A T Chan

Summary

Affiliation: The Chinese University of Hong Kong
Country: China

Publications

  1. pmc Automated extraction protocol for quantification of SARS-coronavirus RNA in serum: an evaluation study
    Rossa W K Chiu
    Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong
    BMC Infect Dis 6:20. 2006
  2. ncbi request reprint Increased incidence of tongue cancer after primary radiotherapy for nasopharyngeal carcinoma--the possibility of radiation carcinogenesis
    P M Teo
    Department of Clinical Oncology, Prince of Wales Hospital, Shatin, Hong Kong, China
    Eur J Cancer 35:219-25. 1999
  3. ncbi request reprint Phase II study of neoadjuvant carboplatin and paclitaxel followed by radiotherapy and concurrent cisplatin in patients with locoregionally advanced nasopharyngeal carcinoma: therapeutic monitoring with plasma Epstein-Barr virus DNA
    Anthony T C Chan
    Department of Clinical Oncology, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
    J Clin Oncol 22:3053-60. 2004
  4. ncbi request reprint Pathogenesis and treatment of nasopharyngeal carcinoma
    Anthony T C Chan
    Department of Clinical Oncology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, N T, Hong Kong
    Semin Oncol 31:794-801. 2004
  5. ncbi request reprint Nasopharyngeal carcinoma
    A T C Chan
    Prince of Wales Hospital, Sir Y K Pao Cancer Center, Chinese University of Hong Kong, People s Republic of China
    Ann Oncol 13:1007-15. 2002
  6. ncbi request reprint Multicenter, phase II study of cetuximab in combination with carboplatin in patients with recurrent or metastatic nasopharyngeal carcinoma
    Anthony T C Chan
    Cancer Therapeutics Reserach Group, Department of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, HKSAR, China
    J Clin Oncol 23:3568-76. 2005
  7. ncbi request reprint The cost of palliative care for hepatocellular carcinoma in Hong Kong
    A T Chan
    Department of Clinical Oncology, Sir YK Pao Cancer Centre, Chinese University of Hong Kong, Prince of Wales Hospital
    Pharmacoeconomics 19:947-53. 2001
  8. ncbi request reprint Phase II study of Temodal in the treatment of patients with advanced nasopharyngeal carcinoma
    A T Chan
    Department of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, China
    Cancer Chemother Pharmacol 42:247-9. 1998
  9. ncbi request reprint Quantitative and temporal correlation between circulating cell-free Epstein-Barr virus DNA and tumor recurrence in nasopharyngeal carcinoma
    Y M Lo
    Department of Chemical Pathology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region
    Cancer Res 59:5452-5. 1999
  10. ncbi request reprint Complete pathological remission is possible with systemic combination chemotherapy for inoperable hepatocellular carcinoma
    T W Leung
    Department of Clinical Oncology, The Chinese University of Hong Kong, Shatin, New Territories
    Clin Cancer Res 5:1676-81. 1999

Collaborators

Detail Information

Publications101 found, 100 shown here

  1. pmc Automated extraction protocol for quantification of SARS-coronavirus RNA in serum: an evaluation study
    Rossa W K Chiu
    Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong
    BMC Infect Dis 6:20. 2006
    ..In this study, we evaluated the feasibility of automating the serum RNA extraction procedure in order to increase the throughput of the assay...
  2. ncbi request reprint Increased incidence of tongue cancer after primary radiotherapy for nasopharyngeal carcinoma--the possibility of radiation carcinogenesis
    P M Teo
    Department of Clinical Oncology, Prince of Wales Hospital, Shatin, Hong Kong, China
    Eur J Cancer 35:219-25. 1999
    ..Awareness of the association should make early diagnosis of this likely radiation-induced cancer possible...
  3. ncbi request reprint Phase II study of neoadjuvant carboplatin and paclitaxel followed by radiotherapy and concurrent cisplatin in patients with locoregionally advanced nasopharyngeal carcinoma: therapeutic monitoring with plasma Epstein-Barr virus DNA
    Anthony T C Chan
    Department of Clinical Oncology, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
    J Clin Oncol 22:3053-60. 2004
    ....
  4. ncbi request reprint Pathogenesis and treatment of nasopharyngeal carcinoma
    Anthony T C Chan
    Department of Clinical Oncology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, N T, Hong Kong
    Semin Oncol 31:794-801. 2004
    ..The addition of neoadjuvant chemotherapy warrants further investigation and appears to be the most likely approach to further improve treatment results...
  5. ncbi request reprint Nasopharyngeal carcinoma
    A T C Chan
    Prince of Wales Hospital, Sir Y K Pao Cancer Center, Chinese University of Hong Kong, People s Republic of China
    Ann Oncol 13:1007-15. 2002
    ..Ongoing studies of targeting agents and immunotherapeutic approaches may further improve treatment results...
  6. ncbi request reprint Multicenter, phase II study of cetuximab in combination with carboplatin in patients with recurrent or metastatic nasopharyngeal carcinoma
    Anthony T C Chan
    Cancer Therapeutics Reserach Group, Department of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, HKSAR, China
    J Clin Oncol 23:3568-76. 2005
    ..To evaluate efficacy and toxicity of cetuximab plus carboplatin in recurrent or metastatic nasopharyngeal carcinoma (NPC) resistant to platinum treatment...
  7. ncbi request reprint The cost of palliative care for hepatocellular carcinoma in Hong Kong
    A T Chan
    Department of Clinical Oncology, Sir YK Pao Cancer Centre, Chinese University of Hong Kong, Prince of Wales Hospital
    Pharmacoeconomics 19:947-53. 2001
    ..Hepatocellular carcinoma (HCC) is endemic in parts of Asia and Africa and most patients are not suitable for treatment with a curative approach. Little is known about the cost of palliative care for HCC...
  8. ncbi request reprint Phase II study of Temodal in the treatment of patients with advanced nasopharyngeal carcinoma
    A T Chan
    Department of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, China
    Cancer Chemother Pharmacol 42:247-9. 1998
    ..A single-institution phase II trial of Temodal (temozolomide, SCH52365) in Chinese patients with advance nasopharyngeal carcinoma was undertaken to determine the efficacy and safety of the drug in this population...
