Heping Cheng

Summary

Affiliation: Peking University
Country: China

Publications

  1. doi request reprint Calcium sparks
    Heping Cheng
    Institute of Molecular Medicine, National Laboratory of Biomembrane and Membrane Biotechnology, Peking University, Beijing, China
    Physiol Rev 88:1491-545. 2008
  2. pmc Superoxide flashes in single mitochondria
    Wang Wang
    Laboratories of Cardiovascular Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Cell 134:279-90. 2008
  3. pmc Imaging ROS signaling in cells and animals
    Xianhua Wang
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Molecular Medicine, Peking Tsinghua Center for Life Sciences, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University, Beijing 100871, China
    J Mol Med (Berl) 91:917-27. 2013
  4. pmc Synergistic triggering of superoxide flashes by mitochondrial Ca2+ uniport and basal reactive oxygen species elevation
    Tingting Hou
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Molecular Medicine, Peking Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
    J Biol Chem 288:4602-12. 2013
  5. doi request reprint Β-adrenergic-stimulated L-type channel Ca²+ entry mediates hypoxic Ca²+ overload in intact heart
    Huiliang Zhang
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
    J Mol Cell Cardiol 65:51-8. 2013
  6. doi request reprint Superoxide flashes: elemental events of mitochondrial ROS signaling in the heart
    Xianhua Wang
    Institute of Molecular Medicine and State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
    J Mol Cell Cardiol 52:940-8. 2012
  7. pmc Superoxide flashes reveal novel properties of mitochondrial reactive oxygen species excitability in cardiomyocytes
    Kaitao Li
    Institute of Molecular Medicine and State Key Laboratory of Biomembrane and Membrane Biotechnology, Center for Life Sciences, Peking University, Beijing, China
    Biophys J 102:1011-21. 2012
  8. doi request reprint Imaging Ca2+ nanosparks in heart with a new targeted biosensor
    Wei Shang
    From the State Key Laboratory of Biomembrane and Membrane Biotechnology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking Tsinghua Center for Life Sciences W S, F L, T S, J X, Y W, G W, L C, X W, H C and State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Science L L L, S Q W, Peking University, Beijing, China and Department of Physiology and Pharmacology, University of Bristol, City of Bristol, United Kingdom M B C
    Circ Res 114:412-20. 2014
  9. doi request reprint ROS regulation of microdomain Ca(2+) signalling at the dyads
    Huiliang Zhang
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking Tsinghua Center for Life Sciences, Institute of Molecular Medicine, Peking University, Beijing 100871, China
    Cardiovasc Res 98:248-58. 2013
  10. doi request reprint Calcium gradients underlying cell migration
    Chaoliang Wei
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Center for Life Sciences, The Institute of Molecular Medicine, Peking University, Beijing 100871, China
    Curr Opin Cell Biol 24:254-61. 2012

