X M Xu

Summary

Affiliation: Sun Yat-sen University
Country: China

Publications

  1. ncbi request reprint [Capillary free zone electrophoresis of globin chains]
    Y Liao
    Department of Pediatrics, Nanfang Hospital, First Military Medical University, Guangzhou, 510515 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 16:180-4. 1999
  2. ncbi request reprint Molecular characterization and PCR detection of a deletional HPFH: application to rapid prenatal diagnosis for compound heterozygotes of this defect with beta-thalassemia in a Chinese family
    X M Xu
    Department of Cellular Biology and Medical Genetics, First Military Medical University, Guangzhou, Peoples Republic of China
    Am J Hematol 65:183-8. 2000
  3. ncbi request reprint [Rapid detection of the common alpha-thalassemia-2 determinants by PCR assay]
    Y Zhao
    Department of Cell Biology and Medical Genetics, The First Military Medical University, Guangzhou, Guangdong 510515 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 18:216-8. 2001
  4. ncbi request reprint [An improved PCR-based megaprimer method for site-directed mutagenesis]
    Qiuhua Mo
    Department of Cell Biology and Medical Genetics, First Military Medical University, Guangzhou, Guangdong, 510515 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 19:68-71. 2002
  5. pmc Alpha0 thalassaemia as a result of a novel 11.1 kb deletion eliminating both of the duplicated alpha globin genes
    S Q Jia
    Department of Medical Genetics, First Military Medical University, Guangzhou 510515, Guangdong, PR China
    J Clin Pathol 57:164-7. 2004
  6. pmc The prevalence and spectrum of alpha and beta thalassaemia in Guangdong Province: implications for the future health burden and population screening
    X M Xu
    Department of Medical Genetics, First Military Medical University, Guangzhou 510515, Guangdong, PR China
    J Clin Pathol 57:517-22. 2004
  7. pmc Rapid, accurate genotyping of the common -alpha(4.2) thalassaemia deletion based on the use of denaturing HPLC
    H Ou-Yang
    Department of Medical Genetics, First Military Medical University, Guangzhou 510515, Guangdong, PR China
    J Clin Pathol 57:159-63. 2004
  8. pmc MS analysis of single-nucleotide differences in circulating nucleic acids: Application to noninvasive prenatal diagnosis
    Chunming Ding
    Bioinformatics Program and Center for Advanced Biotechnology, Boston University, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 101:10762-7. 2004
  9. ncbi request reprint A rare beta-thalassaemia mutation (C-T) at position -90 of the beta-globin gene discovered in a Chinese family
    Shiqi Jia
    Haematologica 88:1191-3. 2003
  10. ncbi request reprint De novo synthesis of PCR templates for the development of SARS diagnostic assay
    Jia Zhang
    Genomapping Inc, Tianjin
    Mol Biotechnol 25:107-12. 2003

Collaborators

  • J Li
  • Z Liu
  • Z Q Wang
  • David H K Chui
  • Chunming Ding
  • Ym Dennis Lo
  • Tse N Leung
  • Pimlak Charoenkwan
  • Qiuhua Mo
  • Peng Yi
  • Q H Mo
  • S Q Jia
  • H Ou-Yang
  • Shiqi Jia
  • Jia Zhang
  • Wenjun Li
  • Ren Cai
  • Y Zhao
  • Wenqing Zhang
  • Chenglin Xiao
  • Qiang Li
  • Shengwei Huang
  • Y Liao
  • Cunli Zhong
  • Fang Yu
  • Yuan Yang
  • L Y Li
  • C Liao
  • L Hua
  • Kai Li
  • Jianying Ma
  • Bingyang Zhu
  • Zifen Guo
  • Xu Zhang
  • Peggy P Lee
  • Tianhong Zhou
  • Xiongwu Lao
  • Zemin Deng
  • Yinghe Hu
  • Bo Meng
  • Cuiying Peng
  • Duanfang Liao
  • Lvyi Zhou
  • Linling Chen
  • Hong Ouyang
  • Xin Liang
  • Qiangui Zhu
  • Xionglin Zhong
  • Lizhen Pan
  • Liu Su
  • Liyan Li
  • Lihua Huang
  • M Zhong
  • X Qian

