIDs and gastrointestinal haemorrhage
    Francis K L Chan
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Eur J Gastroenterol Hepatol 14:1-3. 2002
    ..Among H. pylori-positive patients with a history of ulcer bleeding who are taking low-dose aspirin, the eradication of H. pylori has been shown to be comparable to omeprazole in preventing recurrent bleeding...
  18. ncbi request reprint Eradication of Helicobacter pylori and risk of peptic ulcers in patients starting long-term treatment with non-steroidal anti-inflammatory drugs: a randomised trial
    Francis K L Chan
    Departments of Medicine and Therapeutics, The Chinese University of Hong Kong, Special Administrative Region of China, Hong Kong
    Lancet 359:9-13. 2002
    ..We hypothesised that eradication of H pylori infection would reduce the risk of ulcers for patients starting long-term NSAID treatment...
  19. ncbi request reprint Peptic-ulcer disease
    Francis K L Chan
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, China
    Lancet 360:933-41. 2002
    ..With the fall in rates of H pylori infection, the proportion of ulcers not related to this organism and NSAIDs has risen, which will affect the management of peptic ulcer...
  20. ncbi request reprint Celecoxib versus diclofenac and omeprazole in reducing the risk of recurrent ulcer bleeding in patients with arthritis
    Francis K L Chan
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, China
    N Engl J Med 347:2104-10. 2002
    ..We assessed whether celecoxib would be similar to diclofenac plus omeprazole in reducing the risk of recurrent ulcer bleeding in patients at high risk for bleeding...
  21. ncbi request reprint COX-2 inhibition, H. pylori infection and the risk of gastrointestinal complications
    Francis K L Chan
    Department of Medicine and Therapeutics, Prince of Wales Hospital, 30 32 Ngan Shing Street, Shatin, Hong Kong
    Curr Pharm Des 9:2213-9. 2003
    ..Limited data showed that COX-2 expression was also increased in human gastric ulcer regardless of the H. pylori status. The functional significance of COX-2 in human gastric ulcer is unknown...
  22. ncbi request reprint Celecoxib versus diclofenac plus omeprazole in high-risk arthritis patients: results of a randomized double-blind trial
    Francis K L Chan
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR
    Gastroenterology 127:1038-43. 2004
    ..We studied the ulcer incidence and factors predicting ulcer recurrence in a prospective, double-blinded trial...
  23. ncbi request reprint Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding
    Francis K L Chan
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong, China
    N Engl J Med 352:238-44. 2005
    ..guidelines also recommend clopidrogel for patients who have major gastrointestinal intolerance of aspirin. We compared clopidogrel with aspirin plus esomeprazole for the prevention of recurrent bleeding from ulcers in high-risk patients...
  24. ncbi request reprint Should we eradicate Helicobacter pylori infection in patients receiving nonsteroidal anti-inflammatory drugs or low-dose aspirin?
    Francis K L Chan
    Division of Gastroenterology and Hepatology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
    Chin J Dig Dis 6:1-5. 2005
    ..There is no convincing evidence that eradication of H. pylori has any clinically important adverse effect on the healing and prevention of ulcers in NSAIDs users...
  25. ncbi request reprint NSAID-induced peptic ulcers and Helicobacter pylori infection: implications for patient management
    Francis K L Chan
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Shatin, Hong Kong SAR
    Drug Saf 28:287-300. 2005
    ..In light of potential cardiovascular risk with COX-2 selective NSAIDs, it is important to weigh the potential adverse effects against the benefits for an individual patient...
  26. ncbi request reprint Management of high-risk patients on non-steroidal anti-inflammatory drugs or aspirin
    Francis K L Chan
    Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, People s Republic of China
    Drugs 66:23-8; discussion 29-33. 2006
    ..In patients with increased cardiovascular risk requiring anti-inflammatory analgesics, the combination of a non-selective NSAID, low-dose aspirin and a PPI is the preferred treatment...
  27. ncbi request reprint Primer: managing NSAID-induced ulcer complications--balancing gastrointestinal and cardiovascular risks
    Francis K L Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Nat Clin Pract Gastroenterol Hepatol 3:563-73. 2006
    ..Naproxen is the preferred NSAID because it is not associated with excess cardiovascular risk. Patients with a high cardiovascular risk and a very high gastrointestinal risk should avoid using NSAIDs or COX2 inhibitors...
  28. ncbi request reprint Combination of a cyclo-oxygenase-2 inhibitor and a proton-pump inhibitor for prevention of recurrent ulcer bleeding in patients at very high risk: a double-blind, randomised trial
    Francis Ka Leung Chan
    Institute of Digestive Disease, Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    Lancet 369:1621-6. 2007
    ....
