Xu Lin

Summary

Affiliation: Shanghai Institutes for Biological Sciences
Country: China

Publications

  1. pmc Effects of a flaxseed-derived lignan supplement in type 2 diabetic patients: a randomized, double-blind, cross-over trial
    An Pan
    Key Laboratory of Systems Biology, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 2:e1148. 2007
  2. pmc Joint analysis of multiple biomarkers for identifying type 2 diabetes in middle-aged and older Chinese: a cross-sectional study
    Hongyu Wu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    BMJ Open 1:e000191. 2011
  3. doi Dairy consumption, type 2 diabetes, and changes in cardiometabolic traits: a prospective cohort study of middle-aged and older Chinese in Beijing and Shanghai
    Geng Zong
    Corresponding author Xu Lin
    Diabetes Care 37:56-63. 2014
  4. pmc Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians
    H Li
    Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People s Republic of China
    Diabetologia 55:981-95. 2012
  5. pmc Self-Rated Health in middle-aged and elderly Chinese: distribution, determinants and associations with cardio-metabolic risk factors
    Nazanin Haseli-Mashhadi
    Unilever R and D, Colworth Science Park, Sharnbrook, Bedfordshire, UK
    BMC Public Health 9:368. 2009
  6. pmc Sleep quality in middle-aged and elderly Chinese: distribution, associated factors and associations with cardio-metabolic risk factors
    Nazanin Haseli-Mashhadi
    Unilever R and D, Colworth Science Park, Sharnbrook, Bedfordshire, UK
    BMC Public Health 9:130. 2009
  7. pmc Associations of erythrocyte palmitoleic acid with adipokines, inflammatory markers, and the metabolic syndrome in middle-aged and older Chinese
    Geng Zong
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Graduate University of the Chinese Academy of Sciences, Shanghai, China
    Am J Clin Nutr 96:970-6. 2012
  8. doi Effects of a flaxseed-derived lignan supplement on C-reactive protein, IL-6 and retinol-binding protein 4 in type 2 diabetic patients
    An Pan
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, 294 Tai Yuan Road, Shanghai 200031, China
    Br J Nutr 101:1145-9. 2009
  9. doi Independent and opposite associations of trunk and leg fat depots with adipokines, inflammatory markers, and metabolic syndrome in middle-aged and older Chinese men and women
    Hongyu Wu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of Chinese Academy of Sciences, Shanghai 200031, China
    J Clin Endocrinol Metab 95:4389-98. 2010
  10. doi Associations of resistin with inflammatory and fibrinolytic markers, insulin resistance, and metabolic syndrome in middle-aged and older Chinese
    Qibin Qi
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
    Eur J Endocrinol 159:585-93. 2008

Collaborators

  • Huaixing Li
  • Frank B Hu
  • Ling Lu
  • Yong Liu
  • Liang Sun
  • Oscar H Franco
  • Hongyu Wu
  • Yan Chen
  • Qi Sun
  • Chen Liu
  • Jing Wang
  • Wendy Demark-Wahnefried
  • Ying Wu
  • Gang Liu
  • Xin Liu
  • Kirsten L Rennie
  • Dong Xie
  • Jing Fang
  • Zhijie Yu
  • Xingwang Ye
  • An Pan
  • Geng Zong
  • Qibin Qi
  • Jingwen Zhu
  • Geng Zhang
  • Wei Gan
  • Xiafei Chen
  • Danxia Yu
  • Pang Yao
  • He Zheng
  • Ruth J F Loos
  • Nazanin Haseli-Mashhadi
  • Qianlu Jin
  • Li Hua Chen
  • Wenjia Gu
  • Rong Zeng
  • Rong Xia Li
  • Yao Hu
  • Lixin Tang
  • Yongxian Zhang
  • Jia Rui Wu
  • Zhi Duan Su
  • Xinwei Hou
  • Vasanti S Malik
  • Donna Spiegelman
  • Yifu Qiu
  • Zhi Jie Yu
  • ShuFang Jiao
  • Hong Liu
  • Xinghuo Pang
  • Zheng Zhang
  • Shurong Zou
  • Ling Yang
  • Jianqin Sun
  • Yanfang Wang
