Guang Hu

Summary

Affiliation: Suzhou University
Country: China

Publications

  1. ncbi Protein-Protein Interface and Disease: Perspective from Biomolecular Networks
    Guang Hu
    Center for Systems Biology, School of Electronic and Information Engineering, Soochow University, Suzhou, 215006, China
    Adv Biochem Eng Biotechnol . 2016
  2. ncbi Protein Structure Network-based Drug Design
    Zhongjie Liang
    Center for Systems Biology, Soochow University, Suzhou 215006, China
    Mini Rev Med Chem 16:1330-1343. 2016
  3. ncbi Drug Design based on Protein Structure Network
    Zhongjie Liang
    Center for Systems Biology, Soochow University, Suzhou 215006, China
    Mini Rev Med Chem . 2016
  4. doi Residue interaction network analysis of Dronpa and a DNA clamp
    Guang Hu
    Center for Systems Biology, Soochow University, Suzhou 215006, China Electronic address
    J Theor Biol 348:55-64. 2014
  5. ncbi The topology and dynamics of protein complexes: insights from intra- molecular network theory
    Guang Hu
    Center for Systems Biology, Soochow University, No 1st, Shizi Street, Suzhou, Jiangsu 215006, China
    Curr Protein Pept Sci 14:121-32. 2013
  6. doi The construction of an amino acid network for understanding protein structure and function
    Wenying Yan
    Center for Systems Biology, Soochow University, Suzhou, 215006, Jiangsu, China
    Amino Acids 46:1419-39. 2014
  7. doi Amino acid contact energy networks impact protein structure and evolution
    Wenying Yan
    Center for Systems Biology, Soochow University, No 1, Shizi Street, Suzhou, Jiangsu 215006, China
    J Theor Biol 355:95-104. 2014
  8. pmc Tumor necrosis factor-α as a diagnostic marker for neonatal sepsis: a meta-analysis
    Bokun Lv
    Systems Sepsis Team, Soochow University Affiliated Children s Hospital, Suzhou 215003, China Center for Systems Biology, Soochow University, Suzhou 215006, China
    ScientificWorldJournal 2014:471463. 2014
  9. pmc Molecular dynamic simulation to explore the molecular basis of Btk-PH domain interaction with Ins(1,3,4,5)P4
    Dan Lu
    Center for Systems Biology, Soochow University, Suzhou 215006, China
    ScientificWorldJournal 2013:580456. 2013
  10. ncbi Amino acid network for prediction of catalytic residues in enzymes: a comparison survey
    Jianhong Zhou
    Center for Systems Biology, Soochow University, Suzhou, Jiangsu, China
    Curr Protein Pept Sci 17:41-51. 2016

Collaborators

  • Bairong Shen
  • Wanwipa Vongsangnak
  • Hualiang Jiang
  • Hao Hu
  • Cheng Luo
  • Wenying Yan
  • Zhongjie Liang
  • Jianhong Zhou
  • Jiajia Chen
  • Bokun Lv
  • Maomin Sun
  • Haining Yuan
  • Pan Xu
  • Zhi Jiang
  • Ran Zhou
  • Jian Wang
  • Jie Huang
  • Dan Lu
  • Wenjin Xue
  • Jin Zhang
  • Kunqian Yu
  • Yujun George Zheng
  • Viral Sanjay Patel
  • Yiqian Xie
  • Yiran Huang
  • Wenyu Zhang
  • Biao Chen
  • Junfeng Jiang

