Shanghai Institutes for Biological Sciences

Summary

Organization: Shanghai Institutes for Biological Sciences
Country: China

Top Publications

  1. pmc Human transcriptional interactome of chromatin contribute to gene co-expression
    Xiao Dong
    Key Lab of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, PR China
    BMC Genomics 11:704. 2010
  2. pmc An integrated genetic linkage map for silkworms with three parental combinations and its application to the mapping of single genes and QTL
    Shuai Zhan
    Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200032, PR China
    BMC Genomics 10:389. 2009
  3. pmc cmdABCDEF, a cluster of genes encoding membrane proteins for differentiation and antibiotic production in Streptomyces coelicolor A3(2)
    Pengfei Xie
    Key Laboratory of Synthetic Biology, Shanghai Institute of Plant Physiology and Ecology, Shanghai, PR China
    BMC Microbiol 9:157. 2009
  4. doi In vitro production of haploid sperm cells from male germ cells of foetal cattle
    Wu Zi Dong
    Institute of Stem Cell Engineering and Technology, Northwest A and F University, Yangling 712100, People s Republic of China
    Anim Reprod Sci 118:103-9. 2010
  5. pmc Retinal pigment epithelial cells secrete neurotrophic factors and synthesize dopamine: possible contribution to therapeutic effects of RPE cell transplantation in Parkinson's disease
    Ming Ming
    Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, PR China
    J Transl Med 7:53. 2009
  6. doi Hyper-excitability in low threshold mechanical A fibers is potentially involved in scorpion BmK sting pain
    Ying Liu
    Graduate School of the Chinese Academy of Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Brain Res Bull 80:116-21. 2009
  7. pmc Estimating accuracy of RNA-Seq and microarrays with proteomics
    Xing Fu
    Key Lab of Systems Biology, Shanghai Institutes for Biological Sciences, China Academy of Sciences, Shanghai, 200031, PR China
    BMC Genomics 10:161. 2009
  8. doi The alpha-like scorpion toxin BmK I enhances membrane excitability via persistent sodium current by preventing slow inactivation and deactivation of rNav1.2a expressed in Xenopus Oocytes
    Mang Mang Zhu
    Graduate School of Chinese Academy of Sciences, Shanghai Institute of Physiology, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, PR China
    Toxicol In Vitro 23:561-8. 2009
  9. doi Low-grade fibromyxoid sarcoma versus fibromatosis: a comparative study of clinicopathological and immunohistochemical features
    Guo Zhao Meng
    Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Diagn Cytopathol 37:96-102. 2009
  10. pmc Elevated CXCL12 expression in the bone marrow of NOD mice is associated with altered T cell and stem cell trafficking and diabetes development
    Qibin Leng
    Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    BMC Immunol 9:51. 2008

Detail Information

Publications62

  1. pmc Human transcriptional interactome of chromatin contribute to gene co-expression
    Xiao Dong
    Key Lab of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, PR China
    BMC Genomics 11:704. 2010
    ..Recently based on Hi-C experiment, a genome-wide picture of chromatin interactions in human cells was presented. It provides a useful material for analysing whether the mechanism of transcriptional interactome is common...
  2. pmc An integrated genetic linkage map for silkworms with three parental combinations and its application to the mapping of single genes and QTL
    Shuai Zhan
    Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200032, PR China
    BMC Genomics 10:389. 2009
    ..The purpose of this work was to develop a dense and informative linkage map that would assist in the preliminary mapping and dissection of quantitative trait loci (QTL) in a variety of silkworm strains...
  3. pmc cmdABCDEF, a cluster of genes encoding membrane proteins for differentiation and antibiotic production in Streptomyces coelicolor A3(2)
    Pengfei Xie
    Key Laboratory of Synthetic Biology, Shanghai Institute of Plant Physiology and Ecology, Shanghai, PR China
    BMC Microbiol 9:157. 2009
    ..g. bld genes for aerial growth and whi genes for sporulation) and antibiotics production (including actII-orf4, redD, cdaR as pathway-specific regulatory genes and afsR, absA1/A2 as pleiotropic regulatory genes)...
  4. doi In vitro production of haploid sperm cells from male germ cells of foetal cattle
    Wu Zi Dong
    Institute of Stem Cell Engineering and Technology, Northwest A and F University, Yangling 712100, People s Republic of China
    Anim Reprod Sci 118:103-9. 2010
    ..Our investigation further demonstrated that foetal cattle mGCs could be induced in vitro into haploid sperm in the short term...