  29. doi request reprint A novel composite endpoint to evaluate the gastrointestinal (GI) effects of nonsteroidal antiinflammatory drugs through the entire GI tract
    Francis K L Chan
    The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong
    J Rheumatol 37:167-74. 2010
    ..The objective of this report is to introduce a novel composite endpoint that measures damage to the entire GI tract - clinically significant upper and lower GI events (CSULGIE) - in patients with NSAID-induced GI damage...
  30. doi request reprint Celecoxib versus omeprazole and diclofenac in patients with osteoarthritis and rheumatoid arthritis (CONDOR): a randomised trial
    Francis K L Chan
    Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
    Lancet 376:173-9. 2010
    ..We aimed to compare risk of gastrointestinal events associated with celecoxib versus diclofenac slow release plus omeprazole...
  31. doi request reprint Continuation of low-dose aspirin therapy in peptic ulcer bleeding: a randomized trial
    Joseph J Y Sung
    Institute of Digestive Disease, Chinese University of Hong Kong, Sha Tin, New Territories, Hong Kong
    Ann Intern Med 152:1-9. 2010
    ..It is uncertain whether aspirin therapy should be continued after endoscopic hemostatic therapy in patients who develop peptic ulcer bleeding while receiving low-dose aspirin...
  32. doi request reprint Association of distal hyperplastic polyps and proximal neoplastic lesions: a prospective study of 5613 subjects
    Martin C S Wong
    Institute of Digestive Disease, Chinese University of Hong Kong, Shatin, Hong Kong, HKSAR, China School of Public Health and Primary Care, Chinese University of Hong Kong, Shatin, Hong Kong, HKSAR, China
    Gastrointest Endosc 83:555-62. 2016
    ..Current evidence of whether distal hyperplastic polyps (HPs) are markers of proximal neoplasia (PN) is mixed. We evaluated the association between distal neoplasia and synchronous PN in asymptomatic subjects...
  33. pmc Validation of a risk prediction score for proximal neoplasia in colorectal cancer screening: a prospective colonoscopy study
    Martin C S Wong
    Institute of Digestive Disease, Chinese University of Hong Kong, Shatin, Hong Kong, HKSAR, China
    Sci Rep 6:20396. 2016
    ..24-1.84, pā€‰<ā€‰0.001) higher risk of PN than the AR group. The overall c-statistics of the prediction model was 0.71(0.02). The scoring system is useful in predicting the risk of PN to prioritize patients for colonoscopy. ..
  34. pmc Colorectal Cancer Screening Based on Age and Gender: A Cost-Effectiveness Analysis
    Martin C S Wong
    From the Institute of Digestive Disease, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong SAR, China MCSW, JYLC, VCWC, TYTL, AKCL, SHW, SCN, SSN, JCYW, FKLC, JJYS, and School of Public Health and Primary Care, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong SAR, China MCSW
    Medicine (Baltimore) 95:e2739. 2016
    ..Future research should study the acceptability, feasibility, and feasibility of this risk-based strategy in different populations. ..
  35. ncbi request reprint Quantitative detection of promoter hypermethylation in multiple genes in the serum of patients with colorectal cancer
    Wai K Leung
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Shatin, Hong Kong
    Am J Gastroenterol 100:2274-9. 2005
    ....
  36. ncbi request reprint Effects of long-term rofecoxib on gastric intestinal metaplasia: results of a randomized controlled trial
    Wai K Leung
    Institute of Digestive Disease, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Clin Cancer Res 12:4766-72. 2006
    ..Gastric cancer and its premalignant gastric lesion, intestinal metaplasia (IM), frequently express cyclooxygenase-2 (COX-2) at high levels. We tested whether long-term use of specific COX-2 inhibitors regress gastric IM...
  37. pmc The discriminatory capability of existing scores to predict advanced colorectal neoplasia: a prospective colonoscopy study of 5,899 screening participants
    Martin C S Wong
    Institute of Digestive Disease, Chinese University of Hong Kong, 7 F, Lui Che Woo Clinical Science Building, Prince of Wales Hospital, Shatin, NT, HKSAR
    Sci Rep 6:20080. 2016
    ..The existing scoring systems have variable capability to predict advanced neoplasia among asymptomatic Chinese subjects, and further external validation should be performed. ..
