Wei Shen

Summary

Country: China

Publications

  1. pmc Growth of mouse oocytes to maturity from premeiotic germ cells in vitro
    Zhi Peng Zhang
    Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, Qingdao Agricultural University, Qingdao, China
    PLoS ONE 7:e41771. 2012
  2. ncbi request reprint [Accelerated somatic cell senescence and changes in p16INK4a expression after exogenous DNA transfection]
    Wei Shen
    Institute of Biotechnology, Academy of Military Medical Science, Beijing 100071, China
    Yi Chuan 28:1383-8. 2006
  3. doi request reprint Di-(2-ethylhexyl) phthalate and bisphenol A exposure impairs mouse primordial follicle assembly in vitro
    Teng Zhang
    Laboratory of Germ Cell Biology, Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, College of Animal Science and Technology, Qingdao Agricultural University, Qingdao, China
    Environ Mol Mutagen 55:343-53. 2014
  4. doi request reprint Fetal exposure to bisphenol A affects the primordial follicle formation by inhibiting the meiotic progression of oocytes
    Han Qiong Zhang
    Laboratory of Germ Cell Biology, Qingdao Agricultural University, Qingdao, 266109, China
    Mol Biol Rep 39:5651-7. 2012
  5. doi request reprint Diethylhexyl phthalate exposure impairs follicular development and affects oocyte maturation in the mouse
    Xi Feng Zhang
    Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, Qingdao Agricultural University, Qingdao 266109, China
    Environ Mol Mutagen 54:354-61. 2013
  6. doi request reprint Bisphenol A exposure modifies methylation of imprinted genes in mouse oocytes via the estrogen receptor signaling pathway
    Hu He Chao
    Laboratory of Germ Cell Biology, Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, Qingdao Agricultural University, Qingdao, China
    Histochem Cell Biol 137:249-59. 2012
  7. doi request reprint Exposure to bisphenol A results in a decline in mouse spermatogenesis
    Guo Liang Zhang
    Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, Qingdao Agricultural University, Qingdao 266109, China
    Reprod Fertil Dev 25:847-59. 2013
  8. doi request reprint Expression and epigenetic dynamics of transcription regulator Lhx8 during mouse oogenesis
    Lian Jun Zhang
    Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, Qingdao Agricultural University, Qingdao, 266109, China
    Gene 506:1-9. 2012
  9. doi request reprint A co-culture system with preantral follicular granulosa cells in vitro induces meiotic maturation of immature oocytes
    Zhanbiao Li
    Laboratory of Germ Cell Biology, College of Animal Science and Technology, Qingdao Agricultural University, Qingdao, 266109, China
    Histochem Cell Biol 135:513-22. 2011
  10. doi request reprint Maternal imprinting during mouse oocyte growth in vivo and in vitro
    Zhenhua Song
    Qingdao Agricultural University, China
    Biochem Biophys Res Commun 387:800-5. 2009

Collaborators

  • Lan Li
  • Hong Chen
  • Bo Chen
  • Massimo De Felici
  • Zhong yi Sun
  • Min Zhang
  • Ying Jiang
  • Ping Chen
  • Yong Zhao
  • Zheng Tian Yang
  • Bo Xu
  • Qing Yuan Sun
  • Jie Qiao
  • Wei Zheng
  • Wei Ge
  • Xi Feng Zhang
  • Xiao Feng Sun
  • Lian Jun Zhang
  • Bo Pan
  • Teng Zhang
  • Hu He Chao
  • Yang Zhou
  • Lin Qing Wang
  • Qing Jie Pan
  • Jin Mei Ma
  • Yan Min Feng
  • Yan Ni Feng
  • Guo Liang Zhang
  • Qing hua Shi
  • Qinghua Shi
  • Pan Zhang
  • Yuan Chao Sun
  • Huan Zhang
  • Rui Sun
  • Shun Feng Cheng
  • Guo Qing Qin
  • Chun lei Chen
  • Xun Si Qin
  • Ling Jiang Min
  • Evanna Huynh
  • Gui Jin Liang
  • Han Qiong Zhang
  • Zhi Peng Zhang
  • Zhanbiao Li
  • Huhe Chao
  • Qingjie Pan
  • Zhenhua Song
  • Qin Kai Zhang
  • Deng Gao Xu
  • Jun Jie Wang
  • Guo Bo Quan
  • Qiaomei Hao
  • Hua Gang Ma
  • Xing Hong Sun
  • Xiaohua Jiang
  • Juan Hua
  • Mei Li Teng
  • Tieliang Ma
  • Yuanwei Zhang
  • Zhu Mei Hou
  • Huan Qi Liu
  • Howard J Cooke
  • Xia Fei Fu
  • Liu Wang
  • Yong De Chen
  • Hong Ying Zhang
  • Xiu Juan Li
  • Zhipeng Zhang
  • Xiaofeng Sun
  • Lingjiang Min

