Z Chen

Summary

Affiliation: Shanghai Jiao Tong University
Country: China

Publications

  1. ncbi Molecular cloning of six novel Krüppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB
    Z G Han
    Chinese National Human Genome Center at Shanghai, 351 Guo Shou Jing Road, 201203 Shanghai, China
    J Biol Chem 274:35741-8. 1999
  2. ncbi [Studies on complex chromosomal translocation and their relevance to clinical prognosis in acute promyelocytic leukemia]
    X Su
    Shanghai Institute of Hematology and Ruijin Hospital, Shanghai Second Medical University, Shanghai, 200025 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 15:198-201. 1998
  3. ncbi [Chinese Human Genome Project--opportunity and challenge]
    Z Chen
    Shanghai Human Genome Center, Shanghai Institute of Hematology and Ruijin Hospital, Shanghai Second Medical University, Shanghai, 200025 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 15:195-7. 1998
  4. pmc Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia
    S J Chen
    Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Second Medical University, China
    J Clin Invest 91:2260-7. 1993
  5. ncbi Localization of the chromosome 15 breakpoints and expression of multiple PML-RAR alpha transcripts in acute promyelocytic leukemia: a study of 28 Chinese patients
    J P Geng
    Laboratory of Molecular Biology, Rui Jin Hospital, Shanghai Second Medical University, China
    Leukemia 7:20-6. 1993
  6. pmc Cloning of a gene (RIG-G) associated with retinoic acid-induced differentiation of acute promyelocytic leukemia cells and representing a new member of a family of interferon-stimulated genes
    M Yu
    Key Laboratory of Genome Research, Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Second Medical University, Shanghai, 200025, People s Republic of China
    Proc Natl Acad Sci U S A 94:7406-11. 1997
  7. doi Overexpression of Csk-binding protein contributes to renal cell carcinogenesis
    X Feng
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Oncogene 28:3320-31. 2009
  8. doi Newly diagnosed acute lymphoblastic leukemia in China (I): abnormal genetic patterns in 1346 childhood and adult cases and their comparison with the reports from Western countries
    B Chen
    State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Leukemia 26:1608-16. 2012
  9. pmc Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia
    Z Chen
    Shanghai Institute of Haematology, Rui Jin Hospital, Shanghai Second Medical University, China
    EMBO J 12:1161-7. 1993
  10. doi Methylation-mediated silencing of the miR-124 genes facilitates pancreatic cancer progression and metastasis by targeting Rac1
    P Wang
    1 Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, China 2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
    Oncogene 33:514-24. 2014

Collaborators

  • S J Chen
  • S Waxman
  • J Li
  • B Chen
  • J Wang
  • X Wang
  • Z Wang
  • L Wang
  • Z Zhang
  • H Li
  • H Wang
  • J Liu
  • J Zhou
  • J Q Mi
  • Z X Shen
  • P Wang
  • J H Tong
  • K Zhang
  • W L Zhao
  • G Q Chen
  • X Feng
  • G Fu
  • Y Zhang
  • H Jiang
  • J Jiang
  • H Chen
  • S M Xiong
  • S Lu
  • B Jiao
  • B W Gu
  • H Yan
  • L Chen
  • Y Huang
  • Q Zhao
  • L Ma
  • L Q Jiang
  • L Zhang
  • J Dai
  • Y Liu
  • J Zheng
  • X Li
  • Y Yu
  • J Zhang
  • M Zheng
  • Z Shen
  • J Luo
  • L Zhao
  • X Cai
  • W Xu
  • L Xu
  • M Lanotte
  • Y Yang
  • A Ullrich
  • C Zhang
  • H Lu
  • L Yu
  • Y F Liu
  • X Niu
  • E Hu
  • Y Liang
  • H Watanabe
  • J Y Tang
  • X X Jiang
  • L J Gu
  • Y Hong
  • Y Sakaki
  • Z G Han
  • Q L Zhang
  • S H Shen
  • Z Q Meng
  • Y Yao
  • L M Liu
  • Z Li
  • P Zhang
  • S X Ren
  • M Jin
  • S Qin
  • X Qi
  • A Cheng
  • W Zhou
  • C Hurtaud
  • W Huang
  • J Kim
  • R He
  • Y Shen
  • W R Jin
  • Y Xin
  • J Gao
  • X Gu
  • Y Chen

Detail Information

Publications112 found, 100 shown here

  1. ncbi Molecular cloning of six novel Krüppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB
    Z G Han
    Chinese National Human Genome Center at Shanghai, 351 Guo Shou Jing Road, 201203 Shanghai, China
    J Biol Chem 274:35741-8. 1999
    ..The results indicated that ZNF255 might be a conditional transactivator, whereas ZNF253 and ZNF191 displayed a suppressive effect on the transcription in yeast and/or mammalian systems...
  2. ncbi [Studies on complex chromosomal translocation and their relevance to clinical prognosis in acute promyelocytic leukemia]
    X Su
    Shanghai Institute of Hematology and Ruijin Hospital, Shanghai Second Medical University, Shanghai, 200025 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 15:198-201. 1998
    ..To study the relationship between the complex chromosome translocation in acute promyelocytic leukemia(APL, M3) and clinical therapy and prognosis...
  3. ncbi [Chinese Human Genome Project--opportunity and challenge]
    Z Chen
    Shanghai Human Genome Center, Shanghai Institute of Hematology and Ruijin Hospital, Shanghai Second Medical University, Shanghai, 200025 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 15:195-7. 1998
    ....
  4. pmc Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia
    S J Chen
    Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Second Medical University, China
    J Clin Invest 91:2260-7. 1993
    ....