  5. pmc Retinal pigment epithelial cells secrete neurotrophic factors and synthesize dopamine: possible contribution to therapeutic effects of RPE cell transplantation in Parkinson's disease
    Ming Ming
    Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, PR China
    J Transl Med 7:53. 2009
    ..In the present study, we investigated whether the beneficial effects of this therapy are related to the trophic properties of RPE cells and their ability to synthesize DA...
  6. doi Hyper-excitability in low threshold mechanical A fibers is potentially involved in scorpion BmK sting pain
    Ying Liu
    Graduate School of the Chinese Academy of Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Brain Res Bull 80:116-21. 2009
    ....
  7. pmc Estimating accuracy of RNA-Seq and microarrays with proteomics
    Xing Fu
    Key Lab of Systems Biology, Shanghai Institutes for Biological Sciences, China Academy of Sciences, Shanghai, 200031, PR China
    BMC Genomics 10:161. 2009
    ..At present, high throughput sequencing is emerging as an alternative methodology for transcriptome studies. Although free of many limitations imposed by microarray design, its potential to estimate absolute transcript levels is unknown...
  8. doi The alpha-like scorpion toxin BmK I enhances membrane excitability via persistent sodium current by preventing slow inactivation and deactivation of rNav1.2a expressed in Xenopus Oocytes
    Mang Mang Zhu
    Graduate School of Chinese Academy of Sciences, Shanghai Institute of Physiology, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, PR China
    Toxicol In Vitro 23:561-8. 2009
    ..2a and induce the I(NaP) by preventing the development of slow inactivation and deactivation from the open-state, leading to the enhancement of membrane excitability, which may be involved in the BmK I-induced epilepsy...
  9. doi Low-grade fibromyxoid sarcoma versus fibromatosis: a comparative study of clinicopathological and immunohistochemical features
    Guo Zhao Meng
    Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Diagn Cytopathol 37:96-102. 2009
    ..Thus, we consider that LGFMS can be distinguished from fibromatosis by clinicopathological features, and assessments of the immunohistochemical expression level of cyclinD1, p53, nm23, and Ki-67 are helpful in the differential diagnosis...
  10. pmc Elevated CXCL12 expression in the bone marrow of NOD mice is associated with altered T cell and stem cell trafficking and diabetes development
    Qibin Leng
    Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    BMC Immunol 9:51. 2008
    ..Despite these initial observations, however, how CXCL12 affects development of TID has not been fully investigated...
  11. pmc Functional imaging of interleukin 1 beta expression in inflammatory process using bioluminescence imaging in transgenic mice
    Limei Li
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, ChineseAcademy of Sciences, Shanghai, PR China
    BMC Immunol 9:49. 2008
    ..5-kb fragment of the human IL-1beta gene promoter. Luciferase gene expression was monitored in live mice under anesthesia using bioluminescence imaging in a number of inflammatory disease models...
  12. pmc Peripheral arterial occlusive disease: global gene expression analyses suggest a major role for immune and inflammatory responses
    Shijun Fu
    Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai, PR China
    BMC Genomics 9:369. 2008
    ..However, mechanisms underlying the genesis and progression of the disease are far from clear. Genome-wide gene expression profiling of clinical samples may represent an effective approach to gain relevant information...
  13. pmc The combination approach of SVM and ECOC for powerful identification and classification of transcription factor
    Guangyong Zheng
    Department of Computing and Information Technology, Fudan University, 220 Handan Road, Shanghai 200433, PR China
    BMC Bioinformatics 9:282. 2008
    ..With the fast growing number of new proteins, more precise algorithms for identifying TFs from new proteins and classifying the consequent TFs are in a high demand...
  14. pmc MOS1 osmosensor of Metarhizium anisopliae is required for adaptation to insect host hemolymph
    Chengshu Wang
    Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 300 Fenglin Road, Shanghai 200032, China
    Eukaryot Cell 7:302-9. 2008
    ..Insect bioassays confirmed that Mos1 knockdown significantly reduces virulence. Overall, our data show that M. anisopliae MOS1 mediates cellular responses to high osmotic pressure and subsequent adaptations to colonize host hemolymph...
