D Ma

Summary

Affiliation: Shanghai Institute of Organic Chemistry
Country: China

Publications

  1. ncbi CuI/L-proline-catalyzed coupling reactions of aryl halides with activated methylene compounds
    Xiaoan Xie
    Department of Chemistry, Fudan University, Shanghai 200433, China
    Org Lett 7:4693-5. 2005
  2. ncbi Mild method for Ullmann coupling reaction of amines and aryl halides
    Dawei Ma
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, 354 Fenglin Lu, Shanghai 200032, China
    Org Lett 5:2453-5. 2003
  3. ncbi Aromatic nucleophilic substitution or CuI-catalyzed coupling route to martinellic acid
    Dawei Ma
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, China
    J Org Chem 68:442-51. 2003
  4. ncbi Synthesis of 7-substituted benzolactam-V8s and their selectivity for protein kinase C isozymes
    Dawei Ma
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, 354 Fenglin Lu, Shanghai 200032, China
    Org Lett 4:2377-80. 2002
  5. ncbi N,N-dimethyl glycine-promoted Ullmann coupling reaction of phenols and aryl halides
    Dawei Ma
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China
    Org Lett 5:3799-802. 2003
  6. ncbi CuI-catalyzed coupling reaction of beta-amino acids or esters with aryl halides at temperature lower than that employed in the normal Ullmann reaction. Facile synthesis of SB-214857
    D Ma
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, 354 Fenglin Lu, Shanghai 200032, China
    Org Lett 3:2583-6. 2001
  7. ncbi First total synthesis of martinellic acid, a naturally occurring bradykinin receptor antagonist
    D Ma
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, 354 Fenglin Lu, Shanghai 200032, China
    Org Lett 3:2189-91. 2001
  8. ncbi Synthesis of 7,8-disubstituted benzolactam-V8 and its binding to protein kinase C
    D Ma
    State Key Laboratory of Bio organic and Natural Product Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
    Bioorg Med Chem Lett 11:99-101. 2001
  9. ncbi Recent advances in the discovery of protein kinase C modulators based on the structures of natural protein kinase C activators
    D Ma
    Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China
    Curr Med Chem 8:191-202. 2001
  10. ncbi General route to 2,4,5-trisubstituted piperidines from enantiopure beta-amino esters. Total synthesis of pseudodistomin B triacetate and pseudodistomin F
    D Ma
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China
    J Org Chem 65:6009-16. 2000

Collaborators

Detail Information

Publications72

  1. ncbi CuI/L-proline-catalyzed coupling reactions of aryl halides with activated methylene compounds
    Xiaoan Xie
    Department of Chemistry, Fudan University, Shanghai 200433, China
    Org Lett 7:4693-5. 2005
    ..Both aryl iodides and aryl bromides are compatible with these reaction conditions...
  2. ncbi Mild method for Ullmann coupling reaction of amines and aryl halides
    Dawei Ma
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, 354 Fenglin Lu, Shanghai 200032, China
    Org Lett 5:2453-5. 2003
    ....
  3. ncbi Aromatic nucleophilic substitution or CuI-catalyzed coupling route to martinellic acid
    Dawei Ma
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, China
    J Org Chem 68:442-51. 2003
    ..Guanylation of 3 under mild condition followed by deprotection results in the synthesis of martinellic acid 1...
  4. ncbi Synthesis of 7-substituted benzolactam-V8s and their selectivity for protein kinase C isozymes
    Dawei Ma
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, 354 Fenglin Lu, Shanghai 200032, China
    Org Lett 4:2377-80. 2002
    ..This intermediate is converted into 7-substituted benzolactam-V8s using an asymmetric Strecker reaction as the key step. The target molecules show a different pattern of isozyme selectivity relative to the 8-substituted benzolactam-V8s...
  5. ncbi N,N-dimethyl glycine-promoted Ullmann coupling reaction of phenols and aryl halides
    Dawei Ma
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China
    Org Lett 5:3799-802. 2003
    ..reaction: see text] Ullmann-type diaryl ether synthesis can be performed at 90 degrees C using either aryl iodides or aryl bromides as the substrates under the assistance of N,N-dimethylglycine...
  6. ncbi CuI-catalyzed coupling reaction of beta-amino acids or esters with aryl halides at temperature lower than that employed in the normal Ullmann reaction. Facile synthesis of SB-214857
    D Ma
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, 354 Fenglin Lu, Shanghai 200032, China
    Org Lett 3:2583-6. 2001
    ..This coupling reaction can be used to prepare enantiopure N-aryl beta-amino acids. An efficient synthetic route to SB214857, a potent GPIIb/IIIa receptor antagonist, is developed using this method...
