Feifan Guo

Summary

Affiliation: Shanghai Institutes for Biological Sciences
Country: China

Publications

  1. doi ATF4/ATG5 Signaling in Hypothalamic Proopiomelanocortin Neurons Regulates Fat Mass via Affecting Energy Expenditure.
    Yuzhong Xiao
    Diabetes 66:1146-1158. 2017
  2. pmc Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways
    Fei Xiao
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, The Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Diabetes 60:746-56. 2011
  3. pmc Leucine deprivation decreases fat mass by stimulation of lipolysis in white adipose tissue and upregulation of uncoupling protein 1 (UCP1) in brown adipose tissue
    Ying Cheng
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, The Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Diabetes 59:17-25. 2010
  4. pmc S6K1 in the central nervous system regulates energy expenditure via MC4R/CRH pathways in response to deprivation of an essential amino acid
    Tingting Xia
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Diabetes 61:2461-71. 2012
  5. doi PAQR3 has modulatory roles in obesity, energy metabolism, and leptin signaling
    Lingdi Wang
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, China
    Endocrinology 154:4525-35. 2013
  6. pmc Leptin signaling is required for leucine deprivation-enhanced energy expenditure
    Qian Zhang
    From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, University of Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China
    J Biol Chem 289:1779-87. 2014
  7. pmc ATF4 deficiency protects hepatocytes from oxidative stress via inhibiting CYP2E1 expression
    Chunxia Wang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, The Graduate School of the Chinese Academy of Sciences, Shanghai, China
    J Cell Mol Med 18:80-90. 2014
  8. pmc Leucine deprivation stimulates fat loss via increasing CRH expression in the hypothalamus and activating the sympathetic nervous system
    Ying Cheng
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
    Mol Endocrinol 25:1624-35. 2011
  9. doi ATF4 deficiency protects mice from high-carbohydrate-diet-induced liver steatosis
    Houkai Li
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Chinese Academy of Sciences, The Graduate School of the Chinese Academy of Sciences, Shanghai, People s Republic of China
    Biochem J 438:283-9. 2011
  10. doi Effects of ATF4 on PGC1α expression in brown adipose tissue and metabolic responses to cold stress
    Chunxia Wang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, The Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Metabolism 62:282-9. 2013

Collaborators

  • Bin Liu
  • Qian Zhang
  • Ying Cheng
  • Yong Liu
  • Xiao Wang
  • Yan Chen
  • Xiang Gao
  • Ying Yu
  • Jian Zhang
  • Jia Li
  • Chunxia Wang
  • Shanghai Chen
  • Fei Xiao
  • Ying Du
  • Junjie Yu
  • Tingting Xia
  • Qingshu Meng
  • Houkai Li
  • Kai Li
  • Zhiying Huang
  • Yuzhong Xiao
  • Shuai Yan
  • Yajie Guo
  • Lingdi Wang
  • Yalan Deng
  • Hao Ying
  • Feixiang Yuan
  • Zhigang Li
  • Hao Liu
  • Zhixue Liu
  • Qiwei Zhai
  • Yuanyang Wang
  • Juan Tang
  • Yi Zhou
  • Jianmin Zhu
  • Xiaojing Zhong
  • Garret A Fitzgerald
  • Jiali Deng
  • Hongguang Sheng
  • Ziquan Lv
  • Lu Zhu
  • Zhenghu Li
  • Yongxian Zhang
  • Yi Pan