  5. ncbi Localization of the chromosome 15 breakpoints and expression of multiple PML-RAR alpha transcripts in acute promyelocytic leukemia: a study of 28 Chinese patients
    J P Geng
    Laboratory of Molecular Biology, Rui Jin Hospital, Shanghai Second Medical University, China
    Leukemia 7:20-6. 1993
    ..The primary structure of a 1.4 kb DNA segment flanking the 5' part of the PML gene and that of the bcr3 cluster (2.1 kb) were also established...
  6. pmc Cloning of a gene (RIG-G) associated with retinoic acid-induced differentiation of acute promyelocytic leukemia cells and representing a new member of a family of interferon-stimulated genes
    M Yu
    Key Laboratory of Genome Research, Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Second Medical University, Shanghai, 200025, People s Republic of China
    Proc Natl Acad Sci U S A 94:7406-11. 1997
    ..A synergistic induction of RIG-G expression in NB4 cells by combined treatment with ATRA and IFNs suggests that a collaboration exists between their respective signaling pathways...
  7. doi Overexpression of Csk-binding protein contributes to renal cell carcinogenesis
    X Feng
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Oncogene 28:3320-31. 2009
    ..These results provided new insights into the function of Cbp in modulating RhoA activation, by which Cbp might contribute to renal cell carcinogenesis...
  8. doi Newly diagnosed acute lymphoblastic leukemia in China (I): abnormal genetic patterns in 1346 childhood and adult cases and their comparison with the reports from Western countries
    B Chen
    State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Leukemia 26:1608-16. 2012
    ..69% vs 4-11%). In general, it seems that Chinese ALL patients bear more adverse prognostic factors than their Western counterparts do...
  9. pmc Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia
    Z Chen
    Shanghai Institute of Haematology, Rui Jin Hospital, Shanghai Second Medical University, China
    EMBO J 12:1161-7. 1993
    ....
  10. doi Methylation-mediated silencing of the miR-124 genes facilitates pancreatic cancer progression and metastasis by targeting Rac1
    P Wang
    1 Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, China 2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
    Oncogene 33:514-24. 2014
    ..Our findings suggest a previously unidentified molecular mechanism involved in the progression and metastasis of pancreatic cancer. ..
  11. doi How to manage acute promyelocytic leukemia
    J Q Mi
    State Key Laboratory for Medical Genomics and Department of Hematology, Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Leukemia 26:1743-51. 2012
    ....
  12. doi K-ras mutational status predicts poor prognosis in unresectable pancreatic cancer
    H Chen
    Department of Hepatobiliary and Pancreatic Oncology, Cancer Hospital, Fudan University, Shanghai, China
    Eur J Surg Oncol 36:657-62. 2010
    ..To determine the prognostic value of K-ras mutations in plasma DNA of unresectable pancreatic cancer patients...
  13. ncbi Desferrioxamine induces leukemic cell differentiation potentially by hypoxia-inducible factor-1 alpha that augments transcriptional activity of CCAAT/enhancer-binding protein-alpha
    Y Jiang
    Department of Pathophysiology, Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Second Medical University SSMU, Shanghai, China
    Leukemia 19:1239-47. 2005
    ..Taken together, these results provided novel evidence for a role of HIF-1 alpha in AML cell differentiation, and suggested that C/EBP alpha might be a downstream effector for HIF-1 alpha-mediated differentiation...
  14. doi Newly diagnosed acute lymphoblastic leukemia in China (II): prognosis related to genetic abnormalities in a series of 1091 cases
    J Q Mi
    State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Leukemia 26:1507-16. 2012
    ....
  15. doi The proteasome inhibitor bortezomib interacts synergistically with the histone deacetylase inhibitor suberoylanilide hydroxamic acid to induce T-leukemia/lymphoma cells apoptosis
    Q L Zhang
    State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Shanghai Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Leukemia 23:1507-14. 2009
    ....
  16. pmc Genetic diversity and population structure of six Chinese indigenous pig breeds in the Taihu Lake region revealed by sequencing data
    Z Wang
    Department of Animal Science, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China
    Anim Genet 46:697-701. 2015
    ....
  17. pmc RIG-E, a human homolog of the murine Ly-6 family, is induced by retinoic acid during the differentiation of acute promyelocytic leukemia cell
    M Mao
    Key Laboratory of Human Genome Research and Shangai Institute of Hematology, Shanghai, China
    Proc Natl Acad Sci U S A 93:5910-4. 1996
    ..It seems that so far RIG-E is the closest human homolog of the LY-6 family. Expression of RIG-E is not restricted to myeloid differentiation, because it is also present in thymocytes and in a number of other tissues at different levels...
  18. ncbi Rapid induction of cAMP/PKA pathway during retinoic acid-induced acute promyelocytic leukemia cell differentiation
    Q Zhao
    State Key Lab for Human Genome Research SKLHGR, Shanghai Institute of Hematology, Ruijin Hospital, Samuel Waxman Cancer Research Foundation Laboratory of Shanghai Second Medical University SSMU, Shanghai, China
    Leukemia 18:285-92. 2004
    ..Taken together, we suggested a crosstalk between ATRA-induced cytosolic pathway and nuclear pathway in APL cell differentiation...
  19. doi Trastuzumab (herceptin) targets gastric cancer stem cells characterized by CD90 phenotype
    J Jiang
    China Novartis Institutes for BioMedical Research, Shanghai, China
    Oncogene 31:671-82. 2012
    ..In conclusion, the results from this study provide new insights into the gastric tumorigenic process and offer potential implications for the development of anticancer drugs as well as therapeutic treatment of gastric cancers...