  7. ncbi First total synthesis of martinellic acid, a naturally occurring bradykinin receptor antagonist
    D Ma
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, 354 Fenglin Lu, Shanghai 200032, China
    Org Lett 3:2189-91. 2001
    ....
  8. ncbi Synthesis of 7,8-disubstituted benzolactam-V8 and its binding to protein kinase C
    D Ma
    State Key Laboratory of Bio organic and Natural Product Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
    Bioorg Med Chem Lett 11:99-101. 2001
    ..6, 91.1, and 121.3 nM to PKCalpha, delta, and epsilon, respectively), indicating that introduction of a suitable substituent at the 7-position of 8-decynyl-benzolactam-V8 only slightly reduces the PKC binding affinity...
  9. ncbi Recent advances in the discovery of protein kinase C modulators based on the structures of natural protein kinase C activators
    D Ma
    Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China
    Curr Med Chem 8:191-202. 2001
    ....
  10. ncbi General route to 2,4,5-trisubstituted piperidines from enantiopure beta-amino esters. Total synthesis of pseudodistomin B triacetate and pseudodistomin F
    D Ma
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China
    J Org Chem 65:6009-16. 2000
    ..The key steps for these transformations include Curtius rearrangement and Julia olefination...
  11. ncbi Synthesis of enantiopure alpha,alpha-disubstituted amino acids from the asymmetric Strecker reaction products of aldehydes
    D Ma
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, 354 Fenglin Lu, Shanghai 200032, China
    Org Lett 2:2515-7. 2000
    ..Deprotection of these products afforded the corresponding enantiopure alpha,alpha-dialkyl amino acids...
  12. ncbi A simple and stereospecfic route to 2,6-disubstituted 4-hydroxypiperidines. Synthesis of dendrobate alkaloid (+)-241D and formal synthesis of (-)-indolizidine 167B
    D Ma
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China
    Org Lett 2:2503-5. 2000
    ..The condensation of enantiopure beta-amino esters with beta-ketoesters followed by cyclization and decarboxylation afforded 2,3-dihydro-4-pyridones 3, which were selectively hydrogenated to provide 2,6-disubstituted 4-hydroxypiperdines...
  13. ncbi Synthesis of an oxazoline analogue of apratoxin A
    Bin Zou
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China
    Org Lett 5:3503-6. 2003
    ..Connection of 11 with the l-proline moiety and subsequent installation of an oxazoline ring affords 16, which is coupled with tripeptide 21; subsequent macrocyclization then furnishes 4, an oxazoline analogue of apratoxin A...
  14. ncbi Mild and nonracemizing conditions for Ullmann-type diaryl ether formation between aryl iodides and tyrosine derivatives
    Qian Cai
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China
    J Org Chem 71:5268-73. 2006
    ..But their reaction yields are moderate. On the basis of these studies, shorter protocols for assembling (S,S)-isodityrosine and K-13 are developed...
  15. doi A novel allergen Tab y 1 with inhibitory activity of platelet aggregation from salivary glands of horseflies
    S An
    Biotoxin Units of Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, China
    Allergy 66:1420-7. 2011
    ..Horsefly sting causes allergic reactions in human body. However, our knowledge on horsefly allergens remains poor...
  16. ncbi Asymmetric total synthesis of (-)-alkaloid 223A and its 6-epimer
    Xiaotao Pu
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, China
    J Org Chem 68:4400-5. 2003
    ....
  17. ncbi Assembly of conjugated enynes and substituted indoles via CuI/amino acid-catalyzed coupling of 1-alkynes with vinyl iodides and 2-bromotrifluoroacetanilides
    Feng Liu
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China
    J Org Chem 72:4844-50. 2007
    ..Both aryl acetylenes and O-protected propargyl alcohol can be applied, leading to 5-, 6-, or 7-substituted 2-aryl and protected 2-hydroxymethyl indoles in good yields. With simple aliphatic alkynes, however, lower yields were observed...
  18. doi Copper/amino acid catalyzed cross-couplings of aryl and vinyl halides with nucleophiles
    Dawei Ma
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai, China
    Acc Chem Res 41:1450-60. 2008
    ..These conveniently available and inexpensive catalytic systems not only accelerate the reactions but also tolerate many more functional groups. Thus, they should find considerable application in organic synthesis...