  • Huiyong Yin
  • Hong Ding
  • Yiwei Ma
  • Xinming Xu
  • Feijie Wang
  • Renming Hu
  • Linong Ji
  • Honglei Chen
  • Yuan Si
  • Hongguang Sheng
  • Zunji Ke
  • Hanqing Ding
  • Chuan Tian
  • Zhenni Zhu
  • Gregory J Anderson
  • Shi lin Zhao
  • Yu Bo Ding
  • Fulong Wang
  • Qian Wu
  • Fang Ying Xia
  • Robert A Gibson
  • Yunhua Zhou
  • Kan Liao
  • Qing Run Li
  • Li Jing
  • Yi Pan
  • Johnna Wu
  • Fudi Wang
  • Yuan Yuan Xiao
  • Sheng Ruan
  • Yu Guan
  • Yu Yu
  • Heng Huang
  • Maria Makrides
  • Peng An

Detail Information

Publications75

  1. pmc Effects of a flaxseed-derived lignan supplement in type 2 diabetic patients: a randomized, double-blind, cross-over trial
    An Pan
    Key Laboratory of Systems Biology, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 2:e1148. 2007
    ..The study aimed to investigate the effect of a flaxseed-derived lignan supplement on glycemic control, lipid profiles and insulin sensitivity in type 2 diabetic patients...
  2. pmc Joint analysis of multiple biomarkers for identifying type 2 diabetes in middle-aged and older Chinese: a cross-sectional study
    Hongyu Wu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    BMJ Open 1:e000191. 2011
    ..More prospective data are warranted to confirm this observation...
  3. doi Dairy consumption, type 2 diabetes, and changes in cardiometabolic traits: a prospective cohort study of middle-aged and older Chinese in Beijing and Shanghai
    Geng Zong
    Corresponding author Xu Lin
    Diabetes Care 37:56-63. 2014
    ..02), which was attenuated after adjustment for dairy consumption (Ptrend = 0.15). CONCLUSIONS Dairy consumption was associated with a significantly lower risk of type 2 diabetes and favorable changes of cardiometabolic traits in Chinese. ..
  4. pmc Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians
    H Li
    Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People s Republic of China
    Diabetologia 55:981-95. 2012
    ..To test whether there is an association of the FTO locus with obesity and type 2 diabetes, we conducted a meta-analysis of 32 populations including 96,551 East and South Asians...
  5. pmc Self-Rated Health in middle-aged and elderly Chinese: distribution, determinants and associations with cardio-metabolic risk factors
    Nazanin Haseli-Mashhadi
    Unilever R and D, Colworth Science Park, Sharnbrook, Bedfordshire, UK
    BMC Public Health 9:368. 2009
    ..We aimed to evaluate the distribution and factors associated with SRH and its association with biomarkers of cardio-metabolic diseases among middle-aged and elderly Chinese...
  6. pmc Sleep quality in middle-aged and elderly Chinese: distribution, associated factors and associations with cardio-metabolic risk factors
    Nazanin Haseli-Mashhadi
    Unilever R and D, Colworth Science Park, Sharnbrook, Bedfordshire, UK
    BMC Public Health 9:130. 2009
    ..However, limited information exists on the distribution and determinants of sleep quality and its associations with cardio-metabolic risk factors in Chinese populations. We aimed to evaluate this in the current study...
  7. pmc Associations of erythrocyte palmitoleic acid with adipokines, inflammatory markers, and the metabolic syndrome in middle-aged and older Chinese
    Geng Zong
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Graduate University of the Chinese Academy of Sciences, Shanghai, China
    Am J Clin Nutr 96:970-6. 2012
    ..Palmitoleic acid has been shown to regulate adipokine expression and systemic metabolic homeostasis in animal studies. However, its association with human metabolic diseases remains controversial...
