Junbao Du

Summary

Affiliation: Peking University
Country: China

Publications

  1. ncbi request reprint [Endogenous H2S is involved in the development of spontaneous hypertension]
    Junbao Du
    Department of Pediatrics, Peking University First Hospital, Beijing 100034, China
    Beijing Da Xue Xue Bao 35:102. 2003
  2. ncbi request reprint Effect of L-arginine on collagen of high flow-induced pulmonary arterial remodeling
    Du Junbao
    Department of Pediatrics, First Hospital, Peking University, and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, China
    Circ J 69:603-8. 2005
  3. ncbi request reprint The possible role of hydrogen sulfide as a smooth muscle cell proliferation inhibitor in rat cultured cells
    Junbao Du
    Department of Pediatrics, Peking University, First Hospital, Xi An Men Str No 1, West District, 100034, Beijing, PR China
    Heart Vessels 19:75-80. 2004
  4. doi request reprint Endogenous hydrogen sulfide regulates pulmonary artery collagen remodeling in rats with high pulmonary blood flow
    Xiaohui Li
    Department of Pediatrics, Peking University First Hospital, Xi An Men Street No 1, West District, Beijing, 100034, People s Republic of China
    Exp Biol Med (Maywood) 234:504-12. 2009
  5. doi request reprint Flow-mediated vasodilation as a predictor of therapeutic response to midodrine hydrochloride in children with postural orthostatic tachycardia syndrome
    Ying Liao
    Department of Pediatrics, Peking University First Hospital, Beijing 100034, People s Republic of China
    Am J Cardiol 112:816-20. 2013
  6. ncbi request reprint The regulatory effect of endogenous hydrogen sulfide on pulmonary vascular structure and gasotransmitters in rats with high pulmonary blood flow
    Xiaohui Li
    Department of Pediatrics, Peking University First Hospital, Xi An Men Street No 1, Beijing, 100034, People s Republic of China
    Life Sci 81:841-9. 2007
  7. doi request reprint Endogenous sulfur dioxide protects against isoproterenol-induced myocardial injury and increases myocardial antioxidant capacity in rats
    Yinfang Liang
    Department of Pediatrics, Peking University First Hospital, Beijing, PR China
    Lab Invest 91:12-23. 2011
  8. doi request reprint Role of hydrogen sulfide in the development of atherosclerotic lesions in apolipoprotein E knockout mice
    Yanfei Wang
    Department of Pediatrics, Peking University First Hospital, Xi An Men Street No 1, West District, Beijing 100034, PR China
    Arterioscler Thromb Vasc Biol 29:173-9. 2009
  9. pmc The ERK1/2 signaling pathway is involved in sulfur dioxide preconditioning-induced protection against cardiac dysfunction in isolated perfused rat heart subjected to myocardial ischemia/reperfusion
    Pan Huang
    Department of Pediatrics, Peking University First Hospital, Xi An Men Str No 1, West District, Beijing 100034, China
    Int J Mol Sci 14:22190-201. 2013
  10. doi request reprint Postural orthostatic tachycardia syndrome with increased erythrocytic hydrogen sulfide and response to midodrine hydrochloride
    Jinyan Yang
    Department of Pediatrics, Peking University First Hospital, Beijing, PR China
    J Pediatr 163:1169-73.e2. 2013

Collaborators

  • Chaoshu Tang
  • Yuli Wang
  • Ping Liu
  • Bin Geng
  • Yan Sun
  • Juan Zhao
  • Jing Lin
  • Jia Liu
  • Li Chen
  • Wei Li
  • Hui Yan
  • Xiaohui Li
  • Cheng Wang
  • Li Wang
  • Ying Han
  • Hong Tian
  • Juxiang Li
  • Hongfang Jin
  • Qingyou Zhang
  • Ying Liao
  • Hongxia Li
  • Jinyan Yang
  • Siyao Chen
  • Yaqian Huang
  • Stella Chen
  • Fengwen Zhang
  • Die Liu
  • Angie Dong Liu
  • Todd Ochs
  • Pan Huang
  • Mingzhu Zhu
  • Chunyu Zhang
  • Lukas Holmberg
  • Shuxu Du
  • Yonghong Chen
  • Shanshan Chen
  • Yinfang Liang
  • Wen Yu
  • Jianguang Qi
  • Liman Luo
  • Rongyuan Zhang
  • Heng Zhang
  • Shasha Feng
  • Zhenzhen Li
  • Xueli Feng
  • Dingfang Bu
  • Manman Zhao
  • Xiuying Tang
  • Lulu Zhu
  • Bin Zhao
  • Lin Chang
  • Suqing Zhang
  • Qiuyu Yao
  • Baohong Zhang
  • Zhizhou Shen
  • Selena Chen
  • Bing Wei
  • Qinghua Chen
  • Zhenhui Han
  • Yanfang Zong
  • Lili Sun
  • Wenjun Deng
  • Li Li
  • Bifeng Chen
  • Yu Chen
  • Wei Lu
  • Zhiwei Liu
  • Yi Ai
  • Xueqin Liu
  • Zhongdong Du
  • Yan Hui
  • Hongling Wei
  • Bing He
  • Yongfen Qi
  • Ying Liu
  • Jie Mi
  • Tianshui Li
  • Hongfeng Jiang
  • Du Junbao
  • Yuansheng Gao
  • Chufan Sun
  • GuangZhen Zhong
  • Limin Gong
  • Yali Ren
  • Kun Li
  • Chen Liang
  • Lin Shi
  • Da Zhang
  • Zhiyu Huang
  • Guang Wang

Detail Information

Publications94

  1. ncbi request reprint [Endogenous H2S is involved in the development of spontaneous hypertension]
    Junbao Du
    Department of Pediatrics, Peking University First Hospital, Beijing 100034, China
    Beijing Da Xue Xue Bao 35:102. 2003
    ..In conclusion, the reduced production of endogenous H2S in aorta is involved in the pathogenesis of spontaneous hypertension and is of great biological importance in modulating vasorelaxation...