  38. doi request reprint A validated tool to predict colorectal neoplasia and inform screening choice for asymptomatic subjects
    Martin C S Wong
    Institute of Digestive Disease, Chinese University of Hong Kong, Shatin, Hong Kong School of Public Health and Primary Care, Chinese University of Hong Kong, Shatin, Hong Kong
    Gut 63:1130-6. 2014
    ..We aim to develop and validate a clinical scoring system to predict the risks of colorectal neoplasia to better inform screening participants and facilitate their screening test choice...
  39. doi request reprint Prospective cohort study of compliance with faecal immunochemical tests for colorectal cancer screening in Hong Kong
    Martin C S Wong
    Institute of Digestive Disease, Faculty of Medicine, Chinese University of Hong Kong, 7 F, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Prev Med 57:227-31. 2013
    ..This study aims to examine the rate and determinants of faecal immunochemical test (FIT) compliance over a four-year period among asymptomatic participants in a colorectal cancer (CRC) screening programme in Hong Kong...
  40. ncbi request reprint The effect of endoscopic therapy in patients receiving omeprazole for bleeding ulcers with nonbleeding visible vessels or adherent clots: a randomized comparison
    Joseph J Y Sung
    Endoscopy Center, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong
    Ann Intern Med 139:237-43. 2003
    ..The optimal treatment of ulcers with nonbleeding visible vessels and adherent clots is unclear...
  41. ncbi request reprint Long-term outcome of Helicobacter pylori-negative idiopathic bleeding ulcers: a prospective cohort study
    Lawrence C T Hung
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    Gastroenterology 128:1845-50. 2005
    ..Helicobacter pylori-negative idiopathic ulcers are increasingly recognized. The secular trend and long-term outcome of this condition are unknown...
  42. doi request reprint Increased risk of advanced neoplasms among asymptomatic siblings of patients with colorectal cancer
    Siew C Ng
    Department of Medicine and Therapeutics, Institute of Digestive Disease, Li Ka Shing Institute of Health Sciences, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
    Gastroenterology 144:544-50. 2013
    ..Relatives of patients with CRC have an increased risk of colorectal neoplasm. We assessed the prevalence of advanced neoplasms among asymptomatic siblings of patients with CRC...
  43. ncbi request reprint Initial treatment with lansoprazole in young dyspeptic patients with negative urea breath test result: a randomized controlled trial with 12-month follow-up
    Wai K Leung
    Institute of Digestive Disease, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Am J Gastroenterol 102:1483-8. 2007
    ..We evaluated the long-term effects of an initial 12-wk course of lansoprazole in young dyspeptic patients without Helicobacter pylori (H. pylori) infection...
  44. ncbi request reprint Targeted inhibition of COX-2 expression by RNA interference suppresses tumor growth and potentiates chemosensitivity to cisplatin in human gastric cancer cells
    Michael W Y Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, PR China
    Oncol Rep 18:1557-62. 2007
    ..RNA interference may be a promising alternative to specific COX-2 inhibitors in the prevention and treatment of gastric cancer...
  45. doi request reprint Predicting mortality in patients with bleeding peptic ulcers after therapeutic endoscopy
    Philip W Y Chiu
    Department of Surgery, Institute of Digestive Disease, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong
    Clin Gastroenterol Hepatol 7:311-6; quiz 253. 2009
    ..Despite advances in management of patients with bleeding peptic ulcers, mortality is still 10%. This study aimed to identify predictive factors and to develop a prediction model for mortality among patients with bleeding peptic ulcers...
  46. doi request reprint Methylation of protocadherin 10, a novel tumor suppressor, is associated with poor prognosis in patients with gastric cancer
    Jun Yu
    Institute of Digestive Disease and Department of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Gastroenterology 136:640-51.e1. 2009
    ..We analyzed its epigenetic inactivation, biological effects, and prognostic significance in gastric cancer...
  47. doi request reprint Natural History of Elderly-onset Ulcerative Colitis: Results from a Territory-wide Inflammatory Bowel Disease Registry
    Hai Yun Shi
    Department of Medicine and Therapeutics, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong
    J Crohns Colitis 10:176-85. 2016
    ..Data on the natural history of elderly-onset ulcerative colitis [UC] are limited. We aimed to investigate clinical features and outcomes of patients with elderly-onset UC...
  48. doi request reprint Xenophagy in Helicobacter pylori- and Epstein-Barr virus-induced gastric cancer
    Lin Zhang
    Institute of Digestive Diseases and State Key Laboratory of Digestive Diseases, LKS Institute of Health Sciences and Department of Medicine and Therapeutics, Faculty of Medicine, Chinese University of Hong Kong, China
    J Pathol 233:103-12. 2014
    ..Elucidating the molecular aspects of H. pylori- and EBV-induced autophagy will help us better understand the pathogenesis of gastric cancer and promote the development of autophagy modulators as antimicrobial agents...