  15. pmc GEOGLE: context mining tool for the correlation between gene expression and the phenotypic distinction
    Yao Yu
    Key Lab of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, PR China
    BMC Bioinformatics 10:264. 2009
    ....
  16. pmc Different responsiveness to a high-fat/cholesterol diet in two inbred mice and underlying genetic factors: a whole genome microarray analysis
    Mingzhe Zhu
    Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai, PR China
    Nutr Metab (Lond) 6:43. 2009
    ..abstract:..
  17. pmc Divergence of exonic splicing elements after gene duplication and the impact on gene structures
    Zhenguo Zhang
    The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences SIBS, Chinese Academy of Sciences CAS and Shanghai Jiao Tong University School of Medicine SJTUSM, 225 South Chong Qing Road, Shanghai 200025, PR China
    Genome Biol 10:R120. 2009
    ..Here we examine a novel way that new gene structures could originate, namely through the evolution of new alternative splicing isoforms after gene duplication...
  18. doi Development of retinol-binding protein 4 immunocolloidal gold fast test strip using high-sensitivity monoclonal antibodies generated by DNA immunization
    Chao Bian
    Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China
    Acta Biochim Biophys Sin (Shanghai) 42:847-53. 2010
    ..Consequently, it could be useful for more convenient and faster RBP4 determination in the clinic...
  19. pmc Modification of nonstructural protein 1 of influenza A virus by SUMO1
    Ke Xu
    Laboratory of Molecular Virology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 225 South Chongqing Road, Shanghai 200025, China
    J Virol 85:1086-98. 2011
    ..Together, these results indicate that sumoylation enhances NS1 stability and thus promotes rapid growth of influenza A virus...
  20. pmc Identifying dysfunctional crosstalk of pathways in various regions of Alzheimer's disease brains
    Zhi Ping Liu
    Key Laboratory of Systems Biology and SIBS Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    BMC Syst Biol 4:S11. 2010
    ..Thus identification and analysis of crosstalk among dysregulated pathways as well as identification of their clusters in various diseased brain regions are expected to provide deep insights into the pathogenetic mechanism...
  21. ncbi Structural identification of a new tri-p-coumaroylspermidine with serotonin transporter inhibition from safflower
    Gang Zhao
    Cell Star Bio Technologies Co, Limited, Shanghai, China
    Chem Pharm Bull (Tokyo) 58:950-2. 2010
    ..Preliminary pharmacological study demonstrated that CX was a potent SERT inhibitor...
  22. doi Mechanistic insights into acquired drug resistance in epidermal growth factor receptor mutation-targeted lung cancer therapy
    Hongbin Ji
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Cancer Sci 101:1933-8. 2010
    ....
  23. ncbi [Cloning and identification of telomere and internal origin of the endophytic Streptomyces linear plasmid pYY8L from Allium fistulosum]
    Yong Yang
    Key Laboratory of Synthetic Biology, Shanghai Institute of Plant Physiology and Ecology, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China
    Wei Sheng Wu Xue Bao 50:452-8. 2010
    ..Strain 36R-2-1B was isolated from Allium fistulosum and identified as Streptomyces spp., harboring an approximate 280 kb linear plasmid designated pYY8L...
  24. doi microRNAs: critical regulators in Th17 cells and players in diseases
    Bin Wei
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Cell Mol Immunol 7:175-81. 2010
    ....
  25. ncbi [Sequencing and analysis of thermophylic Streptomyces plasmid pTSC2 and characterization of its rolling-circle replication]
    Zifei Zhang
    Key Laboratory of Synthetic Biology, Shanghai Institute of Plant Physiology and Ecology, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China
    Wei Sheng Wu Xue Bao 50:41-7. 2010
    ..A Streptomyces strain X3 -3, growing up to 50 degrees C, was isolated from the composts prepared from swine manure and straw. This strain harbored a -7-kb plasmid pTSC2...
  26. doi Exploring mitochondrial evolution and metabolism organization principles by comparative analysis of metabolic networks
    Xiao Chang
    Bioinformatics Center, Key Lab of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Genomics 95:339-44. 2010
    ..This work provided insight to the understanding of mitochondria evolution, and the organization principle of mitochondrial metabolic network at the network level...