  8. doi Effects of a flaxseed-derived lignan supplement on C-reactive protein, IL-6 and retinol-binding protein 4 in type 2 diabetic patients
    An Pan
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, 294 Tai Yuan Road, Shanghai 200031, China
    Br J Nutr 101:1145-9. 2009
    ..001 following lignan and placebo treatments, respectively). The study suggests that lignan might modulate CRP levels in type 2 diabetics. These results need to be confirmed by further large clinical trials of longer duration...
  9. doi Independent and opposite associations of trunk and leg fat depots with adipokines, inflammatory markers, and metabolic syndrome in middle-aged and older Chinese men and women
    Hongyu Wu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of Chinese Academy of Sciences, Shanghai 200031, China
    J Clin Endocrinol Metab 95:4389-98. 2010
    ..The objective was to investigate associations of regional fat depots with adipokines, inflammatory markers, and risk of metabolic syndrome (MetS) in a Chinese population...
  10. doi Associations of resistin with inflammatory and fibrinolytic markers, insulin resistance, and metabolic syndrome in middle-aged and older Chinese
    Qibin Qi
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
    Eur J Endocrinol 159:585-93. 2008
    ..However, the role of resistin in human disease remains controversial. We aimed to assess plasma resistin levels and their associations with inflammatory and fibrinolytic markers, IR and metabolic syndrome (MetS) among Chinese...
  11. doi Elevated plasma retinol-binding protein 4 is associated with increased risk of type 2 diabetes in middle-aged and elderly Chinese adults
    Liang Sun
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences
    J Nutr 144:722-8. 2014
    ..026 for nonlinearity). Our study indicates that plasma RBP4 is independently associated with the 6-y risk of developing type 2 diabetes. ..
  12. doi Associations of physical activity with inflammatory factors, adipocytokines, and metabolic syndrome in middle-aged and older chinese people
    Zhijie Yu
    Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Circulation 119:2969-77. 2009
    ..Our objective was to investigate single and joint associations of physical activity with inflammatory factors, adipocytokines, and the metabolic syndrome among middle-aged and older Chinese people...
  13. pmc Lifestyle counseling and supplementation with flaxseed or walnuts influence the management of metabolic syndrome
    Hongyu Wu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
    J Nutr 140:1937-42. 2010
    ..Flaxseed and walnut supplementation may ameliorate central obesity. Further studies with larger sample sizes and of longer duration are needed to examine the role of these foods in the prevention and management of MetS...
  14. pmc Effects of body fat on the associations of high-molecular-weight adiponectin, leptin and soluble leptin receptor with metabolic syndrome in Chinese
    Danxia Yu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 6:e16818. 2011
    ..Also few studies elucidate the effects of inflammation and body fat mass on the relations...
  15. ncbi Insulin resistance and depressive symptoms in middle-aged and elderly Chinese: findings from the Nutrition and Health of Aging Population in China Study
    An Pan
    Key Laboratory of Systems Biology, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    J Affect Disord 109:75-82. 2008
    ..Nevertheless, only a few studies have explored the association between insulin resistance and depression with contradictory results, and none have been conducted in Chinese populations...
  16. doi Obesity related metabolic abnormalities: distribution and geographic differences among middle-aged and older Chinese populations
    Zhijie Yu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, 294 Tai Yuan Rd, Shanghai, 200031, China
    Prev Med 48:272-8. 2009
    ..To investigate geographic differences in obesity related metabolic abnormalities in middle-aged and older Chinese people with different levels of adiposity...
  17. pmc A marker of endotoxemia is associated with obesity and related metabolic disorders in apparently healthy Chinese
    Liang Sun
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Diabetes Care 33:1925-32. 2010
    ..We aimed to investigate the association between plasma LBP and metabolic disorders in apparently healthy Chinese...
  18. pmc Snoring, inflammatory markers, adipokines and metabolic syndrome in apparently healthy Chinese
    Liang Sun
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 6:e27515. 2011
    ..We aimed to investigate whether a cluster of cytokines are related to snoring frequency and its association with MetS in apparently healthy Chinese...