  49. pmc FK-16 derived from the anticancer peptide LL-37 induces caspase-independent apoptosis and autophagic cell death in colon cancer cells
    Shun X Ren
    School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
    PLoS ONE 8:e63641. 2013
    ..Our study also uncovered previously unknown reciprocal regulation between these two cell death pathways...
  50. doi request reprint Long-term follow-up of ulcerative colitis in the Chinese population
    Dorothy K L Chow
    Department of Medicine and Therapeutics, Institute of Digestive Disease, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, China
    Am J Gastroenterol 104:647-54. 2009
    ..We set out determine the incidence, prevalence, and survival rate of UC in the Chinese population and phenotypic stability by longitudinal follow-up...
  51. ncbi request reprint Anti-sense trefoil factor family-3 (intestinal trefoil factor) inhibits cell growth and induces chemosensitivity to adriamycin in human gastric cancer cells
    Michael W Y Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Life Sci 76:2581-92. 2005
    ..Our results demonstrated that blocking the expression of ITF inhibits growth of gastric cancer cells and enhances the response to chemotherapy...
  52. doi request reprint Interaction of Helicobacter pylori infection and low-dose aspirin in the upper gastrointestinal tract: implications for clinical practice
    En Ling Leung Ki
    Department of Medicine and Therapeutics, Institute of Digestive Disease, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong, S A R, PR China
    Best Pract Res Clin Gastroenterol 26:163-72. 2012
    ..pylori in upper gastrointestinal tract injury in low-dose ASA users and on the effectiveness of H. pylori eradication in reducing the risk of complications such as rebleeding in high-risk patients...
  53. doi request reprint Dysregulation and crosstalk of cellular signaling pathways in colon carcinogenesis
    William K K Wu
    Institute of Digestive Disease, LKS Institute of Health Sciences and Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong
    Crit Rev Oncol Hematol 86:251-77. 2013
    ..Understanding their relative importance and crosstalk will provide a rational basis for anticancer drug development...
  54. ncbi request reprint Inactivation of helicase-like transcription factor by promoter hypermethylation in human gastric cancer
    Wai K Leung
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Mol Carcinog 37:91-7. 2003
    ..These results suggest that HLTF promoter hypermethylation is frequently demonstrated in human gastric cancer, and inactivation of HLTF or the chromatin-remodeling complex may play a crucial role in gastric carcinogenesis...
  55. pmc MicroRNA-18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer
    Chung Wah Wu
    Institute of Digestive Disease and Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region, People s Republic of China
    PLoS ONE 8:e57036. 2013
    ..miR-18a is one of the most up-regulated miRNAs in colorectal cancers (CRC) based on miRNA profiling. In this study, we examined the functional significance of miR-18a in CRC...
  56. pmc MicroRNA-218 inhibits cell cycle progression and promotes apoptosis in colon cancer by downregulating BMI1 polycomb ring finger oncogene
    Xinqi He
    Institute of Digestive Disease and Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China
    Mol Med 18:1491-8. 2013
    ..05) and promoted cell cycle arrest in the G2 phase (P < 0.01). In conclusion, miR-218 plays a pivotal role in CRC development through inhibiting cell proliferation and cycle progression and promoting apoptosis by downregulating BMI-1...
  57. ncbi request reprint Omeprazole before endoscopy in patients with gastrointestinal bleeding
    James Y Lau
    Institute of Digestive Disease, Chinese University of Hong Kong, Shatin, Hong Kong, China
    N Engl J Med 356:1631-40. 2007
    ..A neutral gastric pH is critical for the stability of clots over bleeding arteries. We investigated the effect of preemptive infusion of omeprazole before endoscopy on the need for endoscopic therapy...
  58. ncbi request reprint Comparison of EUS and ERCP in the investigation with suspected biliary obstruction caused by choledocholithiasis: a randomized study
    Yuk Tong Lee
    Institute of Digestive Disease, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    Gastrointest Endosc 67:660-8. 2008
    ..EUS may be used to reduce the need of diagnostic ERCP...
  59. doi request reprint Upper gastrointestinal tract phenotype of Crohn's disease is associated with early surgery and further hospitalization
    Dorothy K L Chow
    Institute of Digestive Disease, Chinese University of Hong Kong, Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong
    Inflamm Bowel Dis 15:551-7. 2009
    ..We studied the clinical course of CD in Chinese patients presenting with the L4 phenotype and factors predicting its occurrence upon longitudinal follow-up...