  2. ncbi request reprint Effect of L-arginine on collagen of high flow-induced pulmonary arterial remodeling
    Du Junbao
    Department of Pediatrics, First Hospital, Peking University, and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, China
    Circ J 69:603-8. 2005
    ..In the present study the effects of L-arginine on the collagen metabolism of pulmonary arteries in rats with high pulmonary blood flow-induced PH were investigated to elucidate its mechanism...
  3. ncbi request reprint The possible role of hydrogen sulfide as a smooth muscle cell proliferation inhibitor in rat cultured cells
    Junbao Du
    Department of Pediatrics, Peking University, First Hospital, Xi An Men Str No 1, West District, 100034, Beijing, PR China
    Heart Vessels 19:75-80. 2004
    ..37% ( P >> 0.05), 23.39%, and 33.57%, respectively ( P << 0.01). The results demonstrated that H(2)S could dose-dependently suppress the proliferation of VSMCs through the MAPK pathway...
  4. doi request reprint Endogenous hydrogen sulfide regulates pulmonary artery collagen remodeling in rats with high pulmonary blood flow
    Xiaohui Li
    Department of Pediatrics, Peking University First Hospital, Xi An Men Street No 1, West District, Beijing, 100034, People s Republic of China
    Exp Biol Med (Maywood) 234:504-12. 2009
    ..01). This study suggests that endogenous H2S exerts an important regulatory effect on pulmonary collagen remodeling induced by high pulmonary blood flow...
  5. doi request reprint Flow-mediated vasodilation as a predictor of therapeutic response to midodrine hydrochloride in children with postural orthostatic tachycardia syndrome
    Ying Liao
    Department of Pediatrics, Peking University First Hospital, Beijing 100034, People s Republic of China
    Am J Cardiol 112:816-20. 2013
    ..FMD of 9.85% had a high sensitivity (1-month therapy: 71.6%; 3-month therapy: 74.4%) and specificity (1-month therapy 77.8%; 3-month therapy: 80%). In conclusion, FMD is a predictor of the efficacy of MD for treating children with POTS. ..
  6. ncbi request reprint The regulatory effect of endogenous hydrogen sulfide on pulmonary vascular structure and gasotransmitters in rats with high pulmonary blood flow
    Xiaohui Li
    Department of Pediatrics, Peking University First Hospital, Xi An Men Street No 1, Beijing, 100034, People s Republic of China
    Life Sci 81:841-9. 2007
    ..H(2)S exerted a protective effect on PVSR, and the inhibition of the NO/NOS pathway and the augmentation of the CO/HO pathway might be involved in the mechanisms by which H(2)S regulates PVSR in rats with high pulmonary flow...
  7. doi request reprint Endogenous sulfur dioxide protects against isoproterenol-induced myocardial injury and increases myocardial antioxidant capacity in rats
    Yinfang Liang
    Department of Pediatrics, Peking University First Hospital, Beijing, PR China
    Lab Invest 91:12-23. 2011
    ..SO(2) protects against ISO-induced myocardial injury associated with increased myocardial antioxidant capacity in rats...
  8. doi request reprint Role of hydrogen sulfide in the development of atherosclerotic lesions in apolipoprotein E knockout mice
    Yanfei Wang
    Department of Pediatrics, Peking University First Hospital, Xi An Men Street No 1, West District, Beijing 100034, PR China
    Arterioscler Thromb Vasc Biol 29:173-9. 2009
    ..We explored the effect of hydrogen sulfide (H(2)S) on atherosclerotic progression, particularly on intracellular adhesion molecule-1 (ICAM-1) in apolipoprotein-E knockout (apoE(-/-)) mice and human umbilical vein endothelial cells (HUVECs)...
  9. pmc The ERK1/2 signaling pathway is involved in sulfur dioxide preconditioning-induced protection against cardiac dysfunction in isolated perfused rat heart subjected to myocardial ischemia/reperfusion
    Pan Huang
    Department of Pediatrics, Peking University First Hospital, Xi An Men Str No 1, West District, Beijing 100034, China
    Int J Mol Sci 14:22190-201. 2013
    ..In conclusion, SO2 preconditioning protected against cardiac dysfunction in isolated rat heart subjected to I/R via suppression of the over-activation of the ERK1/2 signaling pathway. ..
  10. doi request reprint Postural orthostatic tachycardia syndrome with increased erythrocytic hydrogen sulfide and response to midodrine hydrochloride
    Jinyan Yang
    Department of Pediatrics, Peking University First Hospital, Beijing, PR China
    J Pediatr 163:1169-73.e2. 2013
    ..To evaluate the use of erythrocytic hydrogen sulfide (H2S) in predicting the therapeutic efficacy of midodrine hydrochloride for children with postural orthostatic tachycardia syndrome (POTS)...
  11. doi request reprint Brg1-dependent epigenetic control of vascular smooth muscle cell proliferation by hydrogen sulfide
    Li Li
    Department of Pediatrics, Peking University First Hospital, Beijing, People s Republic of China
    Biochim Biophys Acta 1833:1347-55. 2013
    ....
  12. doi request reprint Midregional pro-adrenomedullin as a predictor for therapeutic response to midodrine hydrochloride in children with postural orthostatic tachycardia syndrome
    Fengwen Zhang
    Department of Pediatrics, Peking University First Hospital, Beijing, China
    J Am Coll Cardiol 60:315-20. 2012
    ....
  13. doi request reprint Flow-mediated vasodilation and endothelium function in children with postural orthostatic tachycardia syndrome
    Ying Liao
    Department of Pediatrics, Peking University First Hospital, Beijing, People s Republic of China
    Am J Cardiol 106:378-82. 2010
    ..01). In addition, there was a significant correlation between FMD and the NOS activity. In conclusion, augmented FMD and abnormal function of vascular endothelium may play an important role in POTS in children...