  19. pmc Lean body mass, interleukin 18, and metabolic syndrome in apparently healthy Chinese
    Liang Sun
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 6:e18104. 2011
    ..We aimed to investigate how lean body mass is related to circulating Interleukin 18 (IL-18) and its association with metabolic syndrome (MetS) among apparently healthy Chinese...
  20. pmc Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population
    Ying Wu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Diabetes 57:2834-42. 2008
    ..We aimed to replicate these observations in a population-based cohort of Chinese Hans and examine the associations of these variants with type 2 diabetes and diabetes-related phenotypes...
  21. doi Ferritin concentrations, metabolic syndrome, and type 2 diabetes in middle-aged and elderly chinese
    Liang Sun
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, 294 Tai Yuan Rd, Shanghai 200031, China
    J Clin Endocrinol Metab 93:4690-6. 2008
    ..Few studies, however, have systematically evaluated the effect of these risk factors on ferritin-diabetes association, particularly in Chinese populations...
  22. doi Effects of flaxseed supplementation on erythrocyte fatty acids and multiple cardiometabolic biomarkers among Chinese with risk factors of metabolic syndrome
    Geng Zong
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, 294 Tai Yuan Road, Shanghai 200031, China
    Eur J Nutr 52:1547-51. 2013
    ....
  23. doi Independent associations of body-size adjusted fat mass and fat-free mass with the metabolic syndrome in Chinese
    Jing Wang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Ann Hum Biol 36:110-21. 2009
    ..Excess fat leads to adverse health outcomes. Most previous studies investigating body fatness using BMI or fat percentage, which contain both fat mass and fat-free mass, were not able to differentiate the exposure...
  24. pmc MTNR1B rs10830963 is associated with fasting plasma glucose, HbA1C and impaired beta-cell function in Chinese Hans from Shanghai
    Chen Liu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    BMC Med Genet 11:59. 2010
    ..This study aimed to investigate the effects of MTNR1B rs10830963 on fasting glucose, type 2 diabetes and sleep status in Chinese Hans...
  25. pmc Association of PCSK1 rs6234 with obesity and related traits in a Chinese Han population
    Qibin Qi
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 5:e10590. 2010
    ..Common variants in PCSK1 have been reported to be associated with obesity in populations of European origin. We aimed to replicate this association in Chinese...
  26. doi Associations of inflammatory factors with glycaemic status among middle-aged and older Chinese people
    Xingwang Ye
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Clin Endocrinol (Oxf) 70:854-62. 2009
    ..Low-grade chronic inflammation is associated with risk for type 2 diabetes. We investigated the associations between inflammatory factors and glycaemic status in a middle-aged and older Chinese population...
  27. doi Adiponectin and metabolic syndrome in middle-aged and elderly Chinese
    Jing Wang
    Key Laboratory of Systems Biology, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Obesity (Silver Spring) 16:172-8. 2008
    ..The aim of this study was to investigate the association between plasma adiponectin levels and MetS in middle-aged and elderly Chinese from both urban and rural areas of northern and southern China...
  28. pmc Thiamine nutritional status and depressive symptoms are inversely associated among older Chinese adults
    Geng Zhang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    J Nutr 143:53-8. 2013
    ..002) for TDP. In conclusion, poorer thiamine nutritional status and higher odds of depressive symptoms were associated among older Chinese adults. This finding should be further investigated in prospective or interventional studies...
  29. doi Elevated plasma ferritin is associated with increased incidence of type 2 diabetes in middle-aged and elderly Chinese adults
    Liang Sun
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, PR China
    J Nutr 143:1459-65. 2013
    ....
  30. doi Effects of a low-carbohydrate diet on weight loss and cardiometabolic profile in Chinese women: a randomised controlled feeding trial
    Xin Liu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, 294 Tai Yuan Road, Shanghai 200031, People s Republic of China
    Br J Nutr 110:1444-53. 2013
    ..Moreover, the LC diet showed beneficial effects on blood lipid profiles...
