Xianhua Wang

Summary

Affiliation: Peking University
Country: China

Publications

  1. doi request reprint Cardioprotection of ischemia/reperfusion injury by cholesterol-dependent MG53-mediated membrane repair
    Xianhua Wang
    Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University, Beijing, China
    Circ Res 107:76-83. 2010
  2. doi request reprint Deficiency of PHB complex impairs respiratory supercomplex formation and activates mitochondrial flashes.
    Chongshu Jian
    J Cell Sci 130:2620-2630. 2017
  3. pmc Protons Trigger Mitochondrial Flashes
    Xianhua Wang
    State Key Laboratory of Membrane Biology, Peking Tsinghua Center for Life Sciences, Institute of Molecular Medicine, Peking University, Beijing, China Electronic address
    Biophys J 111:386-94. 2016
  4. doi request reprint Cyclophilin D regulates mitochondrial flashes and metabolism in cardiac myocytes
    Wei Shang
    State Key Laboratory of Membrane Biology, Institute of Molecular Medicine, Peking Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
    J Mol Cell Cardiol 91:63-71. 2016
  5. pmc Synergistic triggering of superoxide flashes by mitochondrial Ca2+ uniport and basal reactive oxygen species elevation
    Tingting Hou
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Molecular Medicine, Peking Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
    J Biol Chem 288:4602-12. 2013
  6. doi request reprint Superoxide flashes: elemental events of mitochondrial ROS signaling in the heart
    Xianhua Wang
    Institute of Molecular Medicine and State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
    J Mol Cell Cardiol 52:940-8. 2012
  7. doi request reprint Β-adrenergic-stimulated L-type channel Ca²+ entry mediates hypoxic Ca²+ overload in intact heart
    Huiliang Zhang
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
    J Mol Cell Cardiol 65:51-8. 2013
  8. pmc Superoxide flashes reveal novel properties of mitochondrial reactive oxygen species excitability in cardiomyocytes
    Kaitao Li
    Institute of Molecular Medicine and State Key Laboratory of Biomembrane and Membrane Biotechnology, Center for Life Sciences, Peking University, Beijing, China
    Biophys J 102:1011-21. 2012
  9. doi request reprint Imaging Ca2+ nanosparks in heart with a new targeted biosensor
    Wei Shang
    From the State Key Laboratory of Biomembrane and Membrane Biotechnology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking Tsinghua Center for Life Sciences W S, F L, T S, J X, Y W, G W, L C, X W, H C and State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Science L L L, S Q W, Peking University, Beijing, China and Department of Physiology and Pharmacology, University of Bristol, City of Bristol, United Kingdom M B C
    Circ Res 114:412-20. 2014
  10. doi request reprint Calcium gradients underlying cell migration
    Chaoliang Wei
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Center for Life Sciences, The Institute of Molecular Medicine, Peking University, Beijing 100871, China
    Curr Opin Cell Biol 24:254-61. 2012