Detail Information

Publications18

  1. ncbi Protein-Protein Interface and Disease: Perspective from Biomolecular Networks
    Guang Hu
    Center for Systems Biology, School of Electronic and Information Engineering, Soochow University, Suzhou, 215006, China
    Adv Biochem Eng Biotechnol . 2016
    ..Finally, we highlight possible future aspects of this area with respect to both methodology development and applications for disease treatment...
  2. ncbi Protein Structure Network-based Drug Design
    Zhongjie Liang
    Center for Systems Biology, Soochow University, Suzhou 215006, China
    Mini Rev Med Chem 16:1330-1343. 2016
    ....
  3. ncbi Drug Design based on Protein Structure Network
    Zhongjie Liang
    Center for Systems Biology, Soochow University, Suzhou 215006, China
    Mini Rev Med Chem . 2016
    ....
  4. doi Residue interaction network analysis of Dronpa and a DNA clamp
    Guang Hu
    Center for Systems Biology, Soochow University, Suzhou 215006, China Electronic address
    J Theor Biol 348:55-64. 2014
    ..The topological principle underlying residue interaction networks provided insight into the architectural organization of proteins. ..
  5. ncbi The topology and dynamics of protein complexes: insights from intra- molecular network theory
    Guang Hu
    Center for Systems Biology, Soochow University, No 1st, Shizi Street, Suzhou, Jiangsu 215006, China
    Curr Protein Pept Sci 14:121-32. 2013
    ..Finally we describe some web-based resources for protein complexes, as well as protein network servers and related bioinformatics tools...
  6. doi The construction of an amino acid network for understanding protein structure and function
    Wenying Yan
    Center for Systems Biology, Soochow University, Suzhou, 215006, Jiangsu, China
    Amino Acids 46:1419-39. 2014
    ....
  7. doi Amino acid contact energy networks impact protein structure and evolution
    Wenying Yan
    Center for Systems Biology, Soochow University, No 1, Shizi Street, Suzhou, Jiangsu 215006, China
    J Theor Biol 355:95-104. 2014
    ..According to our knowledge, this is the first study to identify the potential role of long-range links and network diameter in protein evolution. ..
  8. pmc Tumor necrosis factor-α as a diagnostic marker for neonatal sepsis: a meta-analysis
    Bokun Lv
    Systems Sepsis Team, Soochow University Affiliated Children s Hospital, Suzhou 215003, China Center for Systems Biology, Soochow University, Suzhou 215006, China
    ScientificWorldJournal 2014:471463. 2014
    ..84) and specificity (0.83). A diagnostic OR analysis found that the study population may be the major reason for the heterogeneity. Accordingly, we suggest that TNF-α is also a valuable marker in the diagnosis of NS...
  9. pmc Molecular dynamic simulation to explore the molecular basis of Btk-PH domain interaction with Ins(1,3,4,5)P4
    Dan Lu
    Center for Systems Biology, Soochow University, Suzhou 215006, China
    ScientificWorldJournal 2013:580456. 2013
    ..This rigorous study of the binding affinity of each of the mutants and their classification provides some new insights into the biological function of the Btk-PH domain and related mutation-causing diseases. ..
  10. ncbi Amino acid network for prediction of catalytic residues in enzymes: a comparison survey
    Jianhong Zhou
    Center for Systems Biology, Soochow University, Suzhou, Jiangsu, China
    Curr Protein Pept Sci 17:41-51. 2016
    ..Advantages and limitations of AAN-based methods, future perspectives on the application of AAN to the study of protein structure-function relationships are discussed. ..
  11. ncbi Amino acid network for the discrimination of native protein structures from decoys
    Jianhong Zhou
    Center for Systems Biology, Soochow University, Suzhou, Jiangsu, China
    Curr Protein Pept Sci 15:522-8. 2014
    ..We concluded with the discussion of the future perspective on the application of AAN for the native folding detecting among the decoy sets. ..
  12. doi SVR_CAF: an integrated score function for detecting native protein structures among decoys
    Jianhong Zhou
    Center for Systems Biology, Soochow University, Suzhou, Jiangsu, 215006, China
    Proteins 82:556-64. 2014
    ..The score function was evaluated with four decoy sets for its discriminative ability and it shows higher overall performance than the state-of-the-art score functions...
  13. doi DNA methyltransferase inhibitors: an updated patent review (2012-2015)
    Pan Xu
    a Center for Systems Biology, Soochow University, Jiangsu, China
    Expert Opin Ther Pat 26:1017-30. 2016
    ..DNMT inhibitors (DNMTi), which can modulate the aberrant DNA methylation pattern in a reversible way via inhibiting DNMT activity, have attracted significant attention in recent years...
  14. pmc Biological Networks for Cancer Candidate Biomarkers Discovery
    Wenying Yan
    Center for Systems Biology, Soochow University, Suzhou, Jiangsu, China
    Cancer Inform 15:1-7. 2016
    ..In this review, the networks constructed for cancer biomarker discovery based on different omics level data are described and illustrated from recent advances in the field. ..
  15. pmc Computational Analysis of the Binding Specificities of PH Domains
    Zhi Jiang
    Center for Systems Biology, Soochow University, Suzhou 215006, China Department of Biochemistry and Molecular Biology, School of Medicine, Soochow University, Suzhou 215123, China
    Biomed Res Int 2015:792904. 2015
    ....
  16. doi Molecular Mechanism underlying PRMT1 Dimerization for SAM Binding and Methylase Activity
    Ran Zhou
    Center for Systems Biology, Soochow University, Jiangsu 215006, China
    J Chem Inf Model 55:2623-32. 2015
    ..These findings illuminate the results of mechanistic studies of PRMT1, which have revealed that dimer formation facilitates SAM binding and catalytic methylation, and provided direction for further allosteric studies of the PRMT family...
  17. pmc Diagnosis value of the serum amyloid A test in neonatal sepsis: a meta-analysis
    Haining Yuan
    Center for Systems Biology, Soochow University, Suzhou 215006, China
    Biomed Res Int 2013:520294. 2013
    ..Heterogeneity between studies was also explained by cut-off point, SAA assay, and age of included neonates. On the basis of our meta-analysis, therefore, SAA could be promising and meaningful in the diagnosis of NS...