  9. ncbi request reprint Quantitative and temporal correlation between circulating cell-free Epstein-Barr virus DNA and tumor recurrence in nasopharyngeal carcinoma
    Y M Lo
    Department of Chemical Pathology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region
    Cancer Res 59:5452-5. 1999
    ..These results suggest that plasma/serum cell-free EBV DNA may be a valuable tool for the monitoring of NPC patients for the early detection of tumor recurrence...
  10. ncbi request reprint Complete pathological remission is possible with systemic combination chemotherapy for inoperable hepatocellular carcinoma
    T W Leung
    Department of Clinical Oncology, The Chinese University of Hong Kong, Shatin, New Territories
    Clin Cancer Res 5:1676-81. 1999
    ..Complete pathological remission is possible with this systemic combination. Apparently, persistent radiological lesions may still represent complete pathological resolution of active disease...
  11. ncbi request reprint Quantitative analysis of cell-free Epstein-Barr virus DNA in plasma of patients with nasopharyngeal carcinoma
    Y M Lo
    Department of Chemical Pathology, The Chinese University of Hong Kong, New Territories, Hong Kong Special Administrative Region
    Cancer Res 59:1188-91. 1999
    ..These results suggest that quantitative analysis of plasma EBV DNA may be a useful clinical and research tool in the screening and monitoring of NPC patients...
  12. ncbi request reprint Lamivudine for the prevention of hepatitis B virus reactivation in hepatitis B s-antigen seropositive cancer patients undergoing cytotoxic chemotherapy
    Winnie Yeo
    MRCP, Department of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong winnieyeo cuhk edu hk
    J Clin Oncol 22:927-34. 2004
    ....
  13. ncbi request reprint A multi-centre randomized phase II study of nolatrexed versus doxorubicin in treatment of Chinese patients with advanced hepatocellular carcinoma
    T S Mok
    Department of Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Cancer Chemother Pharmacol 44:307-11. 1999
    ....
  14. ncbi request reprint Final report of a randomized trial on altered-fractionated radiotherapy in nasopharyngeal carcinoma prematurely terminated by significant increase in neurologic complications
    P M Teo
    Department of Clinical Oncology, Prince of Wales Hospital, Shatin, Hong Kong, People s Republic of China
    Int J Radiat Oncol Biol Phys 48:1311-22. 2000
    ..The aim of the present study was to compare the survival, local control and complications of conventional/accelerated-hyperfractionated radiotherapy and conventional radiotherapy in nonmetastatic nasopharyngeal carcinoma (NPC)...
  15. ncbi request reprint Kinetics of plasma Epstein-Barr virus DNA during radiation therapy for nasopharyngeal carcinoma
    Y M Lo
    Department of Chemical Pathology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Adminstrative Region
    Cancer Res 60:2351-5. 2000
    ....
  16. ncbi request reprint Molecular analysis of circulating tumor cells in peripheral blood from patients with germ cell tumor: a quantitative approach
    I H Wong
    25F, 4B, The Tolo Place, Ma On Shan, Shatin, New Territories, Hong Kong
    Int J Mol Med 6:491-4. 2000
    ..Sequential quantification of alphafp mRNA during the clinical course may provide crucial information for identifying GCT patients at high risk for metastasis...
  17. ncbi request reprint Quantitative analysis of circulating tumor cells in peripheral blood of osteosarcoma patients using osteoblast-specific messenger RNA markers: a pilot study
    I H Wong
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, SAR
    Clin Cancer Res 6:2183-8. 2000
    ..002). Conversely, no metastases were detected in the remaining OS patients with normal COLL mRNA levels. Quantification of COLL mRNA may prove valuable for diagnosing OS micrometastasis and assessing prognosis...
  18. ncbi request reprint Relationship between pretreatment level of plasma Epstein-Barr virus DNA, tumor burden, and metabolic activity in advanced nasopharyngeal carcinoma
    Brigette B Y Ma
    Department of Clinical Oncology at the Sir Y K Pao Centre for Cancer, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, China
    Int J Radiat Oncol Biol Phys 66:714-20. 2006
    ..This study tested the hypotheses that pEBV DNA reflects tumor burden and metabolic activity by evaluating its relationship with tumor volume and 18F-fluorodeoxyglucose (18F-FDG) uptake in NPC...
  19. ncbi request reprint Overall survival after concurrent cisplatin-radiotherapy compared with radiotherapy alone in locoregionally advanced nasopharyngeal carcinoma
    Anthony T C Chan
    Department of Clinical Oncology, Sir Y K Pao Center for Cancer, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, N T Hong Kong
    J Natl Cancer Inst 97:536-9. 2005
    ..013, HR = 0.51 [95% CI = 0.3 to 0.88]), favoring the CRT arm. The regimen of weekly concurrent CRT is a promising standard treatment strategy for locoregionally advanced nasopharyngeal carcinoma patients...
  20. ncbi request reprint Lung metastasis alone in nasopharyngeal carcinoma: a relatively favorable prognostic group. A study by the Hong Kong Nasopharyngeal Carcinoma Study Group
    Edwin P Hui
    Department of Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong
    Cancer 101:300-6. 2004
    ..The current study was conducted to examine the pattern and the predictive factors of distant metastases (DM) in patients with nasopharyngeal carcinoma (NPC) after primary radiotherapy treatment...
  21. ncbi request reprint Prognostic system for hepatitis B virus (HBV)-related hepatocellular carcinoma- Prospective validation of the Chinese University Prognostic Index
    W Yeo
    Chinese Unviersity of Hong Kong, Hong Kong, China Prince of Wales Hospital, Hong Kong, China Chinese University of Hong Kong, Hong Kong, China Hong Kong Sanatorium, Hong Kong, China
    J Clin Oncol 26:4591. 2008
    ....