  19. ncbi Selective inhibition of matrix metalloproteinase isozymes and in vivo protection against emphysema by substituted gamma-keto carboxylic acids
    Dawei Ma
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
    J Med Chem 49:456-8. 2006
    ..Among nine MMP isozymes tested, compound 1j displays selective inhibition of MMP-2, -9, and -12 with IC(50) values between 0.20 and 1.51 microuM, and in male golden Syrian hamsters, it shows protection against PPE-induced emphysema...
  20. doi Synthesis of 1,5-benzothiazepine dipeptide mimetics via two CuI-catalyzed cross coupling reactions
    Jiangang Gan
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China
    Org Lett 11:2788-90. 2009
    ..Cyclization is achieved via a CuI/N,N-dimethylglycine catalyzed intramolecular coupling of aryl iodides with the liberated thiol to afford 1,5-benzothiazepine dipeptide mimetics...
  21. ncbi Total synthesis of the cyclodepsipeptide apratoxin A and its analogues and assessment of their biological activities
    Dawei Ma
    State Key Laboratory of Bioorganic and Natural Products Chemistry Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences 354 Fenglin Lu, Shanghai 200032, China
    Chemistry 12:7615-26. 2006
    ..Further biological analysis revealed that both synthetic apratoxin A and its oxazoline analogue inhibited cell proliferation by causing cell cycle arrest in the G1 phase...
  22. ncbi Total synthesis of clavepictines A and B and pictamine
    Shanghai Yu
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China
    Org Lett 8:3179-82. 2006
    ..The possible stereochemical course for this conjugate addition is discussed...
  23. ncbi Synthesis and biological evaluation of 1,3,3,4-tetrasubstituted pyrrolidine CCR5 receptor antagonists. Discovery of a potent and orally bioavailable anti-HIV agent
    Dawei Ma
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China
    ChemMedChem 2:187-93. 2007
    ..3 nM to 30 nM. This molecule showed oral bioavailabilities of 41.2 % and 21.6 % in rats and dogs, respectively. Thus, compound 30 is a promising candidate for the treatment of HIV-1 infection...
  24. doi A general and efficient approach to aryl thiols: CuI-catalyzed coupling of aryl iodides with sulfur and subsequent reduction
    Yongwen Jiang
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China
    Org Lett 11:5250-3. 2009
    ..A wide range of substituted aryl thiols that bear methoxy, hydroxyl, carboxylate, amido, keto, bromo, and fluoro groups can be assembled through this procedure...
  25. ncbi Highly efficient catalytic system for enantioselective Michael addition of aldehydes to nitroalkenes in water
    Shaolin Zhu
    State Key Laboratory of Bio organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, PR China
    Angew Chem Int Ed Engl 47:545-8. 2008
  26. doi Efficient and economical access to substituted benzothiazoles: copper-catalyzed coupling of 2-haloanilides with metal sulfides and subsequent condensation
    Dawei Ma
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China
    Angew Chem Int Ed Engl 48:4222-5. 2009
    ..A wide range of functional groups are tolerated under the reaction conditions...
  27. ncbi Enantioselective addition of activated terminal alkynes to 1-acylpyridinium salts catalyzed by Cu-Bis(oxazoline) complexes
    Zhankui Sun
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China
    J Am Chem Soc 129:9300-1. 2007
  28. ncbi Total synthesis of cyclic tetrapeptide FR235222, a potent immunosuppressant that inhibits mammalian histone deacetylases
    Weiqing Xie
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China
    Org Lett 7:2775-7. 2005
    ....
  29. ncbi Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors
    Dawei Ma
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China
    Bioorg Med Chem Lett 14:47-50. 2004
    ..In nine MMPs tested, most of the compounds display potent inhibition activity except for MMP-7. Some subtle isozyme selectivity is observed by varying the substituents at the 6- and 7-positions and aromatic ring of arylsulfonyl groups...
  30. doi Enantioselective assembly of substituted dihydropyrones via organocatalytic reaction in water media
    Jing Wang
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China
    Org Lett 10:2561-4. 2008
    ....
  31. doi Total synthesis and structure assignment of papuamide B, a potent marine cyclodepsipeptide with anti-HIV properties
    Weiqing Xie
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China
    Angew Chem Int Ed Engl 47:2844-8. 2008
  32. doi Enantioselective synthesis of polysubstituted cyclopentanones by organocatalytic double Michael addition reactions
    Anqi Ma
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China
    Org Lett 12:3634-7. 2010
    ..This process allows formation of four contiguous stereocenters in the cyclopentanone ring in one-step with excellent enantioselectivity...