  20. ncbi Analysis of hypermutation of the 5' noncoding region in the BCL-6 gene
    L Wang
    Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
    Chin Med J (Engl) 114:286-90. 2001
    ..CONCLUSIONS: The 5' regulatory region of the BCL-6 gene undergoes frequent somatic hypermutation during lymphomagenesis and the identification of BCL-6 gene hypermutations provides a molecular marker for confirmatory diagnosis of B-NHL...
  21. doi The effects of proteasome inhibitor bortezomib on a P-gp positive leukemia cell line K562/A02
    S Lu
    Department of Hematology, Changhai Hospital, Second Military Medical University, Shanghai, China
    Int J Lab Hematol 32:e123-31. 2010
    ..Bortezomib shows a promising effect for the treatment of refractory/relapsed leukemia, but it does not improve the effect of anthracycline to MDR leukemia cells...
  22. pmc Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver
    X R Xu
    Chinese National Human Genome Center at Shanghai, 351 Guo Shou-Jing Road, Shanghai 201203, China
    Proc Natl Acad Sci U S A 98:15089-94. 2001
    ..Notably, the altered transcriptome profiles in HCC could be correlated to a number of chromosome regions with amplification or loss of heterozygosity, providing one of the underlying causes of the transcription anomaly of HCC...
  23. ncbi Genomic sequence and expression analyses of human chromatin assembly factor 1 p150 gene
    H Dong
    Chinese National Human Genome Center at Shanghai, 351 Guo Shou Jing Road, Zhangjiang High Tech Park, Shanghai 201203, P R China
    Gene 264:187-96. 2001
    ..Tissue-correlated alternative splicing forms of the transcript was initially identified by EST clustering analysis, then confirmed by RT-PCR which resulted more splicing forms than computational prediction...
  24. ncbi TGFβ1 gene polymorphisms with the risk of radiation pneumonitis in non-small cell lung cancer in different ethnic study
    X Niu
    Department of Shanghai Lung Cancer Center, Shanghai Chest Hospital, Jiaotong University, Shanghai, China Shanghai Chest Hospital, Shanghai, China Department of Radiotherapy, National Institute of Oncology, Shanghai Chest Hospital, Jiaotong University, Shanghai, China Institutes of Biomedical Sciences, Fudan University, Shanghai, China Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    J Clin Oncol 29:10606. 2011
    ....
  25. doi Risk factors associated with inhibitor development in Chinese patients with haemophilia B
    J Zhou
    State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Haemophilia 21:e286-93. 2015
    ..Current research examined the association between inhibitor development and F9 genotypes and polymorphisms in immune response genes in Chinese HB patients...
  26. doi TRIM35 Interacts with pyruvate kinase isoform M2 to suppress the Warburg effect and tumorigenicity in hepatocellular carcinoma
    Z Chen
    1 Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China 2 State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Oncogene 34:3946-56. 2015
    ..Collectively, our data reveal a new function for TRIM35, which is to regulate the Warburg effect and tumorigenicity through interaction with PKM2 in HCC. ..
  27. doi Shp2 promotes metastasis of prostate cancer by attenuating the PAR3/PAR6/aPKC polarity protein complex and enhancing epithelial-to-mesenchymal transition
    K Zhang
    State Key Laboratory of Oncogenes and Related Genes, Renji MedX Clinical Stem Cell Research Center, Ren Ji Hospital, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China
    Oncogene 35:1271-82. 2016
    ..These findings provide a novel mechanism by which oncogenic signal-transduction molecules regulate cell polarity and induction of EMT. ..
  28. ncbi Cobalt chloride and low oxygen tension trigger differentiation of acute myeloid leukemic cells: possible mediation of hypoxia-inducible factor-1alpha
    Y Huang
    Department of Pathophysiology of Basic Medical College, Shanghai Second Medical University, Shanghai, China
    Leukemia 17:2065-73. 2003
    ....
  29. doi Knockdown of zinc finger protein X-linked inhibits prostate cancer cell proliferation and induces apoptosis by activating caspase-3 and caspase-9
    H Jiang
    Department of Urology, Huashan Hospital, Fudan University, Shanghai, China
    Cancer Gene Ther 19:684-9. 2012
    ..Moreover, inhibition of ZFX-induced cell apoptosis by activating caspase-1, -3 and -9. In conclusion, ZFX represents the prominent role in the progression of prostate cancer and may be a promising therapy target for prostate cancer...
  30. ncbi Csk-binding protein (Cbp) negatively regulates epidermal growth factor-induced cell transformation by controlling Src activation
    L Q Jiang
    Key Laboratory of Proteomics, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Oncogene 25:5495-506. 2006
    ....
  31. ncbi Molecular response in acute promyelocytic leukemia: a direct comparison of regular and real-time RT-PCR
    Y F Liu
    Department of Hematology, State Key Laboratory for Medical Genomics, Shanghai Institute of Hematology, Ruijin Hospital, Jiaotong University School of Medicine, Jiaotong University, Shanghai, China
    Leukemia 20:1393-9. 2006
    ....
  32. ncbi Glial cell line-derived neurotrophic factor promotes survival and induces differentiation through the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathway respectively in PC12 cells
    Z Chen
    Department of Neurobiology, The Second Military Medical University, 800 Xiangyin Road, 200433, Shanghai, China
    Neuroscience 104:593-8. 2001
    ..Therefore, it is inferred that similar intracellular signaling components are used by distinct growth factors toward a common biological effect...
  33. ncbi Effects of RNA interference on CD80 and CD86 expression in bone marrow-derived murine dendritic cells
    X Gu
    Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, China
    Scand J Immunol 64:588-94. 2006
    ..This approach is a useful tool by which costimulatory molecules of DC can be studied as well as a potential therapeutic option for allograft rejection...