  22. ncbi request reprint Serial alpha-feto protein in predicting radiological response and overall survival of patient with inoperable hepatocellular carcinoma (HCC) during chemotherapy
    S L Chan
    Department of Clinical Oncology, The Chinese University of Hong Kong, Hong Kong Sir YK Pao Centre for Cancer, Hong Kong State Key Laboratory in Oncology in South China, Hong Kong Hong Kong Cancer Institute, Prince of Wales Hospital, Hong Kong
    J Clin Oncol 26:4602. 2008
    ..4602 Background: Although alpha-feto protein (AFP) is frequently measured during treatment of hepatocellular carcinoma (HCC), the trend of AFP in predicting response and survival of HCC patients is not clear...
  23. ncbi request reprint A phase II study of concurrent cetuximab-cisplatin and intensity-modulated radiotherapy (IMRT) in locoregionally advanced nasopharyngeal carcinoma (NPC) with correlation using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)
    B B Ma
    Chinese University of Hong Kong, State Key Lab South China, Hong Kong, China Prince of Wales Hospital, Hong Kong, China
    J Clin Oncol 26:6055. 2008
    ..The effect of cetuximab on DCE-MRI parameters in primary NPC was also studied...
  24. ncbi request reprint Pharmacokinetic study of intralesional cisplatin for the treatment of hepatocellular carcinoma
    T S Mok
    Department of Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Cancer 91:2369-77. 2001
    ..In the current study the authors examined the pharmacokinetics of direct intralesional injection of cisplatin/epinephrine/bovine collagen gel in patients with hepatocellular carcinoma and cirrhosis...
  25. ncbi request reprint Preliminary results of a randomized study (NPC-9902 Trial) on therapeutic gain by concurrent chemotherapy and/or accelerated fractionation for locally advanced nasopharyngeal carcinoma
    Anne W M Lee
    Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Hong Kong, China
    Int J Radiat Oncol Biol Phys 66:142-51. 2006
    ..To compare the benefit achieved by concurrent chemoradiotherapy (CRT) and/or accelerated fractionation (AF) vs. radiotherapy (RT) alone with conventional fractionation (CF) for patients with T3-4N0-1M0 nasopharyngeal carcinoma (NPC)...
  26. ncbi request reprint Pharmacoproteomics study of cetuximab in nasopharyngeal carcinoma
    Fion L Sung
    Hong Kong Cancer Institute, Department of Clinical Oncology, The Sir Y K Pao Center for Cancer, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, People s Republic of China
    J Proteome Res 5:3260-7. 2006
    ..Pharmacoproteomic study may also help to identify clinical responders for drug treatment and provide insight for new drug development...
  27. ncbi request reprint Survival outcome of patients with nasopharyngeal carcinoma with first local failure: a study by the Hong Kong Nasopharyngeal Carcinoma Study Group
    Kwok Hung Yu
    Department of Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Head Neck 27:397-405. 2005
    ..The purpose of this article is to report the overall survival (OS) outcome of patients with nasopharyngeal carcinoma (NPC) with local failure who received salvage treatment and to identify prognostic factors for OS...
  28. ncbi request reprint Plasma Epstein-Barr virus DNA and residual disease after radiotherapy for undifferentiated nasopharyngeal carcinoma
    Anthony T C Chan
    Department of Clinical Oncology, Sir Y K Pao Centre for Cancer, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region
    J Natl Cancer Inst 94:1614-9. 2002
    ..We designed a prospective study in Hong Kong, China, to investigate the value of plasma EBV DNA as a prognostic factor for NPC...
  29. ncbi request reprint Plasma Epstein-Barr viral deoxyribonucleic acid quantitation complements tumor-node-metastasis staging prognostication in nasopharyngeal carcinoma
    Sing Fai Leung
    Department of Clinical Oncology, Sir YK Pao Centre for Cancer, Centre for Clinical Trials, Hong Kong, People s Republic of China
    J Clin Oncol 24:5414-8. 2006
    ..To evaluate the effect of combining circulating Epstein-Barr viral (EBV) DNA load data with TNM staging data in pretherapy prognostication of nasopharyngeal carcinoma (NPC)...
  30. doi request reprint Reverse phase protein array identifies novel anti-invasion mechanisms of YC-1
    Bo Hong
    Cancer Signaling Laboratory, Department of Clinical Oncology, The Chinese University of Hong Kong, Hong Kong
    Biochem Pharmacol 79:842-52. 2010
    ..In summary, we have identified several novel anti-invasion mechanisms of YC-1 that could impact NPC, and possibly other cancers as well...
  31. ncbi request reprint Dose-response relationship of nasopharyngeal carcinoma above conventional tumoricidal level: a study by the Hong Kong nasopharyngeal carcinoma study group (HKNPCSG)
    Peter M L Teo
    Department of Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, China
    Radiother Oncol 79:27-33. 2006
    ..To define the dose-response relationship of nasopharyngeal carcinoma (NPC) above the conventional tumoricidal dose level of 66 Gy when the basic radiotherapy (RT) course was given by the 2D Ho's technique...
  32. ncbi request reprint Dose-volume analysis of radiation dermatitis among nasopharyngeal carcinoma patients treated with comcurrent cetuximab-cisplatin and intensity-modulated radiotherapy
    M K Kam
    Prince of Wales Hospital, CUHK, Hong Kong, Hong Kong
    J Clin Oncol 26:17015. 2008
    ....
  33. ncbi request reprint Molecular prognostication of nasopharyngeal carcinoma by quantitative analysis of circulating Epstein-Barr virus DNA
    Y M Lo
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories
    Cancer Res 60:6878-81. 2000
    ..6 (95% confidence interval, 1.1-2.1 for each 10-fold increase in serum EBV DNA concentration; P = 0.007)]. The quantitation of circulating EBV DNA may thus allow improved prognostication of NPC...
  34. ncbi request reprint Application of classification tree and neural network algorithms to the identification of serological liver marker profiles for the diagnosis of hepatocellular carcinoma
    T C Poon
    Department of Clinical Oncology, Sir Y.K. Pao Centre for Cancer, Chinese University of Hong Kong, Hong Kong
    Oncology 61:275-83. 2001
    ..By incorporating serological levels of other liver markers and including data from a large number of patients and control subjects, it should prove possible to develop a versatile neural network for early diagnosis of HCC...