Detail Information

Publications26

  1. pmc Growth of mouse oocytes to maturity from premeiotic germ cells in vitro
    Zhi Peng Zhang
    Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, Qingdao Agricultural University, Qingdao, China
    PLoS ONE 7:e41771. 2012
    ..About 35% of the in vitro matured oocytes were fertilized and 53.44% of them were able to reach the 2-cell stage. Finally, around 7% of the 2-cell embryos developed to the morula/blastocyst stage...
  2. ncbi request reprint [Accelerated somatic cell senescence and changes in p16INK4a expression after exogenous DNA transfection]
    Wei Shen
    Institute of Biotechnology, Academy of Military Medical Science, Beijing 100071, China
    Yi Chuan 28:1383-8. 2006
    ..The senescent transfected MEF cells as donors of nuclei could support the early development of cloned embryos after nuclear transfer...
  3. doi request reprint Di-(2-ethylhexyl) phthalate and bisphenol A exposure impairs mouse primordial follicle assembly in vitro
    Teng Zhang
    Laboratory of Germ Cell Biology, Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, College of Animal Science and Technology, Qingdao Agricultural University, Qingdao, China
    Environ Mol Mutagen 55:343-53. 2014
    ..In conclusion, BPA and DEHP exposures impair mouse primordial follicle assembly in vitro...
  4. doi request reprint Fetal exposure to bisphenol A affects the primordial follicle formation by inhibiting the meiotic progression of oocytes
    Han Qiong Zhang
    Laboratory of Germ Cell Biology, Qingdao Agricultural University, Qingdao, 266109, China
    Mol Biol Rep 39:5651-7. 2012
    ..01). Decreased mRNA expression of specific meiotic genes including Stra8, Dmc1, Rec8 and Scp3 were observed. In conclusion, BPA exposure can affect the formation of primordial follicle by inhibiting meiotic progression of oocytes...
  5. doi request reprint Diethylhexyl phthalate exposure impairs follicular development and affects oocyte maturation in the mouse
    Xi Feng Zhang
    Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, Qingdao Agricultural University, Qingdao 266109, China
    Environ Mol Mutagen 54:354-61. 2013
    ..These results show that DEHP may have a number of adverse effects on oogenesis, especially when exposure occurs during early postnatal age, arising concerns about the exposure of human female infants and children to this compound...
  6. doi request reprint Bisphenol A exposure modifies methylation of imprinted genes in mouse oocytes via the estrogen receptor signaling pathway
    Hu He Chao
    Laboratory of Germ Cell Biology, Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, Qingdao Agricultural University, Qingdao, China
    Histochem Cell Biol 137:249-59. 2012
    ..In conclusion, neonatal exposure to BPA inhibits methylation of imprinted genes during oogenesis via the ER signaling pathway in CD-1 mice...
  7. doi request reprint Exposure to bisphenol A results in a decline in mouse spermatogenesis
    Guo Liang Zhang
    Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, Qingdao Agricultural University, Qingdao 266109, China
    Reprod Fertil Dev 25:847-59. 2013
    ..In addition, exposure of male mice to BPA resulted in abnormal offspring that were smaller with a low-quality pelage when they were 35 days old. In conclusion, BPA hampers spermatogenesis and the subsequent development of offspring...
  8. doi request reprint Expression and epigenetic dynamics of transcription regulator Lhx8 during mouse oogenesis
    Lian Jun Zhang
    Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, Qingdao Agricultural University, Qingdao, 266109, China
    Gene 506:1-9. 2012
    ..In conclusion, Lhx8 expression is related with the activation of primordial follicles, which is highly correlated with the demethylation of Lhx8-3' untranslated region and the high acetylation of histone H3...
  9. doi request reprint A co-culture system with preantral follicular granulosa cells in vitro induces meiotic maturation of immature oocytes
    Zhanbiao Li
    Laboratory of Germ Cell Biology, College of Animal Science and Technology, Qingdao Agricultural University, Qingdao, 266109, China