  34. ncbi Arsenic trioxide and acute promyelocytic leukemia: clinical and biological
    Z Chen
    Shanghai Institute of Hematology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, 197 Rui Jin Road II, 200025 Shanghai, People s Republic of China
    Curr Top Microbiol Immunol 313:129-44. 2007
    ..Indeed, arsenic trioxide combined with all-trans retinoic acid shows a synergistic effect. Mechanistically, arsenic targets the key leukemogenic protein PML-RARalpha, setting up a new example of molecular target-based cancer therapy...
  35. ncbi Ramdomized 3-armed phase III study of S-1 monotherapy versus S-1/CDDP (SP) versus 5-FU/CDDP (FP) in patients (pts) with advanced gastric cancer (AGC): SC-101 study
    M Jin
    Beijing Cancer Hospital, Beijing, China The Affiliated Union Hospital of Fujian Medical University, Fuzhou, China Cancer Hospital of Fudan University, Shanghai, China First Affiliated Hospital of Anhui Medical University, Hefei, China Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, China Shandong Tumor Hospital and Institute, Jinan, China PLA Cancer Centre, the 81st Hospital of PLA, Nanjing, China First Affiliated Hospital of Dalian Medical University, Dalian, China Fuzhou General Hospital of Nanjing Military Area Command, Fuzhou, China
    J Clin Oncol 26:4533. 2008
    ..The primary endpoint was response rate (RR) and secondary endpoints were time to treatment failure (TTF), overall survival (OS) and safety...
  36. doi Host immunological response and factors associated with clinical outcome in patients with the novel influenza A H7N9 infection
    Z Shen
    Department of Clinical Laboratory Medicine, Shanghai Public Health Clinical Centre, Shanghai, China
    Clin Microbiol Infect 20:O493-500. 2014
    ..Though immunomodulatory treatment has potential benefits, the focus of clinical management should be on preventing the intense cytokine response by early diagnosis and effective antiviral treatment. ..
  37. ncbi Invasive neuroendocrine carcinoma of the breast: a prognostic research of 107 Chinese patients
    Y Zhang
    Department of Pathology, Fudan University, Shanghai, China
    Neoplasma 60:215-22. 2013
    ..NEC of the breast is a distinct type of neoplasm with higher malignancy. Novel therapies such as the endocrine therapy should be explored and studies with larger case number and longer follow-up will be needed...
  38. doi Correlation study between image features and mechanical properties of Han Chinese facial skin
    L Ma
    Skin and Cosmetic Research Department, Shanghai Skin Disease Hospital, Shanghai, 200443, China
    Int J Cosmet Sci . 2016
    ..Wrinkles and skin roughness are the two main features in aged skin. The purpose of this study is to characterize the relationship between facial skin mechanical properties and image features using quantitative methods...
  39. doi Synergistic targeted therapy for acute promyelocytic leukaemia: a model of translational research in human cancer
    J Q Mi
    State Key Laboratory for Medical Genomics and Department of Hematology, Shanghai Institute of Hematology, Collaborative Innovation Center of Systems Biomedicine, Pôle Sino Français des Sciences du Vivant et Genomique, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    J Intern Med 278:627-42. 2015
    ....
  40. doi Nicotine elevates sperm motility and induces Pfn1 promoter hypomethylation in mouse testis
    J Dai
    School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China
    Andrology 3:967-78. 2015
    ..Interestingly, elevated sperm motility parameters were observed in nicotine-treated mice. We assume that nicotine-induced PFN1 over-expression in mouse spermatids may promote actin polymerization and ultimately enhance sperm motility. ..
  41. ncbi High expression of nuclear factor of activated T cells in Chinese primary non-small cell lung cancer tissues
    K Zhang
    State Key Laboratory of Genetic Engineering, Department of Biochemistry, School of Life Sciences, Fudan University, Shanghai, China
    Int J Biol Markers 22:221-5. 2007
    ..This research was the first to investigate NFAT protein expression in primary non-small cell lung cancer (NSCLC) tissues from Chinese patients...
  42. ncbi Clinical and cytogenetic features of 508 Chinese patients with myelodysplastic syndrome and comparison with those in Western countries
    B Chen
    State Key Lab for Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Second Medical University, Shanghai, China
    Leukemia 19:767-75. 2005
    ....
  43. ncbi African origin of modern humans in East Asia: a tale of 12,000 Y chromosomes
    Y Ke
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, 220 Handan Road, Shanghai, China
    Science 292:1151-3. 2001
    ..Therefore, the data do not support even a minimal in situ hominid contribution in the origin of anatomically modern humans in East Asia...
  44. doi Isolation of Photobacterium sp. LuB-1 and its application in rapid assays for chemical toxicants in water
    Y Hong
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Lett Appl Microbiol 51:308-12. 2010
    ..To isolate marine bacteria with strong bioluminescence in a wide range of NaCl concentration, especially at low salt conditions...
  45. doi AML1-ETO9a is correlated with C-KIT overexpression/mutations and indicates poor disease outcome in t(8;21) acute myeloid leukemia-M2
    B Jiao
    State Key Laboratory of Medical Genomics, Institute of Health Sciences, Shanghai Institutes for Biological Sciences and Graduate School, Chinese Academy of Sciences and Shanghai Institute of Hematology, Rui Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Leukemia 23:1598-604. 2009
    ..0072 and P=0.0076, respectively). Taken together, these data suggest that AML1-ETO9a is correlated with C-KIT overexpression/mutations and indicates poor disease outcome in t(8;21) AML-M2...
  46. ncbi Antisense Smo under the control of the PTCH1 promoter delivered by an adenoviral vector inhibits the growth of human pancreatic cancer
    J Gao
    Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, China
    Gene Ther 13:1587-94. 2006
    ..Our study suggests that targeting at the Hh signaling pathway may be an effective novel gene therapeutic strategy alone or in combination with other agents for the treatment of pancreatic cancer...