Collaborators

Detail Information

Publications24

  1. doi request reprint Cardioprotection of ischemia/reperfusion injury by cholesterol-dependent MG53-mediated membrane repair
    Xianhua Wang
    Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University, Beijing, China
    Circ Res 107:76-83. 2010
    ..MG53, a newly identified striated muscle-specific protein, is involved in skeletal muscle membrane repair. But the role of MG53 in the heart has not been determined...
  2. doi request reprint Deficiency of PHB complex impairs respiratory supercomplex formation and activates mitochondrial flashes.
    Chongshu Jian
    J Cell Sci 130:2620-2630. 2017
    ..Our findings identify the PHB complex as a new regulator of RSC formation and mitoflash signaling, and delineate a general relationship among RSC formation, basal ROS production and mitoflash biogenesis...
  3. pmc Protons Trigger Mitochondrial Flashes
    Xianhua Wang
    State Key Laboratory of Membrane Biology, Peking Tsinghua Center for Life Sciences, Institute of Molecular Medicine, Peking University, Beijing, China Electronic address
    Biophys J 111:386-94. 2016
    ..This finding suggests that mitoflash genesis is functionally and mechanistically integrated with mitochondrial energy metabolism. ..
  4. doi request reprint Cyclophilin D regulates mitochondrial flashes and metabolism in cardiac myocytes
    Wei Shang
    State Key Laboratory of Membrane Biology, Institute of Molecular Medicine, Peking Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
    J Mol Cell Cardiol 91:63-71. 2016
    ..In addition, tissue-specific CyP-D expression may partly explain the differential regulation of mitoflashes in the two types of striated muscles. ..
  5. pmc Synergistic triggering of superoxide flashes by mitochondrial Ca2+ uniport and basal reactive oxygen species elevation
    Tingting Hou
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Molecular Medicine, Peking Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
    J Biol Chem 288:4602-12. 2013
    ..Thus, physiological levels of mitochondrial Ca(2+) and ROS synergistically regulate stochastic mPTP opening and quantal ROS production in intact cells, marking the flash as a coincidence detector of mitochondrial Ca(2+) and ROS signals...
  6. doi request reprint Superoxide flashes: elemental events of mitochondrial ROS signaling in the heart
    Xianhua Wang
    Institute of Molecular Medicine and State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
    J Mol Cell Cardiol 52:940-8. 2012
    ..Future investigation is warranted to uncover the cellular logic and molecular pathways of local dynamic mitoROS signaling in heart muscle cells and many other cell types...
  7. doi request reprint Β-adrenergic-stimulated L-type channel Ca²+ entry mediates hypoxic Ca²+ overload in intact heart
    Huiliang Zhang
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
    J Mol Cell Cardiol 65:51-8. 2013
    ..Taken together, we conclude that Ca(2+) entry through β-adrenergic-stimulated LTCC underlies hypoxia-induced [Ca(2+)]i overload and the ensuing loss of mitochondrial function in intact heart...
  8. pmc Superoxide flashes reveal novel properties of mitochondrial reactive oxygen species excitability in cardiomyocytes
    Kaitao Li
    Institute of Molecular Medicine and State Key Laboratory of Biomembrane and Membrane Biotechnology, Center for Life Sciences, Peking University, Beijing, China
    Biophys J 102:1011-21. 2012
    ..We propose that superoxide flash production is a regenerative process dominated by stochastic, autonomous recruitment of a limited number of units (e.g., mPTPs) in single mitochondria...
  9. doi request reprint Imaging Ca2+ nanosparks in heart with a new targeted biosensor
    Wei Shang
    From the State Key Laboratory of Biomembrane and Membrane Biotechnology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking Tsinghua Center for Life Sciences W S, F L, T S, J X, Y W, G W, L C, X W, H C and State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Science L L L, S Q W, Peking University, Beijing, China and Department of Physiology and Pharmacology, University of Bristol, City of Bristol, United Kingdom M B C
    Circ Res 114:412-20. 2014
    ..Existing probes do not report such local Ca2+ signals because of probe diffusion, so a junction-targeted Ca2+ sensor should reveal new information on cardiac excitation-contraction coupling and its modification in disease states...
  10. doi request reprint Calcium gradients underlying cell migration
    Chaoliang Wei
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Center for Life Sciences, The Institute of Molecular Medicine, Peking University, Beijing 100871, China
    Curr Opin Cell Biol 24:254-61. 2012
    ..These recent findings provide a glimpse into how spatiotemporally coordinated calcium gradients orchestrate cellular behavior as complex as directional movement...
  11. pmc Imaging ROS signaling in cells and animals
    Xianhua Wang
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Molecular Medicine, Peking Tsinghua Center for Life Sciences, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University, Beijing 100871, China