  35. ncbi request reprint Quantitative relationship of the circulating tumor burden assessed by reverse transcription-polymerase chain reaction for cytokeratin 19 mRNA in peripheral blood of colorectal cancer patients with Dukes' stage, serum carcinoembryonic antigen level and tum
    I H Wong
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Cancer Lett 162:65-73. 2001
    ..0001). Of relevance, the CK19 mRNA level increased with advancing Dukes' stage and correlated directly with the serum CEA level (P=0.016). CK19 mRNA quantification may prove valuable for cancer staging and disease monitoring...
  36. ncbi request reprint Treatment of nasopharyngeal carcinoma with intensity-modulated radiotherapy: the Hong Kong experience
    Michael K M Kam
    Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    Int J Radiat Oncol Biol Phys 60:1440-50. 2004
    ..To evaluate the efficacy of using intensity-modulated radiotherapy (IMRT) in the primary treatment of nasopharyngeal carcinoma (NPC), including the role of dose escalation above 66 Gy level...
  37. ncbi request reprint Radiotherapy for nasopharyngeal carcinoma--transition from two-dimensional to three-dimensional methods
    Peter M L Teo
    Department of Clinical Oncology, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    Radiother Oncol 73:163-72. 2004
    ..Application of IMRT within the context of altered fractionation, dose escalation and concurrent chemotherapy were discussed. The article concluded with a suggested treatment approach and research direction for different stages of NPC...
  38. ncbi request reprint False-negative rate of abdominal sonography for detecting hepatocellular carcinoma in patients with hepatitis B and elevated serum alpha-fetoprotein levels
    Tony S K Mok
    Department of Clinical Oncology, The Chinese University of Hong Kong, Hong Kong, China
    AJR Am J Roentgenol 183:453-8. 2004
    ....
  39. ncbi request reprint The tumor suppressor Wnt inhibitory factor 1 is frequently methylated in nasopharyngeal and esophageal carcinomas
    Stephen L Chan
    Cancer Epigenetics Laboratory, State Key Laboratory in Oncology in South China, Department of Clinical Oncology, Sir YK Pao Center for Cancer, Hong Kong
    Lab Invest 87:644-50. 2007
    ..WIF1 methylation could also serve as a specific biomarker for these tumors...
  40. doi request reprint Epigenetic identification of ubiquitin carboxyl-terminal hydrolase L1 as a functional tumor suppressor and biomarker for hepatocellular carcinoma and other digestive tumors
    Jun Yu
    Department of Medicine, Institute of Digestive Disease, Chinese University of Hong Kong, Hong Kong
    Hepatology 48:508-18. 2008
    ..Moreover, UCHL1 directly interacts with p53 and stabilizes p53 through the ubiquitination pathway...
  41. doi request reprint Quantitative analysis of the transrenal excretion of circulating EBV DNA in nasopharyngeal carcinoma patients
    K C Allen Chan
    State Key Laboratory in Oncology in South China, Sir Y K Pao Centre for Cancer, Shatin, New Territories, Hong Kong Special Administrative Region, China
    Clin Cancer Res 14:4809-13. 2008
    ..In this study, we used NPC as a model to investigate if circulating EBV DNA can be excreted into urine and to quantify the contribution of renal excretion to the clearance of plasma EBV DNA...
  42. ncbi request reprint Coexpression of hypoxia-inducible factors 1alpha and 2alpha, carbonic anhydrase IX, and vascular endothelial growth factor in nasopharyngeal carcinoma and relationship to survival
    Edwin P Hui
    Departments of Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Clin Cancer Res 8:2595-604. 2002
    ....
  43. ncbi request reprint Primary mediastinal malignant germ cell tumour. Single institution experience in Chinese patients and correlation with specific alpha-fetoprotein bends
    A T Chan
    Department of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Acta Oncol 35:221-7. 1996
    ..In each case the change in NSGCT-specific AFP concentration in response to therapy closely paralleled that of total AFP. Estimation of NSGCT-specific AFP offers no apparent advantage in monitoring disease response or progression...
  44. ncbi request reprint Quantitative correlation of cytokeratin 19 mRNA level in peripheral blood with disease stage and metastasis in breast cancer patients: potential prognostic implications
    I H Wong
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, P R China
    Int J Oncol 18:633-8. 2001
    ..045). Quantification of CK19 mRNA may prove useful for cancer staging, disease monitoring and prognostic assessment among BC patients...
  45. ncbi request reprint Prognostic significance of tumor angiogenesis, Ki 67, p53 oncoprotein, epidermal growth factor receptor and HER2 receptor protein expression in undifferentiated nasopharyngeal carcinoma--a prospective study
    Brigette B Y Ma
    Department of Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territory, Hong Kong SAR, China
    Head Neck 25:864-72. 2003
    ....
  46. ncbi request reprint Rapid clearance of plasma Epstein-Barr virus DNA after surgical treatment of nasopharyngeal carcinoma
    Edward W H To
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, China
    Clin Cancer Res 9:3254-9. 2003
    ..However, this postulation would hold true only if EBV DNA is rapidly eliminated from the circulation. In this study, we determined the in vivo elimination rate of plasma EBV DNA in NPC patients...
  47. doi request reprint Accelerated fractionation radiotherapy and late intensification with 2 intra-arterial cisplatin infusions for locally advanced head and neck squamous cell carcinoma
    Kwok Hung Yu
    Department of Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Head Neck 32:913-20. 2010
    ..This study was established to determine the maximum tolerated dose of intra-arterial cisplatin (IAC) concurrent with accelerated fractionation radiotherapy for locally advanced head and neck squamous cell carcinoma (HNSCC)...
  48. ncbi request reprint Quantification and utility of monosialylated alpha-fetoprotein in the diagnosis of hepatocellular carcinoma with nondiagnostic serum total alpha-fetoprotein
    Terence C W Poon
    Department of Clinical Oncology, the Sir Y K Pao Centre for Cancer, The Chinese University of Hong Kong, Shatin, Hong Kong
    Clin Chem 48:1021-7. 2002
    ..We describe two strategies for quantitative analysis of msAFP and explore their diagnostic accuracy in cases of HCC with nondiagnostic serum total AFP concentrations...