Collaborators

Detail Information

Publications43

  1. doi request reprint Calcium sparks
    Heping Cheng
    Institute of Molecular Medicine, National Laboratory of Biomembrane and Membrane Biotechnology, Peking University, Beijing, China
    Physiol Rev 88:1491-545. 2008
    ..These recent advances in "sparkology" thus promise to unify the simplicity and complexity of Ca(2+) signaling in biology...
  2. pmc Superoxide flashes in single mitochondria
    Wang Wang
    Laboratories of Cardiovascular Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Cell 134:279-90. 2008
    ..We propose that superoxide flashes could serve as a valuable biomarker for a wide variety of oxidative stress-related diseases...
  3. pmc Imaging ROS signaling in cells and animals
    Xianhua Wang
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Molecular Medicine, Peking Tsinghua Center for Life Sciences, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University, Beijing 100871, China
    J Mol Med (Berl) 91:917-27. 2013
    ..This review aims at providing an update of the current status in ROS imaging, while identifying areas of insufficient knowledge and highlighting emerging research directions. ..
  4. pmc Synergistic triggering of superoxide flashes by mitochondrial Ca2+ uniport and basal reactive oxygen species elevation
    Tingting Hou
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Molecular Medicine, Peking Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
    J Biol Chem 288:4602-12. 2013
    ..Thus, physiological levels of mitochondrial Ca(2+) and ROS synergistically regulate stochastic mPTP opening and quantal ROS production in intact cells, marking the flash as a coincidence detector of mitochondrial Ca(2+) and ROS signals...
  5. doi request reprint Β-adrenergic-stimulated L-type channel Ca²+ entry mediates hypoxic Ca²+ overload in intact heart
    Huiliang Zhang
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
    J Mol Cell Cardiol 65:51-8. 2013
    ..Taken together, we conclude that Ca(2+) entry through β-adrenergic-stimulated LTCC underlies hypoxia-induced [Ca(2+)]i overload and the ensuing loss of mitochondrial function in intact heart...
  6. doi request reprint Superoxide flashes: elemental events of mitochondrial ROS signaling in the heart
    Xianhua Wang
    Institute of Molecular Medicine and State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
    J Mol Cell Cardiol 52:940-8. 2012
    ..Future investigation is warranted to uncover the cellular logic and molecular pathways of local dynamic mitoROS signaling in heart muscle cells and many other cell types...
  7. pmc Superoxide flashes reveal novel properties of mitochondrial reactive oxygen species excitability in cardiomyocytes
    Kaitao Li
    Institute of Molecular Medicine and State Key Laboratory of Biomembrane and Membrane Biotechnology, Center for Life Sciences, Peking University, Beijing, China
    Biophys J 102:1011-21. 2012
    ..We propose that superoxide flash production is a regenerative process dominated by stochastic, autonomous recruitment of a limited number of units (e.g., mPTPs) in single mitochondria...
  8. doi request reprint Imaging Ca2+ nanosparks in heart with a new targeted biosensor
    Wei Shang
    From the State Key Laboratory of Biomembrane and Membrane Biotechnology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking Tsinghua Center for Life Sciences W S, F L, T S, J X, Y W, G W, L C, X W, H C and State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Science L L L, S Q W, Peking University, Beijing, China and Department of Physiology and Pharmacology, University of Bristol, City of Bristol, United Kingdom M B C
    Circ Res 114:412-20. 2014
    ..Existing probes do not report such local Ca2+ signals because of probe diffusion, so a junction-targeted Ca2+ sensor should reveal new information on cardiac excitation-contraction coupling and its modification in disease states...
  9. doi request reprint ROS regulation of microdomain Ca(2+) signalling at the dyads
    Huiliang Zhang
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking Tsinghua Center for Life Sciences, Institute of Molecular Medicine, Peking University, Beijing 100871, China
    Cardiovasc Res 98:248-58. 2013
    ..These new understandings should be leveraged to harness ROS for their beneficial roles while avoiding deleterious effects in the heart...
  10. doi request reprint Calcium gradients underlying cell migration
    Chaoliang Wei
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Center for Life Sciences, The Institute of Molecular Medicine, Peking University, Beijing 100871, China
    Curr Opin Cell Biol 24:254-61. 2012
    ..These recent findings provide a glimpse into how spatiotemporally coordinated calcium gradients orchestrate cellular behavior as complex as directional movement...
  11. pmc Kissing and nanotunneling mediate intermitochondrial communication in the heart
    Xiaohu Huang
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Molecular Medicine, Peking Tsinghua Center for Life Sciences, and College of Engineering, Peking University, Beijing 100871, China
    Proc Natl Acad Sci U S A 110:2846-51. 2013
    ..We propose that, through kissing and nanotunneling, the otherwise static mitochondria in a cardiomyocyte form one dynamically continuous network to share content and transfer signals...
  12. pmc Rhesus macaques develop metabolic syndrome with reversible vascular dysfunction responsive to pioglitazone
    Xiuqin Zhang
    Institute of Molecular Medicine, Peking University, No 5 Yiheyuan Rd, Haidian District, Beijing 100871, China
    Circulation 124:77-86. 2011