    J Mol Med (Berl) 91:917-27. 2013
    ..This review aims at providing an update of the current status in ROS imaging, while identifying areas of insufficient knowledge and highlighting emerging research directions. ..
  12. pmc Dysregulation of mitochondrial calcium signaling and superoxide flashes cause mitochondrial genomic DNA damage in Huntington disease
    Jiu Qiang Wang
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
    J Biol Chem 288:3070-84. 2013
    ..Our results also indicate that reducing mitochondrial Ca(2+) uptake could be a therapeutic strategy for HD...
  13. doi request reprint ROS regulation of microdomain Ca(2+) signalling at the dyads
    Huiliang Zhang
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking Tsinghua Center for Life Sciences, Institute of Molecular Medicine, Peking University, Beijing 100871, China
    Cardiovasc Res 98:248-58. 2013
    ..These new understandings should be leveraged to harness ROS for their beneficial roles while avoiding deleterious effects in the heart...
  14. pmc Mitoflash altered by metabolic stress in insulin-resistant skeletal muscle
    Yi Ding
    Institute of Molecular Medicine, Peking University, Beijing, China
    J Mol Med (Berl) 93:1119-30. 2015
    ..These findings indicate that mitoflash activity may serve as an optical functional readout of the mitochondria, a robust and sensitive biomarker to gauge IR stresses and their amelioration by therapeutic interventions...
  15. doi request reprint Identification of EFHD1 as a novel Ca(2+) sensor for mitoflash activation
    Tingting Hou
    State Key Laboratory of Membrane Biology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking Tsinghua Center for Life Sciences, Peking University, Beijing, China
    Cell Calcium 59:262-70. 2016
    ..These results indicate that EFHD1 functions as a novel mitochondrial Ca(2+) sensor underlying Ca(2+)-dependent activation of mitoflashes...
  16. pmc Regulation of Mitoflash Biogenesis and Signaling by Mitochondrial Dynamics
    Wenwen Li
    State Key Laboratory of Membrane Biology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking Tsinghua Center for Life Sciences, Institute of Molecular Medicine, Peking University, Beijing, China
    Sci Rep 6:32933. 2016
    ..In addition, our data support a stochastic trigger model for the ignition of mitoflashes. ..
  17. pmc Kissing and nanotunneling mediate intermitochondrial communication in the heart
    Xiaohu Huang
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Molecular Medicine, Peking Tsinghua Center for Life Sciences, and College of Engineering, Peking University, Beijing 100871, China
    Proc Natl Acad Sci U S A 110:2846-51. 2013
    ..We propose that, through kissing and nanotunneling, the otherwise static mitochondria in a cardiomyocyte form one dynamically continuous network to share content and transfer signals...
  18. doi request reprint Regulation of superoxide flashes by transient and steady mitochondrial calcium elevations
    Chongshu Jian
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking Tsinghua Center for Life Sciences, Peking University, Beijing, 100871, China
    Sci China Life Sci 57:495-501. 2014
    ....
  19. doi request reprint MG53 constitutes a primary determinant of cardiac ischemic preconditioning
    Chun mei Cao
    Institute of Molecular Medicine, Peking University, Beijing, China
    Circulation 121:2565-74. 2010
    ..Nevertheless, the fundamental mechanism underlying IPC is poorly understood...
  20. pmc Remodeling of Mitochondrial Flashes in Muscular Development and Dystrophy in Zebrafish
    Meiling Zhang
    Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking University, Beijing, China
    PLoS ONE 10:e0132567. 2015
    ....
  21. pmc Central role of mitofusin 2 in autophagosome-lysosome fusion in cardiomyocytes
    Ting Zhao
    Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
    J Biol Chem 287:23615-25. 2012
    ....
  22. pmc Imaging superoxide flash and metabolism-coupled mitochondrial permeability transition in living animals
    Huaqiang Fang
    Institute of Molecular Medicine, College of Life Science, Peking University, Beijing 100871, China
    Cell Res 21:1295-304. 2011
    ....
  23. pmc Mitochondrial flashes: new insights into mitochondrial ROS signalling and beyond
    Tingting Hou
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking Tsinghua Center for Life Sciences, Peking University, Beijing, 100871, China
    J Physiol 592:3703-13. 2014
    ..These recent advances shed new light on the role of mitochondrial functional dynamics in health and disease. ..
  24. doi request reprint Flickering calcium microdomains signal turning of migrating cells
    Chaoliang Wei
    Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University, Beijing 100871, China
    Can J Physiol Pharmacol 88:105-10. 2010
    ..Furthermore, we present a new model for patterned calcium flicker activity as the mechanism for steering the turning of a migrating cell...