  14. ncbi request reprint The upregulation of endothelial nitric oxide synthase and urotensin-II is associated with pulmonary hypertension and vascular diseases in rats produced by aortocaval shunting
    Jianguang Qi
    Department of Pediatrics, First Hospital of Peking University, Xi An Men Street No 1, 100034, Beijing, P R China
    Heart Vessels 19:81-8. 2004
    ..Nitric oxide, as a modifying factor, might be involved in the regulation of pulmonary vascular structural remodeling...
  15. doi request reprint Sodium hydrosulfide alleviates pulmonary artery collagen remodeling in rats with high pulmonary blood flow
    Xiaohui Li
    Department of Pediatrics, Peking University First Hospital and Key Laboratory of Molecular Cardiology, Ministry of Education, Xi An Men Street No 1, West District, Beijing, 100034, P R China
    Heart Vessels 23:409-19. 2008
    ..The downregulation of H(2)S is involved in the development of pulmonary artery collagen remodeling induced by high pulmonary blood flow...
  16. doi request reprint Modified Calgary score in differential diagnosis between cardiac syncope and postural orthostatic tachycardia syndrome-associated syncope in children
    Jinyan Yang
    Department of Pediatrics, Peking University First Hospital, Beijing, China
    Cardiol Young 23:400-4. 2013
    ..The modified Calgary score could be used to make an initial differential diagnosis between cardiac syncope and postural orthostatic tachycardia syndrome-associated syncope in the clinic...
  17. doi request reprint Sulfur dioxide upregulates the inhibited endogenous hydrogen sulfide pathway in rats with pulmonary hypertension induced by high pulmonary blood flow
    Liman Luo
    Department of Pediatrics, Peking University First Hospital, Beijing 100034, China
    Biochem Biophys Res Commun 433:519-25. 2013
    ..However, SO2 could reduce pulmonary arterial pressure and improve the pulmonary vascular pathological changes in association with upregulating endogenous H2S pathway...
  18. ncbi request reprint H2S generated by heart in rat and its effects on cardiac function
    Bin Geng
    Institute of Cardiovascular Research, Peking University First Hospital, PR China
    Biochem Biophys Res Commun 313:362-8. 2004
    ..The present findings suggested that H2S could be endogenously produced by heart tissues, as a physiological cardiac function regulator, mediated by KATP channel pathway...
  19. ncbi request reprint Hydrogen sulfide inhibits myocardial injury induced by homocysteine in rats
    Lin Chang
    Institute of Cardiovascular Research, Peking University, Xishuku Street 8, West District, 100034 Beijing, People s Republic of China
    Amino Acids 34:573-85. 2008
    ....
  20. doi request reprint Effects of sulfur dioxide on hypoxic pulmonary vascular structural remodeling
    Yan Sun
    Department of Pediatrics, Peking University First Hospital, Beijing 100034, China
    Lab Invest 90:68-82. 2010
    ..The downregulated sulfur dioxide/glutamate oxaloacetate transaminase pathway may be involved in the mechanisms responsible for pulmonary hypertension and pulmonary vascular structural remodeling...
  21. doi request reprint Hydrogen sulfide attenuates hyperhomocysteinemia-induced cardiomyocytic endoplasmic reticulum stress in rats
    Hongling Wei
    Department of Pediatrics, Peking University First Hospital, Xi An Men Street No 1, West District, Beijing, P R China
    Antioxid Redox Signal 12:1079-91. 2010
    ..The results suggest that H(2)S can attenuate cardiomyocytic ER stress in HHcy-induced cardiomyocytic injury...
  22. ncbi request reprint Modulating effect of hydrogen sulfide on gamma-aminobutyric acid B receptor in recurrent febrile seizures in rats
    Ying Han
    Department of Pediatrics, Peking University First Hospital, No 1 Xi An Men Street, Beijing 100034, PR China
    Neurosci Res 53:216-9. 2005
    ..These results suggest that H2S plays a regulatory role through modulating GABA(B)R function in the pathogenesis of recurrent FS...
  23. ncbi request reprint [Changes of plasma intermedin during head-up tilt test in children with postural tachycardia syndrome and its significance]
    Hongxia Li
    Department of Pediatrics, Peking University First Hospital, Beijing 100034, China
    Zhonghua Er Ke Za Zhi 53:375-8. 2015
    ..To explore possible mechanisms of postural tachycardia syndrome (POTS) by comparing plasma intermedin (IMD) during head-up tilt test (HUTT) in children with POTS...
  24. pmc A cross-sectional study on upright heart rate and BP changing characteristics: basic data for establishing diagnosis of postural orthostatic tachycardia syndrome and orthostatic hypertension
    Juan Zhao
    Department of Pediatrics, Peking University First Hospital, Beijing, People s Republic of China
    BMJ Open 5:e007356. 2015
    ..We aimed to determine upright heart rate and blood pressure (BP) changes to suggest diagnostic criteria for postural orthostatic tachycardia syndrome (POTS) and orthostatic hypertension (OHT) in Chinese children...
  25. pmc Downregulation of Endogenous Hydrogen Sulfide Pathway Is Involved in Mitochondrion-Related Endothelial Cell Apoptosis Induced by High Salt
    Yanfang Zong
    Department of Pediatrics, Peking University First Hospital, Beijing 100034, China
    Oxid Med Cell Longev 2015:754670. 2015
    ..The study aimed to investigate whether endogenous H2S pathway was involved in high-salt-stimulated mitochondria-related vascular endothelial cell (VEC) apoptosis...
  26. doi request reprint Total peripheral vascular resistance, cardiac output, and plasma C-type natriuretic Peptide level in children with postural tachycardia syndrome
    Hongxia Li
    Department of Pediatrics, Peking University First Hospital, Beijing, P R China
    J Pediatr 166:1385-9.e1-2. 2015
    ..To investigate the total peripheral vascular resistance (TPVR), cardiac output (CO), and plasma C-type natriuretic peptide (CNP) levels in children with postural tachycardia syndrome (POTS) during supine, upright, and return to supine...