  31. doi Soy protein intake has sex-specific effects on the risk of metabolic syndrome in middle-aged and elderly Chinese
    An Pan
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    J Nutr 138:2413-21. 2008
    ..049). It was not associated with any component in women. In conclusion, habitual soy protein intake may have sex-dependent effects on risk of MetS in middle-aged and elderly Chinese...
  32. pmc Associations of amylin with inflammatory markers and metabolic syndrome in apparently healthy Chinese
    Xinwei Hou
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 6:e24815. 2011
    ....
  33. doi Common variants in KCNQ1 are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population
    Qibin Qi
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Hum Mol Genet 18:3508-15. 2009
    ..7 x 10(-5)), and lower HOMA-B values (beta = -4.41 +/- 1.62, P = 0.006). These results suggest that KCNQ1 is a major type 2 diabetes gene in the Chinese Hans and it may confer type 2 diabetes risk by impaired beta-cell function...
  34. doi Associations of erythrocyte fatty acids in the de novo lipogenesis pathway with risk of metabolic syndrome in a cohort study of middle-aged and older Chinese
    Geng Zong
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate University of the Chinese Academy of Sciences, Shanghai, China
    Am J Clin Nutr 98:319-26. 2013
    ..Few prospective studies have been conducted, especially among populations with a high carbohydrate intake, to determine whether DNL fatty acids are associated with the risk of the metabolic syndrome (MetS)...
  35. pmc Interaction between a common variant in FADS1 and erythrocyte polyunsaturated fatty acids on lipid profile in Chinese Hans
    Jingwen Zhu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate University of Chinese Academy of Sciences, Shanghai, People s Republic of China
    J Lipid Res 54:1477-83. 2013
    ..02 and 0.03, respectively). These data suggested that FADS1 genetic variant was associated with circulating PUFA and lipid levels and that its effect on HDL cholesterol might depend on PUFA status in the Han Chinese population...
  36. doi Erythrocyte n-3 fatty acids and metabolic syndrome in middle-aged and older Chinese
    Geng Zhang
    Institute for Nutritional Sciences, Chinese Academy of Sciences, 294 Tai Yuan Road, Shanghai 200031, China
    J Clin Endocrinol Metab 97:E973-7. 2012
    ..Few studies examined associations of circulating n-3 fatty acid levels with metabolic syndrome (MetS) among Chinese populations who have low consumption of these fatty acids and high risk of developing MetS...
  37. doi Hypertriglyceridemic waist, cytokines and hyperglycaemia in Chinese
    Zhijie Yu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Eur J Clin Invest 42:1100-11. 2012
    ..Abdominal obesity and hypertriglyceridemia confer high risk for cardiometabolic disease. Few studies have investigated the associations of hypertriglyceridemic waist with cytokines and hyperglycaemia in Chinese...
  38. doi Association between depressive symptoms and 25-hydroxyvitamin D in middle-aged and elderly Chinese
    An Pan
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, 200031, China
    J Affect Disord 118:240-3. 2009
    ..Therefore, we aimed to determine this association in middle-aged and elderly Chinese...
  39. pmc Variants in GLIS3 and CRY2 are associated with type 2 diabetes and impaired fasting glucose in Chinese Hans
    Chen Liu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 6:e21464. 2011
    ..This is a replication study to examine whether such associations are also observed in Chinese Hans...
  40. pmc A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans
    Huaixing Li
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Diabetes 62:291-8. 2013
    ..0169) but not with fasting glucose. Our findings not only provide new insights into the pathophysiology of T2D, but may also shed light on the ethnic differences in T2D susceptibility...
  41. doi Association of PPP1R3B polymorphisms with blood lipid and C-reactive protein levels in a Chinese population (PPP1R3B C )
    Yongxian Zhang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
    J Diabetes 5:275-81. 2013
    ..The aim of the present study was to investigate whether the PPP1R3B variants are associated with plasma levels of lipids and inflammation factors in Chinese Han...