  33. ncbi Total synthesis and cytotoxicity studies of a cyclic depsipeptide with proposed structure of palau'amide
    Bin Zou
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China
    Org Lett 7:4237-40. 2005
    ....
  34. ncbi CuI-catalyzed domino process to 2,3-disubstituted benzofurans from 1-bromo-2-iodobenzenes and beta-keto esters
    Biao Lu
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China
    J Org Chem 72:5337-41. 2007
    ..Benzofurans with different substituents at the 5- and 6-position are accessible by employing the corresponding 1-bromo-2-iodobenzenes...
  35. ncbi Highly convergent route to cyclopeptide alkaloids: total synthesis of ziziphine N
    Gang He
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai, China
    Org Lett 9:1367-9. 2007
    ..The key elements include construction of its aryl ether unit via Mitsunobu reaction, installation of its enamide part via CuI/N,N-dimethylglycine-catalyzed coupling reaction, and ring closure with coupling agents such as FDDP and DPPA...
  36. ncbi Facile entry to substituted decahydroquinoline alkaloids. Total synthesis of lepadins A-E and H
    Xiaotao Pu
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China
    J Org Chem 71:6562-72. 2006
    ..By comparison of the rotations and NMR data, the stereochemistry of lepadins D, E, and H is assigned as 2S,3R,4aS,5S,8aR,5'R...
  37. doi Studies on the structure-activity relationship of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists. Part 1: Tuning the N-substituents
    Li Ben
    Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 319 Yueyang Lu, Shanghai 200031, China
    Bioorg Med Chem Lett 20:4012-4. 2010
    ..Potent analogues with low toxic properties were successfully developed by formation of urea and amide bonds at the nitrogen at position 4- of the pyrrolidine ring...
  38. ncbi Recent progress on the total synthesis of natural products in China
    Qingquan Wu
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai, 200032, China
    Nat Prod Rep 23:772-88. 2006
    ..In addition, some significant results on the novel synthesis and structure-activity relationship (SAR) studies of several natural products are introduced...
  39. doi A concise route to the proposed structure of lydiamycin B, an antimycobacterial depsipeptide
    Wenhua Li
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China
    Org Lett 11:5694-7. 2009
    ..None of them shows identical NMR data with those reported for natural lydiamycin B, indicating that further structural revisions are required...
  40. ncbi Total synthesis of lepadins B, d, e, and h; determination of the configuration of the latter three alkaloids
    Xiaotao Pu
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China
    Angew Chem Int Ed Engl 43:4222-5. 2004
  41. doi CuI/4-hydro-L-proline as a more effective catalytic system for coupling of aryl bromides with N-boc hydrazine and aqueous ammonia
    Liqin Jiang
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China
    J Org Chem 74:4542-6. 2009
    ..These processes allow assembly of N-aryl hydrazides and primary arylamines that bear a wide range of functional groups including hydroxyl, amine, trifluoromethyl, ester, nitro, and ketone...
  42. ncbi Asymmetric total syntheses of marine cyclic depsipeptide halipeptins A-D
    Shouyun Yu
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China
    Chemistry 12:6572-84. 2006
    ....
  43. ncbi Two-component method to enantiopure quinolizidinones and Indolizidinones. Total synthesis of (-)-lasubine II
    D Ma
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China
    Org Lett 3:3927-9. 2001
    ..Hydrolysis of 4 to the corresponding carboxylic acids followed by treatment of acetic anhydride/triethylamine gives 3 in high yields. Using 3a as a key intermediate, (-)-lasubine II is synthesized in four steps. [reaction: see text]..
  44. pmc A novel family of RGD-containing disintegrins (Tablysin-15) from the salivary gland of the horsefly Tabanus yao targets αIIbβ3 or αVβ3 and inhibits platelet aggregation and angiogenesis
    D Ma
    Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China
    Thromb Haemost 105:1032-45. 2011
    ..The RGD motif in the unique sequence of Tablysin-15 represents a novel template for studying the structure-function relationship of the disintegrin family of inhibitors...
  45. ncbi Preparation of syn-delta-hydroxy-beta-amino esters via an intramolecular hydrogen bond directed diastereoselective hydrogenation. Total synthesis of (3S,4aS,6R,8S)-hyperaspine
    Wei Zhu
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China
    Org Lett 5:5063-6. 2003
    ..By using this method and a Dieckmann reaction as the key steps, (3S,4aS,6R,8S)-hyperaspine, a new type of ladybird alkaloid, is synthesized. [reaction: see text]..