  27. doi request reprint Value of history taking in children and adolescents with cardiac syncope
    Qingyou Zhang
    Department of Pediatrics, Peking University First Hospital, Beijing, China
    Cardiol Young 23:54-60. 2013
    ..This study was designed to investigate the value of history taking in identifying children with cardiac syncope, and to improve diagnostic efficiency and accuracy in children with cardiac syncope...
  28. doi request reprint Sulfur dioxide restores calcium homeostasis disturbance in rat with isoproterenol-induced myocardial injury
    Shanshan Chen
    Department of Pediatrics, Peking University First Hospital, Beijing, China
    Histol Histopathol 27:1219-26. 2012
    ..This study aims to explore whether the protective effect of SO₂ on ISO-induced myocardial injury was mediated by the restoration of calcium homeostasis disturbance in cardiomyocyte...
  29. doi request reprint Plasma hydrogen sulfide in differential diagnosis between vasovagal syncope and postural orthostatic tachycardia syndrome in children
    Fengwen Zhang
    Department of Pediatrics, Peking University First Hospital, Beijing, China
    J Pediatr 160:227-31. 2012
    ..To explore the predictive value of plasma hydrogen sulfide (H(2)S) in differentiating between vasovagal syncope (VVS) and postural orthostatic tachycardia syndrome (POTS) in children...
  30. ncbi request reprint The possible role of hydrogen sulfide on the pathogenesis of spontaneous hypertension in rats
    Hui Yan
    Department of Pediatrics, Peking University First Hospital, PR China
    Biochem Biophys Res Commun 313:22-7. 2004
    ..Exogenous H(2)S could exert beneficial effect on the pathogenesis of spontaneous hypertension...
  31. doi request reprint Regulatory effects of sulfur dioxide on the development of atherosclerotic lesions and vascular hydrogen sulfide in atherosclerotic rats
    Wei Li
    Department of Pediatrics, Peking University First Hospital, Beijing 100034, China
    Atherosclerosis 215:323-30. 2011
    ..This study was designed to examine the effect of sulfur dioxide (SO(2)) on atherosclerotic progression and endogenous vascular hydrogen sulfide (H(2)S) in rats with atherosclerosis (AS)...
  32. ncbi request reprint Hydrogen sulfide and carbon monoxide are in synergy with each other in the pathogenesis of recurrent febrile seizures
    Ying Han
    Department of Pediatrics, Peking University First Hospital, Peking, P R China
    Cell Mol Neurobiol 26:101-7. 2006
    ..3. Our data demonstrate that endogenous H(2)S and CO are in synergy with each other in recurrent FS...
  33. doi request reprint The vasodilatory effect of sulfur dioxide via SGC/cGMP/PKG pathway in association with sulfhydryl-dependent dimerization
    Qiuyu Yao
    Department of Pediatrics, Peking University First Hospital, Beijing, People s Republic of China
    Am J Physiol Regul Integr Comp Physiol 310:R1073-80. 2016
    ..These findings revealed a new mode of action and mechanisms by which SO2 regulated the vascular tone. ..
  34. pmc Sulfur Dioxide Protects Against Collagen Accumulation in Pulmonary Artery in Association With Downregulation of the Transforming Growth Factor β1/Smad Pathway in Pulmonary Hypertensive Rats
    Wen Yu
    Department of Pediatrics, Peking University First Hospital, Beijing, China
    J Am Heart Assoc 5:. 2016
    ..We aimed to explore the role of endogenous sulfur dioxide (SO2) in pulmonary vascular collagen remodeling induced by monocrotaline and its mechanisms...
  35. pmc Hydrogen Sulfide Inhibits High-Salt Diet-Induced Renal Oxidative Stress and Kidney Injury in Dahl Rats
    Pan Huang
    Department of Pediatrics, Peking University First Hospital, Beijing 100034, China
    Oxid Med Cell Longev 2016:2807490. 2016
    ..CONCLUSIONS. H2S protected against high-salt diet-induced renal injury associated with enhanced antioxidant capacity and inhibited renal oxidative stress...
  36. pmc Plasma C-type natriuretic peptide as a predictor for therapeutic response to metoprolol in children with postural tachycardia syndrome
    Jing Lin
    Department of Pediatrics, Peking University First Hospital, Beijing, China
    PLoS ONE 10:e0121913. 2015
    ..8% and specificity of 70% in predicting therapeutic efficacy of metoprolol on POTS children. Plasma CNP might serve as a useful predictor for the therapeutic efficacy of metoprolol on POTS in children. ..
  37. doi request reprint Erythrocytic hydrogen sulfide production is increased in children with vasovagal syncope
    Jinyan Yang
    Department of Pediatrics, Peking University First Hospital, Beijing, P R China
    J Pediatr 166:965-9. 2015
    ..To explore the differences in erythrocyte hydrogen sulfide (H2S) production in children with vasovagal syncope (VVS)...
  38. pmc The role of sulfur dioxide in the regulation of mitochondrion-related cardiomyocyte apoptosis in rats with isopropylarterenol-induced myocardial injury
    Hongfang Jin
    Department of Pediatrics, Peking University First Hospital, Xi An Men Str No 1, West District, Beijing 100034, China
    Int J Mol Sci 14:10465-82. 2013
    ..Hence, SO2 attenuated myocardial injury in association with the inhibition of apoptosis in myocardial tissues, and the bcl-2/cytc/caspase-9/caspase-3 pathway was possibly involved in this process...
  39. doi request reprint Sulfur dioxide inhibits excessively activated endoplasmic reticulum stress in rats with myocardial injury
    Shanshan Chen
    Department of Pediatrics, Peking University First Hospital, Xi An Men Str No 1, West District, Beijing 100034, China
    Heart Vessels 27:505-16. 2012
    ..In conclusion, the endogenous AAT/SO(2) pathway was probably responsible for the inhibition of excessively activated ERS, which might be involved in the mechanism of ISO-induced myocardial injury...