  60. doi request reprint NSAID-induced gastrointestinal and cardiovascular injury
    Siew C Ng
    Institute of Digestive Disease, Chinese University of Hong Kong, Department of Medicine and Therapeutics, Prince of Wales Hospital, Shalin, NT, Hong Kong
    Curr Opin Gastroenterol 26:611-7. 2010
    ..To review recent publications related to NSAID-induced adverse effects on the gastrointestinal and cardiovascular systems...
  61. pmc Low-dose azathioprine is effective in maintaining remission in steroid-dependent ulcerative colitis: results from a territory-wide Chinese population-based IBD registry
    Hai Yun Shi
    Department of Medicine and Therapeutics, Institute of Digestive Disease, State Key Laboratory of Digestive Disease, LKS Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China Department of Gastroenterology and Hepatology, Beijing Friendship Hospital, Capital Medical University, Beijing Digestive Disease Center, National Clinical Research Center for Digestive Diseases, China
    Therap Adv Gastroenterol 9:449-56. 2016
    ..Whether low-dose azathioprine (AZA) is effective in maintaining remission in patients with steroid-dependent ulcerative colitis (UC) remains unclear. We assessed the efficacy and safety of low-dose AZA in a Chinese population with UC...
  62. doi request reprint Screening strategies for colorectal cancer among patients with nonalcoholic fatty liver disease and family history
    Martin C S Wong
    Institute of Digestive Disease, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, HKSAR, China
    Int J Cancer 138:576-83. 2016
    ..These indicated that screening patients with family history or NAFLD by colonoscopy at 50 years was economically favorable. ..
  63. pmc Determinants of Bowel Preparation Quality and Its Association With Adenoma Detection: A Prospective Colonoscopy Study
    Martin C S Wong
    From the Institute of Digestive Disease MCSW, JYLC, VCWC, TYTL, AKCL, RSYT, SHW, SCN, SSMN, JCYW, FKLC, JJYS and School of Public Health and Primary Care MCSW, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong SAR
    Medicine (Baltimore) 95:e2251. 2016
    ..Strategies should be implemented to improve bowel cleansing, which is now demonstrated as a definite quality indicator...
  64. doi request reprint Identification of subjects at risk of proximal advanced neoplasia for colorectal cancer screening
    Martin C S Wong
    Institute of Digestive Disease, Chinese University of Hong Kong, 7 F, Lui Che Woo Clinical Science Building, Prince of Wales Hospital, Shatin, NT, Hong Kong Special Administrative Region School of Public Health and Primary Care, Chinese University of Hong Kong, 4 F, School of Public Health and Primary Care, Prince of Wales Hospital, Shatin, NT, Hong Kong Special Administrative Region
    Eur J Cancer 51:37-44. 2015
    ..60%), whilst maintaining a high level of specificity (81.9%). Clinicians may use this scoring system to inform subjects and facilitate their choice between colonoscopy and FS. ..
  65. doi request reprint Tumor suppressor functions of miR-133a in colorectal cancer
    Yujuan Dong
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Mol Cancer Res 11:1051-60. 2013
    ..Moreover, miR-133a sensitized colon cancer cells to doxorubicin and oxaliplatin by enhancing apoptosis and inhibiting cell proliferation. These data add weight to the significance of miR-133a in the development of CRC...
  66. pmc Perceived obstacles of colorectal cancer screening and their associated factors among 10,078 Chinese participants
    Martin C S Wong
    Institute of Digestive Disease, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong SAR, China
    PLoS ONE 8:e70209. 2013
    ..to evaluate the proportion of self-referred screening participants having various psychological barriers and the factors associated with these barriers...
  67. ncbi request reprint Cyclooxygenase-2 upregulates vascular endothelial growth factor expression and angiogenesis in human gastric carcinoma
    Wai K Leung
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Int J Oncol 23:1317-22. 2003
    ..Future studies should evaluate the potential anti-angiogenic effect of COX-2 inhibitors on human gastric cancer...
  68. doi request reprint Changes in the choice of colorectal cancer screening tests in primary care settings from 7,845 prospectively collected surveys
    Martin C S Wong
    School of Public Health and Primary Care, Faculty of Medicine, Chinese University of Hong Kong, 4 F, School of Public Health and Primary Care, Prince of Wales Hospital, Shatin, NT, Hong Kong SAR, China
    Cancer Causes Control 23:1541-8. 2012
    ..This study examined factors influencing the choice of participants between colonoscopy and fecal immunochemical test (FIT) in a screening program and the impact of an unbiased educational session on influencing this decision...