  46. doi Total synthesis of antimicrobial and antitumor cyclic depsipeptides
    Wenhua Li
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China
    Chem Commun (Camb) 46:5403-20. 2010
    ..Furthermore, through construction from scratch, ambiguities regarding the structure of several members of that compound class could be successfully clarified and derivatives for structure-activity-relationship (SAR) studies obtained...
  47. ncbi Total synthesis of microsclerodermin E
    Jidong Zhu
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China
    Angew Chem Int Ed Engl 42:5348-51. 2003
  48. ncbi Mild Ullmann-type biaryl ether formation reaction by combination of ortho-substituent and ligand effects
    Qian Cai
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China
    Angew Chem Int Ed Engl 45:1276-9. 2006
  49. ncbi Total synthesis of halipeptin A: a potent antiinflammatory cyclic depsipeptide
    Shouyun Yu
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China
    Angew Chem Int Ed Engl 44:135-8. 2004
  50. doi Total synthesis and absolute stereochemical assignment of (-)-communesin F
    Zhiwei Zuo
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China
    J Am Chem Soc 132:13226-8. 2010
    ..Along with the total synthesis, we were able to assign the absolute configuration of natural communesin F as 6R,7R,8R,9S,11R...
  51. ncbi Assembly of 3-acyloxindoles via cui/L-proline-catalyzed intramolecular arylation of beta-keto amides
    Biao Lu
    Department of Chemistry, Fudan University, and State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai 200032, China
    Org Lett 8:6115-8. 2006
    ..Electronic effects on the aromatic ring have little influence on this reaction. Variations at the 1, 3, 4, 5, and 6 positions of the oxindoles were achieved by employing the corresponding amides...
  52. pmc Control of basal autophagy by calpain1 mediated cleavage of ATG5
    Hong Guang Xia
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China
    Autophagy 6:61-6. 2010
    ..We conclude that calpain1 plays an important role in controlling the levels of autophagy in normal living cells by regulating the levels of a key signaling molecule, ATG12-ATG5 conjugate...
  53. ncbi Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50
    Yi Feng Xia
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
    J Immunol 173:4207-17. 2004
    ..Notably, it had no suppressive effect on IkappaBalpha degradation, p50 and p65 nuclear translocation, or cell growth rates. Our results thus reveal a unique pharmacological mechanism of Andro's protective anti-inflammatory actions...
  54. ncbi Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative
    Kai Long
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China
    Bioorg Med Chem Lett 15:3849-52. 2005
    ..Based on the SAR results, salubrinal was converted into a biotinylated derivative which retains activity and can be used as a biological tool for target identification...
  55. pmc Cyclodepsipeptide toxin promotes the degradation of Hsp90 client proteins through chaperone-mediated autophagy
    Shensi Shen
    Shanghai Institute of Materia Medica, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201203, China
    J Cell Biol 185:629-39. 2009
    ..Our study provides the first examples for the ability of CMA to mediate degradation of membrane receptors and cross talks of CMA and proteasomal degradation mechanisms...
  56. doi Total synthesis of salinamide A: a potent anti-inflammatory bicyclic depsipeptide
    Li Tan
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China
    Angew Chem Int Ed Engl 47:3614-7. 2008
  57. ncbi Structural basis of RasGRP binding to high-affinity PKC ligands
    Suo Bao Rong
    Drug Discovery Program, Department of Neurology, Georgetown University Medical Center, 3970 Reservoir Road, Washington, D C 20007, USA
    J Med Chem 45:853-60. 2002
    ..Taken together, our experimental and modeling studies provide us with a better understanding of the structural basis of the binding of PKC ligands to the novel phorbol ester receptor RasGRP...
  58. ncbi A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress
    Michael Boyce
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Science 307:935-9. 2005
    ..More broadly, salubrinal demonstrates the feasibility of selective pharmacological targeting of cellular dephosphorylation events...
  59. doi Synthesis and antitumor activity of cyclodepsipeptide zygosporamide and its analogues
    You Wang
    Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, China
    Bioorg Med Chem Lett 18:4385-7. 2008
    ..The potencies of the synthetic zygosporamide are similar to those reported for the natural product toward all cancer cell lines examined with the exception of SF-268, the underlying cause of which remains to be elucidated...