  40. doi request reprint Sulfur dioxide derivatives improve the vasorelaxation in the spontaneously hypertensive rat by enhancing the vasorelaxant response to nitric oxide
    Wei Lu
    Department of Pediatrics, Peking University First Hospital, Beijing 100034, China
    Exp Biol Med (Maywood) 237:867-72. 2012
    ..The results suggest that SO(2) reduced blood pressure and increased vasorelaxation in SHR arteries via enhancing the vasorelaxant response to NO in isolated aortic rings and increasing the NO level of aortic tissues...
  41. ncbi request reprint Effects of onion extract on endogenous vascular H2S and adrenomedulin in rat atherosclerosis
    Wei Li
    Department of Pediatrics, Peking University First Hospital, Beijing 100034, China
    Curr Pharm Biotechnol 12:1427-39. 2011
    ..This study aimed to explore the effect of onion extract on endogenous hydrogen sulfide (H2S) and adrenomedulin (ADM) and on atherosclerotic progression in rats with atherosclerosis (AS)...
  42. doi request reprint Endogenous sulfur dioxide aggravates myocardial injury in isolated rat heart with ischemia and reperfusion
    Suqing Zhang
    Department of Pediatrics, Peking University First Hospital, Beijing, China
    Transplantation 87:517-24. 2009
    ..Ischemia-reperfusion (I/R) injury is an important clinical problem. This article investigated the role of sulfur dioxide (SO2) in the regulation of cardiac function and in the pathogenesis of cardiac I/R injury in isolated rat heart...
  43. doi request reprint Study on the reference values of serum lipids in children aged 3-18 years old in Beijing, China
    Ying Liao
    Department of Pediatrics, Peking University First Hospital, Beijing 100034, PR China
    Pediatr Int 52:472-9. 2010
    ..The present study was designed to explore the reference values of serum lipids in children in Beijing...
  44. ncbi request reprint Effects of adrenomedullin, C-type natriuretic peptide, and parathyroid hormone-related peptide on calcification in cultured rat vascular smooth muscle cells
    Zhiyu Huang
    Department of Physiology and Pathophysiology, Health Science Center, Peking University, Beijing, PR China
    J Cardiovasc Pharmacol 42:89-97. 2003
    ..This study could be of help in understanding the pathogenesis of vascular calcification, and providing new target for clinical treatment of cardiovascular diseases associated with vascular calcification...
  45. pmc Baroreflex Sensitivity Predicts Short-Term Outcome of Postural Tachycardia Syndrome in Children
    Hongxia Li
    Department of Pediatrics, Peking University First Hospital, Beijing, P R China
    PLoS ONE 11:e0167525. 2016
    ..The study was designed to examine if baroreflex sensitivity (BRS) could predict the short-term outcome of postural tachycardia syndrome (POTS) in children...
  46. doi request reprint Body Mass Index (BMI) is Associated with the Therapeutic Response to Oral Rehydration Solution in Children with Postural Tachycardia Syndrome
    Hongxia Li
    Department of Pediatrics, Peking University First Hospital, Beijing, 100034, People s Republic of China
    Pediatr Cardiol 37:1313-8. 2016
    ..A cutoff value of the BMI of 18.02 kg/m(2) had high sensitivity (92 %) and high specificity (82.8 %) for predicting the effect of ORS treatment for POTS. BMI is associated with the therapeutic response to ORS in children with POTS. ..
  47. doi request reprint Plasma H2S predicts coronary artery lesions in children with Kawasaki disease
    Yan Sun
    Department of Pediatrics, Peking University First Hospital
    Pediatr Int 57:840-4. 2015
    ..The aim of this study was to determine whether plasma hydrogen sulfide (H2S) is a biomarker for predicting coronary artery lesions (CAL) in children with Kawasaki disease (KD)...
  48. ncbi request reprint [Predictive value of baseline plasma midregional fragment of pro-adrenomedullin level on long-term outcome of postural tachycardia syndrome children treated with midodrine hydrochloride]
    Hongxia Li
    Department of Pediatrics, Peking University First Hospital, Beijing 100034, China
    Zhonghua Xin Xue Guan Bing Za Zhi 43:507-10. 2015
    ..To explore the predictive value of baseline plasma midregional fragment of pro-adrenomedullin level (MR-proADM) on long-term survival of postural tachycardia syndrome (POTS) children treated with midodrine hydrochloride...
  49. ncbi request reprint [Evaluation of the changes in heart rate during head-up test predicting the efficacy of oral rehydration salts on postural tachycardia syndrome in children]
    Jing Lin
    Department of Pediatrics, Peking University First Hospital, Beijing 100034, China
    Zhonghua Er Ke Za Zhi 53:25-9. 2015
    ..To predict the therapeutic efficacy of oral rehydration salts (ORS) by quantifying changes in heart rate during the head-up test (HUT) in children with postural tachycardia syndrome (POTS)...
  50. pmc L-cystathionine inhibits the mitochondria-mediated macrophage apoptosis induced by oxidized low density lipoprotein
    Mingzhu Zhu
    Department of Pediatrics, Peking University First Hospital, Beijing 100034, China
    Int J Mol Sci 15:23059-73. 2014
    ..Taken together, our results suggested that l-cystathionine could antagonize mitochondria-mediated human macrophage apoptosis induced by ox-LDL via inhibition of cytc release and caspase activation. ..
  51. doi request reprint Difference between supine and upright blood pressure associates to the efficacy of midodrine on postural orthostatic tachycardia syndrome (POTS) in children
    Wenjun Deng
    Department of Pediatrics, Peking University First Hospital, Beijing, 100034, China
    Pediatr Cardiol 35:719-25. 2014
    ..The area under the curve was 0.744 and 0.809, respectively. Hence, the results suggested that looking at the changes in blood pressure during the HUT was useful in predicting the response to midodrine hydrochloride in children with POTS...