Detail Information

Publications12

  1. ncbi request reprint [Capillary free zone electrophoresis of globin chains]
    Y Liao
    Department of Pediatrics, Nanfang Hospital, First Military Medical University, Guangzhou, 510515 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 16:180-4. 1999
    ..To introduce a new technique for rapid separation of globin chains from clinical samples...
  2. ncbi request reprint Molecular characterization and PCR detection of a deletional HPFH: application to rapid prenatal diagnosis for compound heterozygotes of this defect with beta-thalassemia in a Chinese family
    X M Xu
    Department of Cellular Biology and Medical Genetics, First Military Medical University, Guangzhou, Peoples Republic of China
    Am J Hematol 65:183-8. 2000
    ..The fetal genomic DNA diagnosis showed the same results as those in propositus, i.e., both of them inherited the deletion from their mother and inherited a codons 14-15 (+G) frameshift mutation causing beta-thalassemia from their father...
  3. ncbi request reprint [Rapid detection of the common alpha-thalassemia-2 determinants by PCR assay]
    Y Zhao
    Department of Cell Biology and Medical Genetics, The First Military Medical University, Guangzhou, Guangdong 510515 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 18:216-8. 2001
    ..The purpose of this study is to develop a reliable PCR protocol specific for the two common alpha-thalassemia-2 determinants with internal control...
  4. ncbi request reprint [An improved PCR-based megaprimer method for site-directed mutagenesis]
    Qiuhua Mo
    Department of Cell Biology and Medical Genetics, First Military Medical University, Guangzhou, Guangdong, 510515 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 19:68-71. 2002
    ..To establish an improved, simple and convenient megaprimer PCR method for site-directed mutagenesis(SDM)...
  5. pmc Alpha0 thalassaemia as a result of a novel 11.1 kb deletion eliminating both of the duplicated alpha globin genes
    S Q Jia
    Department of Medical Genetics, First Military Medical University, Guangzhou 510515, Guangdong, PR China
    J Clin Pathol 57:164-7. 2004
    ..To characterise a novel 11.1 kb deletion that eliminated both of the duplicated alpha globin genes, giving rise to a typical alpha0 thalassaemia phenotype in four carriers from a Chinese family...
  6. pmc The prevalence and spectrum of alpha and beta thalassaemia in Guangdong Province: implications for the future health burden and population screening
    X M Xu
    Department of Medical Genetics, First Military Medical University, Guangzhou 510515, Guangdong, PR China
    J Clin Pathol 57:517-22. 2004
    ..Accurate population frequency data are needed for planning the control of thalassaemia in the high risk Guangdong Province of southern China...
  7. pmc Rapid, accurate genotyping of the common -alpha(4.2) thalassaemia deletion based on the use of denaturing HPLC
    H Ou-Yang
    Department of Medical Genetics, First Military Medical University, Guangzhou 510515, Guangdong, PR China
    J Clin Pathol 57:159-63. 2004
    ..To develop an alternative assay for specific genotyping of the -alpha(4.2) thalassaemia deletion based on the DNA sequence features surrounding the breakpoint...
  8. pmc MS analysis of single-nucleotide differences in circulating nucleic acids: Application to noninvasive prenatal diagnosis
    Chunming Ding
    Bioinformatics Program and Center for Advanced Biotechnology, Boston University, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 101:10762-7. 2004
    ..This analytical approach also will have implications for many other applications of circulating nucleic acids in areas such as oncology and transplantation...
  9. ncbi request reprint A rare beta-thalassaemia mutation (C-T) at position -90 of the beta-globin gene discovered in a Chinese family
    Shiqi Jia
    Haematologica 88:1191-3. 2003
    ..The mutation (-90 C-T) changes the conserved promoter sequence within the proximal CACCC box of the beta-globin gene; this can reduce beta-globin transcription significantly...
  10. ncbi request reprint De novo synthesis of PCR templates for the development of SARS diagnostic assay
    Jia Zhang
    Genomapping Inc, Tianjin
    Mol Biotechnol 25:107-12. 2003
    ..This highly efficient and safe strategy for obtaining SARS gene fragments is useful for the development of PCR assays, as well as for the preparation of reliable positive controls for PCR testing kits...
  11. ncbi request reprint [Prevalence survey and molecular characterization of alpha and beta thalassemia in Liuzhou city of Guangxi]
    Ren Cai
    Women and Children s Health Care Hospital of Liuzhou City, Guangxi, Liuzhou 545001, China
    Zhonghua Liu Xing Bing Xue Za Zhi 23:281-5. 2002
    ..To investigate the gene frequencies and mutation patterns of alpha thalassemia (alpha-thal) and beta thalassemia (beta-thal) in Liuzhou city of Guangxi Zhuang Autonomous Region...
  12. doi request reprint Identification of a novel frameshift mutation at codon 53 (-T) in the beta-globin gene causing dominantly inherited beta-thalassemia in a Chinese Miao family
    Peng Yi
    Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, Guangdong Province, People s Republic of China
    Blood Cells Mol Dis 41:56-9. 2008
    ..Thus, a novel frameshift cd53 (-T) mutation may lead to mild thalassemia intermedia even though there is no statistically significant difference in beta-globin messenger RNA (mRNA) level between six heterozygotes and six normal subjects...