  27. doi AChE deficiency or inhibition decreases apoptosis and p53 expression and protects renal function after ischemia/reperfusion
    Weiyuan Ye
    Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, China
    Apoptosis 15:474-87. 2010
    ..These findings suggest that AChE inhibitors may represent a therapeutic strategy for protection against ischemic acute renal failure...
  28. doi Molecular cloning and functional analysis of Chinese sturgeon (Acipenser sinensis) growth hormone receptor
    ZhiYong Liao
    College of Life and Environmental Science, Wenzhou University, Wenzhou, 325035, China
    Sci China C Life Sci 52:911-21. 2009
    ..These findings might provide new insights into thoroughly understanding the regulatory mechanism of Chinese sturgeon growth...
  29. ncbi Phenotypic inheritance induced by hairpin RNA in Drosophila
    Huaguang Li
    CAS MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Shanghai 200031, China
    Acta Biochim Biophys Sin (Shanghai) 41:922-8. 2009
    ..The penetrance of mutant phenotypes was reduced when the mutants were crossed to ago1 and piwi mutants. Our data suggest that hairpin RNA can induce phenotypic inheritance in Drosophila...
  30. pmc IFN-gamma triggered STAT1-PKB/AKT signalling pathway influences the function of alloantigen reactive regulatory T cells
    B Wei
    Transplantation Research Immunology Group, Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK
    Am J Transplant 10:69-80. 2010
    ..Overall, these findings suggest that the IFN-gamma-induced STAT1-PKB/AKT signaling pathway plays a key role in upregulating the ability of alloantigen reactive Tregs to control graft rejection in vivo...
  31. ncbi The Metarhizium anisopliae Perilipin Homolog MPL1 Regulates Lipid Metabolism, Appressorial Turgor Pressure, and Virulence
    Chengshu Wang
    Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032 China
    J Biol Chem 282:21110-5. 2007
    ..Expression of Mpl1 in yeast cells, a fungus that lacks a perilipin-like gene, blocked their ability to mobilize lipids during starvation conditions...
  32. ncbi Prediction of subcellular protein localization based on functional domain composition
    PeiLin Jia
    Bioinformatics Center, Key Lab of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China
    Biochem Biophys Res Commun 357:366-70. 2007
    ..We also provide an implementation of our Subcellular Location Prediction System (SLPS), which is available at http://pcal.biosino.org...
  33. ncbi Simultaneous determination of six phenolic constituents of danshen in human serum using liquid chromatography/tandem mass spectrometry
    Xiaochuan Li
    Department of Pharmacology, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China Graduate School of the Chinese Academy of Sciences, China
    J Chromatogr B Analyt Technol Biomed Life Sci 820:41-7. 2005
    ..This quantitation method was successfully applied to a pharmacokinetic study of i.v. drip infusion of Danshen injection fluid in human...
  34. ncbi [Progress in the investigation of Avian sex determination and sex identification]
    Rui Ying Hu
    Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China
    Yi Chuan 27:297-301. 2005
    ..In this paper, we review the recent progress in this field. The investigation of functions of sex determinate genes and methods of sexing identification in birds are also discussed...
  35. ncbi Recovery of single-band proteins from polyacrylamide gels by using electrophoresis in solutions with different ionic strengths and specific weights
    Ding Gan Liu
    Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, People s Republic of China
    Anal Biochem 339:351-2. 2005
  36. ncbi Identification of connexin 50 and 57 mRNA in A-type horizontal cells of the rabbit retina
    He Huang
    Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China
    Cell Res 15:207-11. 2005
    ..Using specific primers designed against the rabbit sequences, we identified mRNAs of connexin 50 and/or 57 in visually selected single A-type HC using multiplex RT-PCR...
  37. ncbi [Community structure and seasonal change of soil micro-arthropodes in the Lower Reaches of Liaohe River Plain under different land utilization]
    Xin Ke
    Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China
    Ying Yong Sheng Tai Xue Bao 15:600-4. 2004
    ..The vertical distribution in both density and group number of arthropods in soil was in the order of surface > middle > bottom...
  38. pmc Monoclonal antibodies assisting refolding of firefly luciferase
    Qin Xu
    Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    Protein Sci 13:1851-8. 2004
    ..These results have also shed light on the structural features of the intermediate and its interface involved in protein aggregate formation, contributing to the understanding of the protein folding mechanism...