  52. doi request reprint Diagnostic value of serum brain natriuretic peptide in syncope in children and adolescents
    Qingyou Zhang
    Department of Pediatrics, Peking University First Hospital, Beijing, China
    Acta Paediatr 102:e210-4. 2013
    ..This study was designed to evaluate the diagnostic value of B-type natriuretic peptide (BNP) in syncope in children and adolescents...
  53. ncbi request reprint Therapeutic effects of ghrelin on endotoxic shock in rats
    Lin Chang
    Cardiovascular Research Institute, The First Hospital of Peking University, Beijing 100034, PR China
    Eur J Pharmacol 473:171-6. 2003
    ..The results suggest that ghrelin could have therapeutic value for endotoxic shock...
  54. ncbi request reprint The role of hydrogen sulfide generation in the pathogenesis of hypertension in rats induced by inhibition of nitric oxide synthase
    GuangZhen Zhong
    Department of Cardiology, The Third Hospital, Peking University, Beijing, China
    J Hypertens 21:1879-85. 2003
    ..The present study intended to investigate whether the impaired H2S synthase/H2S pathway is associated with hypertension...
  55. ncbi request reprint [Effects of high pulmonary blood flow on pulmonary vascular structure and the gene expression of cystathionine-gamma-lyase]
    Lin Shi
    Department of Pediatrics, Peking University First Hospital, Beijing 100034, China
    Beijing Da Xue Xue Bao 35:566-70. 2003
    ..To examine the alteration of pathologic structure and endogenous hydrogen sulfide pathway in rats with pulmonary hypertension induced by high pulmonary blood flow...
  56. ncbi request reprint Midodrine hydrochloride is effective in the treatment of children with postural orthostatic tachycardia syndrome
    Li Chen
    Department of Pediatrics, Peking University First Hospital, Beijing, China
    Circ J 75:927-31. 2011
    ..The study was carried out to examine the effect of selective α1 adrenoceptor agonist midodrine hydrochloride vs. β-adrenergic blockade metoprolol in the treatment of children with postural orthostatic tachycardia syndrome (POTS)...
  57. pmc Endogenous Sulfur Dioxide Inhibits Vascular Calcification in Association with the TGF-β/Smad Signaling Pathway
    Zhenzhen Li
    Department of Pediatrics, Peking University First Hospital, Beijing 100034, China
    Int J Mol Sci 17:266. 2016
    ..In brief, SO₂ significantly ameliorated vascular calcification in association with downregulation of the TGF-β/Smad pathway. ..
  58. pmc Endogenous sulfur dioxide is a novel adipocyte-derived inflammatory inhibitor
    Heng Zhang
    Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
    Sci Rep 6:27026. 2016
    ..This is the first report to suggest that endogenous SO2 is a novel adipocyte-derived inflammatory inhibitor. ..
  59. doi request reprint H2S inhibits pulmonary arterial endothelial cell inflammation in rats with monocrotaline-induced pulmonary hypertension
    Shasha Feng
    Department of Pediatrics, Peking University First Hospital, Beijing, China
    Lab Invest . 2016
    ..H2S attenuated endothelial inflammation by inhibiting the NF-κB pathway.Laboratory Investigation advance online publication, 12 December 2016; doi:10.1038/labinvest.2016.129...
  60. pmc Endogenous sulfur dioxide alleviates collagen remodeling via inhibiting TGF-β/Smad pathway in vascular smooth muscle cells
    Yaqian Huang
    Department of Pediatrics, Peking University First Hospital, Beijing 100034, P R China
    Sci Rep 6:19503. 2016
    ..These findings indicated that endogenous SO2 alleviated collagen remodeling by controlling TGF-β1/TβRI/Smad2/3-mediated modulation of collagen synthesis and degradation. ..
  61. pmc L-cystathionine inhibits oxidized low density lipoprotein-induced THP-1-derived macrophage inflammatory cytokine monocyte chemoattractant protein-1 generation via the NF-κB pathway
    Mingzhu Zhu
    Department of Pediatrics, Peking University First Hospital, Beijing 100034, P R China
    Sci Rep 5:10453. 2015
    ....
  62. pmc Hydrogen sulfide alleviates myocardial collagen remodeling in association with inhibition of TGF-β/Smad signaling pathway in spontaneously hypertensive rats
    Lili Sun
    Department of Emergency Medicine, Beijing Jishuitan Hospital, Beijing, China
    Mol Med 20:503-15. 2014
    ..In conclusion, the results suggested that H2S could prevent myocardial collagen remodeling in SHR. The mechanism might be associated with inhibition of collagen synthesis via TGF-β1/Smad signaling pathway. ..
  63. doi request reprint Endogenous generation of sulfur dioxide in rat tissues
    Liman Luo
    Department of Pediatrics, Peking University First Hospital, Beijing 100034, China
    Biochem Biophys Res Commun 415:61-7. 2011
    ..These observed differences among tissues endogenously generating SO(2) and associated enzymes are important in implicating the discovery of SO(2) as a novel endogenous signaling molecule...
  64. pmc Hydrogen sulfide inhibits L-type calcium currents depending upon the protein sulfhydryl state in rat cardiomyocytes
    Rongyuan Zhang
    Department of Pediatrics, Peking University First Hospital, Beijing, People s Republic of China
    PLoS ONE 7:e37073. 2012
    ..Therefore, our results suggest that H(2)S might inhibit L-type calcium currents depending on the sulfhydryl group in rat cardiomyocytes...
  65. ncbi request reprint Randomized comparison of metoprolol versus conventional treatment in preventing recurrence of vasovagal syncope in children and adolescents
    Qingyou Zhang
    Department of Pediatrics, Peking University First Hospital, and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, China
    Med Sci Monit 14:CR199-203. 2008
    ..We sought to evaluate the effectiveness of metoprolol versus conventional treatment in preventing the recurrence of syncope in children and adolescents...
  66. ncbi request reprint The modulating effect of L-arginine on collagen metabolism of pulmonary artery in pulmonary hypertension induced by a left-to-right shunt
    Bing Wei
    Department of Pediatrics, First Hospital, Peking University, Beijing 100034, China
    Zhonghua Yi Xue Za Zhi 82:1273-5. 2002
    ..To explore the modulating effect of L-arginine on collagen metabolism of pulmonary artery in rats with high pulmonary blood flow-induced pulmonary hypertension and its molecular mechanism...