  60. pmc Design of wide-spectrum inhibitors targeting coronavirus main proteases
    HaiTao Yang
    Tsinghua IBP Joint Research Group for Structural Biology, Tsinghua University, Beijing, China
    PLoS Biol 3:e324. 2005
    ..Further modification could rapidly lead to the discovery of a single agent with clinical potential against existing and possible future emerging CoV-related diseases...
  61. ncbi Enantioselective arylation of 2-methylacetoacetates catalyzed by CuI/trans-4-hydroxy-L-proline at low reaction temperatures
    Xiaoan Xie
    Department of Chemistry, Fudan University, Shanghai 200433, China
    J Am Chem Soc 128:16050-1. 2006
    ..Up to 93% ee was achieved when tert-butyl ester was used. The combination of ligand, ortho substituent (participation of NHCOCF3), and solvent effects was shown to account for these unprecedentedly mild reaction conditions...
  62. ncbi Amino acid promoted CuI-catalyzed C-N bond formation between aryl halides and amines or N-containing heterocycles
    Hui Zhang
    Department of Chemistry, Fudan University, Shanghai 200433, China
    J Org Chem 70:5164-73. 2005
    ..The possible action of amino acids in these coupling reactions is discussed...
  63. ncbi Diastereoselective aldol reaction of N,N-dibenzyl-alpha-amino aldehydes with ketones catalyzed by proline
    Qiangbiao Pan
    Department of Chemistry, Fudan University, Shanghai 200433, China
    Org Lett 6:1009-12. 2004
    ....
  64. ncbi Cascade coupling/cyclization process to N-substituted 1,3-dihydrobenzimidazol-2-ones
    Benli Zou
    Department of Chemistry, Fudan University, Shanghai 200433, China
    Org Lett 9:4291-4. 2007
    ..A number of functional groups are tolerated by these reaction conditions, including vinyl, nitro, carboxylate, amide, ester, ketone, and silyl ether groups...
  65. ncbi Facile access to polysubstituted indoles via a cascade Cu-catalyzed arylation-condensation process
    Yu Chen
    Department of Chemistry, Fudan University, Shanghai, China
    J Org Chem 72:9329-34. 2007
    ..Polysubstituted indoles can be prepared from substituted 2-halotrifluoroacetanilides with high regioselectivity...
  66. doi Elaboration of 2-(trifluoromethyl)indoles via a cascade coupling/condensation/deacylation process
    Yu Chen
    Department of Chemistry, Fudan University, Shanghai 200433, China
    Org Lett 10:625-8. 2008
    ..This reaction is suggested to occur via a novel coupling/condensation/deacylation mechanism, and many functional groups are tolerated under these conditions...
  67. ncbi Synthesis of 1,2-disubstituted benzimidazoles by a Cu-catalyzed cascade aryl amination/condensation process
    Benli Zou
    Department of Chemistry, Fudan University, Shanghai, PR China
    Angew Chem Int Ed Engl 46:2598-601. 2007
  68. doi Assembly of isoquinolines via CuI-catalyzed coupling of beta-keto esters and 2-halobenzylamines
    Bao Wang
    Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, China
    Org Lett 10:2761-3. 2008
    ....
  69. ncbi 1H, 13C and 15N backbone resonance assignments of matrilysin (MMP7) complexed with a sulfonamide hydroxamate-type inhibitor
    Li Ou
    J Biomol NMR 29:537-8. 2004
  70. ncbi Synthesis of aryl sulfones via L-proline-promoted CuI-catalyzed coupling reaction of aryl halides with sulfinic acid salts
    Wei Zhu
    Department of Chemistry, Fudan University, Shanghai 200433, China
    J Org Chem 70:2696-700. 2005
    ..Using this method, 4-phenylsulfonyl- and 4-methanesulfonyl-substituted L-phenylalanine derivatives are prepared...
  71. doi A one-pot coupling/hydrolysis/condensation process to pyrrolo[1,2-a]quinoxaline
    Qiliang Yuan
    Department of Chemistry, Fudan University, Shanghai 200433, China
    J Org Chem 73:5159-62. 2008
    ..Indole-2-carboxylate esters underwent the same process smoothly to provide the corresponding tetracyclic products...
  72. ncbi Co-recycling of MT1-MMP and MT3-MMP through the trans-Golgi network. Identification of DKV582 as a recycling signal
    Xing Wang
    Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 279:9331-6. 2004
    ..These results suggest that MT-MMPs may coordinate their proteolytic activities through the cellular trafficking machinery...