  49. ncbi request reprint Predictors of treatment outcomes in early stage hepatocellular carcinoma (HCC) detected in a surveillance program
    S L Chan
    The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    J Clin Oncol 27:4584. 2009
    ..J Clin Oncol 05). In current study, we aim to identify predictive factors for treatment outcomes in HCC detected from our surveillance program...
  50. ncbi request reprint The use of brush cytology and directed biopsies for the detection of nasopharyngeal carcinoma and precursor lesions
    A R Chang
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Head Neck 23:637-45. 2001
    ..The concept of a cytologic test for NPC, similar to the Pap test for the prevention of uterine cervix cancer, has still to be realized...
  51. ncbi request reprint A multicenter phase II trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, Triapine) and gemcitabine in advanced non-small-cell lung cancer with pharmacokinetic evaluation using peripheral blood mononuclear cells
    Brigette Ma
    Department of Clinical Oncology, Sir Y K Pao Center for Cancer, Hong Kong Cancer Institute, State Key Laboratory in Oncology in South China, Chinese University of Hong Kong, Ngan Shing Street, Shatin, New Territories, Hong Kong
    Invest New Drugs 26:169-73. 2008
    ..We tested the hypothesis that 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, Triapine) may enhance response to re-treatment with gemcitabine by enhancing intracellular uptake of gemcitabine in a phase II study...
  52. doi request reprint A novel application of plasma and cerebrospinal fluid level of epstein barr virus DNA in the diagnosis of leptomeningeal metastasis from nasopharyngeal carcinoma. A case report
    Ada T W Ma
    Department of Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, SAR, China
    Oncology 74:119-22. 2008
    ..We report a case of leptomeningeal recurrence in NPC that was diagnosed using imaging and plasma and cerebrospinal fluid EBV DNA assays, followed by a review of the literature...
  53. doi request reprint The prognostic significance of tumor vascular invasion and its association with plasma Epstein-Barr virus DNA, tumor volume and metabolic activity in locoregionally advanced nasopharyngeal carcinoma
    Brigette B Y Ma
    Department of Clinical Oncology, Sir Y K Pao Centre for Cancer, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Oral Oncol 44:1067-72. 2008
    ..Parapharyngeal and cavernous sinus invasion were not significant predictors of distant recurrence following chemoradiotherapy in our cohort with locoregionally advanced NPC...
  54. doi request reprint Proteomic comparison of nasopharyngeal cancer cell lines C666-1 and NP69 identifies down-regulation of annexin II and beta2-tubulin for nasopharyngeal carcinoma
    Charles M L Chan
    Department of Clinical Oncology, Sir Y K Pao Centre for Cancer, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong Special Administrative Region, China
    Arch Pathol Lab Med 132:675-83. 2008
    ..Since the prognosis of locally advanced and metastatic diseases is poor, increased understanding of the pathogenesis of NPC would be important for discovering novel markers for patients' management...
  55. doi request reprint Transarterial ethanol ablation of hepatocellular carcinoma with lipiodol ethanol mixture: phase II study
    Simon C H Yu
    Department of Diagnostic Radiology and Organ Imaging, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    J Vasc Interv Radiol 19:95-103. 2008
    ..This prospective trial aimed to evaluate the safety and effectiveness of transarterial ethanol ablation (TEA) of intrahepatic lesions of hepatocellular carcinoma (HCC) with a Lipiodol-ethanol mixture...
  56. doi request reprint Primary nasopharyngeal carcinoma: diagnostic accuracy of MR imaging versus that of endoscopy and endoscopic biopsy
    Ann D King
    Department of Diagnostic Radiology and Organ Imaging, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, 30 32 Ngan Shing Street, Shatin, New Territories, Hong Kong SAR, China
    Radiology 258:531-7. 2011
    ....
  57. ncbi request reprint Dosimetric comparison between 2-dimensional radiation therapy and intensity modulated radiation therapy in treatment of advanced T-stage nasopharyngeal carcinoma: to treat less or more in the planning organ-at-risk volume of the brainstem and spinal cord
    Ricky M C Chau
    Department of Clinical Oncology, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, China
    Med Dosim 32:263-70. 2007
    ....
  58. ncbi request reprint Phase II study of docetaxel and epirubicin in Chinese patients with metastatic breast cancer
    Winnie Yeo
    Department of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Anticancer Drugs 13:655-62. 2002
    ..We conclude that docetaxel-epirubicin chemotherapy is highly effective for recurrent metastatic/locoregional breast cancer, with myelosuppression being the main toxicity...
  59. doi request reprint TOP2A overexpression in hepatocellular carcinoma correlates with early age onset, shorter patients survival and chemoresistance
    Nathalie Wong
    Department of Anatomical and Cellular Pathology, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Shatin, Hong Kong, China
    Int J Cancer 124:644-52. 2009
    ..5 to 10-fold compared to Doxorubicin alone (p<0.028). Our study highlighted for the first time the prognostic value of TOP2A in HCC and the potential use of TOP2A reactive agents in therapy...
  60. doi request reprint New utility of an old marker: serial alpha-fetoprotein measurement in predicting radiologic response and survival of patients with hepatocellular carcinoma undergoing systemic chemotherapy
    Stephen L Chan
    Department of Clinical Oncology, State Key Laboratory in Oncology in South China, Sir YK Pao Centre for Cancer, Hong Kong Cancer Institute and Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    J Clin Oncol 27:446-52. 2009
    ..The use of serial alpha-fetoprotein (AFP) in monitoring response has not been rigorously evaluated. We aimed to study the clinical value of AFP trend in an attempt to validate AFP as a surrogate serologic end point...
  61. ncbi request reprint Clinical predictors of response to cetuximab-chemotherapy in metastatic colorectal cancer
    Ada T W Ma
    State Key Laboratory in Oncology in South China, Sir YK Pao Centre for Cancer, Department of Clinical Oncology, Hong Kong Cancer Institute, The Chinese University of Hong Kong, Shatin, Hong Kong
    Hong Kong Med J 16:207-12. 2010
    ..To identify clinical markers to predict which patients with advanced colorectal cancers are likely to benefit from cetuximab-chemotherapy...
