Huichang Bi

Summary

Affiliation: Sun Yat-sen University
Country: China

Publications

  1. pmc Targeted Metabolomics of Serum Acylcarnitines Evaluates Hepatoprotective Effect of Wuzhi Tablet (Schisandra sphenanthera Extract) against Acute Acetaminophen Toxicity
    Huichang Bi
    School of Pharmaceutical Sciences, Sun Yat Sen University, 132 Waihuandong Road, University City, Guangzhou 510006, China Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Evid Based Complement Alternat Med 2013:985257. 2013
  2. pmc Optimization of harvesting, extraction, and analytical protocols for UPLC-ESI-MS-based metabolomic analysis of adherent mammalian cancer cells
    Huichang Bi
    School of Pharmaceutical Sciences, Sun Yat Sen University, 132 Waihuandong Road, Guangzhou University City, Guangzhou 510006, China
    Anal Bioanal Chem 405:5279-89. 2013
  3. doi request reprint Therapeutic efficacy of Wuzhi tablet (Schisandra sphenanthera Extract) on acetaminophen-induced hepatotoxicity through a mechanism distinct from N-acetylcysteine
    Xiaomei Fan
    School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou, China X F, Y J, Yi W, H T, H Z, Yo W, M H, H B The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China P C and Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD A Q, F J G
    Drug Metab Dispos 43:317-24. 2015
  4. doi request reprint Hepato-protective effect of resveratrol against acetaminophen-induced liver injury is associated with inhibition of CYP-mediated bioactivation and regulation of SIRT1-p53 signaling pathways
    Ying Wang
    School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou, China
    Toxicol Lett 236:82-9. 2015
  5. pmc Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration
    Yiming Jiang
    School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou 510006, China and Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    Toxicol Sci 143:107-15. 2015
  6. doi request reprint Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation
    Yiming Jiang
    School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou, China
    Chem Biol Interact 231:83-9. 2015
  7. doi request reprint SUMOylation of pregnane X receptor suppresses rifampicin-induced CYP3A4 and P-gp expression and activity in LS174T cells
    Huasen Tan
    Laboratory of Drug Metabolism and Pharmacokinetics, School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou, Guangdong 510006, China
    J Pharmacol Sci 130:66-71. 2016
  8. doi request reprint Schisandra sphenanthera Extract Facilitates Liver Regeneration after Partial Hepatectomy in Mice
    Xi Li
    School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou X L, D L, X Z, H Z, Y W, Y Z, Y C, M H, H B Shenzhen Bao an Maternal and Child Health Hospital, Shenzhen X F, People s Republic of China
    Drug Metab Dispos 44:647-52. 2016
  9. doi request reprint Oleanolic acid attenuates obstructive cholestasis in bile duct-ligated mice, possibly via activation of NRF2-MRPs and FXR antagonism
    Pan Chen
    School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou 510006, PR China Department of Pharmacy, the First Affiliated Hospital of Sun Yat Sen University, Guangzhou 510080, PR China
    Eur J Pharmacol 765:131-9. 2015
  10. pmc Metabolomics reveals that tumor xenografts induce liver dysfunction
    Fei Li
    Laboratory of Metabolism, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Proteomics 12:2126-35. 2013

Collaborators

  • Frank J Gonzalez
  • Xiaomei Fan
  • Min Huang
  • Hang Zeng
  • Pan Chen
  • Yiming Jiang
  • Huasen Tan
  • Ying Wang
  • Yongtao Wang
  • Xi Li
  • Dongshun Li
  • Hui Liu
  • Aijuan Qu
  • Fei Li
  • Yingmei Li
  • Yixin Chen
  • Yawen Zhou
  • Xiao Chen
  • Chenshu Xu
  • Xuezhen Zeng
  • Liang Ding
  • Xiang Gao
  • Rongrong Deng
  • Pinjin Hu
  • Jingjie Li
  • Fangbin Zhang
  • Yu Zhang
  • Kristopher W Krausz
  • John A Cook
  • Changtao Jiang
  • James B Mitchell
  • Anastasia L Sowers
  • Andrew D Patterson