  47. ncbi Chronic morphine treatment inhibits oxytocin release from the supraoptic nucleus slices of rats
    J Li
    Department of Neurobiology, Second Military Medical University, 800 Xiangyin Road, 200433, Shanghai, China
    Neurosci Lett 300:54-8. 2001
    ..These results indicated that the neurons within SON could develop dependence on morphine in vitro, and these effects might be exerted via mu-opioid receptor in oxytocin neurons of the SON...
  48. ncbi Randomized phase III trial of sorafenib versus placebo in Asian patients with advanced hepatocellular carcinoma
    A Cheng
    National Taiwan University Hospital, Taipei, Taiwan Asan Medical Center, Seoul, Democratic People s Republic of Korea First Affiliated Hospital of Anhui Medical Univers, Hefei, China Chi Mei Medical Center, Liou Ying Campus, Tainan, Taiwan Nanjing Bayi Hospital, Nanjing, China Korea Univeristy Guro Hospital, Seoul, Democratic People s Republic of Korea Bayer Vital GmbH, Leverkusen, Germany Bayer Schering Pharma, Shanghai, China Bayer Schering Pharma, Wuppertal, Germany Sun Yat Sen University Cancer Center, Guangzhou, China
    J Clin Oncol 26:4509. 2008
    ..Here we report efficacy and safety results of a phase III trial of Sor in HCC patients from the Asia-Pacific region...
  49. doi SU-F-T-199: A New Strategy for Integrating Photon with Proton and Carbon Ion in the Treatment Planning
    Z Chen
    Fudan University Shanghai Cancer Center, Shanghai, Shanghai
    Med Phys 43:3507-3508. 2016
    ..The aim of this study was to develop a viable strategy to integrate photon plan and proton/carbon ion plan based on deformable registration...
  50. doi Preparation and evaluation of monoclonal antibodies against chlamydial protease-like activity factor to detect Chlamydia pneumoniae antigen in early pediatric pneumonia
    J Zheng
    Shanghai Public Health Clinical Center, Fudan University, Shanghai, China
    Eur J Clin Microbiol Infect Dis 34:1319-26. 2015
    ..Our results show that these mAbs have excellent specificity and may be used to develop new screening tools for the diagnosis of early pediatric pneumonia. ..
  51. pmc Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
    R M Hu
    Rui Jin Hospital, Shanghai Institute of Endocrinology, Shanghai Second Medical University, China
    Proc Natl Acad Sci U S A 97:9543-8. 2000
    ..All of these data may contribute to the understanding of the neuroendocrine regulation of human life...
  52. doi Development of universal influenza vaccines based on influenza virus M and NP genes
    M Zheng
    Shanghai Institute of Biological Products, Shanghai, 200052, China
    Infection 42:251-62. 2014
    ..Therefore, developing a universal influenza vaccine (UIV) that induces broad-spectrum and long-term immunity has become a major trend in influenza vaccine research and development...
  53. doi Chemerin suppresses murine allergic asthma by inhibiting CCL2 production and subsequent airway recruitment of inflammatory dendritic cells
    L Zhao
    Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China
    Allergy 69:763-74. 2014
    ..However, the effect of chemerin in allergic asthma has not yet been explored. We sought to investigate the role of chemerin in the murine model of allergic asthma and explore the underlying mechanism...
  54. doi Pharmaco-induced erections for penile color-duplex ultrasound: oral PDE5 inhibitors or intracavernosal injection?
    Y Yang
    Department of Urology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Int J Impot Res 24:191-5. 2012
    ....
  55. ncbi Diagnostic value and complications of fine needle aspiration for primary liver cancer and its influence on the treatment outcome-a study based on 3011 patients in China
    P Wang
    Department of Hepatobiliary and Pancreatic Oncology, Cancer Hospital, Fudan University, Shanghai, China
    Eur J Surg Oncol 34:541-6. 2008
    ..To determine the diagnostic value and major complications of fine-needle aspiration (FNA) for primary liver cancer (PLC) and its influence on the treatment outcome and prognosis...
  56. ncbi Molecular rearrangements of the MYL gene in acute promyelocytic leukemia (APL, M3) define a breakpoint cluster region as well as some molecular variants
    J H Tong
    Shanghai Institute of Hematology, Shanghai Rui Jin Hospital, Shanghai Second Medical University, China
    Oncogene 7:311-6. 1992
    ..The variation of chromosome breakpoints within the MYL gene may explain size heterogeneity previously observed in some MYL-RARA fusion transcripts expressed in APL cells...
  57. ncbi Arg485Lys polymorphism of factor V increases the risk of coronary artery disease in a Chinese population
    W Le
    Department of Cardiology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
    Chin Med J (Engl) 113:963-6. 2000
    ..To explore the relationship between genetic variation in coagulation factor V and the occurrence of coronary arterial disease (CAD)...
  58. ncbi Molecular cloning, sequencing, functional analysis and expression in E. coli of major core protein gene (S3) of rice dwarf virus Chinese isolate
    F Zhang
    National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing, P R of China
    Acta Virol 41:161-8. 1997
    ..The full length cDNA sequence failed to be expressed in E. coli, but the partial sequence was successfully expressed there as confirmed by the Western blot analysis. Further analysis of RDV P3 is under way...
  59. ncbi Murine lymphotactin: gene structure, post-translational modification and inhibition of expression by CD28 costimulation
    D Hautamaa
    Department of Microbiology, University of Minnesota Medical School, Minneapolis 55455, USA
    Cytokine 9:375-82. 1997
    ....