    ....
  13. pmc Imaging superoxide flash and metabolism-coupled mitochondrial permeability transition in living animals
    Huaqiang Fang
    Institute of Molecular Medicine, College of Life Science, Peking University, Beijing 100871, China
    Cell Res 21:1295-304. 2011
    ....
  14. doi request reprint Regulation of superoxide flashes by transient and steady mitochondrial calcium elevations
    Chongshu Jian
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking Tsinghua Center for Life Sciences, Peking University, Beijing, 100871, China
    Sci China Life Sci 57:495-501. 2014
    ....
  15. pmc Overnutrition stimulates intestinal epithelium proliferation through β-catenin signaling in obese mice
    Jiaming Mao
    Institute of Molecular Medicine, Peking University, Beijing, China
    Diabetes 62:3736-46. 2013
    ..Manipulating the GSK-3β/β-catenin signaling pathway in intestinal epithelium might become a therapeutic intervention for obesity induced by overnutrition. ..
  16. doi request reprint Cardioprotection of ischemia/reperfusion injury by cholesterol-dependent MG53-mediated membrane repair
    Xianhua Wang
    Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University, Beijing, China
    Circ Res 107:76-83. 2010
    ..MG53, a newly identified striated muscle-specific protein, is involved in skeletal muscle membrane repair. But the role of MG53 in the heart has not been determined...
  17. pmc Central role of mitofusin 2 in autophagosome-lysosome fusion in cardiomyocytes
    Ting Zhao
    Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
    J Biol Chem 287:23615-25. 2012
    ....
  18. pmc A method to measure myocardial calcium handling in adult Drosophila
    Na Lin
    Institute of Molecular Medicine, Peking University, Beijing, China
    Circ Res 108:1306-15. 2011
    ..However, a genetically robust system for unbiased screens of mutations that affect Ca(2+) handling remains a challenge...
  19. pmc Beta-adrenergic signaling accelerates and synchronizes cardiac ryanodine receptor response to a single L-type Ca2+ channel
    Peng Zhou
    State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Peking University, Beijing 100871, China
    Proc Natl Acad Sci U S A 106:18028-33. 2009
    ..This molecular mechanism of sympathetic regulation will permit more fundamental studies of altered betaAR effects in cardiovascular diseases...
  20. pmc Cardioprotection by CaMKII-deltaB is mediated by phosphorylation of heat shock factor 1 and subsequent expression of inducible heat shock protein 70
    Wei Peng
    Institute of Molecular Medicine, Peking University, Beijing, People s Republic of China
    Circ Res 106:102-10. 2010
    ..Although previous studies have established an essential role of CaMKII-deltaC in cardiomyocyte apoptosis, the functional role of the more abundant isoform, CaMKII-deltaB, remains elusive...
  21. doi request reprint Flickering calcium microdomains signal turning of migrating cells
    Chaoliang Wei
    Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University, Beijing 100871, China
    Can J Physiol Pharmacol 88:105-10. 2010
    ..Furthermore, we present a new model for patterned calcium flicker activity as the mechanism for steering the turning of a migrating cell...
  22. ncbi request reprint Calmodulin regulation of excitation-contraction coupling in cardiac myocytes
    Dongmei Yang
    National Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Peking University, Beijing, China
    Circ Res 92:659-67. 2003
    ..A novel finding of this study is that expression of a Ca2+-insensitive CaM mutant can lead to activation of CaMKII in cardiac myocytes...
  23. ncbi request reprint Adaptive mechanisms of intracellular calcium homeostasis in mammalian hibernators
    Shi Qiang Wang
    National Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Peking University, Beijing 100871, China
    J Exp Biol 205:2957-62. 2002
    ..Understanding the adaptive mechanisms of Ca(2+) regulation in hibernating mammals may suggest new strategies to protect nonhibernator cells, including those of humans, from Ca(2+)-induced dysfunction...
  24. doi request reprint Rad as a novel regulator of excitation-contraction coupling and beta-adrenergic signaling in heart
    Gang Wang
    Institute of Molecular Medicine, College of Life Science, Peking University, Beijing, China
    Circ Res 106:317-27. 2010
    ..Emerging evidence suggests that Rad is an important player in cardiac arrhythmogenesis and hypertrophic remodeling. However, whether and how Rad involves in the regulation of excitation-contraction (EC) coupling is unknown...
  25. ncbi request reprint Bidirectional regulation of Ca2+ sparks by mitochondria-derived reactive oxygen species in cardiac myocytes
    Yuan Yan
    Institute of Molecular Medicine, National Laboratory of Biomembrane and Membrane Biotechnology, Peking University, Beijing 100871, China
    Cardiovasc Res 77:432-41. 2008
    ..The present study investigated whether and how mitochondria-derived ROS regulate Ca(2+) spark activity in intact cardiac myocytes...
  26. pmc Thermodynamically irreversible gating of ryanodine receptors in situ revealed by stereotyped duration of release in Ca(2+) sparks
    Shi Qiang Wang
    Laboratory of Cardiovascular Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Biophys J 83:242-51. 2002
    ..Modeling suggests that Ca(2+)-induced Ca(2+) release among adjacent RyRs may couple the external energy derived from Ca(2+) gradients across the SR to RyR gating in situ, and drive the irreversible generation of Ca(2+) sparks...
  27. ncbi request reprint Dysfunction of store-operated calcium channel in muscle cells lacking mg29