  39. ncbi [Immunological up-regulation of cyclophosphamide-treated mice by turtle blood extract]
    Ying Wang
    Shanghai Institute of Immunology, Shanghai Second Medical University, Shanghai 200025, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 20:123-5. 2004
    ..To explore the effect of turtle blood extract on murine immune system...
  40. ncbi An overall picture of chemokine receptors: basic research and drug development
    Li Chen
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, People s Republic of China
    Curr Pharm Des 10:1045-55. 2004
    ..In this review, we show an overall picture of chemokine receptors in structure, signal transduction and modulation, physiological and pathological roles, and applying chemokine receptors for drug discovery...
  41. pmc Acetylcholinesterase alterations reveal the fitness cost of mutations conferring insecticide resistance
    Ming An Shi
    Groupe de biotechnologie des protéines, IPBS CNRS, UMR 5089, F 31077 Toulouse, France
    BMC Evol Biol 4:5. 2004
    ..Then, we hypothesized that only alleles linked to the highest fitness in the absence of insecticide are selected...
  42. ncbi [Genetic analysis of a Chinese pedigree with congenital synpolydactyly]
    Wei Qin
    Institute of Nutrition Science, Chinese Academy of Sciences, Bio X Life Science Research Center, Shanghai Jiao Tong University, Shanghai, China
    Yi Chuan Xue Bao 30:973-7. 2003
    ..Our result demonstrates that synpolydactyly locus in the Chinese Han Population is in the region of chromosome 2q31-q32 but a different causal gene can be involved...
  43. ncbi Identification of beta-barrel membrane proteins based on amino acid composition properties and predicted secondary structure
    Qi Liu
    Department of Biomedical Engineering, Shanghai Jiaotong University, P O Box 134, 1954 Huashan Road, 200030, Shanghai, People s Republic of China
    Comput Biol Chem 27:355-61. 2003
    ..Applied to 241 beta-barrel membrane proteins and 3855 soluble proteins with various structures, the method achieves 85.48% (206/241) sensitivity and 92.53% specificity (3567/3855)...
  44. ncbi Identification of proteins separated by one-dimensional sodium dodecyl sulfate/polyacrylamide gel electrophoresis with matrix-assisted laser desorption/ionization ion trap mass spectrometry; comparison with matrix-assisted laser desorption/ionization time
    Rong Zeng
    Research Center for Proteome Analysis, Key Laboratory of Proteomics, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China
    Rapid Commun Mass Spectrom 17:1995-2004. 2003
    ....
  45. ncbi Prediction of prokaryotic promoters based on prediction of transcriptional units
    Jian Cheng Lin
    Bioinformatics Center of Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, Shanghai 200031, China
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 35:317-24. 2003
    ..Based on these predicted TUs, promoter was predicted for each TU using hidden Markov model including explicit state duration density. Both predicted TUs and promoters were satisfying...
  46. ncbi The effect of isoforms of the cell polarity protein, human ASIP, on the cell cycle and Fas/FasL-mediated apoptosis in human hepatoma cells
    Y Hu
    Laboratory of Molecular and Cellular Oncology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Cell Mol Life Sci 62:1974-83. 2005
    ....
  47. ncbi [Analysis and identification of Liriomyza sativae-attractants from cowpea and kidney bean volatiles]
    Ming Wei
    Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China
    Ying Yong Sheng Tai Xue Bao 16:907-10. 2005
    ..sativae in field trapping trials. Detailed analyses indicated that alpha-Ionone and beta-Ionone might play important roles in the searching behavior of L. sativae for host plants...
  48. ncbi The immunopharmacological properties of transforming growth factor beta
    Yingying Le
    Laboratory of Immunologic and Inflammatory Diseases, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, P R China
    Int Immunopharmacol 5:1771-82. 2005
    ....
  49. ncbi EMT or apoptosis: a decision for TGF-beta
    Jianguo Song
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Cell Res 17:289-90. 2007
  50. pmc SARS molecular epidemiology: a Chinese fairy tale of controlling an emerging zoonotic disease in the genomics era
    Guo Ping Zhao
    Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, Building 1, 250 Bi Bo Road, Zhangjiang HiTech Park, Pudong, Shanghai 201203, People s Republic of China
    Philos Trans R Soc Lond B Biol Sci 362:1063-81. 2007
    ....
  51. ncbi Targeting gene-virotherapy of cancer and its prosperity
    Xin Yuan Liu
    Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    Cell Res 16:879-86. 2006
    ..Finally, the concept of Double Controlled Targeting Virus-Dual Gene Therapy for cancer treatment, and the implication of the recent progress in cancer stem cells are also discussed...