  62. doi request reprint An RNA-directed nucleoside anti-metabolite, 1-(3-C-ethynyl-beta-d-ribo-pentofuranosyl)cytosine (ECyd), elicits antitumor effect via TP53-induced Glycolysis and Apoptosis Regulator (TIGAR) downregulation
    Vivian Wai Yan Lui
    Cancer Drug Testing Unit, State Key Laboratory in Oncology in Southern China, Sir Y K Pao Center for Cancer, Department of Clinical Oncology, Hong Kong Cancer Institute and Li Ka Shing Institute for Health Sciences, Chinese University of Hong Kong, Shatin, N T, Hong Kong, China
    Biochem Pharmacol 79:1772-80. 2010
    ..We demonstrated for the first time that an RNA-directed nucleoside analog, ECyd, exerts its antitumor activity via downregulation of a novel regulator of apoptosis, TIGAR. Moreover, ECyd may represent a novel therapy for NPC...
  63. ncbi request reprint Frequency of Epstein-Barr virus-specific cytotoxic T lymphocytes in the blood of Southern Chinese blood donors and nasopharyngeal carcinoma patients
    Bruce M Whitney
    Hong Kong Cancer Institute, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, N T Hong Kong SAR, People s Republic of China
    J Med Virol 67:359-63. 2002
    ....
  64. doi request reprint Cucurbitacin I elicits anoikis sensitization, inhibits cellular invasion and in vivo tumor formation ability of nasopharyngeal carcinoma cells
    Vivian W Y Lui
    Cancer Signaling Laboratory, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region
    Carcinogenesis 30:2085-94. 2009
    ..Taken together, our results suggested that Cucurbitacin I may be a potent chemopreventive agent for NPC with anti-invasion and anoikis-sensitizing activities...
  65. pmc Preclinical activity of gefitinib in non-keratinizing nasopharyngeal carcinoma cell lines and biomarkers of response
    Brigette B Y Ma
    Department of Clinical Oncology, Cancer Drug Testing Unit, State Key Laboratory in Oncology in South China, Hong Kong Cancer Institute, Sir YK Pao Centre for Cancer, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
    Invest New Drugs 28:326-33. 2010
    ....
  66. doi request reprint Role of alpha-fetoprotein in hepatocellular carcinoma: prognostication, treatment monitoring or both?
    Stephen L Chan
    Department of Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
    Future Oncol 5:889-99. 2009
    ..In this review, the evidence regarding the prognostic value of serum alpha-fetoprotein and the value of serial alpha-fetoprotein in the monitoring of treatment efficacy will be discussed, with emphasis on recent data...
  67. doi request reprint The activity of mTOR inhibitor RAD001 (everolimus) in nasopharyngeal carcinoma and cisplatin-resistant cell lines
    Brigette B Y Ma
    State Key Laboratory in Oncology in South China, Sir Y K Pao Centre for Cancer, Department of Clinical Oncology, Cancer Drug Testing Unit, Hong Kong Cancer Institute, Chinese University of Hong Kong, Shatin, Hong Kong
    Invest New Drugs 28:413-20. 2010
    ..AKT upregulation following RAD001 treatment suggests the presence of a feedback loop on AKT signaling in NPC which warrants further investigation...
  68. doi request reprint The preclinical activity of the histone deacetylase inhibitor PXD101 (belinostat) in hepatocellular carcinoma cell lines
    Brigette B Y Ma
    State Key Laboratory in Oncology in South China, Sir YK Pao Centre for Cancer, Department of Clinical Oncology, Hong Kong Cancer Institute, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    Invest New Drugs 28:107-14. 2010
    ..This study provided the basis for a phase II clinical trial of PXD101 in inoperable hepatitis-B associated HCC...
  69. ncbi request reprint Sequential chemotherapy with combination irinotecan and cisplatin followed by docetaxel for treatment-naïve patients with advanced non-small cell lung cancer
    Tony S K Mok
    State Key Laboratory in Oncology in South China, Sir YK Pao Centre for Cancer, Department of Clinical Oncology and Hong Kong Cancer Institute, The Chinese University of Hong Kong, Shatin, New Territories, China
    J Thorac Oncol 2:838-44. 2007
    ..This study was designed to evaluate the efficacy and tolerability of sequential administration of irinotecan and cisplatin and then docetaxel in patients with advanced non-small cell lung cancer (NSCLC)...
  70. ncbi request reprint A phase II study of patients with metastatic or locoregionally recurrent nasopharyngeal carcinoma and evaluation of plasma Epstein-Barr virus DNA as a biomarker of efficacy
    Brigette Ma
    Department of Clinical Oncology and Sir Y K Pao Cancer Center, Prince of Wales Hospital, Shatin, Hong Kong
    Cancer Chemother Pharmacol 62:59-64. 2008
    ..The epidermal growth factor receptor (EGFR) is commonly overexpressed in nasopharyngeal carcinoma (NPC) and gefitinib inhibits NPC growth in vitro...
  71. ncbi request reprint Improved accuracy of detection of nasopharyngeal carcinoma by combined application of circulating Epstein-Barr virus DNA and anti-Epstein-Barr viral capsid antigen IgA antibody
    Sing Fai Leung
    Department of Clinical Oncology, The Chinese University of Hong Kong, Hong Kong SAR, Peoples Republic of China
    Clin Chem 50:339-45. 2004
    ....
  72. pmc Correlation and prognostic significance of beta-galactoside alpha-2,6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma
    Terence C W Poon
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
    World J Gastroenterol 11:6701-6. 2005
    ..To investigate the correlation between tissue ST6Gal I and serum msAFP in HCC patients, and to investigate their prognostic significance...
  73. ncbi request reprint An intensive surveillance program detected a high incidence of hepatocellular carcinoma among hepatitis B virus carriers with abnormal alpha-fetoprotein levels or abdominal ultrasonography results
    Tony S K Mok
    Department of Clinical Oncology, Prince of Wales Hospital, School of Public Health, Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
    J Clin Oncol 23:8041-7. 2005
    ..To study the incidence and treatment outcomes of hepatocellular carcinoma (HCC) detected in an intensive surveillance program (ISP) of hepatitis B virus (HBV) carriers...