  69. doi request reprint The efficacy of cap-assisted colonoscopy in polyp detection and cecal intubation: a meta-analysis of randomized controlled trials
    Siew C Ng
    Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong
    Am J Gastroenterol 107:1165-73. 2012
    ..The role of cap-assisted colonoscopy (CAC) in polyp detection and cecal intubation is unclear. We conducted a meta-analysis to compare the efficacy of CAC vs. standard colonoscopy (SC)...
  70. doi request reprint The risk of peptic ulcer bleeding mortality in relation to hospital admission on holidays: a cohort study on 8,222 cases of peptic ulcer bleeding
    Kelvin K F Tsoi
    Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Am J Gastroenterol 107:405-10. 2012
    ..This study sets to investigate whether mortality among patients with PUB differs between holiday and weekday admissions, and also to investigate the association between mortality and the waiting time for endoscopy...
  71. ncbi request reprint Risk factors associated with the development of intestinal metaplasia in first-degree relatives of gastric cancer patients
    Wai K Leung
    Department of Medicine and Therapeutics, 9th Floor, Clinical Sciences Building, Prince of Wales Hospital, Ngan Shing Street, Shatin, Hong Kong, P R China
    Cancer Epidemiol Biomarkers Prev 14:2982-6. 2005
    ..In conclusion, we have identified risk factors associated with gastric intestinal metaplasia in stomach cancer relatives, which may be useful in the understanding of gastric carcinogenesis in these high-risk individuals...
  72. ncbi request reprint Levofloxacin-resistant Helicobacter pylori in Hong Kong
    Ching Ching Lee
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, SAR, China
    Chemotherapy 54:50-3. 2008
    ..In this study we investigate the resistance mechanism and the antimicrobial susceptibilities of clarithromycin, metronidazole, amoxicillin, tetracycline and telithromycin against levofloxacin-resistant H. pylori in Hong Kong...
  73. doi request reprint Promoter methylation of the Wnt/beta-catenin signaling antagonist Dkk-3 is associated with poor survival in gastric cancer
    Jun Yu
    Institute of Digestive Disease, Department of Medicine, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong SAR
    Cancer 115:49-60. 2009
    ..In this study, the authors investigated the promoter methylation of the dickkopf homolog 3 gene Dkk-3 in these cancers and its prognostic significance in gastric cancer...
  74. doi request reprint Promoter hypermethylation mediates downregulation of thiamine receptor SLC19A3 in gastric cancer
    Xin Liu
    Institute of Digestive Disease, Department of Medicine and Therapeutics, Prince of Wales Hospital, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, SAR, China
    Tumour Biol 30:242-8. 2009
    ..In summary, SLC19A3 was epigenetically downregulated in gastric cancer. Methylation of SLC19A3 promoter could be a novel biomarker for early gastric cancer development...
  75. doi request reprint Comparing the Blatchford and pre-endoscopic Rockall score in predicting the need for endoscopic therapy in patients with upper GI hemorrhage
    Sandy H Pang
    Institute of Digestive Diseases, Chinese University of Hong Kong, Shatin NT, Hong Kong
    Gastrointest Endosc 71:1134-40. 2010
    ..The need for therapeutic endoscopy in patients with upper GI hemorrhage is important in determining the risk and disposition of these patients. Pre-endoscopic risk scores may be helpful in predicting this need...
  76. doi request reprint Effects of intravenous and oral esomeprazole in the prevention of recurrent bleeding from peptic ulcers after endoscopic therapy
    Joseph J Y Sung
    Institute of Digestive Disease, VC Office, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Am J Gastroenterol 109:1005-10. 2014
    ..Studies from Asia indicated that even oral PPI can achieve the same therapeutic effect. This study is designed to compare the efficacy of high-dose intravenous PPI to oral PPI in preventing recurrent bleeding after endoscopic hemostasis...
  77. doi request reprint Genome-wide association and sequencing studies on colorectal cancer
    Sunny H Wong
    Institute of Digestive Disease and State Key Laboratory of Digestive Disease, Department of Medicine and Therapeutics and LKS Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong
    Semin Cancer Biol 23:502-11. 2013
    ..However, challenges remain to address the changing epidemiology of colorectal cancer, issues on genetic testing, and clinical utilization of genomic data. ..
  78. doi request reprint Effect of probiotic bacteria on the intestinal microbiota in irritable bowel syndrome
    Siew Chien Ng
    Institute of Digestive Disease, Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong
    J Gastroenterol Hepatol 28:1624-31. 2013
    ..Probiotic bacteria appear to be therapeutically effective. We characterized the mucosa-associated microbiota, and determined the clinical and microbiological effects of orally administered probiotic bacteria, in patients with IBS...