  52. pmc Unexpected development of autoimmunity in BAFF-R-mutant MRL-lpr mice
    Zhong L Ju
    Shanghai Institute of Immunology, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Immunology 120:281-9. 2007
    ..Thus, these findings could explain the development of autoimmunity and hypergammaglobulinaemia observed in BAFF-R-mutant MRL-lpr mice...
  53. ncbi Luteolin inhibits insulin-like growth factor 1 receptor signaling in prostate cancer cells
    Jing Fang
    The Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Graduate School of Chinese Academy of Sciences, Shanghai 200031, China
    Carcinogenesis 28:713-23. 2007
    ..Immunoblotting of the extracts of tumor tissues showed that luteolin inhibited IGF-1R/AKT signaling. Our results provide a new insight into the mechanisms that luteolin is against cancer cells...
  54. ncbi Triptolide inhibits CC chemokines expressed in rat adjuvant-induced arthritis
    Yifan Wang
    Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, People s Republic of China
    Int Immunopharmacol 6:1825-32. 2006
    ..These results may contribute to the therapeutic effects of triptolide in rheumatoid arthritis...
  55. ncbi Insig-dependent ubiquitination and degradation of 3-hydroxy-3-methylglutaryl coenzyme a reductase stimulated by delta- and gamma-tocotrienols
    Bao Liang Song
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    J Biol Chem 281:25054-61. 2006
    ..Taken together, these results provide a biochemical mechanism for the hypocholesterolemic effects of vitamin E that have been observed in animals and humans...
  56. ncbi Roles of the Nanog protein in murine F9 embryonal carcinoma cells and their endoderm-differentiated counterparts
    Yanmei Chen
    Laboratory of Molecular and Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
    Cell Res 16:641-50. 2006
    ....
  57. pmc Demonstration of two novel methods for predicting functional siRNA efficiency
    PeiLin Jia
    Bioinformatics Center, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China
    BMC Bioinformatics 7:271. 2006
    ..Therefore, there is high demand for reliable siRNAs prediction tools and for the design methods able to pick up high silencing potential siRNAs...
  58. ncbi Developmental regulation of intracellular calcium homeostasis in early cardiac myocytes
    Ji Dong Fu
    Key Laboratory of Stem Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025, China E mail
    Sheng Li Xue Bao 58:95-103. 2006
    ..This paper briefly summarizes the Ca(2+) homeostasis during early development of cardiomyocytes and reviews current knowledge of the regulatory mechanisms controlling Ca(2+) homeostasis during cardiomyocyte development...
  59. ncbi Trimetazidine improved Ca2+ handling in isoprenaline-mediated myocardial injury of rats
    Dan Meng
    Research Institute of Cardiovascular Disease, First Affiliated Hospital, Human Functional Genetics Laboratory of Jiangsu Province of Nanjing Medical University, Nanjing, 210029 corrected China
    Exp Physiol 91:591-601. 2006
    ..These changes in Ca2+ handling could help to explain the favourable action of TMZ in myocardial injury...
  60. ncbi Molecular cloning and functional analysis of ESGP, an embryonic stem cell and germ cell specific protein
    Yan Mei Chen
    Laboratory of Molecular and Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
    Acta Biochim Biophys Sin (Shanghai) 37:789-96. 2005
    ..Despite its specific expression, forced expression of ESGP is not indispensable for the effect of Oct-4 on ES cell self-renewal, and does not affect the differentiation to three germ layers...
  61. ncbi Radiation-induced changes in gene expression in the silkworm revealed by serial analysis of gene expression (SAGE)
    J Huang
    Institute of Plant Physiology and Ecology, The Chinese Academy of Sciences, Shanghai, China
    Insect Mol Biol 14:665-74. 2005
    ..In addition, it was noted that the generation of longer cDNA fragments from SAGE tags is an efficient way to identify genes, thereby facilitating the analysis of large numbers of unknown genes...
  62. ncbi Targeting strategies in cancer gene therapy
    Jin Hui Wang
    Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, Shanghai 200031, China
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 35:311-6. 2003
    ..Antisense oligonucleotides, some ribozyme and DNAzyme molecules are developed to inactivate genes that are essential to the development of many tumors...