  74. ncbi request reprint Recent perspectives in the role of chemotherapy in the management of advanced nasopharyngeal carcinoma
    Brigette B Y Ma
    Department of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    Cancer 103:22-31. 2005
    ....
  75. ncbi request reprint Phase II randomized study comparing the toxicity profile of gemcitabine plus cisplatin with gemcitabine plus oral etoposide in the treatment of advanced non-small cell lung cancer
    Tony S K Mok
    Department of Clinical Oncology, Chinese University of Hong Kong, Hong Kong, China
    Oncology 68:485-92. 2005
    ..This is a randomized phase II study designed to compare the toxicity profile of a non-platinum-based with a platinum-based regimen in the treatment of advanced non-small cell lung cancer...
  76. ncbi request reprint Quantitative analysis of cell-free Epstein-Barr virus DNA in plasma of patients with nonnasopharyngeal head and neck carcinomas
    Kwok Hung Yu
    Department of Clinical Oncology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    Clin Cancer Res 10:1726-32. 2004
    ..We investigated the detectability of EBV DNA in the plasma of patients with non-nasopharyngeal head and neck carcinomas (NNHNC). Previous studies have shown that EBV is present in the tumor tissue of some NNHNC...
  77. ncbi request reprint A phase I safety and pharmacokinetic study of OGT 719 in patients with liver cancer
    Tony S K Mok
    Department of Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital, New Territories, Hong Kong, China
    Acta Oncol 43:245-51. 2004
    ..None of the patients had a significant tumor response. Elimination half-life of OGT 719 by 3-h intravenous infusion is short and monophasic. Toxicity was minimal at the highest dose level...
  78. ncbi request reprint Prospective validation of serum CYFRA 21-1, beta-2-microglobulin, and ferritin levels as prognostic markers in patients with nonmetastatic nasopharyngeal carcinoma undergoing radiotherapy
    Brigette B Y Ma
    Department of Clinical Oncology, Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    Cancer 101:776-81. 2004
    ..The prognostic value of these markers has never been validated prospectively...
  79. ncbi request reprint Systemic treatment strategies and therapeutic monitoring for advanced nasopharyngeal carcinoma
    Brigette B Y Ma
    Department of Clinical Oncology, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
    Expert Rev Anticancer Ther 6:383-94. 2006
    ....
  80. ncbi request reprint Nasopharyngeal carcinoma: molecular pathogenesis and therapeutic developments
    Qian Tao
    Sir YK Pao Centre for Cancer, Department of Clinical Oncology, Hong Kong Cancer Institute, Chinese University of Hong Kong, Shatin, Hong Kong
    Expert Rev Mol Med 9:1-24. 2007
    ..Meanwhile, new therapeutic strategies such as intensity-modulated radiation therapy and immuno- and epigenetic therapies might lead to more specific and effective treatments...
  81. ncbi request reprint Molecular characterization of circulating EBV DNA in the plasma of nasopharyngeal carcinoma and lymphoma patients
    K C Allen Chan
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, China
    Cancer Res 63:2028-32. 2003
    ..These results provide fundamental information that may improve our understanding of the release of tumor-derived nucleic acids into the blood of cancer patients...
  82. ncbi request reprint Nasopharyngeal cancers: which method should be used to measure these irregularly shaped tumors on cross-sectional imaging?
    Ann D King
    Department of Diagnostic Radiology and Organ Imaging, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    Int J Radiat Oncol Biol Phys 69:148-54. 2007
    ..To determine whether the standard techniques of measuring tumor size and change in size after treatment could be applied to the measurement of nasopharyngeal cancers, which are often irregular in shape...
  83. ncbi request reprint Pretherapy quantitative measurement of circulating Epstein-Barr virus DNA is predictive of posttherapy distant failure in patients with early-stage nasopharyngeal carcinoma of undifferentiated type
    Sing Fai Leung
    Department of Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Cancer 98:288-91. 2003
    ..This issue has management implications because different therapeutic strategies currently are employed for patients with good-risk and those with poor-risk NPC...
  84. ncbi request reprint Prevention of hepatitis B virus reactivation in patients with nasopharyngeal carcinoma with lamivudine
    Winnie Yeo
    Department of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Am J Clin Oncol 28:379-84. 2005
    ..This study assessed the role of lamivudine in preventing HBV reactivation and its associated morbidity in NPC patients who have chronic HBV infection and are undergoing chemotherapy...
  85. pmc Radiological, pathological and DNA remission in recurrent metastatic nasopharyngeal carcinoma
    Stephen L Chan
    Department of Clinical Oncology, Prince of Wales Hospital, The Chinese University of Hong Kong, 30 32 Ngan Shing Street, Shatin, Hong Kong SAR, China
    BMC Cancer 6:259. 2006
    ..The mainstay of treatment of metastatic NPC is systemic chemotherapy and resection for solitary metastasis. Despite high response rate to chemotherapy, complete remission is uncommonly seen...
  86. ncbi request reprint Effects of patupilone (epothilone B; EPO906), a novel chemotherapeutic agent, in hepatocellular carcinoma: an in vitro study
    Tony S K Mok
    Department of Clinical Oncology, State Key Laboratory in Oncology in South China and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, SAR, China
    Oncology 71:292-6. 2006
    ..In this study, the cytotoxic effects of patupilone (epothilone B; EPO906) were assessed in a panel of hepatocellular carcinoma (HCC) cell lines, and were compared with doxorubicin and the microtubule-stabilizing taxanes...
  87. ncbi request reprint A Phase I-II study of sequential administration of topotecan and oral etoposide (toposiomerase I and II inhibitors) in the treatment of patients with small cell lung carcinoma
    Tony S K Mok
    Department of Clinical Oncology, The Chinese University of Hong Kong, Hong Kong, China
    Cancer 95:1511-9. 2002
    ..The objectives of this study were to establish the maximum tolerated dose and to determine the efficacy of the sequential combination of intravenous topotecan and oral etoposide in the treatment of patients with SCLC...