  79. pmc The knowledge of colorectal cancer symptoms and risk factors among 10,078 screening participants: are high risk individuals more knowledgeable?
    Martin C S Wong
    Institute of Digestive Disease, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong SAR, China
    PLoS ONE 8:e60366. 2013
    ..We tested the a priori hypothesis that self-perceived and real presences of risks for colorectal cancer (CRC) are associated with better knowledge of the symptoms and risk factors for CRC, respectively...
  80. ncbi request reprint EUS in the management of uninvestigated dyspepsia
    Yuk Tong Lee
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, China
    Gastrointest Endosc 56:842-8. 2002
    ..Management of dyspepsia often involves multiple diagnostic tests. By virtue of luminal and extraluminal imaging, EUS may be a satisfactory single test for the evaluation of patients with dyspepsia...
  81. ncbi request reprint Treatment of diarrhea-predominant irritable bowel syndrome with traditional Chinese herbal medicine: a randomized placebo-controlled trial
    Wai K Leung
    Institute of Digestive Disease, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong
    Am J Gastroenterol 101:1574-80. 2006
    ..We investigated the therapeutic efficacy of an ancient herbal Chinese formula in patients with diarrhea-predominant IBS...
  82. doi request reprint Effect of amlodipine on platelet inhibition by clopidogrel in patients with ischaemic heart disease: a randomised, controlled trial
    Andrew Y W Li
    Department of Medicine and Geriatrics, Ruttonjee Hospital, Hong Kong, China
    Heart 99:468-73. 2013
    ..Amlodipine inhibits cytochrome P450 (CYP) enzyme and has the potential to reduce clopidogrel bioactivation in vivo. Reports in previous retrospective studies described greater platelet reactivity in patients on amlodipine...
  83. doi request reprint Helicobacter pylori causes epigenetic dysregulation of FOXD3 to promote gastric carcinogenesis
    Alfred S L Cheng
    Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China
    Gastroenterology 144:122-133.e9. 2013
    ..Promoter hypermethylation occurs during Helicobacter pylori-induced gastritis. We investigated whether the deregulated genes contribute to gastric tumorigenesis...
  84. doi request reprint Capsule endoscopy or angiography in patients with acute overt obscure gastrointestinal bleeding: a prospective randomized study with long-term follow-up
    Wai K Leung
    Institute of Digestive Disease, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, People s Republic of China
    Am J Gastroenterol 107:1370-6. 2012
    ..However, no studies have directly compared the two modalities in patients with overt OGIB. We compared the diagnostic yield and long-term outcomes of patients with overt OGIB randomized to CE or angiogram...
  85. doi request reprint Detection of miR-92a and miR-21 in stool samples as potential screening biomarkers for colorectal cancer and polyps
    Chung Wah Wu
    Institute of Digestive Disease and Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China
    Gut 61:739-45. 2012
    ..The detection of molecular markers in stool samples is a potential strategy for colorectal cancer (CRC) screening. This study evaluated the feasibility of detecting miR-21 and miR-92a in stool samples of patients with CRC or polyps...
  86. doi request reprint Nonsteroid anti-inflammatory drug-induced gastroduodenal injury
    Larry H Lai
    Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong S A R, China
    Curr Opin Gastroenterol 25:544-8. 2009
    ..This article reviews selected publications related to nonsteroid anti-inflammatory drug (NSAID)-induced gastroduodenal toxicity in recent years...
  87. ncbi request reprint Detection of epigenetic changes in fecal DNA as a molecular screening test for colorectal cancer: a feasibility study
    Wai K Leung
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Clin Chem 50:2179-82. 2004
  88. ncbi request reprint Promoter hypermethylation of Death-associated protein-kinase gene associated with advance stage gastric cancer
    Anthony W H Chan
    Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, SAR
    Oncol Rep 13:937-41. 2005
    ..041), advance stage of disease (p=0.029) and a poorer event-free survival (log-rank test p=0.0141). DAP-kinase promoter methylation as a potential prognostic marker for gastric cancer patients deserved further evaluation...
  89. pmc Hydrogen sulfide lowers proliferation and induces protective autophagy in colon epithelial cells
    Ya C Wu
    School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    PLoS ONE 7:e37572. 2012
    ..Collectively, we demonstrate that H(2)S inhibits colon epithelial cell proliferation and induces protective autophagy via the AMPK pathway...
  90. doi request reprint Endoscopic submucosal dissection versus local excision for early rectal neoplasms: a comparative study
    Sophie S F Hon
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    Surg Endosc 25:3923-7. 2011
    ..To date, no report comparing the two approaches can be found in the literature. This study aimed to compare the short-term clinical outcomes between ESD and LE for early rectal neoplasms...