  42. pmc Associations of type 2 diabetes with common variants in PPARD and the modifying effect of vitamin D among middle-aged and elderly Chinese
    Ling Lu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 7:e34895. 2012
    ....
  43. doi Secretome-derived isotope tags (SDIT) reveal adipocyte-derived apolipoprotein C-I as a predictive marker for cardiovascular disease
    Rong Xia Li
    Key Laboratory of Systems Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    J Proteome Res 11:2851-62. 2012
    ..By selectively analyzing adipocyte-secreted proteins in plasma from obese vs lean murine and/or human subjects, we discovered that apoC-I is an adipocyte-secreted plasma protein and a predictive marker for cardiovascular disease...
  44. doi Substituting white rice with brown rice for 16 weeks does not substantially affect metabolic risk factors in middle-aged Chinese men and women with diabetes or a high risk for diabetes
    Geng Zhang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    J Nutr 141:1685-90. 2011
    ..Further studies with larger sample sizes, longer durations of follow-up, and different varieties of rice are needed to carefully examine the role of BR in the prevention and management of diabetes...
  45. pmc RBP4 variants are significantly associated with plasma RBP4 levels and hypertriglyceridemia risk in Chinese Hans
    Ying Wu
    Key Laboratory of Nutrition and Metabolism, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    J Lipid Res 50:1479-86. 2009
    ..However, results of Mendelian randomization do not support the hypothesis that RBP4 levels are causally related to hypertriglyceridemia risk...
  46. pmc The association of depressive symptoms with inflammatory factors and adipokines in middle-aged and older Chinese
    An Pan
    Key Laboratory of Systems Biology, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 3:e1392. 2008
    ..The present study aimed to evaluate the relation of depressive symptoms with inflammatory factors and adipose-derived adipokines in middle-aged and older Chinese...
  47. ncbi Elevated retinol-binding protein 4 levels are associated with metabolic syndrome in Chinese people
    Qibin Qi
    Key Laboratory of Systems Biology, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
    J Clin Endocrinol Metab 92:4827-34. 2007
    ..High retinol-binding protein 4 (RBP4) is thought to be associated with insulin resistance in humans. However, evidence from large-scale populations about the relationship between RBP4 and metabolic diseases is scarce...
  48. pmc Plasma 25-hydroxyvitamin D concentration and metabolic syndrome among middle-aged and elderly Chinese individuals
    Ling Lu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Diabetes Care 32:1278-83. 2009
    ..To evaluate the association between 25-hydroxyvitamin D [25(OH)D] and metabolic syndrome in the Chinese population...
  49. pmc Development of a new risk score for incident type 2 diabetes using updated diagnostic criteria in middle-aged and older chinese
    Xingwang Ye
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and University of Chinese Academy of Sciences, Shanghai, China SIBS Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 9:e97042. 2014
    ..691, 0.737), which performed better than most of existing risk score models developed for eastern Asian populations. This simple, newly constructed score of six parameters may be useful in predicting T2DM in middle-aged and older Chinese...
  50. pmc Associations of CFH polymorphisms and CFHR1-CFHR3 deletion with blood pressure and hypertension in Chinese population
    Wei Gan
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 7:e42010. 2012
    ..259). In conclusion, our results suggest that genetic variations in CFH and its related genes may contribute to hypertension risk in Chinese Hans...
  51. ncbi Distributions of C-reactive protein and its association with metabolic syndrome in middle-aged and older Chinese people
    Xingwang Ye
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    J Am Coll Cardiol 49:1798-805. 2007
    ..We evaluated the distributions of C-reactive protein (CRP) and its association with metabolic syndrome (MetS) in middle-aged and older Chinese people...
  52. pmc Associations of alcohol consumption with diabetes mellitus and impaired fasting glycemia among middle-aged and elderly Chinese
    Chen Liu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    BMC Public Health 10:713. 2010
    ..We aimed to investigate the associations of alcohol consumption with diabetes mellitus and impaired fasting glycemia (IFG) among middle-aged and elderly Chinese...