  88. ncbi request reprint Disparity of sensitivities in detection of radiation-naïve and postirradiation recurrent nasopharyngeal carcinoma of the undifferentiated type by quantitative analysis of circulating Epstein-Barr virus DNA1,2
    Sing Fai Leung
    Department of Clinical Oncology, The Chinese University of Hong Kong, Hong Kong SAR, China
    Clin Cancer Res 9:3431-4. 2003
    ..The purpose of this research was to compare the sensitivities of plasma EBV DNA in detection of postirradiation locally recurrent nasopharyngeal carcinoma (NPC), postirradiation distant metastatic NPC, and radiation-naïve NPC...
  89. ncbi request reprint Therapeutic vaccination with modified vaccinia Ankara (MVA) encoding Epstein-Barr virus (EBV) target antigens in EBV+ nasopharyngeal carcinoma (NPC)
    E P Hui
    The Chinese University of Hong Kong, Shatin, Hong Kong Department of Clinical Oncology at YK Pao Cancer Centre, Shatin, Hong Kong Hong Kong Cancer Institute, Li Ka Shing Institute for Health Sciences, Shatin, Hong Kong State Key Laboratory in Oncology in South China, Shatin, Hong Kong Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham, United Kingdom
    J Clin Oncol 26:3052. 2008
    ..We have developed a novel recombinant MVA vector encoding both the EBNA1 and LMP2 proteins to stimulate both the CD8+ and the CD4+ arms of the T cell immune response (J Virol 2004;78(2):768-78)...
  90. ncbi request reprint Prevalence of snoring and sleep-disordered breathing in a group of commercial bus drivers in Hong Kong
    D S C Hui
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories
    Intern Med J 32:149-57. 2002
    ..To assess the prevalence of sleep-disordered breathing (SDB) and its associated symptoms in a group of commercial bus drivers in Hong Kong...
  91. ncbi request reprint The significance of serum interleukin-10 on the outcome of unresectable hepatocellular carcinoma (HCC)
    S L Chan
    Department of Clinical Oncology, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong
    J Clin Oncol 29:205. 2011
    ..In HBV-related HCC, elevation of serum IL-10 is frequently observed but its significance on the outcome of HCC is unclear...
  92. ncbi request reprint Delayed radiation myelopathy after concurrent chemoradiation for hypopharyngeal-esophageal carcinoma
    Lam Chan
    Acta Oncol 44:177-9. 2005
  93. ncbi request reprint Distribution of cell-free and cell-associated Epstein-Barr virus (EBV) DNA in the blood of patients with nasopharyngeal carcinoma and EBV-associated lymphoma
    Lydia C W Lit
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR
    Clin Chem 50:1842-5. 2004
  94. ncbi request reprint CD4 and CD8 T cell responses to tumour-associated Epstein-Barr virus antigens in nasopharyngeal carcinoma patients
    Xiaorong Lin
    Sir Y K Pao Centre for Cancer, Hong Kong Cancer Institute, The Chinese University of Hong Kong, Hong Kong, China
    Cancer Immunol Immunother 57:963-75. 2008
    ....
  95. ncbi request reprint EBV latent membrane proteins (LMPs) 1 and 2 as immunotherapeutic targets: LMP-specific CD4+ cytotoxic T cell recognition of EBV-transformed B cell lines
    Tracey A Haigh
    Cancer Research United Kingdom Institute for Cancer Studies, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, United Kingdom
    J Immunol 180:1643-54. 2008
    ..We therefore infer that cytotoxic CD4+ T cells to a subset of LMP epitopes could have therapeutic potential against LMP-expressing tumors...
  96. ncbi request reprint Investigation into the origin and tumoral mass correlation of plasma Epstein-Barr virus DNA in nasopharyngeal carcinoma
    K C Allen Chan
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR
    Clin Chem 51:2192-5. 2005
  97. doi request reprint Systemic therapy for hepatocellular carcinoma: cytotoxic chemotherapy, targeted therapy and immunotherapy
    Melanie B Thomas
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 426, Houston, Texas 77030 4009, USA
    Ann Surg Oncol 15:1008-14. 2008
    ..This review summarizes the results of prospective clinical trials of several categories of systemic therapy, with emphasis on the more promising results from recent trials of biologically targeted therapeutic agents in HCC...
  98. ncbi request reprint Chemotherapy in locally advanced nasopharyngeal carcinoma: an individual patient data meta-analysis of eight randomized trials and 1753 patients
    Bertrand Baujat
    Institut Gustave Roussy, Villejuif, France
    Int J Radiat Oncol Biol Phys 64:47-56. 2006
    ..To study the effect of adding chemotherapy to radiotherapy (RT) on overall survival and event-free survival for patients with nasopharyngeal carcinoma...
  99. ncbi request reprint Azacitidine induces demethylation of the Epstein-Barr virus genome in tumors
    Anthony T C Chan
    Department of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin NT, Hong Kong SAR, China
    J Clin Oncol 22:1373-81. 2004
    ..To determine whether therapy with a DNA methyltransferase inhibitor is effective in achieving demethylation and gene re-expression in tumor DNA in patients...
  100. ncbi request reprint Analysis of Epstein-Barr virus latent gene expression in endemic Burkitt's lymphoma and nasopharyngeal carcinoma tumour cells by using quantitative real-time PCR assays
    Andrew I Bell
    Cancer Research UK Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK, and Department of Clinical Oncology, Prince of Wales Hospital, Shatin, Hong Kong
    J Gen Virol 87:2885-90. 2006
    ..These new quantitative assays may help to provide a clearer picture of EBV gene expression in tumour material...
  101. doi request reprint Persistent aberrations in circulating DNA integrity after radiotherapy are associated with poor prognosis in nasopharyngeal carcinoma patients
    K C Allen Chan
    State Key Laboratory in Oncology in South China, Sir Y K Pao Centre for Cancer, China
    Clin Cancer Res 14:4141-5. 2008
    ..In this study, we investigated the plasma DNA integrity in nasopharyngeal carcinoma (NPC) patients and its association with patients' survival after radiotherapy...