  91. ncbi request reprint Magnetic resonance colonography in the detection of colonic neoplasm in high-risk and average-risk individuals
    Wai K Leung
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
    Am J Gastroenterol 99:102-8. 2004
    ..However, the use of MRC in the detection of colorectal neoplasm in average-risk individuals remains unknown. This study determined the performance and the patient's preference of MRC in the detection of colorectal neoplasm...
  92. ncbi request reprint Obstacles to colorectal cancer screening in Chinese: a study based on the health belief model
    Joseph J Y Sung
    School of Public Health, Faculty of Medicine of the Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Am J Gastroenterol 103:974-81. 2008
    ..Colorectal cancer (CRC) has emerged as the second most common cancer in Asia. This study uses the Health Belief Model (HBM) to examine the factors associated with the uptake of CRC testing...
  93. doi request reprint Asia-Pacific Working Group consensus on non-variceal upper gastrointestinal bleeding
    Joseph J Y Sung
    Institute of Digestive Disease, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Gut 60:1170-7. 2011
    ..Aspirin should be resumed soon after stabilisation and clopidogrel alone is no safer than aspirin plus a PPI. When dual antiplatelet agents are used, prophylactic use of a PPI reduces the risk of adverse gastrointestinal events...
  94. ncbi request reprint Expression of trefoil peptides (TFF1, TFF2, and TFF3) in gastric carcinomas, intestinal metaplasia, and non-neoplastic gastric tissues
    Wai K Leung
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    J Pathol 197:582-8. 2002
    ..Progressive loss of TFF1 and TFF2, together with the induction of TFF3, is likely to be involved in the early stage of the multi-step gastric carcinogenesis pathway...
  95. ncbi request reprint Screening for colorectal cancer in Chinese: comparison of fecal occult blood test, flexible sigmoidoscopy, and colonoscopy
    Joseph J Y Sung
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong
    Gastroenterology 124:608-14. 2003
    ..The aim of this study was to compare the accuracy and safety of these 3 screening procedures in a general population of ethnic Chinese...
  96. doi request reprint Management of patients on nonsteroidal anti-inflammatory drugs: a clinical practice recommendation from the First International Working Party on Gastrointestinal and Cardiovascular Effects of Nonsteroidal Anti-inflammatory Drugs and Anti-platelet Agents
    Francis K L Chan
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong
    Am J Gastroenterol 103:2908-18. 2008
    ..Prescribing nonsteroidal antiinflammatory drugs (NSAIDs) is challenging because physicians have to consider gastrointestinal (GI) and cardiovascular (CV) safety issues...
  97. doi request reprint Increased liver stiffness measurement by transient elastography in severe acute exacerbation of chronic hepatitis B
    Grace L H Wong
    Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China
    J Gastroenterol Hepatol 24:1002-7. 2009
    ..We aimed to assess the effect of necroinflammatory activity on LSM in this condition...
  98. ncbi request reprint Empirical treatment based on "typical" reflux symptoms is inappropriate in a population with a high prevalence of Helicobacter pylori infection
    Justin C Y Wu
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Gastrointest Endosc 55:461-5. 2002
    ..The objective of this study was to determine whether diagnosis and empirical treatment based on reflux symptoms alone are appropriate as initial management for patients with gastroesophageal reflux...
  99. ncbi request reprint Intestinal trefoil factor promotes invasion in non-tumorigenic Rat-2 fibroblast cell
    Victor Y W Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong
    Regul Pept 127:87-94. 2005
    ..5-37.8%) in TFF3-transfected cells compared to controls during 48-h incubation. Our results suggested that TFF3 possesses malignant potential through promotion of cell invasiveness and alteration of invasion-related genes...
  100. pmc Effect of oral erythromycin on gastric and small bowel transit time of capsule endoscopy
    Wai K Leung
    Department of Medicine and Therapeutics, Prince of Wales Hospital, 30 32 Ngan Shing Street, Shatin, Hong Kong, China
    World J Gastroenterol 11:4865-8. 2005
    ..To determine the effect of oral erythromycin on gastric and small bowel transit time of capsule endoscopy...
  101. ncbi request reprint Small bowel enteropathy associated with chronic low-dose aspirin therapy
    Wai K Leung
    Institute of Digestive Disease, The Chinese University of Hong Kong and Department of Medicine and Therapeutics, Prince of Wales Hospital, 30 32 Ngan Shing Street, Shatin, Hong Kong, China
    Lancet 369:614. 2007