Detail Information

Publications18

  1. doi ATF4/ATG5 Signaling in Hypothalamic Proopiomelanocortin Neurons Regulates Fat Mass via Affecting Energy Expenditure.
    Yuzhong Xiao
    Diabetes 66:1146-1158. 2017
    ....
  2. pmc Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways
    Fei Xiao
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, The Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Diabetes 60:746-56. 2011
    ..The goal of the current study is to investigate this possibility and elucidate the underlying cellular mechanisms...
  3. pmc Leucine deprivation decreases fat mass by stimulation of lipolysis in white adipose tissue and upregulation of uncoupling protein 1 (UCP1) in brown adipose tissue
    Ying Cheng
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, The Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Diabetes 59:17-25. 2010
    ..The cellular mechanisms responsible for this loss, however, are unclear. The goal of current study is to investigate possible mechanisms...
  4. pmc S6K1 in the central nervous system regulates energy expenditure via MC4R/CRH pathways in response to deprivation of an essential amino acid
    Tingting Xia
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Diabetes 61:2461-71. 2012
    ..Taken together, our studies provide a new perspective for understanding the regulation of energy expenditure by the CNS and the importance of cross-talk between nutritional control and regulation of endocrine signals...
  5. doi PAQR3 has modulatory roles in obesity, energy metabolism, and leptin signaling
    Lingdi Wang
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, China
    Endocrinology 154:4525-35. 2013
    ..In conclusion, this study reveals that PAQR3 has an important physiological function in modulating obesity, energy metabolism, and leptin signaling. ..
  6. pmc Leptin signaling is required for leucine deprivation-enhanced energy expenditure
    Qian Zhang
    From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, University of Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China
    J Biol Chem 289:1779-87. 2014
    ..Overall, our studies describe a novel link between hypothalamic leptin signaling and stimulation of energy expenditure under leucine deprivation. ..
  7. pmc ATF4 deficiency protects hepatocytes from oxidative stress via inhibiting CYP2E1 expression
    Chunxia Wang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, The Graduate School of the Chinese Academy of Sciences, Shanghai, China
    J Cell Mol Med 18:80-90. 2014
    ..Taken together, these observations suggest that ATF4 is a novel regulator of oxidative stress as well as accumulation of TG in response to HFD...
  8. pmc Leucine deprivation stimulates fat loss via increasing CRH expression in the hypothalamus and activating the sympathetic nervous system
    Ying Cheng
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
    Mol Endocrinol 25:1624-35. 2011
    ..These results suggest that CNS plays an important role in regulating fat loss under leucine deprivation and thereby provide novel and important insights concerning the importance of CNS leucine in the regulation of energy homeostasis...
  9. doi ATF4 deficiency protects mice from high-carbohydrate-diet-induced liver steatosis
    Houkai Li
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Chinese Academy of Sciences, The Graduate School of the Chinese Academy of Sciences, Shanghai, People s Republic of China
    Biochem J 438:283-9. 2011
    ..Furthermore, the resistance to hepatic steatosis is at least in part due to suppression of SCD1 expression under HCD...
  10. doi Effects of ATF4 on PGC1α expression in brown adipose tissue and metabolic responses to cold stress
    Chunxia Wang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, The Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Metabolism 62:282-9. 2013
    ..The goal of the current study is to investigate this possibility and elucidate the underlying cellular mechanisms...
  11. pmc PRLR regulates hepatic insulin sensitivity in mice via STAT5
    Junjie Yu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, The Graduate School of the Chinese Academy of Sciences, Shanghai, People s Republic of China
    Diabetes 62:3103-13. 2013
    ..These results demonstrate a novel function for hepatic PRLR in the regulation of insulin sensitivity and provide important insights concerning the nutritional regulation of PRLR expression. ..
  12. pmc Central activating transcription factor 4 (ATF4) regulates hepatic insulin resistance in mice via S6K1 signaling and the vagus nerve
    Qian Zhang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Diabetes 62:2230-9. 2013
    ..These results may lead to the identification of novel therapeutic targets for treating insulin resistance and associated metabolic diseases. ..
  13. doi Isoleucine or valine deprivation stimulates fat loss via increasing energy expenditure and regulating lipid metabolism in WAT
    Ying Du
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, The Graduate School of the Chinese Academy of Sciences, 294 Taiyuan Road, 200031 Shanghai, China
    Amino Acids 43:725-34. 2012
    ..In our current study, we show that valine or isoleucine deficiency has similar effects on reducing fat mass to leucine deprivation, in a similar manner as those observed during leucine deprivation...
  14. doi ATF4 regulates lipid metabolism and thermogenesis
    Chunxia Wang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Cell Res 20:174-84. 2010
    ..Thus, our study identifies a possible new function for ATF4 in regulating lipid metabolism and thermogenesis...
  15. doi Effects of individual branched-chain amino acids deprivation on insulin sensitivity and glucose metabolism in mice
    Fei Xiao
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, The Graduate School of the Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai, China 200031 Electronic address
    Metabolism 63:841-50. 2014
    ..The goal of the present study was to investigate whether the above effects were leucine specific or were also induced by deficiency of other branched chain amino acids including valine and isoleucine...
  16. pmc PAQR3 modulates insulin signaling by shunting phosphoinositide 3-kinase p110α to the Golgi apparatus
    Xiao Wang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Diabetes 62:444-56. 2013
    ..Thus, PAQR3 negatively regulates insulin signaling by shunting cytosolic p110α to the Golgi apparatus while competing with p85 subunit in forming a PI3K complex with p110α...
  17. doi I prostanoid receptor-mediated inflammatory pathway promotes hepatic gluconeogenesis through activation of PKA and inhibition of AKT
    Shuai Yan
    Key Laboratory of Food Safety Research, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
    Diabetes 63:2911-23. 2014
    ..We therefore conclude that suppression of IP modulation of hepatic gluconeogenesis through the PKA/CREB and PI3K-γ/PKC-ζ/TRB3/AKT pathways contributes to the effects of NSAIDs in diabetes...
  18. doi Effects of activating transcription factor 4 deficiency on carbohydrate and lipid metabolism in mammals
    Chunxia Wang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, The Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, China
    IUBMB Life 64:226-30. 2012
    ..This review summarizes the most recent progress in the understanding of the novel roles of ATF4 in the regulation of metabolism...