  53. doi Elevated plasma tumor necrosis factor-α receptor 2 and resistin are associated with increased incidence of kidney function decline in Chinese adults
    Gang Liu
    From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and University of Chinese Academy of Sciences, 320 Yue Yang Rd, Shanghai, 200031, China
    Endocrine 52:541-9. 2016
    ....
  54. doi A dose-response study of vitamin D3 supplementation in healthy Chinese: a 5-arm randomized, placebo-controlled trial
    Pang Yao
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate University of the Chinese Academy of Sciences, 320 Yue Yang Rd, Shanghai, 200031, China
    Eur J Nutr 55:383-92. 2016
    ..To determine the dose-response of vitamin D3 supplementation on serum 25-hydroxyvitamin D [25(OH)D] among Chinese adults...
  55. ncbi Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population
    Huaixing Li
    Key Laboratory of Systems Biology, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Diabetes 57:264-8. 2008
    ..However, their effects in other ethnic populations remain to be elucidated...
  56. doi The development and validation of new equations for estimating body fat percentage among Chinese men and women
    Xin Liu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and University of Chinese Academy of Sciences, 320 Yueyang Road, Shanghai200031, People s Republic of China
    Br J Nutr 113:1365-72. 2015
    ..327; women P= 0.159). The BF% equations might be used as surrogates for DXA to estimate BF% among adult Chinese. More studies are needed to evaluate the application of our equations in different populations...
  57. pmc Associations between ionomic profile and metabolic abnormalities in human population
    Liang Sun
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 7:e38845. 2012
    ..Few studies assessed effects of individual and multiple ions simultaneously on metabolic outcomes, due to methodological limitation...
  58. pmc Associations of genetic risk score with obesity and related traits and the modifying effect of physical activity in a Chinese Han population
    Jingwen Zhu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate University of the Chinese Academy of Sciences, Shanghai, People s Republic of China
    PLoS ONE 9:e91442. 2014
    ..This study aimed to investigate whether BMI-associated loci are, individually and collectively, associated with adiposity-related traits and obesity in Chinese Hans and whether these associations are modified by physical activity (PA)...
  59. doi Associations between common variants in GC and DHCR7/NADSYN1 and vitamin D concentration in Chinese Hans
    Ling Lu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, People s Republic of China
    Hum Genet 131:505-12. 2012
    ..9 × 10(-5)) after adjusting for the other two SNPs in GC. In conclusion, GC and NADSYN1/DHCR7 loci individually and collectively contribute to variation in plasma vitamin D levels in Chinese Hans...
  60. pmc Research advances at the Institute for Nutritional Sciences at Shanghai, China
    Yan Chen
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Adv Nutr 2:428-39. 2011
    ..This review highlights the major research endeavors undertaken by INS scientists in recent years...
  61. doi Association of TMPRSS6 polymorphisms with ferritin, hemoglobin, and type 2 diabetes risk in a Chinese Han population
    Wei Gan
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Am J Clin Nutr 95:626-32. 2012
    ..Multiple common variants in TMPRSS6 were significantly associated with serum iron in recent genome-wide association studies, but their effects in the Chinese remain to be elucidated...
  62. pmc Enterolactone inhibits insulin-like growth factor-1 receptor signaling in human prostatic carcinoma PC-3 cells
    Li Hua Chen
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of Chinese Academy of Sciences, Shanghai 200031, China
    J Nutr 139:653-9. 2009
    ..The finding of this study provides new insights into the molecular mechanisms that enterolactone exerts against prostate cancer...
  63. ncbi Effects of Genetic and Non-genetic Factors on Total and Bioavailable 25(OH)D Responses to Vitamin D Supplementation
    Pang Yao
    1 Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and University of the Chinese Academy of Sciences, Shanghai 200031, China
    J Clin Endocrinol Metab . 2016
    ..Little is known how genetic and non-genetic factors modify responses of vitamin D supplementation in nonwhite populations...