Detail Information

Publications13

  1. pmc Targeted Metabolomics of Serum Acylcarnitines Evaluates Hepatoprotective Effect of Wuzhi Tablet (Schisandra sphenanthera Extract) against Acute Acetaminophen Toxicity
    Huichang Bi
    School of Pharmaceutical Sciences, Sun Yat Sen University, 132 Waihuandong Road, University City, Guangzhou 510006, China Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Evid Based Complement Alternat Med 2013:985257. 2013
    ..Taken together, the current study provides new insights into understanding the hepatoprotective effect of WZ against APAP-induced liver toxicity...
  2. pmc Optimization of harvesting, extraction, and analytical protocols for UPLC-ESI-MS-based metabolomic analysis of adherent mammalian cancer cells
    Huichang Bi
    School of Pharmaceutical Sciences, Sun Yat Sen University, 132 Waihuandong Road, Guangzhou University City, Guangzhou 510006, China
    Anal Bioanal Chem 405:5279-89. 2013
    ....
  3. doi request reprint Therapeutic efficacy of Wuzhi tablet (Schisandra sphenanthera Extract) on acetaminophen-induced hepatotoxicity through a mechanism distinct from N-acetylcysteine
    Xiaomei Fan
    School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou, China X F, Y J, Yi W, H T, H Z, Yo W, M H, H B The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China P C and Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD A Q, F J G
    Drug Metab Dispos 43:317-24. 2015
    ..Thus WZ may represent a new therapy for APAP-induced acute liver injury. ..
  4. doi request reprint Hepato-protective effect of resveratrol against acetaminophen-induced liver injury is associated with inhibition of CYP-mediated bioactivation and regulation of SIRT1-p53 signaling pathways
    Ying Wang
    School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou, China
    Toxicol Lett 236:82-9. 2015
    ..This study demonstrated that RES prevents APAP-induced hepatotoxicity by inhibition of CYP-mediated APAP bioactivation and regulation of SIRT1, p53, cyclin D1 and PCNA to facilitate liver regeneration following APAP-induced liver injury...
  5. pmc Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration
    Yiming Jiang
    School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou 510006, China and Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    Toxicol Sci 143:107-15. 2015
    ....
  6. doi request reprint Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation
    Yiming Jiang
    School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou, China
    Chem Biol Interact 231:83-9. 2015
    ..This study demonstrated that SinA, SinB, SinC, SolA, SolB and SthA exhibited significant protective actions toward APAP-induced liver injury, which was partially associated with the inhibition of CYP-mediated APAP bioactivation. ..
  7. doi request reprint SUMOylation of pregnane X receptor suppresses rifampicin-induced CYP3A4 and P-gp expression and activity in LS174T cells
    Huasen Tan
    Laboratory of Drug Metabolism and Pharmacokinetics, School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou, Guangdong 510006, China
    J Pharmacol Sci 130:66-71. 2016
    ....
  8. doi request reprint Schisandra sphenanthera Extract Facilitates Liver Regeneration after Partial Hepatectomy in Mice
    Xi Li
    School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou X L, D L, X Z, H Z, Y W, Y Z, Y C, M H, H B Shenzhen Bao an Maternal and Child Health Hospital, Shenzhen X F, People s Republic of China
    Drug Metab Dispos 44:647-52. 2016
    ..These results demonstrate that WZ significantly facilitates hepatocyte proliferation and liver regeneration after PHX. ..
  9. doi request reprint Oleanolic acid attenuates obstructive cholestasis in bile duct-ligated mice, possibly via activation of NRF2-MRPs and FXR antagonism
    Pan Chen
    School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou 510006, PR China Department of Pharmacy, the First Affiliated Hospital of Sun Yat Sen University, Guangzhou 510080, PR China
    Eur J Pharmacol 765:131-9. 2015
    ..Taken together, we conclude that OA attenuates obstructive cholestasis in BDL mice, possibly via activation of NRF2-MRPs and FXR antagonism...
  10. pmc Metabolomics reveals that tumor xenografts induce liver dysfunction
    Fei Li
    Laboratory of Metabolism, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Proteomics 12:2126-35. 2013
    ....
  11. doi request reprint The impact of glutathione S-transferase genotype and phenotype on the adverse drug reactions to azathioprine in patients with inflammatory bowel diseases
    Hui Liu
    Department of Pharmacy, The First Affiliated Hospital of Jinan University, Guangzhou, PR China Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou, PR China Electronic address
    J Pharmacol Sci 129:95-100. 2015
    ..0012). The patients with higher GST activity constituted a pharmacogenetic high risk group for leucopenia during AZA treatment. GST-P1 Ile105/Ile105 genotype appeared to be a promising marker indicating predisposition to AZA-related ADRs...
  12. doi request reprint Wuzhi tablet (Schisandra Sphenanthera extract) protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of NRF2-ARE and p53/p21 pathways
    Xiaomei Fan
    School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou, China X F, Y J, Yo W, H T, H Z, Yi W, M H, H B The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China P C and Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland A Q, F J G
    Drug Metab Dispos 42:1982-90. 2014
    ....