  67. pmc Underlying diseases in syncope of children in China
    Li Chen
    Department of Pediatrics, Peking University 1st Hospital, Beijing, China
    Med Sci Monit 17:PH49-53. 2011
    ..This retrospective study aimed to analyze the spectrum of underlying diseases in children with syncope...
  68. ncbi request reprint Changes in arterial hydrogen sulfide (H(2)S) content during septic shock and endotoxin shock in rats
    Yan Hui
    Department of Pediatrics, First Hospital of Peking University, Xi An Men Street No 1, West District, Beijing 100034, People s Republic of China
    J Infect 47:155-60. 2003
    ..To explore the changes of hydrogen sulfide (H(2)S) in vascular tissues of rats with septic shock and endotoxin shock and its possible pathophysiological implication...
  69. doi request reprint Tilt angles and positive response of head-up tilt test in children with orthostatic intolerance
    Jing Lin
    1Department of Pediatrics, Peking University First Hospital, Beijing, China
    Cardiol Young 25:76-80. 2015
    ..Hence, it is suggested that a tilt angle of 60° and head-up tilt test time of 45 minutes should be suitable for children with vasovagal syncope...
  70. doi request reprint The value of acetylcholine receptor antibody in children with postural tachycardia syndrome
    Jiawei Li
    Department of Pediatrics, Peking University First Hospital, Xi An Men Street No 1, West District, Beijing, 100034, China
    Pediatr Cardiol 36:165-70. 2015
    ..658-74.911) were independent risk factors for POTS with AChR-ab positive. In conclusion, POTS with positive AChR-ab was a heterogeneous disorder. Preceding infection, syncope and fatigue were their main clinical characteristics...
  71. doi request reprint Endogeous sulfur dioxide protects against oleic acid-induced acute lung injury in association with inhibition of oxidative stress in rats
    Siyao Chen
    Department of Pediatrics, Peking University First Hospital, Beijing, China
    Lab Invest 95:142-56. 2015
    ..The results suggest that SO2/AAT1/AAT2 pathway might protect against the development of OA-induced ALI by inhibiting oxidative stress. ..
  72. doi request reprint Hydrogen sulfide upregulates KATP channel expression in vascular smooth muscle cells of spontaneously hypertensive rats
    Yan Sun
    Department of Pediatrics, Peking University First Hospital, Xi An Men Street No 1, West District, Beijing, 100034, China
    J Mol Med (Berl) 93:439-55. 2015
    ..1 promoters...
  73. doi request reprint Usefulness of plasma copeptin as a biomarker to predict the therapeutic effectiveness of metoprolol for postural tachycardia syndrome in children
    Juan Zhao
    Department of Pediatrics, Peking University First Hospital, Beijing, PR China
    Am J Cardiol 114:601-5. 2014
    ..6% in predicting the efficacy of metoprolol in children with POTS. In conclusion, the baseline plasma copeptin level can be used as a biomarker to predict the therapeutic effectiveness of metoprolol in children with POTS. ..
  74. doi request reprint A clinical manifestation-based prediction of haemodynamic patterns of orthostatic intolerance in children: a multi-centre study
    Li Chen
    1Department of Pediatrics, Peking University First Hospital, Beijing, China
    Cardiol Young 24:649-53. 2014
    ..Thus, it is important to find objective and safe methods to differentiate haemodynamic patterns of orthostatic intolerance cases...
  75. ncbi request reprint Changes of atrial natriuretic peptide and antidiuretic hormone in children with postural tachycardia syndrome and orthostatic hypertension: a case control study
    Juan Zhao
    Department of Pediatrics, Peking University First Hospital, Beijing 100034, China
    Chin Med J (Engl) 127:1853-7. 2014
    ....
  76. doi request reprint Hydrogen sulfide regulates cardiac sarcoplasmic reticulum Ca(2+) uptake via K(ATP) channel and PI3K/Akt pathway
    Yu Chen
    Department of Physiology and Pathophysiology, School of Basic Medical Science, Peking University, PR China
    Life Sci 91:271-8. 2012
    ..To investigate the effects of hydrogen sulfide (H(2)S) on calcium uptake activity of the rat cardiac sarcoplasmic reticulum (SR) and possible signaling...
  77. ncbi request reprint [The expression of the apoptosis-related genes in calcified vessels]
    Baohong Zhang
    Department of Pediatrics, Peking University First Hospital, Beijing 100034, China
    Beijing Da Xue Xue Bao 35:45-9. 2003
    ..To observe the expression of the apoptosis genes in calcified vessels...
  78. ncbi request reprint Changes of heme oxygenase-carbon monoxide system in vascular calcification in rats
    Baohong Zhang
    Department of Pediatrics, First Hospital, Peking University, Beijing 100034, PR China
    Life Sci 72:1027-37. 2003
    ..Expressions of HO-1 protein and mRNA were significantly decreased compared to control rats. Vascular calcification might induce a down regulation in vascular HO-CO-cGMP pathway...
  79. ncbi request reprint [Effects of hypoxia on heme oxygenase/carbon monoxide and type I collagen in pulmonary artery smooth muscle cells of rats]
    Limin Gong
    Department of Pediatrics, Peking University First Hospital, Beijing 100034 China
    Beijing Da Xue Xue Bao 35:571-5. 2003
    ..To explore changes of expression of heme oxygenase (HO) and production of endogenous carbon monoxide in hypoxic pulmonary artery smooth muscle cells (PASMCs) of rats and study their effects on type I collagen under hypoxia...
  80. doi request reprint Fluorescent probe for highly selective and sensitive detection of hydrogen sulfide in living cells and cardiac tissues
    Bifeng Chen
    State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, No 38 Xueyuan Rd, Beijing 100191, China
    Analyst 138:946-51. 2013
    ..Further in situ visualization of endogenous H(2)S was realized in cardiac tissues of normal rats and atherosclerosis (AS) rats...