  60. ncbi Treatment of acute promyelocytic leukemia with arsenic compounds: in vitro and in vivo studies
    Z Chen
    Shanghai Institute of Hematology, Rui Jin Hospital, People's Republic of China
    Semin Hematol 38:26-36. 2001
    ....
  61. ncbi Cloning and characterization of a novel human class I histone deacetylase that functions as a transcription repressor
    E Hu
    Department of Renal Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19403, USA
    J Biol Chem 275:15254-64. 2000
    ..These results indicate that HDAC8 is a novel member of the histone deacetylase family, which may play a role in the development of a broad range of tissues and potentially in the etiology of cancer...
  62. ncbi Genomic organization and promoter characterization of the rat cyclin B1 gene
    J H Trembley
    Department of Medicine, University of Minnesota Medical School, Box 36 UMHC, 420 Delaware St S E, 55455, Minneapolis, MN, USA
    Gene 255:93-104. 2000
    ..Our results suggest that an E-Box and/or CCAAT binding sites are important for transcription, and that there may be negative regulatory elements present between 1800 and 1100bp upstream of the translation start site...
  63. ncbi Characterization of PCP-2, a novel receptor protein tyrosine phosphatase of the MAM domain family
    H Wang
    Department of Molecular Biology, Max Planck Institute für Biochemie, Germany
    Oncogene 12:2555-62. 1996
    ..A potential role of PCP-2 in cell-cell recognition and adhesion is supported by its co-localization with cell adhesion molecules, such as catenin and E-cadherin, at sites of cell-cell contact...
  64. ncbi Expression of the AMP-activated protein kinase beta1 and beta2 subunits in skeletal muscle
    Z Chen
    St Vincent s Institute of Medical Research, St Vincent s Hospital, 41 Victoria Parade, Fitzroy, Vic, Australia
    FEBS Lett 460:343-8. 1999
    ..Sequence analysis revealed that glycogen synthase, a known AMPK substrate, co-immunoprecipitated with the AMPK alpha2beta2gamma1 complex...
  65. pmc Isolation and characterization of mammalian homologs of the Drosophila gene glial cells missing
    J Kim
    Howard Hughes Medical Institute, Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 95:12364-9. 1998
    ..Thus, certain biochemical properties, although not the specificity of the tissue in which the gene is expressed, have been conserved through the evolution of the Gcm gene family...
  66. ncbi Gene structure of human and mouse methylenetetrahydrofolate reductase (MTHFR)
    P Goyette
    Department of Human Genetics, McGill University Health Center, Montreal, Quebec, Canada H3H 1P3
    Mamm Genome 9:652-6. 1998
    ..The mouse genomic clones will be helpful in designing constructs for gene targeting and generation of mouse models for MTHFR deficiency...
  67. ncbi Cloning and characterization of murine endothelial constitutive nitric oxide synthase
    K Gnanapandithen
    Department of Medicine, St Michael s Hospital, University of Toronto, Canada
    Biochim Biophys Acta 1308:103-6. 1996
    ..DNA sequence analysis indicates a 1202 amino acid protein showing significant sequence identity with human as well as bovine ecNOS...
  68. ncbi Cloning and characterization of the murine homologue of the rat/human MRC OX-2 gene
    Z Chen
    The Toronto Hospital, Dept Surgery, University of Toronto, Ontario, Canada
    Biochim Biophys Acta 1362:6-10. 1997
    ..Several clones were identified which, on DNA sequence analysis, predicted a 218 amino acid protein showing significant homology with the rat and human MRC OX-2 gene product...
  69. ncbi Cloning and characterization of human adenosine 5'-triphosphate-binding cassette, sub-family A, transporter 2 (ABCA2)
    B Vulevic
    Department of Pharmacology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Cancer Res 61:3339-47. 2001
    ..Furthermore, the presence of a lipocalin signature motif in the ABCA2 sequence suggests a possible broad role for this protein in the transport of steroids, lipids, and related molecules...
  70. ncbi Arsenic trioxide-induced mitotic arrest and apoptosis in acute promyelocytic leukemia cells
    X Cai
    National Key Laboratory for Medicinal Genomics, Shanghai Institute of Hematology, Rui Jin Hospital, People s Republic of China
    Leukemia 17:1333-7. 2003
    ..In conclusion, our results strongly support that there is a tight link between As(2)O(3)-induced apoptosis and mitotic arrest, the latter being one of common mechanisms for As(2)O(3)-induced apoptosis in cancer cells...
  71. ncbi Studies on the clinical efficacy and pharmacokinetics of low-dose arsenic trioxide in the treatment of relapsed acute promyelocytic leukemia: a comparison with conventional dosage
    Y Shen
    Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Second Medical University, PR China
    Leukemia 15:735-41. 2001
    ..2865 and 0.7146, respectively). In conclusion, we demonstrated that low-dose As2O3 had the same effect as the conventional dosage and the mechanism of low-dose arsenic seemed to primarily induce differentiation of APL cells...
  72. ncbi [Molecular cloning and sequencing of outer capsid protein gene of rice dwarf virus and its expression in Escherichia coli]
    R Lu
    National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing 100871
    Wei Sheng Wu Xue Bao 39:305-14. 1999
    ..RDV S2 partial and full-length sequences were then cloned into expression vector pET-11d & pTrcHisC. SDS-PAGE and Western blot proved that amino- and carborn-termini of P2 were successfully expressed in E. coli...
  73. ncbi Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein
    Y Xin
    State Key Laboratory of Genetic Engineering, School of Life Science, Fudan University, Shanghai, 200433, People s Republic of China
    Genomics 74:408-13. 2001
    ..Sequence comparison of the cDNAs and their corresponding genomic sequences shows that GABARAP, GABARAPL1, and GABARAPL2 are composed of four exons each, while GABARAPL3 is distributed only at one exon...