    Histochem Cell Biol 135:513-22. 2011
    ..In conclusion, the co-culture with PAGCs has a beneficial effect on the growth and maturation of immature oocytes...
  10. doi request reprint Maternal imprinting during mouse oocyte growth in vivo and in vitro
    Zhenhua Song
    Qingdao Agricultural University, China
    Biochem Biophys Res Commun 387:800-5. 2009
    ..Furthermore, it demonstrated that the degree of DNA methylation is positively correlated with the size of oocytes in vitro and in vivo, indicating a progressive methylation process during oocyte growth...
  11. doi request reprint Effects of diethylhexyl phthalate (DEHP) given neonatally on spermatogenesis of mice
    Xi Feng Zhang
    Laboratory of Germ Cell Biology, Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, College of Animal Science and Technology, Qingdao Agricultural University, Qingdao, 266109, China
    Mol Biol Rep 40:6509-17. 2013
    ..Treatment with DEHP induced histopathological changes in the testes. Taken together, these results provide a new insight into the molecular mechanisms underlying the detrimental impacts of DEHP in humans and wildlife. ..
  12. ncbi request reprint [The ht-PAm cDNA knock-in the goat beta-casein gene locus]
    Wei Shen
    Institute of Biotechnology, Academy of Military Medical Science, Beijing 100071, China
    Sheng Wu Gong Cheng Xue Bao 20:361-5. 2004
    ..The primary result demonstrated that 31 targeting cell clones with homologous recombination events were obtained, and 2 cell clones was verified by DNA sequence analysis on the homologous recombination region...
  13. doi request reprint Cloning and in vitro function analysis of codon-optimized FatI gene
    Xiao Feng Sun
    Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, Qingdao Agricultural University, Qingdao, People s Republic of China
    Biotechnol Appl Biochem 61:256-63. 2014
    ....
  14. doi request reprint Primordial follicle assembly was regulated by Notch signaling pathway in the mice
    Chun lei Chen
    Laboratory of Germ Cell Biology, Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, College of Animal Science and Technology, Qingdao Agricultural University, Qingdao, 266109, China
    Mol Biol Rep 41:1891-9. 2014
    ..05). In conclusion, Notch signaling pathway may regulate the formation of primordial follicle in mice. ..
  15. doi request reprint Methylation pattern of oncogene HRAS gene promoter region and its clinical relevance to urocystic tumorigenesis
    Xiao Feng Sun
    Laboratory of Germ Cell Biology, Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, College of Animal Science and Technology, Qingdao Agricultural University, Qingdao 266109, China
    Mol Biol Rep 39:8431-7. 2012
    ..0024). Abnormal methylation of the HRAS gene may be an early event during urocystic tumorigenesis and may be further used as a cancer biomarker in bladder tissue for early diagnosis and a potential therapeutic target...
  16. doi request reprint Alteration in methylation pattern of oncogene Akt1 promoter region in bladder cancer
    Xiao Feng Sun
    Laboratory of Germ Cell Biology, College of Animal Science and Technology, Qingdao Agricultural University, Qingdao, 266109, China
    Mol Biol Rep 39:5631-6. 2012
    ..Abnormal methylation of the Akt1 gene may be an early event during urocystic tumorigenesis and should be further evaluated as a tumorigenesis marker for early detection of bladder cancer...
  17. doi request reprint Recovery of functional oocytes from cultured premeiotic germ cells after kidney capsule transplantation
    Bo Chen
    Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, Qingdao Agricultural University, Qingdao, China
    Stem Cells Dev 22:567-80. 2013
    ....
  18. ncbi request reprint In vitro development of mouse fetal germ cells into mature oocytes
    Wei Shen
    College of Animal Science and Technology, Institute of Animal Reproduction Development and Genetic Engineering, Qingdao Agricultural University, Qingdao 266109, China
    Reproduction 134:223-31. 2007
    ..Our results demonstrate that mouse fetal germ cells are able to form primordial follicles with ovarian cells, and that oocytes within the growing follicles are able to mature normally in vitro...