    Zui Pan
    Department of Physiology and Biophysics, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway NJ 08854, USA
    Nat Cell Biol 4:379-83. 2002
    ....
  28. ncbi request reprint Calcium signaling between sarcolemmal calcium channels and ryanodine receptors in heart cells
    Heping Cheng
    Laboratory of Cardiovascular Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Front Biosci 7:d1867-78. 2002
    ..The local stability of CICR is insured because of strong, use-dependent inactivation of RyRs, that terminates Ca2+ sparks and confers persistent local SR refractoriness...
  29. ncbi request reprint Ca(2+) signaling in cardiac myocytes overexpressing the alpha(1) subunit of L-type Ca(2+) channel
    Long Sheng Song
    Laboratory of Cardiovascular Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Circ Res 90:174-81. 2002
    ..These results also suggest that a modest but sustained increase in Ca(2+) influx triggers a coordinated remodeling of Ca(2+) handling to maintain Ca(2+) homeostasis...
  30. pmc p38 Mitogen-activated protein kinase mediates a negative inotropic effect in cardiac myocytes
    Pu Liao
    Department of Physiology, School of Medicine, University of Maryland, Baltimore, MD 21224, USA
    Circ Res 90:190-6. 2002
    ..These findings reveal a novel function of p38 MAPK and shed a new light on our understanding of the coincidence of p38 MAPK activation and the onset of heart failure...
  31. pmc Polymorphism of Ca2+ sparks evoked from in-focus Ca2+ release units in cardiac myocytes
    Jian Xin Shen
    Department of Physiology, Medical School of Xi an Jiaotong University, Xi an 710061, China
    Biophys J 86:182-90. 2004
    ....
  32. ncbi request reprint Imaging microdomain Ca2+ in muscle cells
    Shi Qiang Wang
    Laboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD 21224, USA
    Circ Res 94:1011-22. 2004
    ..In addition, microdomain Ca2+ imaging offers a novel modality that complements electrophysiological approaches in characterizing Ca2+ channels in intact cells...
  33. ncbi request reprint Sustained beta1-adrenergic stimulation modulates cardiac contractility by Ca2+/calmodulin kinase signaling pathway
    Wang Wang
    Laboratory of Cardiovascular Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Circ Res 95:798-806. 2004
    ..This finding may bear important etiological and therapeutical ramifications in understanding beta1AR signaling in chronic heart failure...
  34. pmc Ca2+ blinks: rapid nanoscopic store calcium signaling
    Didier X P Brochet
    Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 102:3099-104. 2005
    ..Visualization of local store Ca(2+) signaling thus broadens our understanding of cardiac store Ca(2+) regulation and function and opens the possibility for local regulation of diverse store-dependent functions...
  35. pmc Nuclear Ca2+ sparks and waves mediated by inositol 1,4,5-trisphosphate receptors in neonatal rat cardiomyocytes
    Dali Luo
    Department of Pharmacology, School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China
    Cell Calcium 43:165-74. 2008
    ....
  36. pmc Orphaned ryanodine receptors in the failing heart
    Long Sheng Song
    Medical Biotechnology Center, University of Maryland Biotechnology Institute, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 103:4305-10. 2006
    ..We conclude that the increased spatial dispersion of the TTs and orphaned RyRs lead to the loss of local control and Ca(2+) instability in heart failure...
  37. ncbi request reprint Ca2+/calmodulin kinase II-dependent phosphorylation of ryanodine receptors suppresses Ca2+ sparks and Ca2+ waves in cardiac myocytes
    Dongmei Yang
    Laboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD 21224, USA
    Circ Res 100:399-407. 2007
    ....
  38. pmc Ser-2030, but not Ser-2808, is the major phosphorylation site in cardiac ryanodine receptors responding to protein kinase A activation upon beta-adrenergic stimulation in normal and failing hearts
    Bailong Xiao
    Cardiovascular Research Group, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
    Biochem J 396:7-16. 2006
    ..Our results also suggest that phosphorylation of RyR2 at Ser-2030 may be an important event associated with altered Ca2+ handling and cardiac arrhythmia that is commonly observed in heart failure upon beta-adrenergic stimulation...
  39. ncbi request reprint High basal protein kinase A-dependent phosphorylation drives rhythmic internal Ca2+ store oscillations and spontaneous beating of cardiac pacemaker cells
    Tatiana M Vinogradova
    Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, NIH, Baltimore, MD 21224 6825, USA
    Circ Res 98:505-14. 2006
    ....
  40. ncbi request reprint Paradoxical cellular Ca2+ signaling in severe but compensated canine left ventricular hypertrophy
    Long Sheng Song
    Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Circ Res 97:457-64. 2005
    ..We conclude that severe LVH with compensation masks cellular and subcellular Ca2+ defects that remain likely contributors to the limited contractile reserve of LVH...
  41. ncbi request reprint Uncontrolled calcium sparks act as a dystrophic signal for mammalian skeletal muscle
    Xu Wang
    Department of Physiology and Biophysics, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Nat Cell Biol 7:525-30. 2005
    ....
  42. pmc Systemic ablation of RyR3 alters Ca2+ spark signaling in adult skeletal muscle
    Noah Weisleder
    Department of Physiology and Biophysics, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, United States
    Cell Calcium 42:548-55. 2007
    ....