  74. ncbi [Expression of extraneuronal monoamine transporter gene and DNA repair gene vis-à-vis with antitumor efficacy of SarCNU in human tumor xenografts]
    Z Chen
    Cancer Institute, Tumor Hospital, Sun Yat-sen University of Medical Sciences, Guangzhou 510060, China
    Zhonghua Zhong Liu Za Zhi 23:122-4. 2001
    ..While DNA repair decreases SarCNU's activity by repairing damaged DNA, EMT appears to enhance its antitumor efficacy...
  75. pmc A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist
    W Xu
    ZymoGenetics Inc, Seattle, WA 98102, USA
    Proc Natl Acad Sci U S A 98:9511-6. 2001
    ..Because IL-22 induces the expression of acute phase reactants, IL-22RA2 may play an important role as an IL-22 antagonist in the regulation of inflammatory responses...
  76. ncbi Arsenic trioxide, a therapeutic agent for APL
    T D Zhang
    The First Hospital affiliated to Harbin Medical University, 23 You Zheng Road, Nangang District, Harbin, 150001, PR China
    Oncogene 20:7146-53. 2001
    ..1 approximately 2.0 microM) induces degradation of a key leukemogenic protein, PML-RARalpha, as well as the wild-type PML, thus setting up a good example of targeting therapy for human cancers...
  77. ncbi Differential expression of MAM-subfamily protein tyrosine phosphatases during mouse development
    M Fuchs
    Department of Molecular Biology, Max Planck Institut fur Biochemie, Martinsried, Germany
    Mech Dev 70:91-109. 1998
    ..Based on our results and previous reports we discuss MAM-PTPases as a new class of morphoregulatory molecules...
  78. ncbi Brain capillary endothelial cells express MBEC1, a protein that is related to the Clostridium perfringens enterotoxin receptors
    Z Chen
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA
    Lab Invest 78:353-63. 1998
    ..Our research thus provides a new molecule for further study of the function of normal and abnormal blood-brain barrier as well as of other specialized endothelia and epithelia...
  79. ncbi [Cloning of liver cancer-related gene HCCA2 and association of that gene with liver cancer]
    Z Wang
    International Co-operation Lab on Cellular Signal Transduction, The East Hospital of Hepatobiliary Surgery, The Second Military Medical University, Shanghai 200438, China
    Zhonghua Yi Xue Za Zhi 81:332-5. 2001
    ..Its expression was associated with the completeness of the tumor envelop and the expression of KI-67 PROTEIN (P < 0.01). CONCLUSION: The novel gene HCCA2 may be related with the infiltration and proliferation of liver cancer...
  80. ncbi Efficient antitumor immunity derived from maturation of dendritic cells that had phagocytosed apoptotic/necrotic tumor cells
    Z Chen
    Saskatoon Cancer Center, Saskatoon, Saskatchewan, Canada
    Int J Cancer 93:539-48. 2001
    ..Therefore, DCs that had phagocytosed apoptotic/necrotic tumor cells appear to offer new strategies in DC cancer vaccines...
  81. ncbi JEM-1, a novel gene encoding a leucine-zipper nuclear factor upregulated during retinoid-induced maturation of NB4 promyelocytic leukaemia
    E Duprez
    Institut National de la Sante et de la Recherche Medical, INSERM U301, Centre G, Hayem, Hopital Saint Louis, Paris, France
    Oncogene 14:1563-70. 1997
    ..We hypothesise that this novel nuclear factor may act as a transcription factor, or a coregulator, involved in either cell growth control and/or maturation...
  82. ncbi A chloroplast DNA deletion located in RNA polymerase gene rpoC2 in CMS lines of sorghum
    Z Chen
    Department of Soil and Crop Sciences, Texas A and M University, College Station 77843 2474
    Mol Gen Genet 236:251-9. 1993
    ..Further studies designed to determine whether or not the deletion is involved in CMS of sorghum are underway...
  83. pmc Structural alterations of the BCR and ABL genes in Ph1 positive acute leukemias with rearrangements in the BCR gene first intron: further evidence implicating Alu sequences in the chromosome translocation
    S J Chen
    Unité INSERM U 301 and SDI CNRS no 159541, CNRS, Hopital Saint Louis, Paris, France
    Nucleic Acids Res 17:7631-42. 1989
    ..In the second leukemia, the breakpoints are not located in Alu sequences, but such repeats are found in their vicinity. The implications of these findings are discussed...
  84. ncbi Sequence of the genome of lactate dehydrogenase-elevating virus: heterogenicity between strains P and C
    G A Palmer
    Department of Microbiology, University of Minnesota Medical School, Minneapolis 55455, USA
    Virology 209:637-42. 1995
    ..All functional motifs of the ORF 1a and ORF 1b proteins were conserved. The ORF 1a protein possesses 11 potential transmembrane segments that flank the serine protease domain...
  85. ncbi Transcriptional enhancer factor 1 disruption by a retroviral gene trap leads to heart defects and embryonic lethality in mice
    Z Chen
    Program in Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    Genes Dev 8:2293-301. 1994
    ..Although transcription of a number of muscle-specific genes believed to be TEF-1 targets appears normal, the defect in cardiogenesis is likely attributable to diminished transcription of one or several cardiac-specific genes...
  86. ncbi Two genes for de novo purine nucleotide synthesis on human chromosome 4 are closely linked and divergently transcribed
    K A Brayton
    Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907
    J Biol Chem 269:5313-21. 1994
    ..Expression of a luciferase reporter from the GPAT promoter was approximately 3-4-fold higher than from the AIRC promoter. The GPAT gene was mapped to the q12 region of chromosome 4...