  81. doi request reprint Twenty-four-hour urinary sodium excretion and postural orthostatic tachycardia syndrome
    Qingyou Zhang
    Department of Pediatrics, Peking University First Hospital, Beijing, China
    J Pediatr 161:281-4. 2012
    ..To investigate whether 24-hour urinary sodium excretion could be an indicator of the effectiveness of salt supplementation in children with postural orthostatic tachycardia syndrome (POTS)...
  82. doi request reprint The diagnostic protocol in children and adolescents with syncope: a multi-centre prospective study
    Qingyou Zhang
    Department of Pediatrics, Peking University First Hospital, Beijing, China
    Acta Paediatr 98:879-84. 2009
    ..The appropriate diagnostic protocol for children with syncope has not been well established. A diagnostic protocol was developed and prospectively implemented to improve the diagnostic performance of paediatricians...
  83. ncbi request reprint Sulfur dioxide: a novel gaseous signal in the regulation of cardiovascular functions
    Die Liu
    Department of Pediatrics, Peking University First Hospital, Beijing, 100034, P R China
    Mini Rev Med Chem 10:1039-45. 2010
    ..These discoveries suggest a novel role of endogenous SO(2) in the modulation of the cardiovascular system and provide a basis for new treatments for cardiovascular diseases...
  84. doi request reprint Risk factors for dyslipidemia in Chinese children
    Ying Liao
    Department of Pediatrics, Peking University First Hospital, Beijing 100034, People Republic of China
    Acta Paediatr 97:1449-53. 2008
    ..We aimed to study the risk factors of dyslipidemia in Chinese children...
  85. ncbi request reprint Meta-analysis of randomized controlled trials on treatment of pulmonary arterial hypertension
    Bing He
    Department of Pediatrics, Renmin Hospital of Wuhan University, Wuhan, China
    Circ J 74:1458-64. 2010
    ..The aim of the present meta-analysis was to evaluate the efficacy and safety of treating pulmonary arterial hypertension (PAH) with inhaled iloprost, oral bosentan and sildenafil...
  86. ncbi request reprint Hydrogen sulfide may improve the hippocampal damage induced by recurrent febrile seizures in rats
    Ying Han
    Department of Pediatrics, Peking University First Hospital, PR China
    Biochem Biophys Res Commun 327:431-6. 2005
    ..The results showed that endogenous H(2)S system was involved in the development of FS. Exogenous H(2)S may exert beneficial effect on the pathogenesis of FS-related brain damage...
  87. doi request reprint Plasma copeptin and therapeutic effectiveness of midodrine hydrochloride on postural tachycardia syndrome in children
    Juan Zhao
    Department of Pediatrics, Peking University First Hospital, Beijing, P R China
    J Pediatr 165:290-294.e1. 2014
    ..This study was designed to explore the changes in plasma copeptin and its predictive value in assessing the therapeutic efficacy of midodrine hydrochloride in children with POTS...
  88. ncbi request reprint Effect of chronic hypoxia on contents of urotensin II and its functional receptors in rat myocardium
    Yonggang Zhang
    Institute of Cardiovascular Research, First Hospital, Peking University, Beijing, People s Republic of China
    Heart Vessels 16:64-8. 2002
    ....
  89. doi request reprint Regulatory effects of hydrogen sulfide on IL-6, IL-8 and IL-10 levels in the plasma and pulmonary tissue of rats with acute lung injury
    Tianshui Li
    Department of Pediatrics, Peking University First Hospital, West District, Beijing 100034, China
    Exp Biol Med (Maywood) 233:1081-7. 2008
    ..Thus, the down-regulation of endogenous H2S production might be involved in the pathogenesis of OA-induced ALI in rats...
  90. pmc Epidemiology and clinical management of pulmonary hypertension in children
    Hongfang Jin
    Department of Pediatrics, Peking University First Hospital, Beijing, China
    Korean Circ J 42:513-8. 2012
    ..This article reviewed recently published researches, as well as presented a comprehensive understanding of PH, including definition, classification, epidemiology, prognosis and treatment...
  91. ncbi request reprint Hydrogen sulfide as a new endogenous gaseous transmitter in the cardiovascular system
    Chaoshu Tang
    Institute of Cardiovascular Research, Peking University First Hospital, Beijing, People s Republic of China
    Curr Vasc Pharmacol 4:17-22. 2006
    ..The genomic basis of cystathioninuria in humans is 2 nonsense and 2 sense mutations in CSE. This review reveals that H(2)S is a new endogenous gaseous transmitter in the cardiovascular system...
  92. doi request reprint alpha-Adrenoceptor agonists for the treatment of vasovagal syncope: a meta-analysis of worldwide published data
    Ying Liao
    Department of Pediatrics, Peking University First Hospital, Beijing, China
    Acta Paediatr 98:1194-200. 2009
    ..The present study was aimed at evaluating present randomized controlled trials (RCTs) regarding the effect of alpha-adrenoceptor agonists on vasovagal syncope (VVS)...
  93. ncbi request reprint Effect of homocysteine on the L-arginine/nitric oxide synthase/nitric oxide pathway in human platelets
    Juxiang Li
    Department of Physiology and Pathophysiology, Health Science Center, Peking University, Beijing, People s Republic of China
    Heart Vessels 16:46-50. 2002
    ..These observations indicate that the L-arginine/NO pathway is involved in the mechanism responsible for the effects of HCY on platelets by diminishing NO production through decreased uptake of L-arginin..
  94. ncbi request reprint Aetiologic and clinical characteristics of syncope in Chinese children
    Li Chen
    Department of Pediatrics, Peking University First Hospital, Beijing, China
    Acta Paediatr 96:1505-10. 2007
    ..This study aimed to improve diagnostic efficacy of syncope in children by analyzing the aetiology and clinical characteristics of syncope in Chinese children...