  64. doi Potential association of INSIG2 rs7566605 polymorphism with body weight in a Chinese subpopulation
    Ling Yang
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai, China
    Eur J Hum Genet 16:759-61. 2008
    ..06), indicating that the C/C genotype may contribute to obesity in certain subpopulation among Chinese under certain environmental settings...
  65. doi Association of genetic predisposition to obesity with type 2 diabetes risk in Han Chinese individuals
    Jingwen Zhu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, 320 Yue Yang Rd, Shanghai, 200031, People s Republic of China
    Diabetologia 57:1830-3. 2014
    ..Obesity is a major risk factor for type 2 diabetes, but little is known about the contribution of BMI-associated loci to type 2 diabetes risk in East Asian populations...
  66. doi Lipopolysaccharide binding protein, obesity status and incidence of metabolic syndrome: a prospective study among middle-aged and older Chinese
    Xin Liu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and University of Chinese Academy of Sciences, 320 Yueyang Road, Shanghai, 200031, People s Republic of China
    Diabetologia 57:1834-41. 2014
    ....
  67. doi Common variants in or near FGF5, CYP17A1 and MTHFR genes are associated with blood pressure and hypertension in Chinese Hans
    Chen Liu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of Chinese Academy of Sciences, Shanghai, China
    J Hypertens 29:70-5. 2011
    ..Recent genome-wide association studies have identified a number of variants influencing blood pressure. We aimed to examine whether these associations can be replicated in Chinese...
  68. pmc Opposite associations of trunk and leg fat depots with plasma ferritin levels in middle-aged and older Chinese men and women
    Hongyu Wu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 5:e13316. 2010
    ..Few data have been published on the associations of ferritin with trunk and leg fat depots. We aimed to investigate these associations in a Chinese population...
  69. ncbi Differences in bone mineral status between urban and rural Chinese men and women
    Wenjia Gu
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 294 Tai Yuan Rd, Shanghai, 200031, China
    Bone 41:393-9. 2007
    ..Such a study may help to identify risk factors of osteoporosis and provide evidence for future preventive strategies...
  70. ncbi Prevalence and geographic disparity of depressive symptoms among middle-aged and elderly in China
    An Pan
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    J Affect Disord 105:167-75. 2008
    ..To evaluate the prevalence of and risk factors for depressive symptoms among middle-aged and elderly Chinese in northern and southern China...
  71. pmc Meta-analysis of the effects of flaxseed interventions on blood lipids
    An Pan
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
    Am J Clin Nutr 90:288-97. 2009
    ..Several clinical trials have investigated the effects of flaxseed and flaxseed-derived products (flaxseed oil or lignans) on blood lipids; however, the findings have been inconsistent...
  72. doi Quantitative detection of single amino acid polymorphisms by targeted proteomics
    Zhi Duan Su
    Key Laboratory of Systems Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
    J Mol Cell Biol 3:309-15. 2011
    ..In addition, the SRM approach allows us for the first time to separately measure the absolute concentration of each SAP peptide in the heterozygotes, which also shows different associations with particular traits...
  73. doi Substituting brown rice for white rice to lower diabetes risk: a focus-group study in Chinese adults
    Geng Zhang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    J Am Diet Assoc 110:1216-21. 2010
    ..These results provide valuable information for the design of the future brown rice intervention trial and highlight the importance of increasing awareness about the nutritional value of brown rice...
  74. pmc A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells
    Yifu Qiu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
    Sci Signal 3:ra7. 2010
    ..Thus, our findings demonstrate that RACK1 functions as a key component in regulating the IRE1alpha signaling pathway in pancreatic beta cells...
  75. ncbi Enterolactone induces apoptosis in human prostate carcinoma LNCaP cells via a mitochondrial-mediated, caspase-dependent pathway
    Li Hua Chen
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Mol Cancer Ther 6:2581-90. 2007
    ..Mechanistic studies suggested roles for Akt, GSK-3beta, MDM2, and p53 in enterolactone-dependent apoptosis. Our findings encourage further studies of enterolactone as a promising chemopreventive agent against prostate cancer...