  19. doi request reprint Reconstitution of gametogenesis in vitro: meiosis is the biggest obstacle
    Yuan Chao Sun
    Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, Qingdao Agricultural University, Qingdao 266109, China
    J Genet Genomics 41:87-95. 2014
    ..Here, we review the stem cell-derived germ cell development, and discuss the potential and challenges in the differentiation of functional germ cells from stem cells. ..
  20. ncbi request reprint [Production of mammary gland bioreactor by gene targeting of somatic cells]
    Wei Shen
    Institute of Biotechnology, Academy of Military Medical Science, Beijing 100071, China
    Sheng Wu Gong Cheng Xue Bao 19:767-70. 2003
    ..With the technology of gene targeting and nuclear transfer, it should provide a general way to produce specific genetic changes in several mammalian species. We are clearly at the dawn of a new era in mammalian genetic technology...
  21. doi request reprint Unstable expression of transgene is associated with the methylation of CAG promoter in the offspring from the same litter of homozygous transgenic mice
    Yang Zhou
    College of Animal Science and Technology, Qingdao Agricultural University, Qingdao, 266109, Shan dong, China
    Mol Biol Rep 41:5177-86. 2014
    ..In conclusion, Dnmt3b-related methylation of CAG promoter can inhibit the transgene expression and may result in the unstable expression of transgene in the offspring from the same litter of homozygous transgenic mice. ..
  22. doi request reprint Exposure to diethylhexyl phthalate (DEHP) results in a heritable modification of imprint genes DNA methylation in mouse oocytes
    Lan Li
    Laboratory of Germ Cell Biology, Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, College of Animal Science and Technology, Qingdao Agricultural University, Qingdao, 266109, China
    Mol Biol Rep 41:1227-35. 2014
    ..In conclusion, DEHP exposure can affect the DNA methylation of imprinting genes not only in fetal mouse germ cells and growing oocytes, but also in offspring's oocytes. ..
  23. ncbi request reprint Targeting the exogenous htPAm gene on goat somatic cell beta-casein locus for transgenic goat production
    Wei Shen
    Department of Animal Sciences, Institute of Animal Reproduction, Development and Genetic Engineering, Laiyang Agricultural University, Qingdao, China
    Mol Reprod Dev 74:428-34. 2007
    ....
  24. doi request reprint Murine folliculogenesis in vitro is stage-specifically regulated by insulin via the Akt signaling pathway
    Pan Zhang
    Laboratory of Germ Cell Biology, Qingdao Agricultural University, Qingdao, China
    Histochem Cell Biol 134:75-82. 2010
    ..Furthermore, in vitro cultures of 3 dpp mouse ovaries with insulin can repress the expression of Pten. In conclusion, folliculogenesis was stage-specifically regulated by insulin via the Akt signaling pathway in vitro...
  25. doi request reprint microRNA 376a regulates follicle assembly by targeting Pcna in fetal and neonatal mouse ovaries
    Huan Zhang
    Hefei National Laboratory for Physical Sciences at MicroscaleSchool of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, People s Republic of ChinaLaboratory of Germ Cell BiologyKey Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, Qingdao Agricultural University, Qingdao, Shandong, ChinaMRC Human Genetics UnitInstitute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UKDepartment of Obstetrics and GynecologyReproductive Medical Centre, Peking University Third Hospital, Beijing, China
    Reproduction 148:43-54. 2014
    ..To our knowledge, this is the first microRNA-target mRNA pair that has been reported to regulate mammalian primordial follicle assembly and further our understanding of the regulation of primordial follicle assembly. ..
  26. ncbi request reprint [Nuclear reprogramming of somatic nuclear transfer embryos]
    Zheng Tian Yang
    Institute of Biotechnology, Academy of Military Medical Sciences, Beijing 100071, China
    Yi Chuan Xue Bao 31:641-6. 2004
    ..There are many aberrant methylation in various genomic regions of cloned embryos. The gene imprinting of cloned embryos are also abnormal...