  87. pmc PLZF-RAR alpha fusion proteins generated from the variant t(11;17)(q23;q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent transactivation of wild-type retinoic acid receptors
    Z Chen
    Shanghai Institute of Hematology, Samuel Waxman Cancer Research Foundation Laboratory of Shanghai Second Medical University, Rui Jin Hospital, China
    Proc Natl Acad Sci U S A 91:1178-82. 1994
    ..These abnormal transactivation properties observed in retinoic acid-sensitive myeloid cells strongly implicate the PLZF-RAR alpha fusion proteins in the molecular pathogenesis of APL...
  88. ncbi Telomerase activity in Kaposi's sarcoma, squamous cell carcinoma, and basal cell carcinoma
    Z Chen
    American Registry of Pathology, Washington, District of Columbia 20306, USA
    Exp Biol Med (Maywood) 226:753-7. 2001
    ..All KS as well as two other skin carcinoma samples revealed positive telomerase activity. Our finding supports telomerase's role in tumor cell immortality and suggests the true neoplastic nature of KS...
  89. ncbi Estrogen receptor alpha mediated induction of the transforming growth factor alpha gene by estradiol and 4-hydroxytamoxifen in MDA-MB-231 breast cancer cells
    J MacGregor Schafer
    Robert H. Lurie Comprehensive Cancer Center, Northwestern University Medical School, Olson Pavilion 8258, 303 East Chicago Avenue, Chicago, IL 60611, USA
    J Steroid Biochem Mol Biol 78:41-50. 2001
    ..We conclude that both E(2) and 4-OHT induce TGF alpha by direct interaction of ER alpha with DNA and that ER beta is not involved in the estrogen-like response to 4-OHT in the MDA-MB-231 cells...
  90. pmc Positional cloning of the mouse saccharin preference (Sac) locus
    A A Bachmanov
    Monell Chemical Senses Center, Philadelphia, PA 19104, USA
    Chem Senses 26:925-33. 2001
    ..This study provides compelling evidence that Tas1r3 is equivalent to the Sac locus and that the T1R3 receptor responds to sweeteners...
  91. ncbi Genes differentially expressed with malignant transformation and metastatic tumor progression of murine squamous cell carcinoma
    G Dong
    Tumor Biology Section, Head and Neck Surgery Branch, NIDCD NIH, Bethesda, Maryland 20892 1419, USA
    J Cell Biochem Suppl 28:90-100. 1997
    ....
  92. ncbi [In vitro effect of lovastatin on NB4 promyelocytic leukemia cells]
    F Guo
    First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Suzhou 215006, China
    Zhonghua Xue Ye Xue Za Zhi 22:584-8. 2001
    ..Inhibition of p21Ras protein isoprenylation is considered to be the major mechanism of LOV affecting NB4 cells...
  93. ncbi Treatment of acute promyelocytic leukemia with arsenic trioxide: clinical and basic studies
    W L Zhao
    Shanghai Institute of Hematology, Rui Jin Hospital Affiliated to Shanghai Second Medical University, People's Republic of China
    Leuk Lymphoma 42:1265-73. 2001
    ..Importantly, at both concentrations, As2O3 can degrade PML (promyelocytic leukemia) -RAR alpha (retinoic acid receptor), an oncoprotein that has a central role in leukemogenesis...
  94. ncbi Rapid isolation of tissue-specific genes from rat kidney
    E Hu
    Department of Renal Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA
    Exp Nephrol 9:156-64. 2001
    ..Our results suggested that tissue-specific genes can be rapidly isolated and characterized using PCR-select techniques and this methodology may be generally applicable to isolate specific genes from a variety of tissues...
  95. ncbi Hornerin gene was involved in a case of acute myeloid leukemia transformed from myelodysplastic syndrome with t(1;2)(q21;q37)
    L Wang
    Leukemia 20:2184-7. 2006
  96. ncbi A genetic analysis of neural progenitor differentiation
    D H Geschwind
    Neurogenetics Program, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Neuron 29:325-39. 2001
    ..This combination of methods demonstrates the power of using custom microarrays derived from RDA-subtracted libraries for both gene discovery and gene expression analysis in the central nervous system...
  97. ncbi Ser(13)-phosphorylated PYY from porcine intestine with a potent biological activity
    Z Chen
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    FEBS Lett 492:119-22. 2001
    ..5 nM compared to 0.15 nM for non-phosphorylated PYY. The finding of phosphorylation of PYY is unusual among hormonal peptides, and emphasizes the importance of direct protein analysis of gene products...
  98. ncbi Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-kappa B, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma
    J B Sunwoo
    Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, Maryland 20892, USA
    Clin Cancer Res 7:1419-28. 2001
    ..We conclude that PS-341 inhibits activation of NF-kappa B pathway components related to cell survival, tumor growth, and angiogenesis in SCC...
  99. ncbi Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2
    Z Chen
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9041, USA
    J Biol Chem 276:16070-5. 2001
    ..Activation of endogenous TAO2 during differentiation of C2C12 myoblasts paralleled activation of p38 but not JNK/SAPK, consistent with the idea that TAO2 is a physiological regulator of p38 under certain circumstances...
  100. ncbi DNA sequence and comparative analysis of chimpanzee chromosome 22
    H Watanabe
    RIKEN, Genomic Sciences Center, Yokohama 230 0045, Japan
    Nature 429:382-8. 2004
    ..The genomic changes after speciation and their biological consequences seem more complex than originally hypothesized...
  101. ncbi A bicistronic retroviral vector to introduce drug resistance genes into human umbilical cord blood CD34+ cells to improve combination chemotherapy tolerance
    J Wang
    Jiangsu Institute of Hematology, First Affiliated Hospital of Suzhou Medical College, Suzhou 215006, China
    Chin Med J (Engl) 114:25-9. 2001
    ....